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ATE231505T1 - Neue heterocyclische/cyclische amine - Google Patents

Neue heterocyclische/cyclische amine

Info

Publication number
ATE231505T1
ATE231505T1 AT92921695T AT92921695T ATE231505T1 AT E231505 T1 ATE231505 T1 AT E231505T1 AT 92921695 T AT92921695 T AT 92921695T AT 92921695 T AT92921695 T AT 92921695T AT E231505 T1 ATE231505 T1 AT E231505T1
Authority
AT
Austria
Prior art keywords
cyclic amine
new heterocyclic
compounds
formula
heterocyclic
Prior art date
Application number
AT92921695T
Other languages
English (en)
Inventor
Anabella Villalobos
Arthur Adam Nagel
Yuhpyng Liang Chen
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of ATE231505T1 publication Critical patent/ATE231505T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
AT92921695T 1991-03-28 1992-03-09 Neue heterocyclische/cyclische amine ATE231505T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67691891A 1991-03-28 1991-03-28
PCT/US1992/001605 WO1992017475A1 (en) 1991-03-28 1992-03-09 Heterocyclic-cyclic amine derivatives

Publications (1)

Publication Number Publication Date
ATE231505T1 true ATE231505T1 (de) 2003-02-15

Family

ID=24716559

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92921695T ATE231505T1 (de) 1991-03-28 1992-03-09 Neue heterocyclische/cyclische amine

Country Status (29)

Country Link
EP (1) EP0646115B1 (de)
JP (3) JP2659107B2 (de)
KR (1) KR0179054B1 (de)
CN (1) CN1044242C (de)
AT (1) ATE231505T1 (de)
AU (2) AU658194B2 (de)
BR (1) BR9205811A (de)
CA (2) CA2195129C (de)
CZ (1) CZ289756B6 (de)
DE (1) DE69232907T2 (de)
DK (1) DK0646115T3 (de)
EG (1) EG20281A (de)
ES (1) ES2188584T3 (de)
FI (1) FI934223A (de)
HU (1) HU225047B1 (de)
IE (1) IE920980A1 (de)
IL (3) IL101327A (de)
MX (1) MX9201419A (de)
MY (1) MY108885A (de)
NO (1) NO304071B1 (de)
NZ (3) NZ250987A (de)
PL (3) PL170567B1 (de)
PT (1) PT100300B (de)
RU (1) RU2119920C1 (de)
SG (1) SG49055A1 (de)
UA (1) UA45944C2 (de)
WO (1) WO1992017475A1 (de)
YU (1) YU31392A (de)
ZA (1) ZA922239B (de)

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US5494908A (en) * 1992-11-23 1996-02-27 Hoechst-Roussel Pharmaceutical Incorporated Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
NZ258747A (en) * 1992-11-23 1997-02-24 Hoechst Marion Roussel Inc Sub 3-heterocyclyalkylamino benzisoxazole derivatives; medicaments
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AU4859596A (en) * 1995-02-15 1996-09-04 Pharmacia & Upjohn Company Imidazo{1,2-a}pyridines for the treatment of cns and cardiac diseases
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DK0833820T3 (da) * 1995-06-06 2001-04-17 Aventis Pharma Inc Benzisoxazol- og indazolderivater som antipsykotiske midler
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GB9914486D0 (en) 1999-06-21 1999-08-18 Smithkline Beecham Plc Medicaments
GB9917406D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
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ES2284519T3 (es) 1999-09-01 2007-11-16 EISAI R&D MANAGEMENT CO., LTD. Derivados de piperidina 4-sustituida.
US6906083B2 (en) 2000-06-21 2005-06-14 Eisai Co., Ltd. 4-substituted piperidine compound
EP1609783A1 (de) * 2004-06-17 2005-12-28 Neuropharma S.A.U. Marine verbindungen mit kalzium-kanal-blockierende eigenschaften zur behandlung der alzheimer-krankheit
DE102005038947A1 (de) * 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
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BRPI0919844A2 (pt) 2008-09-26 2019-09-24 Boehringer Ingelheim Int compostos de azaindazol como antagonistas do receptor ccr1
AU2009325902B2 (en) * 2008-12-12 2015-01-29 Idorsia Pharmaceuticals Ltd 5-amino-2-(1-hydroxy-ethyl)-tetrahydropyran derivatives
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JP5542214B2 (ja) 2009-10-27 2014-07-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ccr1受容体アンタゴニストとしての複素環化合物
CN102905532A (zh) 2010-02-09 2013-01-30 约翰斯.霍普金斯大学 用于改善认知功能的方法和组合物
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JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
CN104837836B (zh) * 2012-11-21 2018-07-03 拉夸里亚创药株式会社 多晶型物
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Also Published As

Publication number Publication date
JP2000154185A (ja) 2000-06-06
WO1992017475A1 (en) 1992-10-15
PL171914B1 (pl) 1997-06-30
JPH10158264A (ja) 1998-06-16
CA2107105A1 (en) 1992-09-29
EP0646115A1 (de) 1995-04-05
NO304071B1 (no) 1998-10-19
PT100300A (pt) 1993-08-31
CN1044242C (zh) 1999-07-21
IE920980A1 (en) 1992-10-07
DE69232907T2 (de) 2003-05-15
ZA922239B (en) 1993-09-27
PL170567B1 (pl) 1997-01-31
AU674477B2 (en) 1996-12-19
CN1065267A (zh) 1992-10-14
CA2107105C (en) 2003-10-07
IL101327A0 (en) 1992-11-15
CZ289756B6 (cs) 2002-04-17
EG20281A (en) 1998-07-30
NZ248946A (en) 1995-04-27
IL116122A0 (en) 1996-01-31
ES2188584T3 (es) 2003-07-01
IL116122A (en) 1998-10-30
JP2659107B2 (ja) 1997-09-30
HU9302733D0 (en) 1993-12-28
AU1878292A (en) 1992-11-02
SG49055A1 (en) 1998-05-18
IL101327A (en) 1998-06-15
RU2119920C1 (ru) 1998-10-10
NO933445D0 (no) 1993-09-27
NZ250987A (en) 1997-06-24
AU2178895A (en) 1995-09-07
FI934223A0 (fi) 1993-09-27
HUT68357A (en) 1995-06-28
DK0646115T3 (da) 2003-04-22
MY108885A (en) 1996-11-30
CA2195129A1 (en) 1992-09-29
HU225047B1 (en) 2006-05-29
BR9205811A (pt) 1994-06-28
DE69232907D1 (de) 2003-02-27
YU31392A (sh) 1994-12-28
CZ395892A3 (en) 1994-04-13
KR0179054B1 (en) 1999-03-20
EP0646115B1 (de) 2003-01-22
MX9201419A (es) 1992-10-01
UA45944C2 (uk) 2002-05-15
JP3051076B2 (ja) 2000-06-12
FI934223A (fi) 1993-09-27
PL171915B1 (pl) 1997-06-30
NO933445L (no) 1993-09-27
NZ242151A (en) 1994-10-26
AU658194B2 (en) 1995-04-06
PT100300B (pt) 1999-09-30
JPH06500794A (ja) 1994-01-27
CA2195129C (en) 2002-09-10

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