ATE229945T1 - Zur behandlung von cmv infektionen geeignete 1,3, 4-thiadiazole - Google Patents
Zur behandlung von cmv infektionen geeignete 1,3, 4-thiadiazoleInfo
- Publication number
- ATE229945T1 ATE229945T1 AT99912221T AT99912221T ATE229945T1 AT E229945 T1 ATE229945 T1 AT E229945T1 AT 99912221 T AT99912221 T AT 99912221T AT 99912221 T AT99912221 T AT 99912221T AT E229945 T1 ATE229945 T1 AT E229945T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- cmv infections
- thiadiazoles
- cmv
- thiadiazoles suitable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7852898P | 1998-03-19 | 1998-03-19 | |
| PCT/US1999/003744 WO1999047507A2 (en) | 1998-03-19 | 1999-03-16 | 1,3,4-thiadiazoles useful for the treatment of cmv infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE229945T1 true ATE229945T1 (de) | 2003-01-15 |
Family
ID=22144610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99912221T ATE229945T1 (de) | 1998-03-19 | 1999-03-16 | Zur behandlung von cmv infektionen geeignete 1,3, 4-thiadiazole |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6150385A (de) |
| EP (1) | EP1064273B1 (de) |
| JP (1) | JP2002506858A (de) |
| AT (1) | ATE229945T1 (de) |
| AU (1) | AU743489B2 (de) |
| CA (1) | CA2320167A1 (de) |
| DE (1) | DE69904576T2 (de) |
| DK (1) | DK1064273T3 (de) |
| ES (1) | ES2189404T3 (de) |
| NZ (1) | NZ507032A (de) |
| WO (1) | WO1999047507A2 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE50008597D1 (de) | 1999-03-08 | 2004-12-16 | Bayer Healthcare Ag | Thiazolylharnstoff-derivate und ihre verwendung als antivirale mittel |
| DOP2000000109A (es) | 1999-12-23 | 2002-08-30 | Gerald Kleymann | Derivados de tiazolilamida |
| DE10129714A1 (de) | 2001-06-22 | 2003-01-02 | Bayer Ag | Topische Anwendung von Thiazolylamiden |
| CA2468544A1 (en) * | 2001-12-10 | 2003-06-19 | Amgen Inc. | Vanilloid receptor ligands |
| US7390813B1 (en) | 2001-12-21 | 2008-06-24 | Xenon Pharmaceuticals Inc. | Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents |
| DK1648874T3 (da) | 2003-07-30 | 2012-01-23 | Xenon Pharmaceuticals Inc | Piperazinderivater samt deres anvendelse som terapeutisk aktive stoffer |
| WO2005072731A1 (en) * | 2004-01-29 | 2005-08-11 | X-Ceptor Therapeutics, Inc. | 3-phenyl-n- ((1, 3, 4) thiadiazol-2-yl) -acrylamide derivatives and related compounds as modulators of estrogen-related receptors for the treatment of e.g. cancer, rheumatoid arthritis or neurological disorders |
| EP1830837B1 (de) * | 2004-09-20 | 2013-09-04 | Xenon Pharmaceuticals Inc. | Heterozyklische derivate zur behandlung von durch stearoyl-coa-desaturase-enzymen verursachte krankheiten |
| WO2006034341A2 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
| MX2007003332A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa. |
| EP1799668A1 (de) | 2004-09-20 | 2007-06-27 | Xenon Pharmaceuticals Inc. | Heterozyklische derivate und ihre verwendung als stearoyl-coa-desaturase-mediatoren |
| BRPI0515488A (pt) | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados de heterocìclicos e seu uso como agentes terapêuticos |
| BRPI0515505A (pt) | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e sua utilização como inibidores da estearoil-coa desaturase |
| US7592343B2 (en) | 2004-09-20 | 2009-09-22 | Xenon Pharmaceuticals Inc. | Pyridazine-piperazine compounds and their use as stearoyl-CoA desaturase inhibitors |
| DE102005014248A1 (de) | 2005-03-30 | 2006-10-05 | Aicuris Gmbh & Co. Kg | Pharmazeutische Zubereitung von N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamid |
| AU2006235759B2 (en) * | 2005-04-06 | 2011-07-28 | Msd K.K. | 1,4-substituted piperazine derivative |
| BRPI0611187A2 (pt) | 2005-06-03 | 2010-08-24 | Xenon Pharmaceuticals Inc | derivados aminotiazàis como inibidores da estearoil-coa desaturase humana |
| EP2086970B1 (de) | 2006-08-24 | 2014-02-26 | Novartis AG | 2-(pyrazin-2-yl)-thiazol und 2-(1h pyrazol-3-yl)-thiazol derivate und verwandte verbindungen als stearoyl-coa desaturase (scd) inhibitoren zur behandlung von stoffwechsel-, herzkreislauf- und anderen erkrankungen |
| CA2711678A1 (en) | 2008-01-09 | 2009-07-16 | Molecular Insight Pharmaceuticals, Inc. | Inhibitors of carbonic anhydrase ix |
| US8562945B2 (en) | 2008-01-09 | 2013-10-22 | Molecular Insight Pharmaceuticals, Inc. | Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof |
| FR2945289A1 (fr) | 2009-05-11 | 2010-11-12 | Sanofi Aventis | Derives de 2-cycloamino-5-(pyridin-4-yl)imidazo°2,1-b! °1,3,4!thiadiazole, leur preparation et leur application en therapeutique |
| AU2010260195B2 (en) | 2009-06-15 | 2014-11-20 | Molecular Insight Pharmaceuticals, Inc. | Process for production of heterodimers of glutamic acid |
| WO2011143466A1 (en) | 2010-05-12 | 2011-11-17 | Vanderbilt University | Heterocyclic sulfone mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| RU2448961C1 (ru) * | 2011-02-03 | 2012-04-27 | Открытое акционерное общество "Всероссийский научный центр по безопасности биологически активных веществ" (ОАО "ВНЦ БАВ") | Фармацевтическая композиция, обладающая противовоспалительной, бронхолитической, противотуберкулезной активностями |
| AU2013207486A1 (en) | 2012-01-06 | 2014-08-21 | Molecular Insight Pharmaceuticals | Metal complexes of poly(carboxyl)amine-containing ligands having an affinity for carbonic anhydrase IX |
| JP6237779B2 (ja) * | 2012-11-03 | 2017-11-29 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | サイトメガロウイルスの阻害薬 |
| JP6468602B2 (ja) | 2013-01-14 | 2019-02-13 | モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド | トリアジン系放射性医薬品及び放射線造影剤 |
| AU2017245679B2 (en) | 2016-04-06 | 2021-07-01 | Innovative Molecules Gmbh | Aminothiazole derivatives useful as antiviral agents |
| HUE061307T2 (hu) | 2017-10-05 | 2023-06-28 | Innovative Molecules Gmbh | Szubsztituált tiazolok enantiomerei mint vírusellenes vegyületek |
| JP7273951B2 (ja) | 2018-09-12 | 2023-05-15 | ノバルティス アーゲー | 抗ウイルス性ピリドピラジンジオン化合物 |
| KR20220070005A (ko) | 2019-09-26 | 2022-05-27 | 노파르티스 아게 | 항바이러스성 피라졸로피리디논 화합물 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT8148047A0 (it) * | 1981-03-18 | 1981-03-18 | Manetti & Roberts Italo Brit | Composti organici derivati da 2-ami no-5-(o-solfamidofenil)-1,3,4-tiadiazolo loro applicazione terapeutica e procedimento per la loro preparazione |
| CA1307222C (en) * | 1985-12-16 | 1992-09-08 | Eli Lilly And Company | Thiadiazole antiviral agents |
| EP0591486A1 (de) * | 1992-04-22 | 1994-04-13 | PEUSCHEL, Karin, Elisabeth | Immunaktivierende und damit antivirale wirking von 4- 3-(subst.-amino)-2-hydroxypropoxy]-1,2,5-thiadiazolverbindungen |
| JPH07149748A (ja) * | 1993-09-30 | 1995-06-13 | Souyaku Gijutsu Kenkyusho:Kk | チアジアゾール誘導体及びその製造法 |
| JPH07188017A (ja) * | 1993-09-30 | 1995-07-25 | Souyaku Gijutsu Kenkyusho:Kk | チアジアゾール誘導体を含有する抗ウイルス剤 |
| WO1996009296A1 (fr) * | 1994-09-22 | 1996-03-28 | Rational Drug Design Laboratories | Derive d'arylthiadiazole et agent antiviral le contenant |
-
1999
- 1999-03-16 AT AT99912221T patent/ATE229945T1/de not_active IP Right Cessation
- 1999-03-16 DK DK99912221T patent/DK1064273T3/da active
- 1999-03-16 DE DE69904576T patent/DE69904576T2/de not_active Expired - Fee Related
- 1999-03-16 JP JP2000536704A patent/JP2002506858A/ja active Pending
- 1999-03-16 US US09/270,429 patent/US6150385A/en not_active Expired - Fee Related
- 1999-03-16 NZ NZ507032A patent/NZ507032A/xx unknown
- 1999-03-16 EP EP99912221A patent/EP1064273B1/de not_active Expired - Lifetime
- 1999-03-16 AU AU30639/99A patent/AU743489B2/en not_active Ceased
- 1999-03-16 CA CA002320167A patent/CA2320167A1/en not_active Abandoned
- 1999-03-16 WO PCT/US1999/003744 patent/WO1999047507A2/en active IP Right Grant
- 1999-03-16 ES ES99912221T patent/ES2189404T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1064273A2 (de) | 2001-01-03 |
| JP2002506858A (ja) | 2002-03-05 |
| US6150385A (en) | 2000-11-21 |
| NZ507032A (en) | 2003-06-30 |
| DK1064273T3 (da) | 2003-03-31 |
| WO1999047507A2 (en) | 1999-09-23 |
| DE69904576T2 (de) | 2003-07-10 |
| WO1999047507A3 (en) | 1999-12-09 |
| EP1064273B1 (de) | 2002-12-18 |
| AU743489B2 (en) | 2002-01-24 |
| AU3063999A (en) | 1999-10-11 |
| CA2320167A1 (en) | 1999-09-23 |
| DE69904576D1 (de) | 2003-01-30 |
| ES2189404T3 (es) | 2003-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1064273 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |