ATE221080T1 - Serine-protease-inhibitoren - Google Patents
Serine-protease-inhibitorenInfo
- Publication number
- ATE221080T1 ATE221080T1 AT97905099T AT97905099T ATE221080T1 AT E221080 T1 ATE221080 T1 AT E221080T1 AT 97905099 T AT97905099 T AT 97905099T AT 97905099 T AT97905099 T AT 97905099T AT E221080 T1 ATE221080 T1 AT E221080T1
- Authority
- AT
- Austria
- Prior art keywords
- protease inhibitors
- serine protease
- serine
- inhibitors
- protease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96200543 | 1996-03-01 | ||
PCT/EP1997/000938 WO1997031937A1 (en) | 1996-03-01 | 1997-02-26 | Serine protease inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE221080T1 true ATE221080T1 (de) | 2002-08-15 |
Family
ID=8223736
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97905099T ATE221080T1 (de) | 1996-03-01 | 1997-02-26 | Serine-protease-inhibitoren |
Country Status (26)
Country | Link |
---|---|
US (1) | US6410684B1 (de) |
EP (1) | EP0886647B1 (de) |
JP (1) | JP2000506837A (de) |
KR (1) | KR19990087415A (de) |
CN (1) | CN1212704A (de) |
AR (1) | AR006310A1 (de) |
AT (1) | ATE221080T1 (de) |
AU (1) | AU709330B2 (de) |
BR (1) | BR9707808A (de) |
CA (1) | CA2246246A1 (de) |
CZ (1) | CZ277898A3 (de) |
DE (1) | DE69714222T2 (de) |
DK (1) | DK0886647T3 (de) |
ES (1) | ES2180933T3 (de) |
HK (1) | HK1021541A1 (de) |
HU (1) | HUP9900390A3 (de) |
IL (1) | IL120310A (de) |
NO (1) | NO983991L (de) |
NZ (1) | NZ331484A (de) |
PL (1) | PL328875A1 (de) |
PT (1) | PT886647E (de) |
RU (1) | RU2178419C2 (de) |
TR (1) | TR199801704T2 (de) |
TW (1) | TW442452B (de) |
WO (1) | WO1997031937A1 (de) |
ZA (1) | ZA971667B (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL328307A1 (en) * | 1996-02-13 | 1999-01-18 | Akzo Nobel Nv | Serinic protease inhibitors |
WO1998051684A1 (en) | 1997-05-15 | 1998-11-19 | Eli Lilly And Company | Antithrombotic compound |
CA2326763A1 (en) | 1998-04-30 | 1999-11-11 | Theodore O. Johnson, Jr. | Antipicornaviral compounds and compositions, their pharmaceutical uses, and methods for their synthesis |
WO2000009542A1 (en) * | 1998-08-17 | 2000-02-24 | Cortech, Inc. | SERINE PROTEASE INHIBITORS COMPRISING α-KETO HETEROCYCLES |
WO2000051623A2 (en) | 1999-03-05 | 2000-09-08 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions |
AU3731400A (en) | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Methods and compositions useful in inhibiting apoptosis |
US6849605B1 (en) | 1999-03-05 | 2005-02-01 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of viral infections |
MXPA02001179A (es) * | 1999-08-04 | 2002-07-30 | Agouron Pharma | Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y materiales para su sintesis. |
MXPA02012456A (es) | 2000-06-14 | 2004-01-26 | Agouron Pharma | Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y materiales para su sintesis. |
JP4452441B2 (ja) * | 2000-07-21 | 2010-04-21 | シェーリング コーポレイション | C型肝炎ウイルスのns3−セリンプロテアーゼ阻害剤としての新規ペプチド |
HU229997B1 (en) | 2000-07-21 | 2015-04-28 | Dendreon Corp San Diego | Peptides as ns3-serine protease inhibitors of hepatitis c virus |
US7244721B2 (en) | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
WO2002060894A2 (en) | 2001-01-30 | 2002-08-08 | Bristol-Myers Squibb Company | Sulfonamide lactam inhibitors of factor xa |
US7405210B2 (en) * | 2003-05-21 | 2008-07-29 | Osi Pharmaceuticals, Inc. | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase |
WO2005085245A1 (en) | 2004-03-08 | 2005-09-15 | Prosidion Limited | Pyrrolopyridine-2-carboxylic acid hydrazides |
DE602005013275D1 (de) | 2004-12-02 | 2009-04-23 | Prosidion Ltd | Pyrrolopyridin-2-karbonsäureamide |
CN102245635B (zh) * | 2008-10-15 | 2016-08-31 | 丹尼斯科美国公司 | 修饰的变体bowman birk蛋白酶抑制剂 |
US10526315B2 (en) | 2016-06-21 | 2020-01-07 | Orion Ophthalmology LLC | Carbocyclic prolinamide derivatives |
MX2018016189A (es) | 2016-06-21 | 2019-06-10 | Orion Ophthalmology LLC | Derivados de prolinamida heterociclica. |
US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4556655A (en) * | 1984-09-24 | 1985-12-03 | Schering Corporation | Antihypertensive compounds having both diuretic and angiotensin converting enzyme inhibitory activity |
ZW11290A1 (en) * | 1989-07-14 | 1990-10-31 | Smithkline Beecham Corp | Hemoregulatory peptides |
AU670381B2 (en) | 1993-04-30 | 1996-07-11 | Merck & Co., Inc. | Thrombin inhibitors |
SE9301916D0 (sv) | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
ZA951618B (en) | 1994-03-04 | 1996-08-27 | Lilly Co Eli | Antithrombotic agents |
IL112795A (en) | 1994-03-04 | 2001-01-28 | Astrazeneca Ab | Derivatives of peptides as antithrombotic drugs, their preparation, and pharmaceutical preparations containing them |
US5561146A (en) | 1994-06-10 | 1996-10-01 | Bristol-Myers Squibb Company | Modified guanidino and amidino thrombin inhibitors |
JPH10503176A (ja) | 1994-06-17 | 1998-03-24 | コーバス インターナショナル, インコーポレイテッド | 酵素インヒビターとしての3−アミノ−2−オキソ−1−ピペリジン酢酸誘導体 |
JPH0820597A (ja) * | 1994-07-07 | 1996-01-23 | Meiji Seika Kaisha Ltd | トロンビン阻害作用を有する複素環カルボニル化合物 |
AU4250596A (en) * | 1994-12-22 | 1996-07-10 | Biochem Pharma Inc. | Low molecular weight bicyclic thrombin inhibitors |
-
1997
- 1997-02-25 TW TW086102261A patent/TW442452B/zh not_active IP Right Cessation
- 1997-02-25 IL IL12031097A patent/IL120310A/en not_active IP Right Cessation
- 1997-02-26 HU HU9900390A patent/HUP9900390A3/hu unknown
- 1997-02-26 DK DK97905099T patent/DK0886647T3/da active
- 1997-02-26 CZ CZ982778A patent/CZ277898A3/cs unknown
- 1997-02-26 BR BR9707808A patent/BR9707808A/pt not_active Application Discontinuation
- 1997-02-26 KR KR1019980706833A patent/KR19990087415A/ko not_active Application Discontinuation
- 1997-02-26 EP EP97905099A patent/EP0886647B1/de not_active Expired - Lifetime
- 1997-02-26 WO PCT/EP1997/000938 patent/WO1997031937A1/en not_active Application Discontinuation
- 1997-02-26 AT AT97905099T patent/ATE221080T1/de not_active IP Right Cessation
- 1997-02-26 RU RU98117949/04A patent/RU2178419C2/ru active
- 1997-02-26 PT PT97905099T patent/PT886647E/pt unknown
- 1997-02-26 NZ NZ331484A patent/NZ331484A/xx unknown
- 1997-02-26 AU AU18775/97A patent/AU709330B2/en not_active Ceased
- 1997-02-26 CN CN97192682A patent/CN1212704A/zh active Pending
- 1997-02-26 JP JP9530600A patent/JP2000506837A/ja not_active Ceased
- 1997-02-26 US US09/142,110 patent/US6410684B1/en not_active Expired - Fee Related
- 1997-02-26 ES ES97905099T patent/ES2180933T3/es not_active Expired - Lifetime
- 1997-02-26 DE DE69714222T patent/DE69714222T2/de not_active Expired - Fee Related
- 1997-02-26 ZA ZA9701667A patent/ZA971667B/xx unknown
- 1997-02-26 PL PL97328875A patent/PL328875A1/xx unknown
- 1997-02-26 CA CA002246246A patent/CA2246246A1/en not_active Abandoned
- 1997-02-26 TR TR1998/01704T patent/TR199801704T2/xx unknown
- 1997-03-03 AR ARP970100833A patent/AR006310A1/es unknown
-
1998
- 1998-08-31 NO NO983991A patent/NO983991L/no not_active Application Discontinuation
-
1999
- 1999-06-22 HK HK99102658A patent/HK1021541A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP2000506837A (ja) | 2000-06-06 |
NO983991D0 (no) | 1998-08-31 |
KR19990087415A (ko) | 1999-12-27 |
AR006310A1 (es) | 1999-08-25 |
DE69714222D1 (de) | 2002-08-29 |
CZ277898A3 (cs) | 1999-06-16 |
ZA971667B (en) | 1997-09-10 |
HUP9900390A3 (en) | 2000-11-28 |
CN1212704A (zh) | 1999-03-31 |
HUP9900390A2 (hu) | 1999-06-28 |
TR199801704T2 (xx) | 1998-12-21 |
PL328875A1 (en) | 1999-03-01 |
EP0886647A1 (de) | 1998-12-30 |
IL120310A0 (en) | 1997-06-10 |
NZ331484A (en) | 2000-01-28 |
RU2178419C2 (ru) | 2002-01-20 |
BR9707808A (pt) | 1999-07-27 |
NO983991L (no) | 1998-10-30 |
HK1021541A1 (en) | 2000-06-16 |
DE69714222T2 (de) | 2003-02-20 |
WO1997031937A1 (en) | 1997-09-04 |
TW442452B (en) | 2001-06-23 |
DK0886647T3 (da) | 2002-11-04 |
AU709330B2 (en) | 1999-08-26 |
CA2246246A1 (en) | 1997-09-04 |
ES2180933T3 (es) | 2003-02-16 |
AU1877597A (en) | 1997-09-16 |
US6410684B1 (en) | 2002-06-25 |
EP0886647B1 (de) | 2002-07-24 |
PT886647E (pt) | 2002-12-31 |
IL120310A (en) | 2002-02-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
REN | Ceased due to non-payment of the annual fee |