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ATE133682T1 - Verfahren zur herstellung von 2-amino-9-(2,3,5- tri-0-benzyl-beta-d-arabinofuranosyl)adenin und neue zwischenprodukte - Google Patents

Verfahren zur herstellung von 2-amino-9-(2,3,5- tri-0-benzyl-beta-d-arabinofuranosyl)adenin und neue zwischenprodukte

Info

Publication number
ATE133682T1
ATE133682T1 AT91901479T AT91901479T ATE133682T1 AT E133682 T1 ATE133682 T1 AT E133682T1 AT 91901479 T AT91901479 T AT 91901479T AT 91901479 T AT91901479 T AT 91901479T AT E133682 T1 ATE133682 T1 AT E133682T1
Authority
AT
Austria
Prior art keywords
beta
arabinofuranosyl
adenine
tri
benzyl
Prior art date
Application number
AT91901479T
Other languages
English (en)
Inventor
Peter Blumbergs
Mohammed S Khan
Richard L Kalamas
Original Assignee
Ash Stevens Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23768933&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE133682(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ash Stevens Inc filed Critical Ash Stevens Inc
Application granted granted Critical
Publication of ATE133682T1 publication Critical patent/ATE133682T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT91901479T 1989-12-04 1990-11-30 Verfahren zur herstellung von 2-amino-9-(2,3,5- tri-0-benzyl-beta-d-arabinofuranosyl)adenin und neue zwischenprodukte ATE133682T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/445,446 US5110919A (en) 1989-12-04 1989-12-04 Process for the preparation of 2-amino-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine and novel intermediates

Publications (1)

Publication Number Publication Date
ATE133682T1 true ATE133682T1 (de) 1996-02-15

Family

ID=23768933

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91901479T ATE133682T1 (de) 1989-12-04 1990-11-30 Verfahren zur herstellung von 2-amino-9-(2,3,5- tri-0-benzyl-beta-d-arabinofuranosyl)adenin und neue zwischenprodukte

Country Status (9)

Country Link
US (2) US5110919A (de)
EP (1) EP0456817B1 (de)
JP (2) JPH07634B2 (de)
AT (1) ATE133682T1 (de)
DE (2) DE456817T1 (de)
DK (1) DK0456817T3 (de)
ES (1) ES2038094T3 (de)
GR (2) GR920300026T1 (de)
WO (1) WO1991008215A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5110919A (en) * 1989-12-04 1992-05-05 Ash Stevens, Inc. Process for the preparation of 2-amino-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine and novel intermediates
CA2091732C (en) * 1992-07-08 1998-07-21 Anica Markovac A process for the preparation of 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine
US5602246A (en) * 1992-11-25 1997-02-11 Schering Aktiengesellschaft Process for the preparation of fludarabine or fludarabine phosphate from guanosine
HU226997B1 (en) * 1997-12-11 2010-04-28 Alcafleu Man Gmbh & Co Kg Method for producing lithium, sodium, potassium, calcium and magnesium salts of fludarabin phosphate purification method for producing fludarabin phosphate and fludarabin phosphate which is at least 99,5% pure
PT1261350E (pt) * 2000-02-18 2006-11-30 Southern Res Inst Processos para síntese de 2-cloro-9-(2-desoxi-2-fluoro-b-d-arabinofuranosil)-9h-purin-6-amina
DE10164510A1 (de) * 2001-12-20 2003-07-10 Schering Ag Orale Fludara reinst Formulierung mit schneller Freisetzung des Wirkstoffes
US7491725B2 (en) 2004-02-06 2009-02-17 Bristol-Myers Squibb Company Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
EP3342778B1 (de) * 2015-08-28 2022-01-12 Zhejiang Hisun Pharmaceutical Co., Ltd. Kristallform von fludarabin-phosphat, herstellungsverfahren dafür und anwendung davon

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3008969A (en) * 1958-05-21 1961-11-14 American Cyanamid Co 4-substituted-7-carboalkoxyamino-coumarins
USRE29835E (en) * 1971-06-01 1978-11-14 Icn Pharmaceuticals 1,2,4-Triazole nucleosides
US4188378A (en) * 1978-01-04 1980-02-12 The United States Of America As Represented By The Department Of Health, Education And Welfare Anticancer and antiviral activity of 9-β-D-arabinofuranosyl-2-fluoroadenine
US5110919A (en) * 1989-12-04 1992-05-05 Ash Stevens, Inc. Process for the preparation of 2-amino-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine and novel intermediates

Also Published As

Publication number Publication date
EP0456817A4 (en) 1992-04-22
JPH04504268A (ja) 1992-07-30
EP0456817A1 (de) 1991-11-21
DE69025176T2 (de) 1996-05-30
JPH07634B2 (ja) 1995-01-11
DK0456817T3 (da) 1996-04-29
GR920300026T1 (en) 1992-08-26
US5110919A (en) 1992-05-05
GR3019656T3 (en) 1996-07-31
ES2038094T3 (es) 1996-06-01
DE456817T1 (de) 1992-04-09
ES2038094T1 (es) 1993-07-16
US5296589A (en) 1994-03-22
WO1991008215A1 (en) 1991-06-13
JPH07138280A (ja) 1995-05-30
EP0456817B1 (de) 1996-01-31
JPH07108912B2 (ja) 1995-11-22
DE69025176D1 (de) 1996-03-14

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee