ATE116303T1 - Aryl-heteroaryl-karbinol-derivate mit analgetischer aktivität. - Google Patents
Aryl-heteroaryl-karbinol-derivate mit analgetischer aktivität.Info
- Publication number
- ATE116303T1 ATE116303T1 AT88400828T AT88400828T ATE116303T1 AT E116303 T1 ATE116303 T1 AT E116303T1 AT 88400828 T AT88400828 T AT 88400828T AT 88400828 T AT88400828 T AT 88400828T AT E116303 T1 ATE116303 T1 AT E116303T1
- Authority
- AT
- Austria
- Prior art keywords
- radical
- heteroaryl
- aryl
- hydrogen atom
- denotes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Pyridine Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8705118A FR2613720B1 (fr) | 1987-04-10 | 1987-04-10 | Derives d'aryl-heteroaryl carbinols avec activite analgesique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE116303T1 true ATE116303T1 (de) | 1995-01-15 |
Family
ID=9350010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88400828T ATE116303T1 (de) | 1987-04-10 | 1988-04-06 | Aryl-heteroaryl-karbinol-derivate mit analgetischer aktivität. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5017596A (de) |
| EP (1) | EP0289380B1 (de) |
| JP (1) | JPH0651678B2 (de) |
| KR (1) | KR930009442B1 (de) |
| AT (1) | ATE116303T1 (de) |
| BR (1) | BR1100931A (de) |
| DE (1) | DE3852565T2 (de) |
| DK (1) | DK172927B1 (de) |
| ES (1) | ES2014523A6 (de) |
| FR (1) | FR2613720B1 (de) |
| GR (1) | GR3015616T3 (de) |
| PT (1) | PT87183B (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2681322B1 (fr) * | 1991-09-12 | 1993-12-17 | Laboratorios Dr Esteve Sa | Derives d'aryl-heteroaryl-{n-[2-(3,4-dimethoxyphenyl)-ethyl]-n-methyl-3-aminopropoxy}-methane leur preparation et leur application en tant que medicaments . |
| WO1995029898A1 (en) * | 1994-05-02 | 1995-11-09 | Zeneca Limited | Herbicidal hydroxybenzyl-substituted heteroaryl compounds and derivatives thereof |
| ES2150353B1 (es) * | 1998-04-15 | 2001-07-01 | Esteve Labor Dr | Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos. |
| ES2137136B1 (es) * | 1998-05-18 | 2000-07-01 | Esteve Labor Dr | Empleo de derivados de aril (o heteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion neurogenica. |
| ES2150378B1 (es) | 1998-08-07 | 2001-07-01 | Esteve Labor Dr | Empleo de derivados de aril(o heteroaril)azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de los trastornos mediados por un exceso de substancia p. |
| DE10335566A1 (de) * | 2003-07-31 | 2005-02-24 | Grünenthal GmbH | Arzneimittel enthaltend Derivate von Aryl( oder Heteroaryl)azolylcarbinolen |
| TW200533657A (en) * | 2004-02-17 | 2005-10-16 | Esteve Labor Dr | Substituted pyrazoline compounds, their preparation and use as medicaments |
| ES2245226B1 (es) * | 2004-04-05 | 2007-02-16 | Laboratorios Del Dr. Esteve, S.A. | Combinacion de substancias activas. |
| CA2562231A1 (en) * | 2004-04-05 | 2005-10-20 | Laboratorios Del Dr. Esteve, S.A. | Active substance combination of a carbinol compound and an opioid |
| EP1584335A3 (de) * | 2004-04-05 | 2006-02-22 | Laboratorios Del Dr. Esteve, S.A. | Zusammensetzung aus Aktiva mit einer Carbinolverbindung und einem Opioid |
| ES2244326B1 (es) * | 2004-04-05 | 2007-02-16 | Laboratorios Del Dr. Esteve, S.A. | Combinacion de substancias activas. |
| US20060040924A1 (en) * | 2004-06-22 | 2006-02-23 | Laboratorios Dr. Esteve S.A. | Derivatives of aryl (or heteroaryl) azolylcarbinols for the treatment of renal colic |
| EP1632227A1 (de) * | 2004-09-07 | 2006-03-08 | Laboratorios del Dr. Esteve S.A. | Aryl- (oder Heteroaryl-) Azolcarbinole (insbesondere Cizolirtin Citrate) für die Behandlung von Opioid Abhängigkeit |
| EP1671968A1 (de) | 2004-12-17 | 2006-06-21 | Laboratorios Del Dr. Esteve, S.A. | Verfahren zur Herstellung von Enantiomeren von Thienylazolylalkoxyethanamines |
| EP1671953A1 (de) | 2004-12-17 | 2006-06-21 | Laboratorios Del Dr. Esteve, S.A. | Verfahren zur Herstellung von Cizolirtine und dessen Enantiomeren |
| EP1674465A1 (de) | 2004-12-27 | 2006-06-28 | Laboratorios Del Dr. Esteve, S.A. | Verfahren zur Gewinnung der Enatiomeren der Thienylazolylalkoxyethanaminen |
| EP1690537A1 (de) * | 2005-02-15 | 2006-08-16 | Laboratorios Del Dr. Esteve, S.A. | Aryl-(oder Heteroaryl-) Azolylcarbynolderivative zur Behandlung von Fibromyalgie |
| WO2006087147A2 (en) * | 2005-02-15 | 2006-08-24 | Laboratorios Del Dr. Esteve, S.A. | Derivatives of aryl (or heteroaryl) azolylcarbinols for the treatment of fibromyalgia |
| EP1695704A1 (de) * | 2005-02-28 | 2006-08-30 | Laboratorios Del Dr. Esteve, S.A. | Aryl- (oder Heteroaryl-) Azolylcarbynolderivative zur Behandlung von Fibromyalgie |
| ES2286920B1 (es) * | 2005-02-15 | 2008-08-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de aril (o heteroaril)azolilcarbinoles para el tratamiento de la fibromialgia. |
| EP1743892A1 (de) * | 2005-07-15 | 2007-01-17 | Laboratorios del Dr. Esteve S.A. | Substituierte Pyrazolin Verbindungen, deren Herstellung und Verwendung als Medikament |
| US7897589B2 (en) * | 2005-07-15 | 2011-03-01 | Laboratorios Del Dr. Esteve, S.A. | Substituted pyrazoline compounds, their preparation and use as medicaments |
| EP1757587A1 (de) * | 2005-07-15 | 2007-02-28 | Laboratorios Del Dr. Esteve, S.A. | Substituierte Pyrazolinderivate, ihre Herstellung und Verwendung als Arzneimittel |
| EP1743890A1 (de) * | 2005-07-15 | 2007-01-17 | Laboratorios Del Dr. Esteve, S.A. | 4,5-Dihydro-1H-Pyrazol-Derivative, Verfahren zur Herstellung und ihre Verwendung als Medikamente. |
| US7592362B2 (en) * | 2006-01-19 | 2009-09-22 | Pfizer Limited | Substituted imidazoles |
| EP1820502A1 (de) | 2006-02-10 | 2007-08-22 | Laboratorios Del Dr. Esteve, S.A. | Wirkstoffzusammensetzungen enthaltend Azolycarbinolderivate |
| EP2151234A1 (de) * | 2008-07-28 | 2010-02-10 | Laboratorios Del. Dr. Esteve, S.A. | Pharmazeutische Formulierung mit einer CB1-Rezeptorverbindung in einer festen Lösung und/oder festen Dispersion |
| WO2010123999A2 (en) * | 2009-04-21 | 2010-10-28 | Auspex Pharmaceuticals, Inc. | 1-methylpyrazole modulators of substance p, calcitonin gene-related peptide, adrenergic receptor, and/or 5-ht receptor |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL39413A0 (en) * | 1971-05-13 | 1972-07-26 | Sparamedica Ag | Benzodiazepine derivatives,their preparation and pharmaceutical compositions containing them |
| BE793407A (fr) * | 1971-12-28 | 1973-06-28 | Hoechst Ag | Imidazolyl - (2) -carbinols ayant une activite hypolipidemique et leur procede de preparation |
| JPS5118950B2 (de) * | 1972-06-30 | 1976-06-14 | ||
| US4853404A (en) * | 1986-10-13 | 1989-08-01 | Tanabe Seiyaku Co., Ltd. | Phenoxyacetic acid derivatives composition and use |
-
1987
- 1987-04-10 FR FR8705118A patent/FR2613720B1/fr not_active Expired - Lifetime
-
1988
- 1988-03-28 DK DK198801701A patent/DK172927B1/da not_active IP Right Cessation
- 1988-03-30 ES ES8800984A patent/ES2014523A6/es not_active Expired - Lifetime
- 1988-04-06 EP EP88400828A patent/EP0289380B1/de not_active Expired - Lifetime
- 1988-04-06 AT AT88400828T patent/ATE116303T1/de not_active IP Right Cessation
- 1988-04-06 DE DE3852565T patent/DE3852565T2/de not_active Expired - Lifetime
- 1988-04-07 PT PT87183A patent/PT87183B/pt not_active IP Right Cessation
- 1988-04-08 JP JP63088020A patent/JPH0651678B2/ja not_active Expired - Lifetime
- 1988-04-11 KR KR1019880004094A patent/KR930009442B1/ko not_active IP Right Cessation
-
1989
- 1989-12-21 US US07/456,077 patent/US5017596A/en not_active Expired - Lifetime
-
1995
- 1995-03-23 GR GR950400692T patent/GR3015616T3/el unknown
-
1997
- 1997-05-14 BR BR1100931-4A patent/BR1100931A/pt active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| DK170188D0 (da) | 1988-03-28 |
| DK172927B1 (da) | 1999-10-04 |
| FR2613720A1 (fr) | 1988-10-14 |
| FR2613720B1 (fr) | 1990-01-19 |
| GR3015616T3 (en) | 1995-06-30 |
| KR930009442B1 (ko) | 1993-10-04 |
| EP0289380B1 (de) | 1994-12-28 |
| KR880012558A (ko) | 1988-11-28 |
| BR1100931A (pt) | 1999-11-23 |
| JPH0651678B2 (ja) | 1994-07-06 |
| ES2014523A6 (es) | 1990-07-16 |
| PT87183B (pt) | 1992-08-31 |
| JPS63267761A (ja) | 1988-11-04 |
| PT87183A (pt) | 1988-05-01 |
| DE3852565T2 (de) | 1995-05-11 |
| DE3852565D1 (de) | 1995-02-09 |
| DK170188A (da) | 1988-10-11 |
| EP0289380A1 (de) | 1988-11-02 |
| US5017596A (en) | 1991-05-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE116303T1 (de) | Aryl-heteroaryl-karbinol-derivate mit analgetischer aktivität. | |
| NO934792D0 (no) | Xantinderivater | |
| DE3369315D1 (en) | Derivatives of 2-amino-3-acylamino-6-benzylamino pyridine with an anti-epileptic activity | |
| FI803277L (fi) | Morfolinderivat | |
| YU217589A (en) | Derivatives of 2-(2;3;4'-threesubstituted benzoyl)-1,3-cyclohexandione | |
| DK671688A (da) | 2-(piperazinyl)-2-oxoethylensubstituerede flavonoidderivater, fremgangsmaader til fremstilling heraf samt farmaceutiske midler indeholdende disse | |
| ES2010537A6 (es) | Procedimiento para la preparacion de derivados de oxazol e isoxazol. | |
| DK59888D0 (da) | Imidazolderivater | |
| DE3060153D1 (en) | Derivatives of substituted 2-benzoyl glycinanilides, their preparation and their use in anxiolytic medicaments | |
| DK526887D0 (da) | Aralkyl-4h-1,2,4-triazolderivater samt deres fremstilling og anvendelse | |
| ATE144900T1 (de) | Verwendung von xanthinderivaten gegen magengeschwüre | |
| ATE134607T1 (de) | Tetrahydronaphtalenderivate, ihre herstellung und ihre therapeutische verwendung | |
| DK460783D0 (da) | 4-hydroxy-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxider, fremgangsmade til deres fremstilling samt deres anvendelse | |
| DE3874982D1 (de) | Antipsychotische zusammensetzungen mit dioxopiperidin-derivaten. | |
| DK231787A (da) | 3-amino-dihydropyridiner, fremgangsmaade til deres fremstilling og deres anvendelse i laegemidler | |
| AU1147383A (en) | Substituted oximoacetanilides | |
| DK501083A (da) | Semicarbazider, fremgangsmaade til deres fremstilling samt deres anvendelse | |
| SE8105297L (sv) | Imidazolderivat | |
| MY102015A (en) | Certain 2-(2-substituted benzoyl)-1, 3- cyclohexanadiones |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |