[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ATE101153T1 - Thiazolopyrimidinderivate als angiotensin-iirezeptorantagonisten: verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. - Google Patents

Thiazolopyrimidinderivate als angiotensin-iirezeptorantagonisten: verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.

Info

Publication number
ATE101153T1
ATE101153T1 AT92401850T AT92401850T ATE101153T1 AT E101153 T1 ATE101153 T1 AT E101153T1 AT 92401850 T AT92401850 T AT 92401850T AT 92401850 T AT92401850 T AT 92401850T AT E101153 T1 ATE101153 T1 AT E101153T1
Authority
AT
Austria
Prior art keywords
derivatives
thiazolopyrimide
ireceptor
angiotensin
antagonists
Prior art date
Application number
AT92401850T
Other languages
English (en)
Inventor
Nicole Bru-Magniez
Eric Nicolai
Jean-Marie Teulon
Original Assignee
Union Pharma Scient Appl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Union Pharma Scient Appl filed Critical Union Pharma Scient Appl
Application granted granted Critical
Publication of ATE101153T1 publication Critical patent/ATE101153T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT92401850T 1991-07-05 1992-06-30 Thiazolopyrimidinderivate als angiotensin-iirezeptorantagonisten: verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. ATE101153T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9108486A FR2678618B1 (fr) 1991-07-05 1991-07-05 Nouveaux derives de triazolo pyrimidine antagonistes des recepteurs a l'angiotensine ii; leurs procedes de preparation, compositions pharmaceutiques les contenant.

Publications (1)

Publication Number Publication Date
ATE101153T1 true ATE101153T1 (de) 1994-02-15

Family

ID=9414783

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92401850T ATE101153T1 (de) 1991-07-05 1992-06-30 Thiazolopyrimidinderivate als angiotensin-iirezeptorantagonisten: verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.

Country Status (23)

Country Link
US (1) US5217973A (de)
EP (1) EP0521768B1 (de)
JP (1) JP3140566B2 (de)
KR (1) KR100243628B1 (de)
AT (1) ATE101153T1 (de)
AU (1) AU655288B2 (de)
CA (1) CA2072233C (de)
CZ (1) CZ284757B6 (de)
DE (1) DE69200045T2 (de)
DK (1) DK0521768T3 (de)
EE (1) EE03003B1 (de)
ES (1) ES2063570T3 (de)
FR (1) FR2678618B1 (de)
HU (2) HU220225B (de)
IE (1) IE65635B1 (de)
IL (1) IL102367A (de)
LV (1) LV10717B (de)
MD (1) MD523G2 (de)
NZ (1) NZ243443A (de)
RU (1) RU2103270C1 (de)
SK (1) SK279902B6 (de)
TW (1) TW221445B (de)
ZA (1) ZA924954B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5358950A (en) * 1991-07-05 1994-10-25 Laboratoires Upsa Triazolopyrimidine derivatives which are angiotensin II receptor antagonists
FR2687677B1 (fr) * 1992-02-24 1996-10-11 Union Pharma Scient Appl Nouveaux derives de polyazaindenes antagonistes des recepteurs a l'angiotensine ii ; leurs procedes de preparation, compositions pharmaceutiques les contenant.
US5387747A (en) * 1992-02-24 1995-02-07 Laboratoires Upsa Triazolopyrimidine derivatives which are angiotensin II receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present
US5389632A (en) * 1992-02-24 1995-02-14 Laboratoires Upsa Pyrazolopyrimidine derivatives which are angiotensin II receptor antagonists
IT1263804B (it) * 1993-01-22 1996-09-03 Luso Farmaco Inst Derivati pirimidinonici fusi con eterocicli azotati ad attivita' a ii antagonista
US5358947A (en) * 1993-09-13 1994-10-25 American Cyanamid Company Angiotensin II receptor blocking 2,3-substituted pyrazolo[1,5-a]-1,3,5-triazin-4(3H)-ones
AU743910B2 (en) 1997-03-24 2002-02-07 Kyowa Hakko Kirin Co., Ltd. {1,2,4}triazolo{1,5-c}pyrimidine derivatives
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
EA020466B1 (ru) 2007-06-04 2014-11-28 Синерджи Фармасьютикалз Инк. Агонисты гуанилатциклазы, пригодные для лечения желудочно-кишечных нарушений, воспаления, рака и других заболеваний
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
GB0719803D0 (en) 2007-10-10 2007-11-21 Cancer Rec Tech Ltd Therapeutic compounds and their use
CA2930674A1 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2009158309A2 (en) * 2008-06-25 2009-12-30 Ligand Pharmaceuticals Inc. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
JP2011528375A (ja) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
AU2014235215A1 (en) 2013-03-15 2015-10-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
US10011637B2 (en) 2013-06-05 2018-07-03 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase C, method of making and using same
WO2023066299A1 (en) * 2021-10-19 2023-04-27 Impact Therapeutics (Shanghai) , Inc Substituted triazoloheteroaryl compounds as usp1 inhibitors and the use thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US269980A (en) * 1883-01-02 Horse power
GB859287A (en) * 1958-10-03 1961-01-18 Ici Ltd Triazolopyrimidine derivatives and their preparation
GB897870A (en) * 1959-06-15 1962-05-30 Ici Ltd s-triazolo[2, 3-c]pyrimidine derivatives
GB951652A (en) * 1960-06-28 1964-03-11 Wallace Broadbent Sulphamyl triazolopyrimidines and their preparation
US4269980A (en) * 1979-12-17 1981-05-26 American Cyanamid Company (Substituted-phenyl)-1,2,4-triazolo[4,3-c]pyrimidines and (substituted-phenyl)-1,2,4-triazolo[1,5-c]pyrimidines
US4572910A (en) * 1983-03-03 1986-02-25 Riker Laboratories, Inc. Triazolo[1,5-c]pyrimidines substituted by nitrogen-containing heterocyclic rings
US4532242A (en) * 1983-05-02 1985-07-30 Riker Laboratories, Inc. Substituted triazolo[4,3-c]pyrimidines
US4528288A (en) * 1983-05-02 1985-07-09 Riker Laboratories, Inc. Substituted triazolo[1,5-c]pyrimidines
US4562192A (en) * 1984-02-03 1985-12-31 G. D. Searle & Co. 6-Substituted-5-phenyltetrazolo[1,5-a][1,2,4]triazole[1,5-c]pyrimidines, and pharmaceutical compositions containing them
US4728652A (en) * 1985-05-20 1988-03-01 E. R. Squibb & Sons, Inc. 2-substituted thio or oxy-4-aryl or heterocyclo-5-carboxy-1,4-dihydropyrimidines, composition containing them, and method of using them to reduce blood pressure
US5010195A (en) * 1988-05-25 1991-04-23 The Dow Chemical Company Herbicidal alkoxy-1,2,4-triazolo(1,5-c)primidine-2-sulfonamides
US5073566A (en) * 1989-11-30 1991-12-17 Eli Lilly And Company Angiotensin ii antagonist 1,3-imidazoles and use thereas
EP0435827A3 (en) * 1989-12-28 1991-11-13 Ciba-Geigy Ag Diaza compounds
WO1991015209A1 (en) * 1990-03-30 1991-10-17 Merck & Co., Inc. Substituted pyrimidines, pyrimidinones and pyridopyrimidines
US5177206A (en) * 1991-10-08 1993-01-05 Dowelanco Process for the preparation of substituted N-(aryl)-1,2,4-triazolopyrimidine-2-sulfonamides

Also Published As

Publication number Publication date
DE69200045D1 (de) 1994-03-17
IL102367A (en) 1997-06-10
SK279902B6 (sk) 1999-05-07
AU655288B2 (en) 1994-12-15
CZ207892A3 (en) 1993-01-13
NZ243443A (en) 1995-01-27
EP0521768B1 (de) 1994-02-02
HU211473A9 (en) 1995-11-28
ZA924954B (en) 1993-04-28
EP0521768A1 (de) 1993-01-07
FR2678618A1 (fr) 1993-01-08
CA2072233C (en) 2003-11-18
DK0521768T3 (da) 1994-08-15
MD523G2 (ro) 1997-01-31
ES2063570T3 (es) 1995-01-01
EE03003B1 (et) 1997-06-16
TW221445B (de) 1994-03-01
CZ284757B6 (cs) 1999-02-17
AU1939692A (en) 1993-01-07
FR2678618B1 (fr) 1993-11-05
HUT63422A (en) 1993-08-30
KR930002349A (ko) 1993-02-23
RU2103270C1 (ru) 1998-01-27
KR100243628B1 (ko) 2000-03-02
IE65635B1 (en) 1995-11-01
JP3140566B2 (ja) 2001-03-05
LV10717B (en) 1995-12-20
DE69200045T2 (de) 1994-05-19
IE922015A1 (en) 1993-01-13
JPH06122685A (ja) 1994-05-06
US5217973A (en) 1993-06-08
CA2072233A1 (en) 1993-01-06
LV10717A (lv) 1995-06-20
HU220225B (hu) 2001-11-28
MD523F1 (en) 1996-04-30
HU9202227D0 (en) 1992-10-28
SK207892A3 (en) 1995-08-09
IL102367A0 (en) 1993-01-14

Similar Documents

Publication Publication Date Title
ATE101153T1 (de) Thiazolopyrimidinderivate als angiotensin-iirezeptorantagonisten: verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
PT73879B (de) 1-carboxyalkanoylindolin-2-carbonsauren verfahren zu ihrer herstellung und pharmazeutische praeparate enthaltend diese verbindungen sowie ihre therapeutische verwendung
DE69828445D1 (de) Heterozyklische verbindungen,und deren verwendung in arzneimittel,verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen
DE58909793D1 (de) Neue Benzopyran-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung sowie die Verbindungen enthaltenden Zubereitungen
AR009849A1 (es) Compuestos estilbenicos de grupo adamantil, composiciones que los contienen y utilizaciones
EA200500882A1 (ru) N-арилсульфонил-3-аминоалкоксииндолы
ATE38988T1 (de) Imidazolylphenyl-tetrahydropyridazine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.
RU94038256A (ru) Производные пиразолопиримидина, способ их получения, фармацевтические композиции на их основе
ATE49970T1 (de) Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
AR005860A1 (es) Compuestos heterociclicos aromaticos, composiciones farmaceuticas y cosmeticas que los contienen, y su utilización.
PT85697A (de) Neue imidazolylguanidinderivate verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ATE41772T1 (de) Polymethoxybenzyl-piperazin-derivate, verfahren zu ihrer herstellung und diese derivate enthaltende pharmazeutische zusammensetzungen.
ATE66230T1 (de) Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
ATE27157T1 (de) Cycloalkylderivate von benzisoselenazolonen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.
EE03046B1 (et) Angiotensiin II retseptorite antagonistide triasolopürimidiinide derivaadid, nende valmistamise meetod ja ravimvormid
ATE73807T1 (de) Neue benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte.
ATE37370T1 (de) Triazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
ES2117114T3 (es) Nuevos derivados de tiaxolidin-diona, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
ATE82016T1 (de) 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
RU2004131220A (ru) Галогенпроизводные гиперфорина, использование таковых и составов, их содержащих
IT1251496B (it) Derivati imidazotiadiazolici ad attivita' diuretica, procedimenti per la loro preparazione e composizioni che li contengono
RU92016559A (ru) Производные диалкокси-пиридинилбензимидазола, фармацевтическая композиция, способ ингибирования или лечения, способ их получения, применение и промежуточные соединения
RU92016587A (ru) Новые производные бензопирана, активатор калиевого канала
TH32887A (th) สารประกอบทางเคมี

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification