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ATE168274T1 - METHOD FOR INACTIVATION OF VIRUSES THAT ARE NOT PROVIDED WITH LIPID COATS - Google Patents

METHOD FOR INACTIVATION OF VIRUSES THAT ARE NOT PROVIDED WITH LIPID COATS

Info

Publication number
ATE168274T1
ATE168274T1 AT94906906T AT94906906T ATE168274T1 AT E168274 T1 ATE168274 T1 AT E168274T1 AT 94906906 T AT94906906 T AT 94906906T AT 94906906 T AT94906906 T AT 94906906T AT E168274 T1 ATE168274 T1 AT E168274T1
Authority
AT
Austria
Prior art keywords
inactivation
viruses
hours
coats
lipid
Prior art date
Application number
AT94906906T
Other languages
German (de)
Inventor
Monika Stadler
Horst Schwinn
Djuro Josic
Werner Gehringer
Frederic Bal
Original Assignee
Octapharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25922869&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE168274(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE4318435A external-priority patent/DE4318435C2/en
Application filed by Octapharma Ag filed Critical Octapharma Ag
Application granted granted Critical
Publication of ATE168274T1 publication Critical patent/ATE168274T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)

Abstract

A method for the inactivation of viruses, in particular those having no lipid coats, in protein-containing compositions from blood, blood plasma or similar natural sources by treating said source, simultaneously or succesively, with an effective amount of dialkyl or trialkyl phosphates and optionally surfactants at an elevated temperature in the range of from 55° C. to 67° C. for five hours to 30 hours.
AT94906906T 1993-02-09 1994-02-05 METHOD FOR INACTIVATION OF VIRUSES THAT ARE NOT PROVIDED WITH LIPID COATS ATE168274T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4303609 1993-02-09
DE4318435A DE4318435C2 (en) 1993-02-09 1993-06-03 Method for inactivating viruses that are not provided with lipid envelopes

Publications (1)

Publication Number Publication Date
ATE168274T1 true ATE168274T1 (en) 1998-08-15

Family

ID=25922869

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94906906T ATE168274T1 (en) 1993-02-09 1994-02-05 METHOD FOR INACTIVATION OF VIRUSES THAT ARE NOT PROVIDED WITH LIPID COATS

Country Status (10)

Country Link
US (1) US6528246B2 (en)
EP (1) EP0683678B1 (en)
JP (1) JPH08506498A (en)
CN (1) CN1064552C (en)
AT (1) ATE168274T1 (en)
AU (1) AU676011B2 (en)
CA (1) CA2155337A1 (en)
ES (1) ES2118386T3 (en)
FI (1) FI953756A (en)
WO (1) WO1994017834A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19506633A1 (en) 1995-02-25 1996-08-29 Octapharma Ag Process for the preparation of factor IX from biological sources
SE9501189D0 (en) * 1995-03-31 1995-03-31 Pharmacia Ab Protein formulation
US6034073A (en) * 1995-04-24 2000-03-07 Novavax, Inc. Solvent detergent emulsions having antiviral activity
US6136865A (en) * 1995-05-20 2000-10-24 Octapharma Ag Method for reduction of the infectiousness of potentially infectious material
DE19623293C2 (en) * 1996-06-11 1998-10-22 Biotest Pharma Gmbh Non-immunogenic factor VIII-containing composition and a process for its preparation
CA2634674A1 (en) 1999-02-22 2000-08-24 Baxter International Inc. Novel albumin-free factor viii formulations
DE19923027C2 (en) 1999-05-19 2002-09-19 Aventis Behring Gmbh Virus inactivation method
US6441144B1 (en) * 1999-05-20 2002-08-27 Alpha Therapeutic Corporation Method for repairing dual virally inactivated immune globulin for intravenous administration
EP1739179A1 (en) 2005-06-30 2007-01-03 Octapharma AG Serum-free stable transfection and production of recombinant human proteins in human cell lines
EP2385825B1 (en) 2008-11-07 2018-10-10 University of Connecticut Factor viii formulations
JP5730211B2 (en) 2008-11-20 2015-06-03 バイオジェン アイデック エムエー インコーポレイティドＢｉｏｇｅｎ Ｉｄｅｃ Ｉｎｃ． Viral arginine inactivation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540573A (en) * 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
US5118795A (en) 1987-05-15 1992-06-02 University Of Southern California Sequential heat treatment of blood-clotting factor products
DE3730533A1 (en) * 1987-09-11 1989-03-30 Biotest Pharma Gmbh METHOD FOR STERILIZING PLASMA OR PLASMA FACTIONS
ATE85221T1 (en) * 1988-11-05 1993-02-15 Octapharma Ag PROCESS FOR THE PREPARATION OF A HIGH PURITY, NON-INFECTIOUS ANTIHAEMOPHILIA FACTOR USING CHROMATOGRAPHY.
JP2926728B2 (en) * 1988-12-29 1999-07-28 吉富製薬株式会社 Method for producing protein-containing composition
ES2057191T5 (en) * 1989-01-13 2003-05-01 Mitsubishi Pharma Corp PRODUCTION METHOD FOR A COMPOSITION CONTAINING PROTEINS.
JP3145696B2 (en) * 1990-10-05 2001-03-12 日本ケミカルリサーチ株式会社 Method for producing secretory immunoglobulin A preparation
AT402891B (en) 1991-06-20 1997-09-25 Immuno Ag METHOD FOR PRODUCING AN INACTIVATED BLOOD PRODUCT

Also Published As

Publication number Publication date
ES2118386T3 (en) 1998-09-16
CN1064552C (en) 2001-04-18
EP0683678A1 (en) 1995-11-29
US20020068355A1 (en) 2002-06-06
US6528246B2 (en) 2003-03-04
CN1118144A (en) 1996-03-06
EP0683678B1 (en) 1998-07-15
FI953756A (en) 1995-09-12
CA2155337A1 (en) 1994-08-18
FI953756A0 (en) 1995-08-08
WO1994017834A1 (en) 1994-08-18
JPH08506498A (en) 1996-07-16
AU676011B2 (en) 1997-02-27
AU6038994A (en) 1994-08-29

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Legal Events

Date Code Title Description
RZN Patent revoked