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ATE161890T1 - Verfahren zur herstellung von s-(+)-2-(- 3benzoylphenyl)propionsäure durch enzym katalysierte enanthioselektieve umesterung in einem organischen lösungsmittel. - Google Patents

Verfahren zur herstellung von s-(+)-2-(- 3benzoylphenyl)propionsäure durch enzym katalysierte enanthioselektieve umesterung in einem organischen lösungsmittel.

Info

Publication number
ATE161890T1
ATE161890T1 AT93912796T AT93912796T ATE161890T1 AT E161890 T1 ATE161890 T1 AT E161890T1 AT 93912796 T AT93912796 T AT 93912796T AT 93912796 T AT93912796 T AT 93912796T AT E161890 T1 ATE161890 T1 AT E161890T1
Authority
AT
Austria
Prior art keywords
organic solvent
propionic acid
enzyme
branched
straight
Prior art date
Application number
AT93912796T
Other languages
English (en)
Inventor
Germano Carganico
Casellas David Mauleon
Benet Albert Palomer
Original Assignee
Menarini Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ES9201191A external-priority patent/ES2050067B1/es
Priority claimed from ES9201190A external-priority patent/ES2048653B1/es
Application filed by Menarini Lab filed Critical Menarini Lab
Application granted granted Critical
Publication of ATE161890T1 publication Critical patent/ATE161890T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT93912796T 1992-06-08 1993-05-26 Verfahren zur herstellung von s-(+)-2-(- 3benzoylphenyl)propionsäure durch enzym katalysierte enanthioselektieve umesterung in einem organischen lösungsmittel. ATE161890T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES9201191A ES2050067B1 (es) 1992-06-08 1992-06-08 Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil) propionico por transesterificacion enantioselectiva con un alcohol bifuncional catalizada enzimaticamente en medio organico.
ES9201190A ES2048653B1 (es) 1992-06-08 1992-06-08 Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil) propionico por transesterificacion enantioselectiva catalizada enzimaticamente en un disolvente organico.

Publications (1)

Publication Number Publication Date
ATE161890T1 true ATE161890T1 (de) 1998-01-15

Family

ID=26154631

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93912796T ATE161890T1 (de) 1992-06-08 1993-05-26 Verfahren zur herstellung von s-(+)-2-(- 3benzoylphenyl)propionsäure durch enzym katalysierte enanthioselektieve umesterung in einem organischen lösungsmittel.

Country Status (5)

Country Link
EP (1) EP0672165B1 (de)
AT (1) ATE161890T1 (de)
AU (1) AU4318293A (de)
DE (1) DE69316238D1 (de)
WO (1) WO1993025704A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912164A (en) * 1993-03-03 1999-06-15 Laboratorios Menarini S.A. Stereoselective hydrolysis of chiral carboxylic acid esters using esterase from ophiostoma or ceratocystis
GB9304256D0 (en) * 1993-03-03 1993-04-21 Chiros Ltd Arylalkanoic acid resolution
US6620600B2 (en) 2000-09-15 2003-09-16 Bristol-Myers Squibb Co. Enzymatic resolution of aryl and thio-substituted acids
AU2006200618B2 (en) * 2000-09-15 2007-08-09 Bristol-Myers Squibb Company Enzymatic resolution of aryl and thio-substituted acids
US7589233B2 (en) 2003-07-29 2009-09-15 Signature R&D Holdings, Llc L-Threonine derivatives of high therapeutic index
US8173840B2 (en) 2003-07-29 2012-05-08 Signature R&D Holdings, Llc Compounds with high therapeutic index
HU231033B1 (hu) 2016-03-22 2019-12-30 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás 3-as kötést tartalmazó optikailag aktív karbonsavak, karbonsav sók és karbonsav származékok előállítására

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU551956B2 (en) * 1981-05-07 1986-05-15 Unilever Plc Fat processing
HU197942B (en) * 1985-12-20 1989-06-28 Wisconsin Alumni Res Found Process for producing (s)-alpha-methyl-aryl-acetic acids
EP0461043A3 (en) * 1990-06-08 1992-11-04 Sepracor, Inc. Enantiomer separation by transesterification
FR2672600B1 (fr) * 1991-02-08 1994-10-14 Synthelabo Procede de preparation du (-)-(2r,3s)-2,3-epoxy-3-(4-methoxyphenyl) propionate de methyle.

Also Published As

Publication number Publication date
DE69316238D1 (de) 1998-02-12
AU4318293A (en) 1994-01-04
EP0672165B1 (de) 1998-01-07
WO1993025704A1 (en) 1993-12-23
EP0672165A1 (de) 1995-09-20

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