ATE157864T1 - Verfahren für die herstellung einer festen dispersion - Google Patents
Verfahren für die herstellung einer festen dispersionInfo
- Publication number
- ATE157864T1 ATE157864T1 AT92925333T AT92925333T ATE157864T1 AT E157864 T1 ATE157864 T1 AT E157864T1 AT 92925333 T AT92925333 T AT 92925333T AT 92925333 T AT92925333 T AT 92925333T AT E157864 T1 ATE157864 T1 AT E157864T1
- Authority
- AT
- Austria
- Prior art keywords
- drug
- producing
- solid dispersion
- polymer
- carrier
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Colloid Chemistry (AREA)
- Glanulating (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Pigments, Carbon Blacks, Or Wood Stains (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Ceramic Products (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80965691A | 1991-12-18 | 1991-12-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE157864T1 true ATE157864T1 (de) | 1997-09-15 |
Family
ID=25201894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT92925333T ATE157864T1 (de) | 1991-12-18 | 1992-11-18 | Verfahren für die herstellung einer festen dispersion |
Country Status (17)
Country | Link |
---|---|
US (3) | US6677362B1 (de) |
EP (1) | EP0617612B1 (de) |
JP (1) | JP3722293B2 (de) |
AT (1) | ATE157864T1 (de) |
AU (1) | AU671811B2 (de) |
CA (1) | CA2124821C (de) |
DE (1) | DE69222182T2 (de) |
DK (1) | DK0617612T3 (de) |
ES (1) | ES2109377T3 (de) |
GR (1) | GR3025501T3 (de) |
IL (1) | IL104179A (de) |
MX (1) | MX9207390A (de) |
NZ (1) | NZ245483A (de) |
PT (1) | PT101132B (de) |
SG (1) | SG43179A1 (de) |
WO (1) | WO1993011749A1 (de) |
ZA (1) | ZA929789B (de) |
Families Citing this family (91)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2108575C (en) * | 1991-04-16 | 2002-10-22 | Kouichi Nakamichi | Method of manufacturing solid dispersion |
CA2124821C (en) | 1991-12-18 | 2003-10-07 | Isaac Ghebre-Sellassie | Novel solid pharmaceutical dispersions |
US5688510A (en) * | 1993-11-18 | 1997-11-18 | Nippon Shinyaku Co. Ltd. | Process for producing stable medicinal composition, and pharmaceutical preparation |
SE9502244D0 (sv) * | 1995-06-20 | 1995-06-20 | Bioglan Ab | A composition and a process for the preparation thereof |
AUPN814496A0 (en) * | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
AU3508097A (en) | 1996-06-26 | 1998-01-14 | Board Of Regents, The University Of Texas System | Hot-melt extrudable pharmaceutical formulation |
ATE273002T1 (de) * | 1996-06-28 | 2004-08-15 | Schering Corp | Feste lösung eines fungizids mit erhöhter bioverfügbarkeit |
US20050004049A1 (en) * | 1997-03-11 | 2005-01-06 | Elan Pharma International Limited | Novel griseofulvin compositions |
US5955475A (en) * | 1997-06-30 | 1999-09-21 | Endo Pharmaceuticals Inc. | Process for manufacturing paroxetine solid dispersions |
HN1998000115A (es) * | 1997-08-21 | 1999-06-02 | Warner Lambert Co | Formas de dosificación farmacéuticas sólidas |
CA2214895C (en) * | 1997-09-19 | 1999-04-20 | Bernard Charles Sherman | Improved pharmaceutical composition comprising fenofibrate |
US6107341A (en) * | 1997-12-19 | 2000-08-22 | Bissell Homecare, Inc. | Aqueous miticide containing benzyl benzoate |
US6376542B1 (en) * | 1997-12-19 | 2002-04-23 | Bissell Homecare, Inc. | Aqueous miticide compositions containing benzyl benzoate |
ZA9811592B (en) * | 1997-12-22 | 1999-06-17 | Schering Corp | Molecular dispersion composition with enhanced bioavailability |
US6706283B1 (en) | 1999-02-10 | 2004-03-16 | Pfizer Inc | Controlled release by extrusion of solid amorphous dispersions of drugs |
DE19913606A1 (de) * | 1999-03-25 | 2000-09-28 | Basf Ag | Pulverförmige Solubilisationshilfsstoffe für feste pharmazeutische Darreichungsformen |
DE19916383A1 (de) * | 1999-03-31 | 2000-10-05 | Schering Ag | Pharmazeutische Zusammensetzung mit einem Extrusionsstoff |
JP2003500439A (ja) * | 1999-05-28 | 2003-01-07 | アボット・ラボラトリーズ | 脂質調節剤を含む新規調合物 |
DE19929361A1 (de) * | 1999-06-25 | 2001-01-04 | Basf Ag | Mechanisch stabile pharmazeutische Darreichungsformen, enthaltend flüssige oder halbfeste oberflächenaktive Substanzen |
JP5767429B2 (ja) * | 1999-11-12 | 2015-08-19 | アッヴィ・インコーポレイテッド | 固体分散剤中の結晶化阻害剤 |
DE10000792A1 (de) | 2000-01-11 | 2001-07-19 | Bernhard C Lippold | Formulierungen von Wirkstoffen in Form einer festen Dispersion |
DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
CZ20033457A3 (cs) | 2001-06-22 | 2004-09-15 | Pfizer Products Inc. | Farmaceutická kompozice zahrnující léčiva s nízkou rozpustností a/nebo léčiva citlivá na kyselinu a neutralizované kyselé polymery |
PT1404300E (pt) | 2001-06-22 | 2009-11-09 | Bend Res Inc | Composições farmacêuticas de dispersões de fármacos e polímeros neutros |
ES2305434T3 (es) * | 2002-02-01 | 2008-11-01 | Pfizer Products Inc. | Composiciones framaceuticas de dispersiones amorfas de farmacos y materiales que forman microfases lipofilas. |
MY140561A (en) * | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
GB0205253D0 (en) * | 2002-03-06 | 2002-04-17 | Univ Gent | Immediate release pharmaceutical granule compositions and a continuous process for making them |
JP2005526083A (ja) * | 2002-03-14 | 2005-09-02 | ワトソン ファーマシューティカルズ, インコーポレイテッド | プロゲステロンの経口薬物送達システム |
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
AU2003240301B2 (en) * | 2002-06-25 | 2008-02-14 | Acrux Dds Pty Ltd | Transdermal delivery rate control using amorphous pharmaceutical compositions |
US20050181032A1 (en) * | 2002-06-25 | 2005-08-18 | Acrux Dds Pty Ltd. | Metastable pharmaceutical compositions |
JP2006518380A (ja) | 2003-01-31 | 2006-08-10 | スミスクライン・ビーチャム・コーポレイション | 固体分散体組成物 |
EP1594468A2 (de) * | 2003-02-03 | 2005-11-16 | Novartis AG | Verfahren zur herstellung eines pharmazeutischen produktes in form einer festen dispersion |
MXPA04008070A (es) | 2003-03-10 | 2004-11-26 | Altana Pharma Ag | Novedoso proceso para la preparacion de roflumilasto. |
RU2339364C2 (ru) * | 2003-04-29 | 2008-11-27 | Н.В.Органон, Nl | Способ затвердевания с применением антирастворителя |
CL2004000983A1 (es) * | 2003-05-08 | 2005-03-04 | Altana Pharma Ag | Composicion farmaceutica oral en forma de tableta que comprende a pantoprazol magnetico dihidratado, en donde la forma de tableta esta compuesto por un nucleo, una capa intermedia y una capa exterior; y uso de la composicion farmaceutica en ulceras y |
PE20050150A1 (es) * | 2003-05-08 | 2005-03-22 | Altana Pharma Ag | Una forma de dosificacion que contiene (s)-pantoprazol como ingrediente activo |
US8273371B2 (en) | 2003-06-27 | 2012-09-25 | Johan Adriaan Martens | Crystalline mesoporous oxide based materials useful for the fixation and controlled release of drugs |
GB0315012D0 (en) * | 2003-06-27 | 2003-07-30 | Leuven K U Res & Dev | Zeotiles |
ATE540671T1 (de) * | 2003-08-04 | 2012-01-15 | Bend Res Inc | Pharmazeutische zusammensetzungen von adsorbaten von amorphen arzneimitteln und lipophilen mikrophasen-bildenden materialien |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
DE102004032051A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
JP5069001B2 (ja) | 2003-10-10 | 2012-11-07 | ベロクシス ファーマシューティカルズ エー/エス | フィブラートを含む固体投与形態 |
ATE399536T1 (de) * | 2003-12-04 | 2008-07-15 | Pfizer Prod Inc | Verfahren zur herstellung von pharmazeutischen multiteilchenförmigen produkten |
KR100629771B1 (ko) * | 2004-01-27 | 2006-09-28 | 씨제이 주식회사 | 결정성이 감소되거나 무정형화된 올티프라즈의 제조방법 |
US20050202079A1 (en) * | 2004-03-15 | 2005-09-15 | Mylan Pharmaceuticals Inc. | Novel orally administrable formulation of nitrofurantoin and a method for preparing said formulation |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
GB2418854B (en) * | 2004-08-31 | 2009-12-23 | Euro Celtique Sa | Multiparticulates |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
EP1861074B1 (de) * | 2005-03-16 | 2013-04-24 | Takeda GmbH | Geschmacksmaskierte dosierform von roflumilast |
KR100627687B1 (ko) * | 2005-04-20 | 2006-09-25 | 주식회사 씨티씨바이오 | 시부트라민 유리염기 함유 조성물 및 이의 제조방법 |
EP1871346A4 (de) * | 2005-04-20 | 2012-07-18 | Ctc Bio Inc | Pharmazeutische zusammensetzung mit freier base aus sibutramin und herstellungsverfahren dafür |
DE102005023803A1 (de) * | 2005-05-19 | 2006-11-23 | Basf Ag | Verfahren zur Herstellung von festen Blends aus Polyvinylpyrrolidonen und ethoxilierten Fettsäurederivaten |
KR20070025070A (ko) * | 2005-08-31 | 2007-03-08 | 주식회사 대웅제약 | 시부트라민 및 계면활성제를 함유하는 고체분산체 및 그의제조방법 |
GB0612695D0 (en) * | 2006-06-27 | 2006-08-09 | Univ Gent | Process for preparing a solid dosage form |
SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
WO2008064259A2 (en) * | 2006-11-21 | 2008-05-29 | Biokey, Inc. | Solid dispersion composition comprising fluvastatin |
US20100016449A1 (en) * | 2006-12-21 | 2010-01-21 | Boehringer Ingelheim International Gmbh | Formulations with Improved Bioavailability |
CA2712010A1 (en) * | 2008-01-11 | 2009-07-12 | Cipla Limited | Solid pharmaceutical dosage form |
NZ586792A (en) | 2008-01-25 | 2012-09-28 | Gruenenthal Chemie | Tamper resistant controlled release pharmaceutical tablets form having convex and concave surfaces |
KR101690094B1 (ko) | 2008-05-09 | 2016-12-27 | 그뤼넨탈 게엠베하 | 분무 응결 단계의 사용하에 중간 분말 제형 및 최종 고체 제형을 제조하는 방법 |
US10080721B2 (en) | 2009-07-22 | 2018-09-25 | Gruenenthal Gmbh | Hot-melt extruded pharmaceutical dosage form |
PL2456424T3 (pl) | 2009-07-22 | 2013-12-31 | Gruenenthal Gmbh | Stabilizowana przed utlenianiem odporna na naruszenie postać dawkowania |
SG10201501054TA (en) * | 2009-10-27 | 2015-04-29 | Lupin Ltd | Solid dispersion of rifaximin |
ES2487244T3 (es) | 2010-09-02 | 2014-08-20 | Grünenthal GmbH | Forma de dosificación resistente a la manipulación que comprende un polímero aniónico |
BR112013005194A2 (pt) | 2010-09-02 | 2016-05-03 | Gruenenthal Gmbh | forma de dosagem resistente à violação compreendendo sal inorgânico |
CN103179959A (zh) | 2010-10-20 | 2013-06-26 | 帝斯曼知识产权资产管理有限公司 | 含悬挂亲水基的可生物降解的组合物和相关器械 |
KR102095698B1 (ko) * | 2010-10-29 | 2020-04-01 | 애브비 인코포레이티드 | 아폽토시스―유도제를 포함하는 고체 분산체 |
LT2736495T (lt) | 2011-07-29 | 2017-11-10 | Grünenthal GmbH | Sugadinimui atspari tabletė, pasižyminti greitu vaisto atpalaidavimu |
KR20140053158A (ko) | 2011-07-29 | 2014-05-07 | 그뤼넨탈 게엠베하 | 즉시 약물 방출을 제공하는 탬퍼-저항성 정제 |
WO2013030789A1 (en) | 2011-08-30 | 2013-03-07 | Ranbaxy Laboratories Limited | Pharmaceutical oral solid dosage form containing a poorly water soluble pde - iv inhibitor |
BR112014019988A8 (pt) | 2012-02-28 | 2017-07-11 | Gruenenthal Gmbh | Forma de dosagem resistente a socamento compreendendo um composto farmacologicamente ativo e um polímero aniônico |
AU2013248351B2 (en) | 2012-04-18 | 2018-04-26 | Grunenthal Gmbh | Tamper resistant and dose-dumping resistant pharmaceutical dosage form |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
KR102191562B1 (ko) * | 2012-11-07 | 2020-12-15 | 에스케이바이오팜 주식회사 | 난용성 약물의 고체분산체 및 이의 제조방법 |
AU2014273227B2 (en) | 2013-05-29 | 2019-08-15 | Grunenthal Gmbh | Tamper-resistant dosage form containing one or more particles |
AR096439A1 (es) | 2013-05-29 | 2015-12-30 | Gruenenthal Gmbh | Forma de dosificación resistente al uso indebido que contiene una o más partículas |
US10624862B2 (en) | 2013-07-12 | 2020-04-21 | Grünenthal GmbH | Tamper-resistant dosage form containing ethylene-vinyl acetate polymer |
WO2015071841A1 (en) | 2013-11-12 | 2015-05-21 | Druggability Technologies Holdings Limited | Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them |
EP3073994A1 (de) | 2013-11-26 | 2016-10-05 | Grünenthal GmbH | Herstellung einer pulverförmigen pharmazeutischen zusammensetzung mittels kryogenen mahlens |
US20150320690A1 (en) | 2014-05-12 | 2015-11-12 | Grünenthal GmbH | Tamper resistant immediate release capsule formulation comprising tapentadol |
EP3148512A1 (de) | 2014-05-26 | 2017-04-05 | Grünenthal GmbH | Gegen entsorgung von ethanolischer dosis gesicherte mehrfachpartikel |
WO2016089796A1 (en) * | 2014-12-04 | 2016-06-09 | Merck Sharp & Dohme Corp. | Formulation inhibiting effects of low acid environment |
CA2983642A1 (en) | 2015-04-24 | 2016-10-27 | Grunenthal Gmbh | Tamper-resistant dosage form with immediate release and resistance against solvent extraction |
AU2016319203A1 (en) | 2015-09-10 | 2018-02-22 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
CN113616599B (zh) * | 2021-09-10 | 2022-11-18 | 宁夏医科大学 | 一种大黄素固体分散体及其制备方法与应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1983000091A1 (en) * | 1981-07-08 | 1983-01-20 | Keith, Alec, Dell | Polymeric diffusion matrix containing 5-ad(3,4-dimethoxyphenethyl)methylaminobd-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile |
JPS6051189A (ja) * | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造法 |
JPS60100516A (ja) * | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
GB8518301D0 (en) * | 1985-07-19 | 1985-08-29 | Fujisawa Pharmaceutical Co | Hydrodynamically explosive systems |
DE3612212A1 (de) | 1986-04-11 | 1987-10-15 | Basf Ag | Verfahren zur herstellung von festen pharmazeutischen formen |
US4980378A (en) * | 1988-06-01 | 1990-12-25 | Odontex, Inc. | Biodegradable absorption enhancers |
DE3839825A1 (de) * | 1988-11-25 | 1990-06-13 | Henning Berlin Gmbh | Feststoffdispersionen enthaltend oxipurinol und/oder seine alkali- oder erdalkalisalze |
US4996193A (en) * | 1989-03-03 | 1991-02-26 | The Regents Of The University Of California | Combined topical and systemic method of administration of cyclosporine |
CA2108575C (en) | 1991-04-16 | 2002-10-22 | Kouichi Nakamichi | Method of manufacturing solid dispersion |
CA2124821C (en) | 1991-12-18 | 2003-10-07 | Isaac Ghebre-Sellassie | Novel solid pharmaceutical dispersions |
-
1992
- 1992-11-18 CA CA002124821A patent/CA2124821C/en not_active Expired - Fee Related
- 1992-11-18 EP EP92925333A patent/EP0617612B1/de not_active Expired - Lifetime
- 1992-11-18 ES ES92925333T patent/ES2109377T3/es not_active Expired - Lifetime
- 1992-11-18 SG SG1996004974A patent/SG43179A1/en unknown
- 1992-11-18 WO PCT/US1992/009989 patent/WO1993011749A1/en active IP Right Grant
- 1992-11-18 AU AU31426/93A patent/AU671811B2/en not_active Ceased
- 1992-11-18 JP JP51091293A patent/JP3722293B2/ja not_active Expired - Fee Related
- 1992-11-18 DE DE69222182T patent/DE69222182T2/de not_active Expired - Fee Related
- 1992-11-18 DK DK92925333.4T patent/DK0617612T3/da active
- 1992-11-18 AT AT92925333T patent/ATE157864T1/de not_active IP Right Cessation
- 1992-12-16 NZ NZ245483A patent/NZ245483A/en unknown
- 1992-12-16 PT PT101132A patent/PT101132B/pt not_active IP Right Cessation
- 1992-12-17 ZA ZA929789A patent/ZA929789B/xx unknown
- 1992-12-17 MX MX9207390A patent/MX9207390A/es unknown
- 1992-12-18 IL IL104179A patent/IL104179A/xx not_active IP Right Cessation
-
1994
- 1994-03-28 US US08/218,495 patent/US6677362B1/en not_active Expired - Fee Related
-
1997
- 1997-11-26 GR GR970403150T patent/GR3025501T3/el unknown
-
2001
- 2001-06-14 US US09/881,366 patent/US20010044409A1/en not_active Abandoned
-
2003
- 2003-12-03 US US10/726,780 patent/US20040110694A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP3722293B2 (ja) | 2005-11-30 |
MX9207390A (es) | 1993-06-01 |
SG43179A1 (en) | 1997-10-17 |
DE69222182D1 (de) | 1997-10-16 |
EP0617612B1 (de) | 1997-09-10 |
ZA929789B (en) | 1993-06-23 |
AU3142693A (en) | 1993-07-19 |
WO1993011749A1 (en) | 1993-06-24 |
DK0617612T3 (da) | 1998-04-14 |
AU671811B2 (en) | 1996-09-12 |
PT101132B (pt) | 2000-02-29 |
CA2124821A1 (en) | 1993-06-24 |
DE69222182T2 (de) | 1998-02-26 |
IL104179A (en) | 1997-11-20 |
GR3025501T3 (en) | 1998-02-27 |
EP0617612A1 (de) | 1994-10-05 |
US20040110694A1 (en) | 2004-06-10 |
JPH07504162A (ja) | 1995-05-11 |
PT101132A (pt) | 1994-03-31 |
ES2109377T3 (es) | 1998-01-16 |
NZ245483A (en) | 1995-12-21 |
CA2124821C (en) | 2003-10-07 |
US20010044409A1 (en) | 2001-11-22 |
IL104179A0 (en) | 1993-05-13 |
US6677362B1 (en) | 2004-01-13 |
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