ATA943376A - Verfahren zur herstellung von neuen cyproheptadinderivaten und von deren pharmazeutisch verwendbaren salzen sowie optischen isomeren - Google Patents

Verfahren zur herstellung von neuen cyproheptadinderivaten und von deren pharmazeutisch verwendbaren salzen sowie optischen isomeren

Info

Publication number: ATA943376A
Authority: AT; Austria
Prior art keywords: pharmaceuticals; sales; well; optical isomers; producing new
Prior art date: 1975-12-22

Application number

AT943376A

Other languages

English (en)

Other versions

AT363936B (de

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-12-22

Filing date

1976-12-20

Publication date

1981-02-15

1976-12-20 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1980-07-11 Priority to AT363080A priority Critical patent/ATA363080A/de

1980-07-11 Priority to AT363180A priority patent/ATA363180A/de

1980-07-11 Priority to AT362980A priority patent/ATA362980A/de

1981-02-15 Publication of ATA943376A publication Critical patent/ATA943376A/de

1981-09-10 Application granted granted Critical

1981-09-10 Publication of AT363936B publication Critical patent/AT363936B/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/38—Halogen atoms or nitro radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/02—Magnesium compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)

AT0943376A 1975-12-22 1976-12-20 Verfahren zur herstellung von neuen cyproheptadinderivaten und von deren pharmazeutisch verwendbaren salzen sowie optischen isomeren AT363936B (de)

Priority Applications (3)

Application Number	Priority Date	Filing Date	Title
AT363080A ATA363080A (de)	1975-12-22	1980-07-11	Verfahren zur herstellung von neuen cyproheptadinderivaten und ihren salzen
AT363180A ATA363180A (de)	1975-12-22	1980-07-11	Verfahren zur herstellung von neuen cyproheptadinderivaten und ihren salzen
AT362980A ATA362980A (de)	1975-12-22	1980-07-11	Verfahren zur herstellung von neuen jod-derivaten des cyproheptadins, seiner salze und enantiomeren

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/642,863 US4031222A (en)	1975-12-22	1975-12-22	Trifluoromethylthio (and sulfonyl) derivatives of cyproheptadine analogs

Publications (2)

Publication Number	Publication Date
ATA943376A true ATA943376A (de)	1981-02-15
AT363936B AT363936B (de)	1981-09-10

Family

ID=24578354

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT0943376A AT363936B (de)	1975-12-22	1976-12-20	Verfahren zur herstellung von neuen cyproheptadinderivaten und von deren pharmazeutisch verwendbaren salzen sowie optischen isomeren

Country Status (26)

Country	Link
US (1)	US4031222A (de)
JP (1)	JPS5278880A (de)
AT (1)	AT363936B (de)
AU (1)	AU506996B2 (de)
BE (1)	BE849678A (de)
CA (1)	CA1085823A (de)
CH (7)	CH625790A5 (de)
DE (1)	DE2657978C3 (de)
DK (1)	DK550976A (de)
ES (6)	ES454468A1 (de)
FI (1)	FI763545A (de)
FR (1)	FR2336133A1 (de)
GB (1)	GB1519080A (de)
GR (1)	GR62010B (de)
HU (1)	HU175018B (de)
IE (1)	IE44362B1 (de)
IL (1)	IL51103A (de)
LU (1)	LU76382A1 (de)
NL (1)	NL7613713A (de)
NO (1)	NO146359C (de)
NZ (1)	NZ182868A (de)
PH (1)	PH14088A (de)
PL (4)	PL116941B1 (de)
PT (1)	PT65956B (de)
SE (1)	SE7613796L (de)
ZA (1)	ZA767579B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4148903A (en) *	1977-07-28	1979-04-10	Merck & Co., Inc.	Antipsychotic, antiserotonin and antihistaminic pyrrolo[2,1-b][3]benzazepines
US4132796A (en) *	1977-12-01	1979-01-02	Merck & Co., Inc.	Antipsychotic 3-trifluoromethylsulfinyl analogs of cyproheptadine
US4285956A (en) *	1978-05-12	1981-08-25	Kefalas A/S	Xanthene and thioxanthene derivatives, compositions thereof and treatment therewith
US4195091A (en) *	1978-11-15	1980-03-25	Merck & Co., Inc.	Appetite stimulating pyrrolo[2,1-b][3]benzazepines
ATE3150T1 (de) *	1979-01-02	1983-05-15	Merck & Co. Inc.	Links- und rechtsdrehende enantiomere von 3halocyproheptadinen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzung.
US4275070A (en) *	1979-05-21	1981-06-23	Merck & Co., Inc.	Antipsychotic pharmaceutical compositions of the levorotatory enantiomers of 3-methoxycyproheptadine and an analog thereof
EP0019797A1 (de) *	1979-05-21	1980-12-10	Merck & Co. Inc.	Links- und rechtsdrehende Enantiomere von 3-Methoxycyproheptadin und ihre Analoge, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen mit antipsychotischer Wirkung
US4220651A (en) *	1979-05-21	1980-09-02	Merck & Co., Inc.	Antipsychotic levorotatory enantiomers of 3-halocyproheptadines, analogs and derivatives
US5231105A (en) *	1987-06-02	1993-07-27	Ajinomoto Co., Inc.	Ethylamine derivatives and antihypertensives containing the same
US5393890A (en)	1988-06-02	1995-02-28	Ajinomoto Co., Inc.	Piperidine derivatives and hypotensives containing the same
US5250681A (en) *	1988-06-02	1993-10-05	Ajinomoto Co., Inc.	Piperidine derivatives and hypotensives containing the same
US5021426A (en) *	1990-02-26	1991-06-04	Merck & Co., Inc.	Method of traeting malaria with cyproheptadine derivatives
US5114919A (en) *	1990-02-26	1992-05-19	Merck & Co., Inc.	Adjuncts in cancer chemotherapy
US4996321A (en) *	1990-02-26	1991-02-26	Merck & Co., Inc.	Dibenzo[a,d]cycloheptenylidene compounds
CN103130708B (zh) *	2011-12-01	2016-08-10	上海药明康德新药开发有限公司	一种n-叔丁氧羰基-4-硝基哌啶的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3851059A (en) *	1970-02-05	1974-11-26	Merck & Co Inc	Method for the stimulation of appetite in patients

1975
- 1975-12-22 US US05/642,863 patent/US4031222A/en not_active Expired - Lifetime
1976
- 1976-12-08 SE SE7613796A patent/SE7613796L/xx not_active Application Discontinuation
- 1976-12-08 DK DK550976A patent/DK550976A/da unknown
- 1976-12-09 NO NO764188A patent/NO146359C/no unknown
- 1976-12-09 FI FI763545A patent/FI763545A/fi not_active Application Discontinuation
- 1976-12-09 NL NL7613713A patent/NL7613713A/xx unknown
- 1976-12-13 PT PT65956A patent/PT65956B/pt unknown
- 1976-12-13 NZ NZ182868A patent/NZ182868A/xx unknown
- 1976-12-13 HU HU76ME2035A patent/HU175018B/hu unknown
- 1976-12-14 AU AU20528/76A patent/AU506996B2/en not_active Expired
- 1976-12-14 CH CH1571276A patent/CH625790A5/de not_active IP Right Cessation
- 1976-12-14 LU LU76382A patent/LU76382A1/xx unknown
- 1976-12-14 IL IL51103A patent/IL51103A/xx unknown
- 1976-12-16 FR FR7637940A patent/FR2336133A1/fr active Granted
- 1976-12-16 CA CA267,998A patent/CA1085823A/en not_active Expired
- 1976-12-16 GR GR52418A patent/GR62010B/el unknown
- 1976-12-16 GB GB52626/76A patent/GB1519080A/en not_active Expired
- 1976-12-17 IE IE2771/76A patent/IE44362B1/en unknown
- 1976-12-20 PL PL1976222975A patent/PL116941B1/pl unknown
- 1976-12-20 PL PL1976194577A patent/PL116346B1/pl unknown
- 1976-12-20 AT AT0943376A patent/AT363936B/de not_active IP Right Cessation
- 1976-12-20 PL PL1976222973A patent/PL116947B1/pl unknown
- 1976-12-20 PL PL1976222974A patent/PL122145B1/pl unknown
- 1976-12-21 ES ES454468A patent/ES454468A1/es not_active Expired
- 1976-12-21 DE DE2657978A patent/DE2657978C3/de not_active Expired
- 1976-12-21 BE BE173486A patent/BE849678A/xx not_active IP Right Cessation
- 1976-12-21 ZA ZA00767579A patent/ZA767579B/xx unknown
- 1976-12-21 PH PH19273A patent/PH14088A/en unknown
- 1976-12-22 JP JP51153529A patent/JPS5278880A/ja active Pending
1978
- 1978-02-01 ES ES466550A patent/ES466550A1/es not_active Expired
- 1978-02-01 ES ES466553A patent/ES466553A1/es not_active Expired
- 1978-02-01 ES ES466552A patent/ES466552A1/es not_active Expired
- 1978-02-01 ES ES466551A patent/ES466551A1/es not_active Expired
- 1978-02-01 ES ES466549A patent/ES466549A1/es not_active Expired
1980
- 1980-11-26 CH CH877180A patent/CH626345A5/de not_active IP Right Cessation
- 1980-11-26 CH CH876980A patent/CH626343A5/de not_active IP Right Cessation
- 1980-11-26 CH CH876880A patent/CH627167A5/de not_active IP Right Cessation
- 1980-11-26 CH CH877080A patent/CH626344A5/de not_active IP Right Cessation
- 1980-11-26 CH CH877280A patent/CH626346A5/de not_active IP Right Cessation
1981
- 1981-06-01 CH CH357381A patent/CH631164A5/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
FR2336133B1 (de)	1978-11-17
DE2657978B2 (de)	1980-06-04
FI763545A (de)	1977-06-23
NO146359C (no)	1982-09-15
IL51103A0 (en)	1977-02-28
LU76382A1 (de)	1977-06-28
DK550976A (da)	1977-06-23
JPS5278880A (en)	1977-07-02
CH625790A5 (de)	1981-10-15
BE849678A (fr)	1977-06-21
DE2657978A1 (de)	1977-06-23
IE44362L (en)	1977-06-22
IE44362B1 (en)	1981-11-04
US4031222A (en)	1977-06-21
PL116346B1 (en)	1981-06-30
PL194577A1 (de)	1980-01-28
PL122145B1 (en)	1982-06-30
ES466553A1 (es)	1978-10-01
GB1519080A (en)	1978-07-26
CH626344A5 (de)	1981-11-13
ZA767579B (en)	1978-08-30
NO146359B (no)	1982-06-07
IL51103A (en)	1980-11-30
ES466551A1 (es)	1978-10-01
CH631164A5 (de)	1982-07-30
ES466549A1 (es)	1978-10-01
PL116947B1 (en)	1981-07-31
CH627167A5 (de)	1981-12-31
AU2052876A (en)	1978-06-22
NZ182868A (en)	1979-03-28
ES466552A1 (es)	1978-10-01
FR2336133A1 (fr)	1977-07-22
PT65956B (en)	1978-11-07
GR62010B (en)	1979-02-15
PT65956A (en)	1977-01-01
AT363936B (de)	1981-09-10
CA1085823A (en)	1980-09-16
NO764188L (de)	1977-06-23
ES454468A1 (es)	1978-04-16
CH626343A5 (de)	1981-11-13
NL7613713A (nl)	1977-06-24
PL116941B1 (en)	1981-07-31
CH626345A5 (de)	1981-11-13
ES466550A1 (es)	1978-10-01
PH14088A (en)	1981-02-10
SE7613796L (sv)	1977-06-23
AU506996B2 (en)	1980-01-31
DE2657978C3 (de)	1981-02-12
CH626346A5 (de)	1981-11-13
HU175018B (hu)	1980-04-28

Publication	Publication Date	Title
AT373239B (de)	1983-12-27	Verfahren zur herstellung von neuen 2-hydroxymethyl-3,4,5-trihydroxypiperidinderivaten
AT356111B (de)	1980-04-10	Verfahren zur herstellung von neuen pyrimidin- derivaten
AT369017B (de)	1982-11-25	Verfahren zur herstellung von neuen derivaten der hydroxycarbonylphosphonsaeure, sowie von deren salzen und optischen antipoden
AT360663B (de)	1981-01-26	Verfahren zur herstellung von neuen 6,7- -benzomorphanen
AT360182B (de)	1980-12-29	Verfahren zur herstellung von neuen, optisch aktiven und racemischen prostaglandin-derivaten
ATA943376A (de)	1981-02-15	Verfahren zur herstellung von neuen cyproheptadinderivaten und von deren pharmazeutisch verwendbaren salzen sowie optischen isomeren
ATA854376A (de)	1979-08-15	Verfahren zur herstellung von neuen amino- alkohol-derivaten
ATA936276A (de)	1980-02-15	Verfahren zur herstellung von neuen, basisch substituierter indolderivate
AT344163B (de)	1978-07-10	Verfahren zur herstellung von neuen oxadiazolinon-derivaten
AT330179B (de)	1976-06-25	Verfahren zur herstellung von neuen 4a-aryl- transdecahydroisochinolinderivaten sowie deren optischen isomeren
AT346829B (de)	1978-11-27	Verfahren zur herstellung von neuen benzophenonderivaten
AT350056B (de)	1979-05-10	Verfahren zur herstellung von neuen pyrido- (2,3-f)-(1,4)-diazepinen, deren optischen isomeren und salzen
AT354434B (de)	1979-01-10	Verfahren zur herstellung von neuen 1,4- diphenyl-3-pyrazolin-5-onen
AT370098B (de)	1983-02-25	Verfahren zur herstellung von neuen thiazolidindionderivaten und von deren salzen, racematen oder optischen isomeren
AT348142B (de)	1979-01-25	Verfahren zur herstellung von neuen 8,8- disubstituierten 6-methylergolinen
ATA190478A (de)	1980-02-15	Verfahren zur herstellung von neuen 1,2,4- -triazin-5-on-derivaten
ATA585476A (de)	1978-02-15	Verfahren zur herstellung von neuem 3,7-dimethyl-3-hydroxyoctannitril
ATA519676A (de)	1978-02-15	Verfahren zur herstellung von neuen behensaureestern, deren isomeren und saureadditionssalzen
AT351188B (de)	1979-07-10	Verfahren zur herstellung von neuen 1,3- benzodioxan-prostansaeurederivaten
ATA407180A (de)	1983-11-15	Verfahren zur herstellung von neuen imidazolinylbenzoaten und den optischen isomeren und isomerengemischen hiervon sowie deren salzen
AT346849B (de)	1978-11-27	Verfahren zur herstellung von neuen phthalazinderivaten und von deren salzen und von deren optischen isomeren
ATA485676A (de)	1980-06-15	Verfahren zur herstellung von neuen 1,4- -dihydropyridinderivaten
AT348998B (de)	1979-03-12	Verfahren zur herstellung von neuen (1- (4-cyclohexylphenyl)-aethylthio-, -sulfinyl- und -sulfonyl)-essigsaeure-derivaten
ATA431776A (de)	1978-02-15	Verfahren zur herstellung von neuen n,n-disubstituierten aminoessigsaurederivaten
AT355037B (de)	1980-02-11	Verfahren zur herstellung von neuen aziridin- und azetidinderivaten und von deren saeure- additionssalzen und optischen isomeren

Legal Events

Date	Code	Title	Description
1983-11-15	ELJ	Ceased due to non-payment of the annual fee