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AT351547B - Verfahren zur herstellung von neuen thieno- (1,5)-benzodiazepinen und deren saeure- additionssalzen - Google Patents

Verfahren zur herstellung von neuen thieno- (1,5)-benzodiazepinen und deren saeure- additionssalzen

Info

Publication number
AT351547B
AT351547B AT898275A AT898275A AT351547B AT 351547 B AT351547 B AT 351547B AT 898275 A AT898275 A AT 898275A AT 898275 A AT898275 A AT 898275A AT 351547 B AT351547 B AT 351547B
Authority
AT
Austria
Prior art keywords
benzodiazepines
acid addition
addition salts
producing new
new thieno
Prior art date
Application number
AT898275A
Other languages
English (en)
Other versions
ATA898275A (de
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10459213&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AT351547(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Publication of ATA898275A publication Critical patent/ATA898275A/de
Application granted granted Critical
Publication of AT351547B publication Critical patent/AT351547B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT898275A 1974-11-26 1975-11-26 Verfahren zur herstellung von neuen thieno- (1,5)-benzodiazepinen und deren saeure- additionssalzen AT351547B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB51240/74A GB1533235A (en) 1974-11-26 1974-11-26 Benzodiazepine derivatives

Publications (2)

Publication Number Publication Date
ATA898275A ATA898275A (de) 1979-01-15
AT351547B true AT351547B (de) 1979-07-25

Family

ID=10459213

Family Applications (1)

Application Number Title Priority Date Filing Date
AT898275A AT351547B (de) 1974-11-26 1975-11-26 Verfahren zur herstellung von neuen thieno- (1,5)-benzodiazepinen und deren saeure- additionssalzen

Country Status (30)

Country Link
JP (1) JPS6044314B2 (de)
AR (1) AR221203A1 (de)
AT (1) AT351547B (de)
AU (1) AU506340B2 (de)
BE (1) BE835932A (de)
BG (1) BG29573A3 (de)
CA (1) CA1075687A (de)
CH (2) CH613455A5 (de)
CS (1) CS236753B2 (de)
DD (1) DD123343A5 (de)
DE (1) DE2552403C2 (de)
DK (1) DK146887C (de)
ES (1) ES443011A1 (de)
FR (1) FR2292479A1 (de)
GB (1) GB1533235A (de)
HK (1) HK58681A (de)
HU (1) HU172493B (de)
IE (1) IE42564B1 (de)
IL (1) IL48502A (de)
KE (1) KE3163A (de)
MY (1) MY8200149A (de)
NL (1) NL186088C (de)
NZ (1) NZ179335A (de)
PH (2) PH11669A (de)
PL (1) PL100135B1 (de)
RO (1) RO69912A (de)
SE (2) SE421209B (de)
SU (2) SU629879A3 (de)
YU (1) YU298375A (de)
ZA (1) ZA757344B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL62792A (en) * 1980-05-07 1985-02-28 Byk Gulden Lomberg Chem Fab Acylated dihydrothienodiazepinone compounds,process for their preparation,and medicaments containing them
GB8819059D0 (en) * 1988-08-11 1988-09-14 Lilly Industries Ltd Benzodiazepine compounds & their use as pharmaceuticals
GB9009229D0 (en) * 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
EP0582368B1 (de) * 1992-05-29 2001-01-24 Eli Lilly And Company Limited Thienobenzodiazepinderivate zur Behandlung von Störungen des Zentralnervensystems
WO1997016430A1 (en) * 1995-11-01 1997-05-09 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
US6043358A (en) 1995-11-01 2000-03-28 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
US6271225B1 (en) * 1997-09-02 2001-08-07 Welfide Corporation Fused thiophene compounds and medicinal use thereof
PL199016B1 (pl) * 2002-06-20 2008-08-29 Adamed Sp Z Oo Sposób wytwarzania olanzapiny
SI21270A (sl) 2002-07-15 2004-02-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Kristalne oblike olanzapina in postopki za njihovo pripravo
DE10301923B3 (de) 2003-01-17 2004-09-16 Krka Tovarna Zdravil, D.D. Verfahren und Zwischenprodukte zur Herstellung von Olanzapin
WO2005070939A1 (en) * 2004-01-27 2005-08-04 Synthon B.V. Synthesis of olanzapine and intermediates thereof
AR048272A1 (es) 2004-03-18 2006-04-12 Lek Pharmaceuticals Sintesis de 2 metil - 4- (4- metil -1- piperazinil) - 10 h- tieno ( 2,3-b) (1,5) benzodiazepina y sus sales, metodos para su preparacion, composiciones farmaceuticas que la contienen y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mentales.
AU2005260636B2 (en) * 2004-06-30 2011-04-14 Athersys, Inc. Substituted azepine derivatives as serotonin receptor modulators
EP2292624A1 (de) 2009-07-20 2011-03-09 LEK Pharmaceuticals d.d. Olanzapinreinigungsverfahren

Also Published As

Publication number Publication date
CS236753B2 (en) 1985-05-15
IE42564B1 (en) 1980-09-10
SU626702A3 (ru) 1978-09-30
ZA757344B (en) 1976-11-24
SE429045B (sv) 1983-08-08
HK58681A (en) 1981-12-04
SU629879A3 (ru) 1978-10-25
PL100135B1 (pl) 1978-09-30
DK146887B (da) 1984-01-30
YU298375A (en) 1982-10-31
IE42564L (en) 1976-05-26
BE835932A (fr) 1976-05-25
DD123343A5 (de) 1976-12-12
KE3163A (en) 1981-10-16
DK146887C (da) 1984-07-09
SE7513185L (sv) 1976-05-27
AU8685875A (en) 1977-05-26
NL186088C (nl) 1990-09-17
DE2552403C2 (de) 1986-06-19
FR2292479A1 (fr) 1976-06-25
JPS5176296A (en) 1976-07-01
IL48502A0 (en) 1976-01-30
RO69912A (ro) 1980-08-15
ATA898275A (de) 1979-01-15
GB1533235A (en) 1978-11-22
DK524175A (da) 1976-05-27
PH24534A (en) 1990-08-03
SE7812194L (sv) 1978-11-27
AU506340B2 (en) 1979-12-20
DE2552403A1 (de) 1976-08-12
FR2292479B1 (de) 1978-07-28
BG29573A3 (en) 1980-12-12
HU172493B (hu) 1978-09-28
JPS6044314B2 (ja) 1985-10-02
NL7513833A (nl) 1976-05-31
AR221203A1 (es) 1981-01-15
SE421209B (sv) 1981-12-07
CH613455A5 (en) 1979-09-28
NL186088B (nl) 1990-04-17
IL48502A (en) 1980-01-31
ES443011A1 (es) 1977-07-01
MY8200149A (en) 1982-12-31
NZ179335A (en) 1978-11-13
CA1075687A (en) 1980-04-15
PH11669A (en) 1978-05-19
CH613454A5 (en) 1979-09-28

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