AT328098B - Verfahren zur herstellung von neuen n-(heteroarylmethyl)-6,14-endoatheno-7alpha-hydroxyalkyl-tetrahydro-nororipavinen und -thebainen - Google Patents

Verfahren zur herstellung von neuen n-(heteroarylmethyl)-6,14-endoatheno-7alpha-hydroxyalkyl-tetrahydro-nororipavinen und -thebainen

Info

Publication number: AT328098B
Authority: AT; Austria
Prior art keywords: nororipavines; endoatheno; thebaines; 7alpha; heteroarylmethyl
Prior art date: 1972-06-21

Application number

AT461874*7A

Other languages

English (en)

Other versions

ATA461874A (de

Original Assignee

Boehringer Sohn Ingelheim

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1972-06-21

Filing date

1973-06-06

Publication date

1976-03-10

1973-06-06 Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim

1975-05-15 Publication of ATA461874A publication Critical patent/ATA461874A/de

1976-03-10 Application granted granted Critical

1976-03-10 Publication of AT328098B publication Critical patent/AT328098B/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

AT461874*7A 1972-06-21 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-6,14-endoatheno-7alpha-hydroxyalkyl-tetrahydro-nororipavinen und -thebainen AT328098B (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2230154A DE2230154A1 (de)	1972-06-21	1972-06-21	N-(heteroaryl-methyl)-6,14-endoaetheno7alpha-hydroxyalkyl-tetrahydro-nororipavine und -thebaine, deren hydrierungsprodukte und saeureadditionssalze sowie verfahren zu deren herstellung

Publications (2)

Publication Number	Publication Date
ATA461874A ATA461874A (de)	1975-05-15
AT328098B true AT328098B (de)	1976-03-10

Family

ID=5848276

Family Applications (7)

Application Number	Title	Priority Date	Filing Date
AT462074*7A AT328100B (de)	1972-06-21	1973-06-06	Verfahren zur herstellung von neuen n-(heteroarylmethyl)-6,14-endoatheno-7alpha-hydroxyalkyl-tetrahydro-northebainen
AT462374*7A AT329198B (de)	1972-06-21	1973-06-06	Verfahren zur herstellung von neuen n-(heteroaryl-methyl)-6,14-endoatheno-7alfa-hydroxyalkyl-tetrahydro-nororipavinen und -thebainen
AT462274*7A AT327409B (de)	1972-06-21	1973-06-06	Verfahren zur herstellung von neuen n-(heteroarylmethyl)-6,14-endoatheno-7alfa-hydroxyalkyltetrahydro-nororipavinen und -thebainen
AT461874*7A AT328098B (de)	1972-06-21	1973-06-06	Verfahren zur herstellung von neuen n-(heteroarylmethyl)-6,14-endoatheno-7alpha-hydroxyalkyl-tetrahydro-nororipavinen und -thebainen
AT494473A AT325219B (de)	1972-06-21	1973-06-06	Verfahren zur herstellung von neuen n-(heteroaryl-methyl)-6, 14-endoätheno-7alpha-hydroxyalkyltetrahydro-nororipavinen und -thebainen
AT461974*7A AT328099B (de)	1972-06-21	1973-06-06	Verfahren zur herstellung von neuen n-(heteroarylmethyl)-6,14-endoatheno-7alpha-hydroxyalkyl-tetrahydro-nororipavinen und -thebainen
AT462174*7A AT328101B (de)	1972-06-21	1973-06-06	Verfahren zur herstellung von neuen n-(heteroarylmethyl)-6,14-endoatheno-7alpha-hydroxyalkyl-tetrahydro-nororipavinen und -thebainen

Family Applications Before (3)

Application Number	Title	Priority Date	Filing Date
AT462074*7A AT328100B (de)	1972-06-21	1973-06-06	Verfahren zur herstellung von neuen n-(heteroarylmethyl)-6,14-endoatheno-7alpha-hydroxyalkyl-tetrahydro-northebainen
AT462374*7A AT329198B (de)	1972-06-21	1973-06-06	Verfahren zur herstellung von neuen n-(heteroaryl-methyl)-6,14-endoatheno-7alfa-hydroxyalkyl-tetrahydro-nororipavinen und -thebainen
AT462274*7A AT327409B (de)	1972-06-21	1973-06-06	Verfahren zur herstellung von neuen n-(heteroarylmethyl)-6,14-endoatheno-7alfa-hydroxyalkyltetrahydro-nororipavinen und -thebainen

Family Applications After (3)

Application Number	Title	Priority Date	Filing Date
AT494473A AT325219B (de)	1972-06-21	1973-06-06	Verfahren zur herstellung von neuen n-(heteroaryl-methyl)-6, 14-endoätheno-7alpha-hydroxyalkyltetrahydro-nororipavinen und -thebainen
AT461974*7A AT328099B (de)	1972-06-21	1973-06-06	Verfahren zur herstellung von neuen n-(heteroarylmethyl)-6,14-endoatheno-7alpha-hydroxyalkyl-tetrahydro-nororipavinen und -thebainen
AT462174*7A AT328101B (de)	1972-06-21	1973-06-06	Verfahren zur herstellung von neuen n-(heteroarylmethyl)-6,14-endoatheno-7alpha-hydroxyalkyl-tetrahydro-nororipavinen und -thebainen

Country Status (14)

Country	Link
US (1)	US3931189A (de)
JP (1)	JPS5614673B2 (de)
AT (7)	AT328100B (de)
BE (1)	BE801271A (de)
CH (7)	CH587264A5 (de)
DE (1)	DE2230154A1 (de)
DK (1)	DK141629C (de)
ES (3)	ES416106A1 (de)
FI (1)	FI57261C (de)
FR (1)	FR2189066B1 (de)
GB (1)	GB1431385A (de)
NL (1)	NL7308555A (de)
NO (1)	NO139050C (de)
SE (1)	SE412235B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4232026A (en) *	1978-07-20	1980-11-04	Merck & Co., Inc.	Diazaditwistanes, and pharmaceutical compositions for treating pain in warm blooded animals containing them
JPS60119848A (ja) *	1983-11-30	1985-06-27	三井建設株式会社	繊維補強コンクリ−ト並びにその施工法
JPS62298530A (ja) *	1986-06-16	1987-12-25	Otsuka Pharmaceut Co Ltd	坐薬用医薬組成物
CN1233645C (zh) *	2001-09-14	2005-12-28	中国人民解放军军事医学科学院毒物药物研究所	新的东罂粟碱衍生物及其医药用途
CN1939920B (zh) *	2005-09-29	2011-08-31	中国人民解放军军事医学科学院毒物药物研究所	东罂粟碱类化合物及其医药用途
UA104004C2 (uk)	2008-07-30	2013-12-25	Пердью Фарма Л.П.	Аналоги бупренорфіну
JP2021104932A (ja) *	2018-03-30	2021-07-26	日本ケミファ株式会社	モルヒナン誘導体の製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3474101A (en) *	1960-09-05	1969-10-21	Reckitt & Sons Ltd	Thebaine and oripavine derivatives
US3285914A (en) *	1964-06-11	1966-11-15	Smith Kline French Lab	3-n-substituted derivatives of oripavine and thebaine
GB1136764A (en) *	1965-08-13	1968-12-18	Reckitt & Sons Ltd	Derivatives of thebaine and oripavine
GB1146272A (en) *	1966-01-17	1969-03-26	Reckitt & Sons Ltd	Novel thebaine and oripavine derivatives
GB1223445A (en) *	1968-07-18	1971-02-24	Reckitt & Colmann Prod Ltd	Improvements in or relating to derivatives of morphine, their salts, and processes for their preparation
DE2107989A1 (de) *	1971-02-19	1972-09-07	Boehringer Sohn Ingelheim	N-(Furyl-methy])-morphinane, deren Säureadditionssalze sowie Verfahren zu deren Herstellung

1972
- 1972-06-21 DE DE2230154A patent/DE2230154A1/de not_active Withdrawn
1973
- 1973-06-06 AT AT462074*7A patent/AT328100B/de not_active IP Right Cessation
- 1973-06-06 AT AT462374*7A patent/AT329198B/de not_active IP Right Cessation
- 1973-06-06 AT AT462274*7A patent/AT327409B/de not_active IP Right Cessation
- 1973-06-06 AT AT461874*7A patent/AT328098B/de not_active IP Right Cessation
- 1973-06-06 AT AT494473A patent/AT325219B/de not_active IP Right Cessation
- 1973-06-06 AT AT461974*7A patent/AT328099B/de not_active IP Right Cessation
- 1973-06-06 AT AT462174*7A patent/AT328101B/de not_active IP Right Cessation
- 1973-06-13 US US05/369,500 patent/US3931189A/en not_active Expired - Lifetime
- 1973-06-18 CH CH1460676A patent/CH587264A5/xx not_active IP Right Cessation
- 1973-06-18 CH CH1461176A patent/CH594673A5/xx not_active IP Right Cessation
- 1973-06-18 CH CH881573A patent/CH585751A5/xx not_active IP Right Cessation
- 1973-06-18 CH CH1460876A patent/CH594672A5/xx not_active IP Right Cessation
- 1973-06-18 CH CH1460976A patent/CH585752A5/xx not_active IP Right Cessation
- 1973-06-18 CH CH1461076A patent/CH585753A5/xx not_active IP Right Cessation
- 1973-06-18 CH CH1460776A patent/CH586224A5/xx not_active IP Right Cessation
- 1973-06-20 DK DK341273A patent/DK141629C/da active
- 1973-06-20 JP JP6969173A patent/JPS5614673B2/ja not_active Expired
- 1973-06-20 NO NO2561/73A patent/NO139050C/no unknown
- 1973-06-20 NL NL7308555A patent/NL7308555A/xx not_active Application Discontinuation
- 1973-06-20 FI FI1989/73A patent/FI57261C/fi active
- 1973-06-20 GB GB2934673A patent/GB1431385A/en not_active Expired
- 1973-06-20 SE SE7308709A patent/SE412235B/xx unknown
- 1973-06-20 ES ES416106A patent/ES416106A1/es not_active Expired
- 1973-06-21 FR FR7322738A patent/FR2189066B1/fr not_active Expired
- 1973-06-21 BE BE132576A patent/BE801271A/xx unknown
1974
- 1974-04-05 ES ES425010A patent/ES425010A1/es not_active Expired
- 1974-04-05 ES ES425015A patent/ES425015A1/es not_active Expired

Also Published As

Publication number	Publication date
DK141629B (da)	1980-05-12
GB1431385A (en)	1976-04-07
AT328101B (de)	1976-03-10
FR2189066A1 (de)	1974-01-25
CH594672A5 (de)	1978-01-13
AT325219B (de)	1975-10-10
BE801271A (fr)	1973-12-21
NO139050C (no)	1979-01-03
CH587264A5 (de)	1977-04-29
FI57261C (fi)	1980-07-10
AT328100B (de)	1976-03-10
ATA462174A (de)	1975-05-15
AT327409B (de)	1976-01-26
ATA462074A (de)	1975-05-15
AT329198B (de)	1976-04-26
NL7308555A (de)	1973-12-27
ATA462374A (de)	1975-07-15
NO139050B (no)	1978-09-18
JPS5614673B2 (de)	1981-04-06
CH586224A5 (de)	1977-03-31
ES425015A1 (es)	1976-07-01
ATA462274A (de)	1975-04-15
AU5721173A (en)	1975-01-09
ATA461874A (de)	1975-05-15
DE2230154A1 (de)	1974-01-17
SE412235B (sv)	1980-02-25
ATA461974A (de)	1975-05-15
AT328099B (de)	1976-03-10
ES425010A1 (es)	1976-06-16
JPS4954390A (de)	1974-05-27
CH594673A5 (de)	1978-01-13
CH585753A5 (de)	1977-03-15
DK141629C (da)	1980-09-29
US3931189A (en)	1976-01-06
ES416106A1 (es)	1976-02-16
CH585752A5 (de)	1977-03-15
FI57261B (fi)	1980-03-31
FR2189066B1 (de)	1976-12-31
CH585751A5 (de)	1977-03-15

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Legal Events

Date	Code	Title	Description
1983-02-15	ELJ	Ceased due to non-payment of the annual fee