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AR247891A1 - Procedimiento para preparar nuevos derivados de 2'-halometilidencitidina y uridina - Google Patents

Procedimiento para preparar nuevos derivados de 2'-halometilidencitidina y uridina

Info

Publication number
AR247891A1
AR247891A1 AR89315416A AR31541689A AR247891A1 AR 247891 A1 AR247891 A1 AR 247891A1 AR 89315416 A AR89315416 A AR 89315416A AR 31541689 A AR31541689 A AR 31541689A AR 247891 A1 AR247891 A1 AR 247891A1
Authority
AR
Argentina
Prior art keywords
formula
uridine
halogen
halomethylidene
ethenylidene
Prior art date
Application number
AR89315416A
Other languages
English (en)
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of AR247891A1 publication Critical patent/AR247891A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

FABRICACION DE COMPUESTOS DE 2'-HALOMETILIDENCITIDINA O URIDINA DE FORMULA I EN LA QUE X1 Y X2 SON H O HALOGENO, SIENDO UNA DE ELLAS HALOGENO Y B TIENE FORMULA II DONDE Y5 ES AMINO O ALCOXILO O SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, QUE COMPRENDE LAS ETAPAS DE: A) HACER REACCIONAR UN DERIVADO DE 3, 5-0-TETRAISOPROPILIDENSILOXANO-1, 3-DIIL-2-CETONUCLEOSIDO DE FORMULA III CON UNAMETILIDENFOSFOROILIDA DE FORMULA IV EN LA QUE XHAL ES HALOGENO, XO ES XHAL O AR-SO2-, DONDE AR ES FENILO; LP ES FENIL-P(O)<, PARA OBTENER 3, 5-0-TETRAISOPROPILSILOXAN- 1, 3-DIIL-HALOMETILIDEN-NUCLEOSIDOS DE FORMULA V; B) HACERLOS REACCIONAR CON F- O ACIDOS PARA SEPARAR EL GRUPO BLOQUEANTE TETRAISOPROPILDISILOXANO PARA FORMAR LOS NUCLEOSIDOS DE FORMULA VI; C) SEPARAR EL GRUPO AR-SO2- POR AMALGAMA DE MERCURIO, AMALGAMA DE SODIO/MERCURIO O HIDRURO DE TRIBUTILESTANO/AZO-BISISOBUTILNITRILO, PARA DAR NUCLEOSIDOS DONDE XO ES H; Y D) CONVERTIR EL GRUPO ALCOXI DONDE Y5 ES AMINO O HO (CETO), HACIENDO REACCI ONAR LOS COMPUESTOS OBTENIDOS CON AMONIACO O UNA BASE.
AR89315416A 1988-11-15 1989-11-10 Procedimiento para preparar nuevos derivados de 2'-halometilidencitidina y uridina AR247891A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27147988A 1988-11-15 1988-11-15

Publications (1)

Publication Number Publication Date
AR247891A1 true AR247891A1 (es) 1995-04-28

Family

ID=23035764

Family Applications (1)

Application Number Title Priority Date Filing Date
AR89315416A AR247891A1 (es) 1988-11-15 1989-11-10 Procedimiento para preparar nuevos derivados de 2'-halometilidencitidina y uridina

Country Status (19)

Country Link
EP (1) EP0372268B1 (es)
JP (1) JP2802947B2 (es)
KR (1) KR0144865B1 (es)
CN (1) CN1022248C (es)
AR (1) AR247891A1 (es)
AT (1) ATE105297T1 (es)
AU (1) AU621160B2 (es)
CA (1) CA2002648C (es)
DE (1) DE68915128T2 (es)
DK (1) DK171844B1 (es)
ES (1) ES2056180T3 (es)
FI (1) FI92588C (es)
HU (3) HU205134B (es)
IE (1) IE63563B1 (es)
IL (1) IL92293A (es)
NO (1) NO172240C (es)
NZ (1) NZ231365A (es)
PT (1) PT92309B (es)
ZA (1) ZA898567B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
KR910008800B1 (ko) * 1987-03-19 1991-10-21 야마사 쇼오유 가부시끼가이샤 2'-알킬리덴 피리미딘 누클레오시드 유도체, 그 제조법, 및 그 용도
NZ234534A (en) * 1989-07-17 1994-12-22 Univ Birmingham Pyrimidine 4'-thionucleoside derivatives and their preparation; intermediates therefor
US5521163A (en) * 1990-07-13 1996-05-28 University Of Birmingham Antiviral pyrimidine nucleosides and methods for using same
FR2668153B1 (fr) * 1990-10-22 1995-03-31 Pasteur Merieux Serums Vacc Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments les contenant.
WO1993022327A1 (en) * 1992-04-23 1993-11-11 Yoshitomi Pharmaceutical Industries, Ltd. 2'-methylidenenucleoside compound and pharmaceutical use thereof
US5589587A (en) * 1992-05-12 1996-12-31 Merrell Pharmaceuticals Inc. Process for the preparation of ribonucleotide reductase inhibitors
EP0640092B1 (en) * 1992-05-12 1996-12-11 Merrell Pharmaceuticals Inc. A process for the preparation of ribonucleotide reductase inhibitors
AU678789B2 (en) * 1992-12-03 1997-06-12 Merrell Dow Pharmaceuticals Inc. Compositions containing acyclovir-like compounds and 2'-vinyl substituted nucleoside analogs for the treatment of viral infections
CN1043231C (zh) * 1994-01-07 1999-05-05 默里尔药物公司 (E)－α－去氧－α－(氟亚甲基)胞苷的一水合物
US5627053A (en) * 1994-03-29 1997-05-06 Ribozyme Pharmaceuticals, Inc. 2'deoxy-2'-alkylnucleotide containing nucleic acid
AU2768295A (en) * 1994-07-11 1996-02-09 Hoechst Marion Roussel, Inc. Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy
EP0770621A4 (en) * 1994-07-12 1998-01-28 Yamasa Corp 2'-DESOXY-2 '- (METHYLIDENE SUBSTITUTED OR NON-SUBSTITUTED) -4'-THIONUCLEOSIDE
WO2003026675A1 (en) * 2001-09-28 2003-04-03 Idenix (Cayman) Limited Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside
BR0307712A (pt) * 2002-02-14 2005-05-24 Pharmasset Ltd Composto, composição e uso dos mesmos no tratamento de infecções por flaviviridae e proliferação celular anormal
KR20040036417A (ko) * 2002-10-25 2004-04-30 정낙신 항암 활성을 갖는 티오뉴클레오시드 유도체 및 이를함유하는 약학적 조성물
CN100389119C (zh) * 2004-10-27 2008-05-21 北京东华康明生物科技有限公司 （反式）-2-脱氧-2-（氟亚甲基）-4-r酰胞苷化合物及其制备方法
GEP20166496B (en) 2011-12-22 2016-06-27 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
MX2015006248A (es) * 2012-11-19 2015-08-14 Merck Sharp & Dohme Derivados de nucleosido 2'-alquinilo sustituido para el tratamiento de enfermedades virales.
WO2018092107A1 (en) * 2016-11-21 2018-05-24 Munisekhar Medasani Novel anti-viral and anti-cancer molecule

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR910008800B1 (ko) * 1987-03-19 1991-10-21 야마사 쇼오유 가부시끼가이샤 2'-알킬리덴 피리미딘 누클레오시드 유도체, 그 제조법, 및 그 용도

Also Published As

Publication number Publication date
CA2002648C (en) 2000-02-29
NO172240C (no) 1993-06-23
CN1022248C (zh) 1993-09-29
EP0372268A1 (en) 1990-06-13
NO894539D0 (no) 1989-11-14
FI895417A0 (fi) 1989-11-14
HU00045A9 (en) 1995-01-30
HU210343A9 (en) 1995-03-28
HU895900D0 (en) 1990-02-28
AU4461189A (en) 1990-05-24
IE63563B1 (en) 1995-05-17
NO894539L (no) 1990-05-16
EP0372268B1 (en) 1994-05-04
FI92588B (fi) 1994-08-31
CA2002648A1 (en) 1990-05-15
DK570089A (da) 1990-05-16
DE68915128D1 (de) 1994-06-09
AU621160B2 (en) 1992-03-05
NO172240B (no) 1993-03-15
ATE105297T1 (de) 1994-05-15
HUT51642A (en) 1990-05-28
DK171844B1 (da) 1997-06-30
IL92293A (en) 1995-01-24
ES2056180T3 (es) 1994-10-01
PT92309B (pt) 1996-06-28
DK570089D0 (da) 1989-11-14
KR0144865B1 (ko) 1998-07-01
KR900007833A (ko) 1990-06-02
IE893651L (en) 1990-05-15
ZA898567B (en) 1990-08-29
JPH02178272A (ja) 1990-07-11
JP2802947B2 (ja) 1998-09-24
FI92588C (fi) 1994-12-12
DE68915128T2 (de) 1994-08-25
IL92293A0 (en) 1990-07-26
HU205134B (en) 1992-03-30
PT92309A (pt) 1990-05-31
NZ231365A (en) 1992-08-26
CN1042715A (zh) 1990-06-06

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