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AR247553A1 - Procedimiento de preparacion de los acidos 4-oxo-3-quinolincarboxilicos utiles como agentes antibacterianos - Google Patents

Procedimiento de preparacion de los acidos 4-oxo-3-quinolincarboxilicos utiles como agentes antibacterianos

Info

Publication number
AR247553A1
AR247553A1 AR88311890A AR31189088A AR247553A1 AR 247553 A1 AR247553 A1 AR 247553A1 AR 88311890 A AR88311890 A AR 88311890A AR 31189088 A AR31189088 A AR 31189088A AR 247553 A1 AR247553 A1 AR 247553A1
Authority
AR
Argentina
Prior art keywords
hydrogen
compound
preparation
formula
oxo
Prior art date
Application number
AR88311890A
Other languages
English (en)
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Application granted granted Critical
Publication of AR247553A1 publication Critical patent/AR247553A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/807—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen all halogen atoms bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

PREPARACION DE UN COMPUESTO DE FORMULA (I), DONDE R ES HIDROGENO O ALQUILO, R' ES HIDROGENO, FLUORO O -SR''', DONDE R''' ES FENILO, BENCILO O ALQUILO, R'' ES HIDROGENO, FLUORO O -SR''', Y CUANDOR'' ES HIDROGENO, R' ES HIDROGENO; O UNA SAL DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS; O UNA SAL DE METAL ALCALINO O DE AMINA DE UN COMPUESTO EN DONDE R ES HIDROGENO, EN DONDE SE HACE REACCIONAR UN COMPUESTO DE FORMULA (II), DONDE R ES ALQUILO INFERIOR, R' Y R'' ES HIDROGENO O FLUORO Y X ES CLORO, BROMO O YODO, CON UN COMPUESTO DE FORMULA III, EN DONDE ALQ ES ALQUILO PARA PREPARAR EL COMPUESTO DE FORMULA I; SI SE DESEA SE HIDROLIZA PARA OBTENER R=HIDROGENO, SI SE DESEA EL COMPUESTO I, DONDE R' ES FLUORO SE HACE REACCIONAR CON UN SULFURO, R'''SH, PARA OBTENER R'=-SR''', CALENTANDOLA CON NIQUEL DE RANEY SE REEMPLAZA -SR''' POR HIDROGENO.
AR88311890A 1987-09-08 1988-09-08 Procedimiento de preparacion de los acidos 4-oxo-3-quinolincarboxilicos utiles como agentes antibacterianos AR247553A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9435987A 1987-09-08 1987-09-08

Publications (1)

Publication Number Publication Date
AR247553A1 true AR247553A1 (es) 1995-01-31

Family

ID=22244685

Family Applications (1)

Application Number Title Priority Date Filing Date
AR88311890A AR247553A1 (es) 1987-09-08 1988-09-08 Procedimiento de preparacion de los acidos 4-oxo-3-quinolincarboxilicos utiles como agentes antibacterianos

Country Status (15)

Country Link
EP (1) EP0309789A1 (es)
JP (1) JPH01100166A (es)
KR (1) KR890005083A (es)
AR (1) AR247553A1 (es)
AU (1) AU598394B2 (es)
DK (1) DK493988A (es)
FI (1) FI884106A (es)
IL (1) IL87569A (es)
MX (1) MX12881A (es)
MY (1) MY103910A (es)
NO (1) NO170930C (es)
NZ (1) NZ225926A (es)
PH (1) PH26759A (es)
PT (1) PT88431B (es)
ZA (1) ZA886400B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169853A (en) * 1987-09-08 1992-12-08 Sterling Drug Inc. Pyridinyl-quinolone compounds, their preparation and use
US5075319A (en) * 1987-09-08 1991-12-24 Sterling Drug Inc. Pyridinyl-quinolone compounds, their preparation and use
US4996355A (en) * 1989-04-14 1991-02-26 Mallinckrodt, Inc. Novel intermediates for the production of 2,4,5-trifluorobenzoyl fluoride
KR100204987B1 (ko) 1990-04-18 1999-06-15 제이코버스 코넬리스 레이서 항미생물성 퀴놀로닐 락탐
CN1338455A (zh) * 2000-08-16 2002-03-06 大连绿源实业有限公司 新的喹诺酮羧酸的制备方法
WO2010058421A2 (en) * 2008-11-18 2010-05-27 Aditya Birla Science & Technology Co. Ltd. A process for synthesis of 2, 4-dichloro-5- fluoroacetophenone (dcfa)
CN107686456B (zh) * 2017-07-25 2018-10-23 杭州师范大学 一种喹喏酮关键中间体乙酯胺化物及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3753993A (en) * 1971-05-17 1973-08-21 Sterling Drug Inc 1,4-dihydro-4-oxo-7-pyridyl-3-quinoline-carboxylic acid derivatives
US3907808A (en) * 1971-05-17 1975-09-23 Sterling Drug Inc 1,4-Dihydro-4-oxo-7-pyridyl-3-quinolinecarboxylic acid derivatives
US4670444B1 (en) * 1980-09-03 1999-02-09 Bayer Ag and-naphthyridine-3-carboxylic acids and antibacte7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-rial agents containing these compounds
NZ208470A (en) * 1983-07-18 1988-06-30 Abbott Lab 6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives and antibacterial compositions containing such
US4529725A (en) * 1984-04-26 1985-07-16 Abbott Laboratories 1-Pyridine substituted quino-benzothiazine
EP0179239A3 (en) * 1984-09-17 1986-08-13 Sterling Drug Inc. 7-(pyridinyl)-/-alkyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid having antibacterial activity and preparation thereof
US4636506A (en) * 1984-12-06 1987-01-13 Pfizer, Inc. 7-heterocyclic-1,4-dihydroquinolones

Also Published As

Publication number Publication date
KR890005083A (ko) 1989-05-11
MY103910A (en) 1993-10-30
FI884106A (fi) 1989-03-09
IL87569A0 (en) 1989-01-31
JPH01100166A (ja) 1989-04-18
PT88431A (pt) 1989-07-31
NO883897D0 (no) 1988-09-01
AU2184388A (en) 1989-03-09
DK493988A (da) 1989-03-09
AU598394B2 (en) 1990-06-21
PH26759A (en) 1992-09-28
NO170930B (no) 1992-09-21
EP0309789A1 (en) 1989-04-05
IL87569A (en) 1992-08-18
MX12881A (es) 1993-08-01
DK493988D0 (da) 1988-09-06
NO883897L (no) 1989-03-09
PT88431B (pt) 1992-10-30
FI884106A0 (fi) 1988-09-06
NZ225926A (en) 1990-04-26
NO170930C (no) 1992-12-30
ZA886400B (en) 1989-04-26

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