AR224786A1 - Un procedimiento para preparar un derivado enzimico - Google Patents
Un procedimiento para preparar un derivado enzimicoInfo
- Publication number
- AR224786A1 AR224786A1 AR283122A AR28312280A AR224786A1 AR 224786 A1 AR224786 A1 AR 224786A1 AR 283122 A AR283122 A AR 283122A AR 28312280 A AR28312280 A AR 28312280A AR 224786 A1 AR224786 A1 AR 224786A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparing
- procedure
- enzyme derivative
- enzyme
- derivative
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3153—Streptokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/99—Enzyme inactivation by chemical treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7938279 | 1979-11-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR224786A1 true AR224786A1 (es) | 1982-01-15 |
Family
ID=10508982
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR283122A AR224786A1 (es) | 1979-11-05 | 1980-11-04 | Un procedimiento para preparar un derivado enzimico |
Country Status (18)
Country | Link |
---|---|
US (1) | US4808405A (es) |
EP (1) | EP0028489B1 (es) |
JP (1) | JPS5678590A (es) |
AR (1) | AR224786A1 (es) |
CA (1) | CA1174621A (es) |
CS (2) | CS391991A3 (es) |
DE (1) | DE3065190D1 (es) |
DK (1) | DK158994C (es) |
ES (1) | ES496586A0 (es) |
GR (1) | GR72121B (es) |
HK (1) | HK65886A (es) |
HU (1) | HU185223B (es) |
IE (1) | IE50174B1 (es) |
IL (1) | IL61408A (es) |
NL (1) | NL930029I2 (es) |
NO (1) | NO163867C (es) |
NZ (1) | NZ195469A (es) |
ZA (1) | ZA806641B (es) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3361610D1 (en) * | 1982-04-07 | 1986-02-06 | Beecham Group Plc | Enzyme derivatives, process for preparing them and pharmaceutical compositions containing them |
EP0125269A1 (en) * | 1982-11-11 | 1984-11-21 | Beecham Group Plc | Pharmaceutically active compounds |
GB8400653D0 (en) * | 1984-01-11 | 1984-02-15 | Beecham Group Plc | Conjugates |
GB8430253D0 (en) * | 1984-11-30 | 1985-01-09 | Beecham Group Plc | Compounds |
US5231006A (en) * | 1986-10-16 | 1993-07-27 | Behringwerke Aktiengesellschaft | Method for the determination of plasminogen |
US5256642A (en) * | 1988-04-01 | 1993-10-26 | The Johns Hopkins University | Compositions of soluble complement receptor 1 (CR1) and a thrombolytic agent, and the methods of use thereof |
JPH0296536A (ja) * | 1988-09-29 | 1990-04-09 | Green Cross Corp:The | プラスミノゲン乾燥製剤 |
AU647391B2 (en) * | 1989-05-01 | 1994-03-24 | University Of Notre Dame Du Lac, The | Methods and materials for expression of human plasminogen in a eukaryotic cell system |
EP0397366A1 (en) * | 1989-05-09 | 1990-11-14 | The Board Of Regents Of The University Of Oklahoma | Hybrid streptokinases with fibrin binding domains and methods for the synthesis of same |
ATE135200T1 (de) * | 1989-05-17 | 1996-03-15 | Res Corp Technologies Inc | Verfahren und zusammensetzung zur thrombosebehandlung beim säugetier |
CA2027936C (en) | 1989-10-23 | 2001-07-24 | Smithkline Beecham Corporation | Cyclic anti-aggregatory peptides |
US5087572A (en) * | 1989-12-01 | 1992-02-11 | Genentech, Inc. | Dna encoding human plasminogen modified at the cleavage site |
US5190756A (en) * | 1989-12-01 | 1993-03-02 | Genentech, Inc. | Methods and materials for expression of human plasminogen variant |
GB8928163D0 (en) * | 1989-12-13 | 1990-02-14 | Beecham Group Plc | Novel treatment |
US6458360B1 (en) | 1990-04-25 | 2002-10-01 | The Johns Hopkins University | Soluble complement regulatory molecules |
US5187069A (en) * | 1990-08-06 | 1993-02-16 | Henry Ford Health System | Active site labelling of plasminogen |
WO1992018139A1 (en) * | 1991-04-09 | 1992-10-29 | Brigham And Women's Hospital | Chimeric molecule with plasminogen activator activity and affinity for atherosclerotic plaques |
US5520912A (en) * | 1993-07-02 | 1996-05-28 | Immuno Aktiengesellschaft | Prevention and treatment of ischemic events and reperfusion injury resulting therefrom using lys-plasminogen |
DE4411143C2 (de) * | 1994-03-30 | 1996-08-01 | Immuno Ag | Thrombosemittel |
US5760028A (en) * | 1995-12-22 | 1998-06-02 | The Dupont Merck Pharmaceutical Company | Integrin receptor antagonists |
US6004955A (en) * | 1996-08-15 | 1999-12-21 | Dupont Pharmaceuticals Company | Cyclic carbamates and isoxazolidines as IIb/IIIa antagonists |
AU8150398A (en) | 1997-06-19 | 1999-01-04 | Du Pont Pharmaceuticals Company | Inhibitors of factor xa with a neutral p1 specificity group |
JP2003508027A (ja) * | 1999-07-29 | 2003-03-04 | ダイアックス コーポレイション | フィブリン結合性部分 |
US6388073B1 (en) | 2000-07-26 | 2002-05-14 | Shire Us Inc. | Method for the manufacture of anagrelide |
KR20010000669A (ko) * | 2000-10-12 | 2001-01-05 | 김기환 | 스트렙토키나제와 사람 혈청알부민의 포합체를유효성분으로 함유하는 전신투여용 지속성 혈전 용해제 |
US6984373B2 (en) * | 2000-12-23 | 2006-01-10 | Dyax Corp. | Fibrin binding moieties useful as imaging agents |
KR100908176B1 (ko) | 2001-09-21 | 2009-07-16 | 브리스톨-마이어스스퀴브컴파니 | 인자 Xa 억제제로서의 락탐-함유 화합물 및 그의 유도체 |
US7550499B2 (en) | 2004-05-12 | 2009-06-23 | Bristol-Myers Squibb Company | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
US7700608B2 (en) | 2004-08-04 | 2010-04-20 | Shire Holdings Ag | Quinazoline derivatives and their use in the treatment of thrombocythemia |
US20060030574A1 (en) * | 2004-08-04 | 2006-02-09 | Shire Holdings Ag | Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors |
US7459564B2 (en) | 2005-01-13 | 2008-12-02 | Bristol-Myers Squibb Company | Substituted biaryl compounds as factor XIa inhibitors |
ATE499370T1 (de) | 2005-01-19 | 2011-03-15 | Bristol Myers Squibb Co | 2-phenoxy-n-(1,3,4-thiadizol-2-yl)pyridin-3- aminderivate und verwandte verbindungen als p2y1- rezeptor-hemmer zur behandlung thromboembolischer erkrankungen |
WO2007002634A1 (en) | 2005-06-27 | 2007-01-04 | Bristol-Myers Squibb Company | Carbocycle and heterocycle antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
AU2006261828A1 (en) | 2005-06-27 | 2007-01-04 | Bristol-Myers Squibb Company | N-linked heterocyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
EP1896417B1 (en) | 2005-06-27 | 2011-03-23 | Bristol-Myers Squibb Company | Linear urea mimics antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
EP1899299B1 (en) | 2005-06-27 | 2010-10-20 | Bristol-Myers Squibb Company | C-linked cyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
US8222453B2 (en) | 2006-06-08 | 2012-07-17 | Bristol-Myers Squibb Company | Benzamide factor VIIa inhibitors useful as anticoagulants |
US7960569B2 (en) | 2006-10-17 | 2011-06-14 | Bristol-Myers Squibb Company | Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
US7910597B2 (en) * | 2006-11-28 | 2011-03-22 | Shire Llc | Substituted quinazolines |
US8304420B2 (en) | 2006-11-28 | 2012-11-06 | Shire Llc | Substituted quinazolines for reducing platelet count |
JP5342450B2 (ja) | 2006-12-15 | 2013-11-13 | ブリストル−マイヤーズ スクイブ カンパニー | 第XIa因子インヒビターとしてのアリールプロピオンアミド、アリールアクリルアミド、アリールプロピンアミド、またはアリールメチルウレアアナログ |
PE20081775A1 (es) | 2006-12-20 | 2008-12-18 | Bristol Myers Squibb Co | Compuestos macrociclicos como inhibidores del factor viia |
US8367709B2 (en) | 2007-06-13 | 2013-02-05 | Bristol-Myers Squibb Company | Dipeptide analogs as coagulation factor inhibitors |
US20090130017A1 (en) * | 2007-11-19 | 2009-05-21 | Searete Llc | Targeted short-lived drug delivery |
EP2300435A2 (en) | 2008-05-19 | 2011-03-30 | Schering Corporation | Heterocyclic compounds as factor ixa inhibitors |
SMT202000093T1 (it) | 2009-06-16 | 2020-03-13 | Pfizer | Forme di dosaggio di apixaban |
WO2011017296A1 (en) | 2009-08-04 | 2011-02-10 | Schering Corporation | 4, 5, 6-trisubstituted pyrimidine derivatives as factor ixa inhibitors |
US8828983B2 (en) | 2010-02-11 | 2014-09-09 | Bristol-Myers Squibb Company | Macrocycles as factor XIa inhibitors |
TW201311689A (zh) | 2011-08-05 | 2013-03-16 | 必治妥美雅史谷比公司 | 作為因子xia抑制劑之新穎巨環化合物 |
TW201319068A (zh) | 2011-08-05 | 2013-05-16 | 必治妥美雅史谷比公司 | 作為xia因子抑制劑之環狀p1接合劑 |
ES2572908T3 (es) | 2011-10-14 | 2016-06-03 | Bristol-Myers Squibb Company | Compuestos de tetrahidroisoquinolina sustituidos como inhibidores del factor XIa |
IN2014CN02805A (es) | 2011-10-14 | 2015-07-03 | Bristol Myers Squibb Co | |
EP2766346B1 (en) | 2011-10-14 | 2017-03-29 | Bristol-Myers Squibb Company | Substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
CA2853024C (en) | 2011-11-11 | 2017-08-22 | Pfizer Inc. | 2-thiopyrimidinones |
CN104334557A (zh) | 2012-04-06 | 2015-02-04 | 辉瑞公司 | 二酰基甘油酰基转移酶2抑制剂 |
MX361370B (es) | 2012-08-03 | 2018-12-05 | Bristol Myers Squibb Co | Dihidropiridona p1 como inhibidores del factor xia. |
CN108250199B (zh) | 2012-08-03 | 2021-07-16 | 百时美施贵宝公司 | 二氢吡啶酮p1作为凝血因子xia抑制剂 |
ES2712699T3 (es) | 2013-03-25 | 2019-05-14 | Bristol Myers Squibb Co | Tetrahidroisoquinolinas que contienen azoles sustituidos como inhibidores del factor XIa |
EP3055300B1 (en) | 2013-10-09 | 2018-03-07 | Pfizer Inc | Antagonists of prostaglandin ep3 receptor |
WO2015116885A1 (en) | 2014-01-31 | 2015-08-06 | Bristol-Myers Squibb Company | Macrocycles with aromatic p2' groups as factor xia inhibitors |
NO2760821T3 (es) | 2014-01-31 | 2018-03-10 | ||
CN106103425A (zh) | 2014-03-17 | 2016-11-09 | 辉瑞公司 | 用于治疗代谢及相关病症的二酰甘油酰基转移酶2抑制剂 |
HUE057876T2 (hu) | 2014-04-04 | 2022-06-28 | Pfizer | Biciklusos-kondenzált heteroaril- vagy aril-vegyületek és ezek IRAK4 inhibitorként történõ alkalmazása |
US9969724B2 (en) | 2014-04-16 | 2018-05-15 | Merck Sharp & Dohme Corp. | Factor IXa inhibitors |
NO2721243T3 (es) | 2014-10-01 | 2018-10-20 | ||
AU2016257179A1 (en) | 2015-05-05 | 2017-11-02 | Pfizer Inc. | 2-thiopyrimidinones |
ES2832893T3 (es) | 2015-06-17 | 2021-06-11 | Pfizer | Compuestos tricíclicos y su uso como inhibidores de la fosfodiesterasa |
WO2016203335A1 (en) | 2015-06-18 | 2016-12-22 | Pfizer Inc. | Novel pyrido[2,3-b]pyrazinones as bet-family bromodomain inhibitors |
EP3868753B1 (en) | 2015-07-29 | 2022-12-21 | Bristol-Myers Squibb Company | Factor xia macrocyclic inhibitors bearing a non-aromatic p2' group |
US10336730B2 (en) | 2015-08-05 | 2019-07-02 | Bristol-Myers Squibb Company | Substituted glycine derived FXIA inhibitors |
LT3341367T (lt) | 2015-08-27 | 2021-04-26 | Pfizer Inc. | Biciklinis sulietas heteroarilas arba arilo junginiai kaip irak4 moduliatoriai |
EP3423458A1 (en) | 2016-03-02 | 2019-01-09 | Bristol-Myers Squibb Company | Diamide macrocycles having factor xia inhibiting activity |
AR109179A1 (es) | 2016-08-19 | 2018-11-07 | Pfizer | Inhibidores de diacilglicerol aciltransferasa 2 |
TWI718644B (zh) | 2018-08-31 | 2021-02-11 | 美商輝瑞股份有限公司 | 用於治療nash/nafld和相關疾病之組合 |
EP4578460A2 (en) | 2019-05-20 | 2025-07-02 | Pfizer Inc. | Combinations comprising benzodioxol as glp-1r agonists for use in the treatment of nash/nafld and related diseases |
EP4185587A1 (en) | 2020-07-22 | 2023-05-31 | JANSSEN Pharmaceutica NV | Compounds useful as factor xia inhibitors |
WO2023026180A1 (en) | 2021-08-26 | 2023-03-02 | Pfizer Inc. | Amorphous form of (s)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-n-(tetrahydrofuran-3- yl)pyrimidine-5-carboxamide |
WO2024118524A1 (en) | 2022-11-28 | 2024-06-06 | Cerevel Therapeutics, Llc | Azaindole compounds and their use as phosphodiesterase inhibitors |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4178368A (en) * | 1971-09-30 | 1979-12-11 | Behringwerke Aktiengesellschaft | Method for the treatment of thromboembolism |
JPS5325775A (en) * | 1976-08-24 | 1978-03-09 | Miller Fluid Power Corp | Module type fluid flow control element |
US4082612A (en) * | 1976-09-24 | 1978-04-04 | Michael Reese Research Foundation | Plasminogen activator complex |
NZ191320A (en) * | 1978-09-07 | 1982-09-14 | Beecham Group Ltd | In vivo fibrinolytic enzyme having active site blocked by hydrolytically removable group pharmaceutical compositions |
-
1980
- 1980-10-27 EP EP80303797A patent/EP0028489B1/en not_active Expired
- 1980-10-27 DE DE8080303797T patent/DE3065190D1/de not_active Expired
- 1980-10-29 ZA ZA00806641A patent/ZA806641B/xx unknown
- 1980-11-03 GR GR63267A patent/GR72121B/el unknown
- 1980-11-04 IL IL61408A patent/IL61408A/xx not_active IP Right Cessation
- 1980-11-04 AR AR283122A patent/AR224786A1/es active
- 1980-11-04 DK DK468880A patent/DK158994C/da not_active IP Right Cessation
- 1980-11-04 CA CA000363957A patent/CA1174621A/en not_active Expired
- 1980-11-04 IE IE2277/80A patent/IE50174B1/en not_active IP Right Cessation
- 1980-11-04 NO NO803304A patent/NO163867C/no unknown
- 1980-11-05 ES ES496586A patent/ES496586A0/es active Granted
- 1980-11-05 HU HU802661A patent/HU185223B/hu not_active IP Right Cessation
- 1980-11-05 NZ NZ195469A patent/NZ195469A/en unknown
- 1980-11-05 JP JP15573380A patent/JPS5678590A/ja active Granted
-
1986
- 1986-08-29 US US06/902,429 patent/US4808405A/en not_active Expired - Lifetime
- 1986-09-04 HK HK658/86A patent/HK65886A/en not_active IP Right Cessation
-
1991
- 1991-12-19 CS CS913919A patent/CS391991A3/cs unknown
- 1991-12-19 CS CS913911A patent/CS391191A3/cs unknown
-
1993
- 1993-04-22 NL NL930029C patent/NL930029I2/nl unknown
Also Published As
Publication number | Publication date |
---|---|
EP0028489B1 (en) | 1983-10-05 |
JPS5678590A (en) | 1981-06-27 |
HU185223B (en) | 1984-12-28 |
JPH0316114B2 (es) | 1991-03-04 |
NO163867C (no) | 1990-08-01 |
NL930029I2 (nl) | 1993-12-01 |
IL61408A0 (en) | 1980-12-31 |
NO803304L (no) | 1981-05-06 |
IE802277L (en) | 1981-05-05 |
US4808405A (en) | 1989-02-28 |
ES8204467A1 (es) | 1982-05-01 |
AU534017B2 (en) | 1983-12-22 |
AU6401180A (en) | 1981-05-14 |
IL61408A (en) | 1983-10-31 |
NO163867B (no) | 1990-04-23 |
ZA806641B (en) | 1981-10-28 |
CA1174621A (en) | 1984-09-18 |
EP0028489A1 (en) | 1981-05-13 |
DK468880A (da) | 1981-05-06 |
IE50174B1 (en) | 1986-02-19 |
NL930029I1 (nl) | 1993-06-01 |
GR72121B (es) | 1983-09-16 |
CS391991A3 (en) | 1992-06-17 |
DK158994B (da) | 1990-08-13 |
CS391191A3 (en) | 1992-08-12 |
DK158994C (da) | 1991-01-07 |
NZ195469A (en) | 1984-05-31 |
ES496586A0 (es) | 1982-05-01 |
DE3065190D1 (en) | 1983-11-10 |
HK65886A (en) | 1986-09-12 |
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