AR111979A1 - ALCOHOL DERIVATIVES AS OPENERS OF THE KV7 POTASSIUM CHANNEL - Google Patents
ALCOHOL DERIVATIVES AS OPENERS OF THE KV7 POTASSIUM CHANNELInfo
- Publication number
- AR111979A1 AR111979A1 ARP180100394A ARP180100394A AR111979A1 AR 111979 A1 AR111979 A1 AR 111979A1 AR P180100394 A ARP180100394 A AR P180100394A AR P180100394 A ARP180100394 A AR P180100394A AR 111979 A1 AR111979 A1 AR 111979A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- openers
- cycloalkyl
- potassium channel
- alcohol derivatives
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente proporciona compuestos que activan los canales de potasio Kv7. Los aspectos separados se refieren a composiciones farmacéuticas que comprenden dichos compuestos y usos de los compuestos para tratar trastornos que responden a la activación de los canales de potasio Kv7. Reivindicación 1: Un compuesto de fórmula (1), donde R¹ se selecciona del grupo que consiste en alquilo C₁₋₆, CF₃, CH₂CF₃, CF₂CHF₂, cicloalquilo C₃₋₈, en la que dicho cicloalquilo C₃₋₈ puede estar sustituido con 1 ó 2 F, CHF₂ o CF₃, y R² es H, alquilo C₁₋₆ o CF₃; o R¹ y R² se combinan para formar cicloalquilo C₃₋₅ opcionalmente sustituido con 1 ó 2 F, CHF₂ o CF₃; R³ es alquilo C₁₋₃ o CH₂O-alquilo C₁₋₃, dicho alquilo C₁₋₃ o CH₂O-alquilo C₁₋₃ puede estar opcionalmente sustituido con 1 ó 2 F; R⁴ se selecciona del grupo que consiste en OCF₃, OCH₂CF₃ o OCHF₂.The present provides compounds that activate Kv7 potassium channels. The separate aspects relate to pharmaceutical compositions comprising said compounds and uses of the compounds for treating disorders that respond to the activation of Kv7 potassium channels. Claim 1: A compound of formula (1), wherein R¹ is selected from the group consisting of C₁₋₆ alkyl, CF₃, CH₂CF₃, CF₂CHF₂, C₃₋₈ cycloalkyl, wherein said C₃₋₈ cycloalkyl may be substituted with 1 or 2 F, CHF₂ or CF₃, and R² is H, C₁₋₆ alkyl or CF₃; or R¹ and R² combine to form C₃₋₅ cycloalkyl optionally substituted with 1 or 2 F, CHF₂ or CF₃; R³ is C₁₋₃ alkyl or CH₂O-C₁₋₃ alkyl, said C₁₋₃ alkyl or CH₂O-C₁₋₃ alkyl may be optionally substituted with 1 or 2 F; R⁴ is selected from the group consisting of OCF₃, OCH₂CF₃, or OCHF₂.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP180100394A AR111979A1 (en) | 2018-02-20 | 2018-02-20 | ALCOHOL DERIVATIVES AS OPENERS OF THE KV7 POTASSIUM CHANNEL |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP180100394A AR111979A1 (en) | 2018-02-20 | 2018-02-20 | ALCOHOL DERIVATIVES AS OPENERS OF THE KV7 POTASSIUM CHANNEL |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR111979A1 true AR111979A1 (en) | 2019-09-11 |
Family
ID=68069952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180100394A AR111979A1 (en) | 2018-02-20 | 2018-02-20 | ALCOHOL DERIVATIVES AS OPENERS OF THE KV7 POTASSIUM CHANNEL |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR111979A1 (en) |
-
2018
- 2018-02-20 AR ARP180100394A patent/AR111979A1/en unknown
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