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AR101060A1 - Conjugados de fviii - Google Patents

Conjugados de fviii

Info

Publication number
AR101060A1
AR101060A1 ARP150100398A ARP150100398A AR101060A1 AR 101060 A1 AR101060 A1 AR 101060A1 AR P150100398 A ARP150100398 A AR P150100398A AR P150100398 A ARP150100398 A AR P150100398A AR 101060 A1 AR101060 A1 AR 101060A1
Authority
AR
Argentina
Prior art keywords
heparosan polymer
factor viii
formula
conjugate
reactive amine
Prior art date
Application number
ARP150100398A
Other languages
English (en)
Inventor
Dr Haller Michael
Dr Deangelis Paul
Behrens Carsten
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of AR101060A1 publication Critical patent/AR101060A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Reivindicación 1: Un conjugado que comprende un polipéptido del Factor VIII, un resto conector y un polímero de heparosano, donde el resto conector entre el polipéptido del Factor VIII y el polímero de heparosano comprende X tal como se indica a continuación: [polímero de heparosano] - [X] - [Factor VIII] donde X comprende un derivado de ácido siálico que está conectado a un resto de acuerdo con la fórmula (1). Reivindicación 11: Una composición farmacéutica que comprende un conjugado de acuerdo con cualquiera de las reivindicaciones anteriores. Reivindicación 15: Un método para conjugar un polímero de heparosano con un polipéptido del FVIII que comprende los siguientes pasos: (i) hacer reaccionar un polímero de heparosano que comprende una amina reactiva [HEP-NH] con un ácido 4-formilbenzoico activado para obtener el compuesto de fórmula (2), donde dicha amina reactiva se puede unir directamente al polímero heparosano o se puede unir a través de un resto conector que conecte la amina reactiva con dicho polímero de heparosano, (ii) hacer reaccionar el compuesto de fórmula (2) con un derivado de ácido siálico activado con CMP en condiciones reductoras, (iii) conjugar el compuesto obtenido en el paso ii) con un polipéptido del Factor VIII.
ARP150100398A 2014-02-12 2015-02-11 Conjugados de fviii AR101060A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14154876 2014-02-12

Publications (1)

Publication Number Publication Date
AR101060A1 true AR101060A1 (es) 2016-11-23

Family

ID=50071544

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150100398A AR101060A1 (es) 2014-02-12 2015-02-11 Conjugados de fviii

Country Status (14)

Country Link
US (2) US20150224203A1 (es)
EP (1) EP3104893A1 (es)
JP (1) JP2017507135A (es)
KR (1) KR20160120296A (es)
CN (1) CN105979972A (es)
AR (1) AR101060A1 (es)
AU (1) AU2015216985A1 (es)
BR (1) BR112016018224A2 (es)
CA (1) CA2939441A1 (es)
IL (1) IL246713A0 (es)
MX (1) MX2016010231A (es)
RU (1) RU2016134357A (es)
TW (1) TW201613650A (es)
WO (1) WO2015121382A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR099340A1 (es) * 2014-02-12 2016-07-13 Novo Nordisk As Conjugados del factor de coagulación ix
KR20190086269A (ko) * 2018-01-12 2019-07-22 재단법인 목암생명과학연구소 체내 지속형 재조합 당단백질 및 이의 제조방법
AU2019366942A1 (en) * 2018-10-23 2021-06-10 The Children's Hospital Of Philadelphia Compositions and methods for modulating factor VIII function
KR101964405B1 (ko) 2018-12-17 2019-04-01 영동이앤지(주) 교량 받침의 연단거리 측정점검 장치

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7211558B2 (en) * 2002-05-22 2007-05-01 The Children's Hospital Of Philadelphia Compositions and methods for the treatment of hemophilia A
WO2007056191A2 (en) * 2005-11-03 2007-05-18 Neose Technologies, Inc. Nucleotide sugar purification using membranes
MX2010009154A (es) * 2008-02-27 2010-09-09 Novo Nordisk As Moleculas conjugadas del factor viii.
US9687559B2 (en) * 2008-03-19 2017-06-27 The Board Of Regents Of The University Of Oklahoma Heparosan polymers and methods of making and using same for the enhancement of therapeutics
EP2341941A4 (en) * 2008-09-09 2014-12-10 Univ Oklahoma HEPAROSANE POLYMERS AND METHODS OF MAKING AND USING THEM TO ENHANCE THERAPEUTIC COMPOUNDS
US20130040888A1 (en) * 2010-02-16 2013-02-14 Novo Nordisk A/S Factor VIII Molecules With Reduced VWF Binding
CN104411323A (zh) * 2012-04-24 2015-03-11 诺和诺德A/S（股份有限公司） 适用于治疗血友病的药物组合物
JP2015515482A (ja) * 2012-04-24 2015-05-28 ノヴォ ノルディスク アー／エス 血友病の治療に適する化合物
EP2970933A2 (en) * 2013-03-12 2016-01-20 Novo Nordisk A/S Thrombin sensitive coagulation factor x molecules
MX2016004702A (es) * 2013-10-15 2016-07-22 Novo Nordisk Healthcare Ag Polipeptidos del factor vii de coagulacion.

Also Published As

Publication number Publication date
RU2016134357A (ru) 2018-03-16
AU2015216985A1 (en) 2016-07-28
JP2017507135A (ja) 2017-03-16
KR20160120296A (ko) 2016-10-17
CN105979972A (zh) 2016-09-28
EP3104893A1 (en) 2016-12-21
WO2015121382A1 (en) 2015-08-20
US20150224203A1 (en) 2015-08-13
US20160120953A1 (en) 2016-05-05
IL246713A0 (en) 2016-08-31
TW201613650A (en) 2016-04-16
BR112016018224A2 (pt) 2017-10-17
MX2016010231A (es) 2016-10-13
CA2939441A1 (en) 2015-08-20

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