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AR105965A1 - Derivados de piperidina puenteados - Google Patents

Derivados de piperidina puenteados

Info

Publication number
AR105965A1
AR105965A1 ARP160102743A ARP160102743A AR105965A1 AR 105965 A1 AR105965 A1 AR 105965A1 AR P160102743 A ARP160102743 A AR P160102743A AR P160102743 A ARP160102743 A AR P160102743A AR 105965 A1 AR105965 A1 AR 105965A1
Authority
AR
Argentina
Prior art keywords
halogen
lower alkyl
hydrogen
compounds
substituted
Prior art date
Application number
ARP160102743A
Other languages
English (en)
Inventor
Ratni Hasane
Bartels Bjrn
Maria Rodriguez Sarmiento Rosa
Neidhart Werner
Limberg Anja
Jakob-Roetne Roland
Galley Guido
Baumann Karlheinz
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR105965A1 publication Critical patent/AR105965A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos de fórmula (1) en la que hetarilo es un grupo heteroarilo de cinco elementos, que contiene 1 ó 3 heteroátomos, seleccionados de entre O, S o N; R¹ es hidrógeno, halógeno, alquilo inferior, alcoxi inferior, alquilo inferior sustituido con halógeno, S-alquilo inferior sustituido con halógeno o alcoxi inferior sustituido con halógeno, o dos átomos de carbono vecinos pueden formar en fenilo un anillo adicional que contiene -O-CH₂-O-; n es 1 a 5; R² es hidrógeno o alquilo inferior sustituido con halógeno; R³ es hidrógeno o alquilo inferior sustituido con halógeno; o a sales de adición de ácido farmacéuticamente aceptable de los mismos, a mezclas racémicas o a los enantiómeros y/o isómeros ópticos y/o estereoisómeros de los mismos correspondientes. Los compuestos pueden utilizarse para el tratamiento de la enfermedad de Alzheimer, la angiopatía amiloide cerebral, la hemorragia cerebral hereditaria con amiloidosis de tipo holandés (HCHWA-D), la demencia multiinfarto, la demencia pugilística o el síndrome de Down.
ARP160102743A 2015-09-09 2016-09-08 Derivados de piperidina puenteados AR105965A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15184480 2015-09-09

Publications (1)

Publication Number Publication Date
AR105965A1 true AR105965A1 (es) 2017-11-29

Family

ID=54072754

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160102743A AR105965A1 (es) 2015-09-09 2016-09-08 Derivados de piperidina puenteados

Country Status (8)

Country Link
US (1) US10604517B2 (es)
EP (1) EP3347363B1 (es)
JP (1) JP6831372B2 (es)
CN (1) CN107922437B (es)
AR (1) AR105965A1 (es)
HK (1) HK1251902A1 (es)
TW (1) TWI716446B (es)
WO (1) WO2017042114A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017042114A1 (en) 2015-09-09 2017-03-16 F. Hoffmann-La Roche Ag Bridged piperidine derivatives
JP7012715B2 (ja) * 2016-06-27 2022-01-28 エフ．ホフマン－ラ ロシュ アーゲー γ－セクレターゼモジュレーターとしてのトリアゾロピリジン
EP3510031B1 (en) 2016-09-09 2020-12-02 H. Hoffnabb-La Roche Ag Process for preparation of 2-(6-nitropyridin-3-yl)-9h-dipyrido[2,3-b;3',4'-d]pyrrole
AR109829A1 (es) * 2016-09-29 2019-01-30 Hoffmann La Roche Derivados de piperidina puenteados
WO2018065340A1 (en) 2016-10-04 2018-04-12 F. Hoffmann-La Roche Ag Bicyclic heteroaryl derivatives
JP7111704B2 (ja) * 2016-11-01 2022-08-02 エフ．ホフマン－ラ ロシュ アーゲー 二環式ヘテロアリール誘導体
EP3728262B1 (en) 2017-12-18 2023-03-15 F. Hoffmann-La Roche AG Triazolo-azepine derivatives
WO2019141832A1 (en) * 2018-01-22 2019-07-25 F. Hoffmann-La Roche Ag Triazolo-azepine derivatives
SI3846903T1 (sl) * 2018-09-03 2024-02-29 F. Hoffmann - La Roche Ag Biciklični heteroarilni derivati
AU2019395774A1 (en) * 2018-12-13 2021-04-08 F. Hoffmann-La Roche Ag 7-phenoxy-N-(3-azabicyclo[3.2.1]octan-8-yl)-6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazol-2-amine derivatives and related compounds as gamma-secretase modulators for the treatment of Alzheimer's disease
CA3137152A1 (en) 2019-04-18 2020-10-22 The Johns Hopkins University Substituted 2-amino-pyrazolyl-[1,2,4]triazolo[1,5a] pyridine derivatives and use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2003068776A1 (ja) * 2002-02-15 2005-06-02 協和醗酵工業株式会社 ［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体
MX2010008700A (es) * 2008-02-22 2010-08-30 Hoffmann La Roche Moduladores de beta-amiloide.
CN102047454B (zh) * 2008-04-16 2013-04-10 Lg伊诺特有限公司 发光器件及其制造方法
CA2743196A1 (en) * 2008-11-10 2010-05-14 F.Hoffmann-La Roche Ag Heterocyclic gamma secretase modulators
TWI461425B (zh) * 2009-02-19 2014-11-21 Janssen Pharmaceuticals Inc 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類
ES2431619T3 (es) * 2009-05-07 2013-11-27 Janssen Pharmaceuticals, Inc. Derivados de indazol y aza-indazol sustituidos como moduladores de gamma-secretasa
WO2010138901A1 (en) * 2009-05-29 2010-12-02 Biogen Idec Ma Inc Carboxylic acid-containing compounds, derivatives thereof, and related methods of use
EP2491524A4 (en) * 2009-10-23 2014-10-01 Apriva Llc SYSTEM AND DEVICE FOR CONSOLIDATING SIM, PERSONAL TOKEN AND ASSOCIATED APPLICATIONS
US20110190269A1 (en) * 2010-02-01 2011-08-04 Karlheinz Baumann Gamma secretase modulators
US8486967B2 (en) * 2010-02-17 2013-07-16 Hoffmann-La Roche Inc. Heteroaryl substituted piperidines
US8703763B2 (en) * 2011-03-02 2014-04-22 Hoffmann-La Roche Inc. Bridged piperidine derivatives
EP2687528A1 (en) * 2012-07-17 2014-01-22 Ares Trading S.A. Fused triazole derivatives as gamma secretase modulators
WO2017042114A1 (en) 2015-09-09 2017-03-16 F. Hoffmann-La Roche Ag Bridged piperidine derivatives

Also Published As

Publication number Publication date
US10604517B2 (en) 2020-03-31
US20180237432A1 (en) 2018-08-23
TWI716446B (zh) 2021-01-21
HK1251902A1 (zh) 2019-04-26
JP6831372B2 (ja) 2021-02-17
CN107922437A (zh) 2018-04-17
CN107922437B (zh) 2021-12-10
WO2017042114A1 (en) 2017-03-16
TW201718601A (zh) 2017-06-01
JP2018526410A (ja) 2018-09-13
EP3347363B1 (en) 2020-01-01
EP3347363A1 (en) 2018-07-18

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