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AR104050A1 - Proceso de producción con iones de cobre controlados - Google Patents

Proceso de producción con iones de cobre controlados

Info

Publication number
AR104050A1
AR104050A1 ARP160100777A ARP160100777A AR104050A1 AR 104050 A1 AR104050 A1 AR 104050A1 AR P160100777 A ARP160100777 A AR P160100777A AR P160100777 A ARP160100777 A AR P160100777A AR 104050 A1 AR104050 A1 AR 104050A1
Authority
AR
Argentina
Prior art keywords
medium
initial medium
production process
desired protein
initial
Prior art date
Application number
ARP160100777A
Other languages
English (en)
Inventor
Terashima Isamu
Doi Hiroyuki
Yamamoto Seiko
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of AR104050A1 publication Critical patent/AR104050A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/70—Undefined extracts
    • C12N2500/80—Undefined extracts from animals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Reproductive Health (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Reivindicación 1: Un método de cultivo celular caracterizado porque comprende añadir un medio para siembra que contiene células a un medio inicial y comenzar a cultivar la célula en el medio inicial, en donde el medio inicial tiene un aditivo de medio de cultivo obtenido de organismos añadido al mismo y el .contenido de cobre del medio inicial al inicio del cultivo de células no es más que 0,02 ppm. Reivindicación 20: Un método de cultivo celular que utiliza un medio inicial caracterizado porque un aditivo de medio de cultivo obtenido de organismos con un contenido de cobre medido ha sido añadido al medio inicial. Reivindicación 26: Un proceso para producir una composición farmacéutica que contiene una proteína deseada, caracterizado porque comprende las etapas de: 1) producir la proteína deseada mediante el proceso de producción de acuerdo a la reivindicación 25; y 2) producir la composición farmacéutica mediante la mezcla de la proteína deseada producida en la etapa 1) con un vehículo y un aditivo que son aceptables para uso farmacéutico y formular la misma.
ARP160100777A 2015-03-26 2016-03-23 Proceso de producción con iones de cobre controlados AR104050A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2015063662 2015-03-26

Publications (1)

Publication Number Publication Date
AR104050A1 true AR104050A1 (es) 2017-06-21

Family

ID=56977504

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160100777A AR104050A1 (es) 2015-03-26 2016-03-23 Proceso de producción con iones de cobre controlados

Country Status (13)

Country Link
US (2) US11046772B2 (es)
EP (2) EP4219694A1 (es)
JP (1) JP6752776B2 (es)
CN (1) CN107406832A (es)
AR (1) AR104050A1 (es)
AU (2) AU2016237086B2 (es)
BR (1) BR112017020401B1 (es)
CA (1) CA2980695A1 (es)
IL (1) IL254668B (es)
MX (2) MX2017012223A (es)
SG (1) SG11201707873TA (es)
TW (1) TWI716392B (es)
WO (1) WO2016153041A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2401040A (en) 2003-04-28 2004-11-03 Chugai Pharmaceutical Co Ltd Method for treating interleukin-6 related diseases
JP5711751B2 (ja) 2009-10-26 2015-05-07 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ グリコシル化された免疫グロブリンの調製方法
CA2817216A1 (en) 2010-11-08 2012-05-18 F. Hoffmann-La Roche Ag Subcutaneously administered anti-il-6 receptor antibody
AR104050A1 (es) * 2015-03-26 2017-06-21 Chugai Pharmaceutical Co Ltd Proceso de producción con iones de cobre controlados
US20220325221A1 (en) * 2019-05-15 2022-10-13 Sekisui Chemical Co., Ltd. Cell culturing scaffolding material and cell culturing vessel

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100249937B1 (ko) 1991-04-25 2000-04-01 나가야마 오사무 인간 인터루킨-6 수용체에 대한 재구성 인간 항체
JP3630453B2 (ja) 1994-09-30 2005-03-16 中外製薬株式会社 Ｉｌ−６レセプター抗体を有効成分とする未熟型骨髄腫細胞治療剤
JP3822137B2 (ja) * 2002-05-20 2006-09-13 中外製薬株式会社 動物細胞培養用培地の添加剤およびそれを用いたタンパク質の製造方法
US8398980B2 (en) 2004-03-24 2013-03-19 Chugai Seiyaku Kabushiki Kaisha Subtypes of humanized antibody against interleuken-6 receptor
JP4818936B2 (ja) * 2005-01-05 2011-11-16 中外製薬株式会社 細胞の培養方法およびその利用
EP2924113B1 (en) * 2007-03-02 2019-04-10 Wyeth LLC Use of copper and glutamate in cell culture for production of polypeptides
TW200902708A (en) 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
JP5711751B2 (ja) * 2009-10-26 2015-05-07 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ グリコシル化された免疫グロブリンの調製方法
DK2590998T3 (en) * 2010-07-08 2018-02-12 Baxalta GmbH PROCEDURE FOR PREPARING RECOMBINANT vWF WITH HIGH MOLECULE WEIGHT IN CELL CULTURE
US9574005B2 (en) * 2011-07-19 2017-02-21 Chugai Seiyaku Kabushiki Kaisha Stable Protein-containing preparation containing argininamide or analogous compound thereof
BR112015022529A2 (pt) * 2013-03-15 2017-07-18 Genentech Inc meios de cultura de células e processos de produção de anticorpo
WO2015024977A1 (en) 2013-08-20 2015-02-26 Lek Pharmaceuticals D.D. CELL CULTURE MEDIUM AND PROCESS FOR CONTROLLING α-AMIDATION AND/OR C-TERMINAL AMINO ACID CLEAVAGE OF POLYPEPTIDES
CN106459180A (zh) 2014-03-23 2017-02-22 爱德技术生物科学有限公司 在铜使用下重组蛋白表达的增强
AR104050A1 (es) * 2015-03-26 2017-06-21 Chugai Pharmaceutical Co Ltd Proceso de producción con iones de cobre controlados

Also Published As

Publication number Publication date
AU2022204600A1 (en) 2022-07-21
US20210269536A1 (en) 2021-09-02
WO2016153041A1 (ja) 2016-09-29
TW201708532A (zh) 2017-03-01
TWI716392B (zh) 2021-01-21
MX2022003016A (es) 2022-04-07
BR112017020401B1 (pt) 2021-04-06
IL254668A0 (en) 2017-11-30
SG11201707873TA (en) 2017-10-30
MX2017012223A (es) 2018-01-30
EP4219694A1 (en) 2023-08-02
BR112017020401A2 (pt) 2018-06-05
EP3276001A1 (en) 2018-01-31
IL254668B (en) 2021-01-31
US20180051090A1 (en) 2018-02-22
US11046772B2 (en) 2021-06-29
CN107406832A (zh) 2017-11-28
EP3276001A4 (en) 2018-09-12
AU2022204600B2 (en) 2024-10-17
AU2016237086A1 (en) 2017-10-19
JPWO2016153041A1 (ja) 2018-01-18
JP6752776B2 (ja) 2020-09-09
CA2980695A1 (en) 2016-09-29
AU2016237086B2 (en) 2022-04-14

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