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AR093753A1 - Microorganismos y metodos para la produccion de 4-hidroxibutirato, 1,4-butanodiol y compuestos relacionados - Google Patents

Microorganismos y metodos para la produccion de 4-hidroxibutirato, 1,4-butanodiol y compuestos relacionados

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Publication number
AR093753A1
AR093753A1 ARP130101961A ARP130101961A AR093753A1 AR 093753 A1 AR093753 A1 AR 093753A1 AR P130101961 A ARP130101961 A AR P130101961A AR P130101961 A ARP130101961 A AR P130101961A AR 093753 A1 AR093753 A1 AR 093753A1
Authority
AR
Argentina
Prior art keywords
expression
genetic modification
hydroxybutyrate
butanediol
decreases
Prior art date
Application number
ARP130101961A
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English (en)
Original Assignee
Genomatica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genomatica Inc filed Critical Genomatica Inc
Publication of AR093753A1 publication Critical patent/AR093753A1/es

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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/18—Polyhydroxylic acyclic alcohols
    • C07C31/20—Dihydroxylic alcohols
    • C07C31/207—1,4-Butanediol; 1,3-Butanediol; 1,2-Butanediol; 2,3-Butanediol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/2805—Compounds having only one group containing active hydrogen
    • C08G18/2815—Monohydroxy compounds
    • C08G18/284—Compounds containing ester groups, e.g. oxyalkylated monocarboxylic acids
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    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/30—Low-molecular-weight compounds
    • C08G18/32—Polyhydroxy compounds; Polyamines; Hydroxyamines
    • C08G18/3203—Polyhydroxy compounds
    • C08G18/3206—Polyhydroxy compounds aliphatic
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    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
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    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/16—Dicarboxylic acids and dihydroxy compounds
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    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/16—Dicarboxylic acids and dihydroxy compounds
    • C08G63/18—Dicarboxylic acids and dihydroxy compounds the acids or hydroxy compounds containing carbocyclic rings
    • C08G63/181—Acids containing aromatic rings
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    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
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    • C12N15/09—Recombinant DNA-technology
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
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    • C12P7/00—Preparation of oxygen-containing organic compounds
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    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01052—Oxoglutarate dehydrogenase (NADP+) (1.2.1.52)
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    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01031—Phosphoenolpyruvate carboxylase (4.1.1.31)
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    • Y02P20/00—Technologies relating to chemical industry
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
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  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Polymers & Plastics (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Reivindicación 1: Un organismo microbiano no natural, dicho organismo microbiano que tiene una ruta de 4-hidroxibutirato y es capaz de producir 4-hidroxibutirato, donde dicho organismo microbiano comprende una modificación genética, dicha modificación genética se selecciona de: (A) una modificación genética que aumenta la expresión de fosfoenolpiruvato carboxilasa; (B) una modificación genética que aumenta la expresión de a-cetoglutarato deshidrogenasa; (C) una modificación genética que aumenta la expresión de un sistema de captación de glucosa no fosfotransferasa (PTS); (D) una modificación genética que aumenta la expresión de una g-butirolactona esterasa; (E) una modificación genética que disminuye la expresión de succinil-CoA sintetasa; (F) una modificación genética que disminuye la expresión de una acil coenzima A tioesterasa; (G) una modificación genética que disminuye la expresión de una alcohol deshidrogenasa; (H) una modificación genética que disminuye la expresión de una NADH deshidrogenasa no productora de energía; (I) una modificación genética que disminuye la expresión de una citocromo oxidasa; y (J) una combinación de dos o más, tres o más, cuatro o más, cinco o más, seis o más, siete o más, ocho o más, o todas las modificaciones genéticas de las partes (A) - (I). Reivindicación 11: Un método para producir 4-hidroxibutirato o 1,4-butanodiol aislado o purificado, que comprende cultivar el organismo microbiano no natural de acuerdo con cualquiera de las reivindicaciones 3 - 6 bajo condiciones y durante un período de tiempo suficiente para producir 4-hidroxibutirato o 1,4-butanodiol, y aislar o purificar el 4-hidroxibutirato o 1,4-butanodiol. Reivindicación 15: Bioderivado 4-hidroxibutirato o 1,4-butanodiol que tiene una relación isotópica de carbono-12, carbono-13 y carbono-14 que refleja una fuente de captación de dióxido de carbono atmosférico y es producido por el organismo microbiano de acuerdo con cualquiera de las reivindicaciones 1 - 6. Reivindicación 18: Una composición que comprende dicho bioderivado 4-hidroxibutirato o 1,4-butanodiol de acuerdo con cualquiera de las reivindicaciones 15 - 17 y un compuesto diferente de dicho bioderivado 4-hidroxibutirato o 1,4-butanodiol. Reivindicación 26: Un método para reducir la producción de g-butirolactona en una célula o cultivo celular, que comprende expresar en la célula un ácido nucleico que codifica una g-butirolactona esterasa.
ARP130101961A 2012-06-04 2013-06-04 Microorganismos y metodos para la produccion de 4-hidroxibutirato, 1,4-butanodiol y compuestos relacionados AR093753A1 (es)

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US201261655429P 2012-06-04 2012-06-04

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AR093753A1 true AR093753A1 (es) 2015-06-24

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US (4) US11932845B2 (es)
EP (2) EP3831951A3 (es)
CN (2) CN104685058B (es)
AR (1) AR093753A1 (es)
BR (1) BR112014030202A2 (es)
SI (1) SI2855687T1 (es)
TW (1) TW201410865A (es)
WO (1) WO2013184602A2 (es)

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