AR091856A1 - Proceso para la preparacion de 4-amino-5-fluor-3-halo-6-(substituido) picolinatos - Google Patents
Proceso para la preparacion de 4-amino-5-fluor-3-halo-6-(substituido) picolinatosInfo
- Publication number
- AR091856A1 AR091856A1 ARP130102597A ARP130102597A AR091856A1 AR 091856 A1 AR091856 A1 AR 091856A1 AR P130102597 A ARP130102597 A AR P130102597A AR P130102597 A ARP130102597 A AR P130102597A AR 091856 A1 AR091856 A1 AR 091856A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- formula
- alkyl
- substituted
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/803—Processes of preparation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Reivindicación 1: Un proceso para preparar un compuesto de la fórmula (1) o una sal, solvato incluyendo un hidrato, isotopólogo, o polimorfo del mismo, en donde: W representa Cl, Br o I; R representa alquilo C₁₋₄, ciclopropilo, alquenilo C₂₋₄ o fenilo substituido con, desde 0 hasta 5 substituyentes independientemente seleccionados desde halógeno, alquilo C₁₋₄, haloalquilo C₁₋₄, alcoxi C₁₋₄ o haloalcoxi C₁₋₄; y R¹ representa alquilo C₁₋₁₂ o un arilalquilo C₇₋₁₁ substituido o no substituido; que comprende: (a) fluoración de un compuesto de la fórmula (2) en donde A⁶ es halógeno o R; con una fuente de iones flúor para formar un compuesto de la fórmula (3); en donde B⁶ es F o R; y transformando el compuesto de la fórmula (3) a un compuesto de la fórmula (4); (b) halogenación de un compuesto de la fórmula (4) con una fuente de halógeno para formar un compuesto de la fórmula (5); y (c) acoplando un compuesto de la fórmula (6) en donde X es Cl, Br, o I; A² es hidrógeno o R¹; A³ es hidrógeno o W; A⁴ es Cl, F, NH₂, NHCOCH₃, o un grupo amino protegido; A⁵ es F o Cl; con un compuesto de la fórmula (7): R-Met, en donde Met es Zn-haluro, Zn-R, tri-(alquil C₁₋₄)estaño, cobre, o B(OR²)(OR³), donde R² y R³ son cada una independientemente, hidrógeno, C₁₋₄ alquilo, o cuando se toman juntas forman un grupo de etileno, o propileno en la presencia de un catalizador de metal de transición para formar un compuesto de la fórmula (8) en donde puede ocurrir la transformación de (c), antes, entre o después de la transformación de (a) y (b).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261675235P | 2012-07-24 | 2012-07-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR091856A1 true AR091856A1 (es) | 2015-03-04 |
Family
ID=48901197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130102597A AR091856A1 (es) | 2012-07-24 | 2013-07-22 | Proceso para la preparacion de 4-amino-5-fluor-3-halo-6-(substituido) picolinatos |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8871943B2 (es) |
| EP (1) | EP2877453B1 (es) |
| JP (1) | JP6046817B2 (es) |
| KR (1) | KR101946681B1 (es) |
| CN (1) | CN104640844B (es) |
| AR (1) | AR091856A1 (es) |
| AU (1) | AU2013293200B2 (es) |
| BR (1) | BR112015001615B8 (es) |
| CA (1) | CA2879530C (es) |
| CO (1) | CO7200265A2 (es) |
| HK (1) | HK1210613A1 (es) |
| IL (1) | IL236816A (es) |
| IN (1) | IN2015DN00821A (es) |
| MX (1) | MX351886B (es) |
| NZ (1) | NZ704103A (es) |
| PL (1) | PL2877453T3 (es) |
| RU (1) | RU2632203C2 (es) |
| TW (1) | TWI577663B (es) |
| UY (1) | UY34946A (es) |
| WO (1) | WO2014018502A1 (es) |
| ZA (1) | ZA201500701B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR092355A1 (es) * | 2012-07-24 | 2015-04-15 | Dow Agrosciences Llc | Fluoruros de fluoropicolinoilo y procesos para su preparacion |
| US8764316B1 (en) * | 2013-05-23 | 2014-07-01 | Corning Cable Systems Llc | Fiber optic connector with vented ferrule holder |
| TW201609651A (zh) | 2013-11-12 | 2016-03-16 | 陶氏農業科學公司 | 用於氟化化合物之過程（一） |
| TW201609652A (zh) | 2013-11-12 | 2016-03-16 | 陶氏農業科學公司 | 用於氟化化合物之過程（三） |
| BR102014028164A2 (pt) * | 2013-11-12 | 2015-09-08 | Dow Agrosciences Llc | processo para fluoração de compostos |
| TWI726900B (zh) | 2015-08-04 | 2021-05-11 | 美商陶氏農業科學公司 | 用於氟化化合物之過程 |
| US10259789B2 (en) * | 2016-01-22 | 2019-04-16 | Dow Agrosciences Llc | Process for the preparation of 4-alkoxy-3-acetoxypicolinic acids |
| EP3458442B1 (en) | 2016-05-19 | 2022-12-28 | Corteva Agriscience LLC | Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct suzuki coupling |
| IL267030B2 (en) * | 2016-12-13 | 2023-11-01 | Corteva Agriscience Llc | A method for preparing benzyl 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)picolinate |
| WO2020061146A1 (en) | 2018-09-19 | 2020-03-26 | Dow Agrosciences Llc | Preparation of halogen analogs of picloram |
| CN114702440B (zh) * | 2022-04-26 | 2024-06-18 | 永农生物科学有限公司 | 一种氨氯吡啶酸的制备方法及制备的氨氯吡啶酸 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2520254B2 (ja) * | 1987-04-28 | 1996-07-31 | イハラケミカル工業株式会社 | ３，４，５−トリフルオロ安息香酸誘導体およびその製造方法 |
| US4847442A (en) * | 1988-07-18 | 1989-07-11 | Allied-Signal Inc. | Process for the preparation of difluorobenzenes |
| US6297197B1 (en) | 2000-01-14 | 2001-10-02 | Dow Agrosciences Llc | 4-aminopicolinates and their use as herbicides |
| AR037228A1 (es) | 2001-07-30 | 2004-11-03 | Dow Agrosciences Llc | Compuestos del acido 6-(aril o heteroaril)-4-aminopicolinico, composicion herbicida que los comprende y metodo para controlar vegetacion no deseada |
| AU2003238390A1 (en) * | 2002-06-04 | 2003-12-19 | Clariant Gmbh | Method for producing a compound containing fluorine via fluorine-halogen exchange by special polyamino phosphazene catalysts |
| UA82358C2 (uk) * | 2003-04-02 | 2008-04-10 | Дау Агросайенсиз Ллс | 6-алкіл або алкеніл-4-амінопіколінати гербіцидна композиція, спосіб боротьби з небажаною рослинністю |
| PL1973881T3 (pl) | 2006-01-13 | 2010-04-30 | Dow Agrosciences Llc | 6-(wielo-podstawione arylo)-4-aminopikoliniany i ich zastosowanie jako herbicydy |
| TWI537252B (zh) | 2011-01-25 | 2016-06-11 | 陶氏農業科學公司 | 用於製備４－胺基－５－氟－３－鹵素－６－（經取代之）吡啶甲酸酯的方法（一） |
| TWI529163B (zh) | 2011-01-25 | 2016-04-11 | 陶氏農業科學公司 | 用於製備４－胺基－５－氟－３－鹵素－６－（經取代之）吡啶甲酸酯的方法 |
-
2013
- 2013-07-22 AR ARP130102597A patent/AR091856A1/es active IP Right Grant
- 2013-07-23 BR BR112015001615A patent/BR112015001615B8/pt active IP Right Grant
- 2013-07-23 EP EP13742581.5A patent/EP2877453B1/en active Active
- 2013-07-23 KR KR1020157004099A patent/KR101946681B1/ko active IP Right Grant
- 2013-07-23 JP JP2015524380A patent/JP6046817B2/ja active Active
- 2013-07-23 RU RU2015106019A patent/RU2632203C2/ru active
- 2013-07-23 AU AU2013293200A patent/AU2013293200B2/en active Active
- 2013-07-23 CA CA2879530A patent/CA2879530C/en active Active
- 2013-07-23 US US13/949,060 patent/US8871943B2/en active Active
- 2013-07-23 PL PL13742581T patent/PL2877453T3/pl unknown
- 2013-07-23 IN IN821DEN2015 patent/IN2015DN00821A/en unknown
- 2013-07-23 NZ NZ704103A patent/NZ704103A/en unknown
- 2013-07-23 CN CN201380048518.6A patent/CN104640844B/zh active Active
- 2013-07-23 MX MX2015001141A patent/MX351886B/es active IP Right Grant
- 2013-07-23 TW TW102126266A patent/TWI577663B/zh active
- 2013-07-23 UY UY0001034946A patent/UY34946A/es active IP Right Grant
- 2013-07-23 WO PCT/US2013/051623 patent/WO2014018502A1/en active Application Filing
-
2015
- 2015-01-20 IL IL236816A patent/IL236816A/en active IP Right Grant
- 2015-01-30 ZA ZA2015/00701A patent/ZA201500701B/en unknown
- 2015-02-06 CO CO15024012A patent/CO7200265A2/es unknown
- 2015-11-18 HK HK15111361.1A patent/HK1210613A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TWI577663B (zh) | 2017-04-11 |
| KR20150036673A (ko) | 2015-04-07 |
| RU2632203C2 (ru) | 2017-10-03 |
| HK1210613A1 (zh) | 2016-04-29 |
| JP2015530367A (ja) | 2015-10-15 |
| IN2015DN00821A (es) | 2015-06-12 |
| CA2879530C (en) | 2019-06-18 |
| CN104640844B (zh) | 2016-11-09 |
| BR112015001615A2 (pt) | 2017-07-04 |
| MX351886B (es) | 2017-11-01 |
| US8871943B2 (en) | 2014-10-28 |
| AU2013293200B2 (en) | 2016-11-17 |
| IL236816A (en) | 2016-11-30 |
| MX2015001141A (es) | 2015-09-08 |
| TW201406726A (zh) | 2014-02-16 |
| ZA201500701B (en) | 2016-10-26 |
| US20140031556A1 (en) | 2014-01-30 |
| NZ704103A (en) | 2016-08-26 |
| EP2877453B1 (en) | 2016-07-06 |
| EP2877453A1 (en) | 2015-06-03 |
| PL2877453T3 (pl) | 2017-08-31 |
| KR101946681B1 (ko) | 2019-02-11 |
| AU2013293200A1 (en) | 2015-02-19 |
| UY34946A (es) | 2014-02-28 |
| CA2879530A1 (en) | 2014-01-30 |
| BR112015001615B8 (pt) | 2022-08-23 |
| CN104640844A (zh) | 2015-05-20 |
| WO2014018502A1 (en) | 2014-01-30 |
| JP6046817B2 (ja) | 2016-12-21 |
| CO7200265A2 (es) | 2015-02-27 |
| RU2015106019A (ru) | 2016-09-10 |
| BR112015001615B1 (pt) | 2019-10-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |