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AR080974A1 - Derivados piridinicos y piperazinicos moduladores de la actividad de los canales del calcio activado por depositos intracelulares(soc), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades inflamatorias y trastornos inmunes, entre otras. - Google Patents

Derivados piridinicos y piperazinicos moduladores de la actividad de los canales del calcio activado por depositos intracelulares(soc), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades inflamatorias y trastornos inmunes, entre otras.

Info

Publication number
AR080974A1
AR080974A1 ARP110101456A ARP110101456A AR080974A1 AR 080974 A1 AR080974 A1 AR 080974A1 AR P110101456 A ARP110101456 A AR P110101456A AR P110101456 A ARP110101456 A AR P110101456A AR 080974 A1 AR080974 A1 AR 080974A1
Authority
AR
Argentina
Prior art keywords
alkyl
aryl
piridinic
piperazinic
soc
Prior art date
Application number
ARP110101456A
Other languages
English (en)
Original Assignee
Calcimedica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calcimedica Inc filed Critical Calcimedica Inc
Publication of AR080974A1 publication Critical patent/AR080974A1/es

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

Reivindicacion 1: Un compuesto que tiene la estructura de formula (1) donde X es CR3 o N; L1 es O, S, o NR11 donde R11 es H, alquenilo C2-6 o alquilo C1-6; L2 es -NH-C(=O)-, o -C(=O)NH-; R1 es arilo o heteroarilo; donde arilo o heteroarilo es opcionalmente sustituido con por lo menos un R3 o forma un sistema bicíclico; R2 es alquilo C1-6, cicloalquilo C3-8, heteroalquilo C1-6, haloalquilo C1-6, heterocicloalquilo C2-8, alquilen C1-4-heterocicloalquilo C2-8, arilo o heteroarilo donde alquilo C1-6, cicloalquilo C3-8, heteroalquilo C1-6, haloalquilo C1-6, heterocicloalquilo C2-8, alquilen C1-4-heterocicloalquilo C2-8, ariIo o heteroarilo es opcionalmente sustituido con por lo menos un R3; R3 se selecciona independientemente entre H, D, F, CI, Br, I, -CN, -NO2, -OH, -CF3, -OCF3, -OR5, -NR5R5, alquilo C1-6, cicloalquilo C3-8, heteroalquilo C1-6, haloalquilo C1-6, heterocicloalquilo C2-8, arilo opcionalmente sustituido, O-arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, -NHS(=O)2R4, -S(=O)2N(R5)2, -N(R5)S(=O)2N(R5)2, -C(=O)CF3, -C(=O)NHS(=O)2R4, -S(=O)2NHC(=O)R4, -N(R5)2, -N(R5)C(=O)R5, -N(R5)C(=O)N(R5)2, -N(R5)C(=O)OR4, -CO2R5, -C(=O)R5, -OC(=O)R4, -OC(=O)N(R5)2, -CON(R5)2, -SR5, -S(=O)R4, y -S(=O)2R4; cada R4 se selecciona independientemente entre alquilo C1-6, haloalquilo C1-6, cicloalquilo C3-8, fenilo y bencilo; cada R5 se selecciona independientemente entre H, alquilo C1-6, haloalquilo C1-6, cicloalquilo C3-5, fenilo y bencilo; n es un numero entero seleccionado entre 0 y 2; o una sal farmacéuticamente aceptable, un solvato farmacéuticamente aceptable, o profármaco farmacéuticamente aceptable del mismo.
ARP110101456A 2010-04-27 2011-04-27 Derivados piridinicos y piperazinicos moduladores de la actividad de los canales del calcio activado por depositos intracelulares(soc), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades inflamatorias y trastornos inmunes, entre otras. AR080974A1 (es)

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US20130345193A1 (en) 2013-12-26
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JP2020114824A (ja) 2020-07-30
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AU2011248877A1 (en) 2012-12-06
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