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AR088509A1 - Combinaciones terapeuticas y metodos para tratar el melanoma - Google Patents

Combinaciones terapeuticas y metodos para tratar el melanoma

Info

Publication number
AR088509A1
AR088509A1 ARP120103974A ARP120103974A AR088509A1 AR 088509 A1 AR088509 A1 AR 088509A1 AR P120103974 A ARP120103974 A AR P120103974A AR P120103974 A ARP120103974 A AR P120103974A AR 088509 A1 AR088509 A1 AR 088509A1
Authority
AR
Argentina
Prior art keywords
inhibitor
map kinase
methods
therapeutic combinations
cytotoxin
Prior art date
Application number
ARP120103974A
Other languages
English (en)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AR088509A1 publication Critical patent/AR088509A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Combinaciones terapéuticas de anticuerpos anti-ETBR e inhibidores de la MAP quinasa, y métodos para utilizarlos en el tratamiento del melanoma. Reivindicación 4: El uso de la reivindicación 1, donde dicho anticuerpo anti-ETBR se conjuga en una citotoxina. Reivindicación 5: El uso de la reivindicación 4, donde dicha citotoxina es un agente citotóxico que se selecciona del grupo que consiste de toxinas, antibióticos, isótopos radioactivos y enzimas nucleolíticas. Reivindicación 7: El uso de la reivindicación 6, donde dicha toxina se selecciona del grupo que consiste de: maitansinoide, caliqueamicina y auristatina. Reivindicación 9: El uso de la reivindicación 1, donde dicho inhibidor de la MAP quinasa es un inhibidor del gen BRAF. Reivindicación 10: El uso de la reivindicación 9, donde dicho inhibidor del gen BRAF es ácido propano-1-sulfónico {3-[5-(4-clorofenil)-1H-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluoro-fenil}-amida. Reivindicación 12: El uso de la reivindicación 1, donde dicho inhibidor de la MAP quinasa es un inhibidor de la MEK. Reivindicación 13: El uso de la reivindicación 12, donde dicho inhibidor de la MEK es (S)-(3,4-difluoro-2-((2-fluoro-4-yodofenil)amino)fenil)(3-hidroxi-3-(piperidin-2il)azetidin-1-il)metanona.
ARP120103974A 2011-10-28 2012-10-24 Combinaciones terapeuticas y metodos para tratar el melanoma AR088509A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161552893P 2011-10-28 2011-10-28
US201261678978P 2012-08-02 2012-08-02

Publications (1)

Publication Number Publication Date
AR088509A1 true AR088509A1 (es) 2014-06-11

Family

ID=48168400

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120103974A AR088509A1 (es) 2011-10-28 2012-10-24 Combinaciones terapeuticas y metodos para tratar el melanoma

Country Status (18)

Country Link
EP (1) EP2776051A4 (es)
JP (2) JP6251682B2 (es)
KR (1) KR20140097205A (es)
CN (1) CN104039340B (es)
AR (1) AR088509A1 (es)
AU (1) AU2012328980A1 (es)
BR (1) BR112014009953A2 (es)
CA (1) CA2850034A1 (es)
CL (1) CL2014001092A1 (es)
CO (1) CO7151543A2 (es)
EA (1) EA201490879A1 (es)
IL (1) IL232135A0 (es)
IN (1) IN2014CN03062A (es)
MX (1) MX2014004991A (es)
PE (1) PE20142312A1 (es)
SG (1) SG11201401815XA (es)
TW (1) TW201325613A (es)
WO (1) WO2013063001A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY170117A (en) 2011-08-01 2019-07-05 Genentech Inc Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors
US9216170B2 (en) 2012-03-19 2015-12-22 Hoffmann-La Roche Inc. Combination therapy for proliferative disorders
AR101210A1 (es) 2014-07-15 2016-11-30 Genentech Inc Métodos de tratamiento de cáncer usando antagonistas de unión al eje pd-1 e inhibidores de mek
BR112017006113A8 (pt) * 2014-10-10 2018-04-24 Pfizer usos de auristatina, composições farmacêuticas, formas de dosagem para o tratamento de câncer e kits.
CN108025035B (zh) * 2015-08-03 2023-06-13 Enb治疗公司 用于治疗与etbr激活相关的癌症的组合物和方法
FR3053042B1 (fr) * 2016-06-24 2018-08-10 Commissariat A L'energie Atomique Et Aux Energies Alternatives Anticorps dirige contre le sous-type b des recepteurs aux endothelines et ses utilisations
MX2019008458A (es) 2017-01-17 2019-12-02 Heparegenix Gmbh Inhibidores de proteina cinasa para promover la regeneracion hepatica o reducir o prevenir la muerte de hepatocitos.
WO2024209089A1 (en) 2023-04-07 2024-10-10 Commissariat A L'energie Atomique Et Aux Energies Alternatives Use of antibody against the endothelin receptor b for diagnostic and therapeutic applications

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JP2018027948A (ja) 2018-02-22
MX2014004991A (es) 2014-05-22
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CA2850034A1 (en) 2013-05-02
CO7151543A2 (es) 2014-12-29
EP2776051A4 (en) 2015-06-17
KR20140097205A (ko) 2014-08-06
AU2012328980A1 (en) 2014-04-24
IL232135A0 (en) 2014-05-28
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EP2776051A1 (en) 2014-09-17
JP6251682B2 (ja) 2017-12-20
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JP2014532648A (ja) 2014-12-08

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