AR084970A1 - Derivados de tetrahidro-pirido-pirimidina, una composicion farmaceutica en base al compuesto y un proceso para su preparacion - Google Patents
Derivados de tetrahidro-pirido-pirimidina, una composicion farmaceutica en base al compuesto y un proceso para su preparacionInfo
- Publication number
- AR084970A1 AR084970A1 ARP110102390A ARP110102390A AR084970A1 AR 084970 A1 AR084970 A1 AR 084970A1 AR P110102390 A ARP110102390 A AR P110102390A AR P110102390 A ARP110102390 A AR P110102390A AR 084970 A1 AR084970 A1 AR 084970A1
- Authority
- AR
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- Prior art keywords
- alkyl
- alkoxy
- amino
- alkylcarbonyl
- halo
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Otolaryngology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Estos compuestos son adecuados para el tratamiento de un trastorno o de una enfermedad que sea mediada por la actividad de las enzimas de PI3K, como los trastornos autoinmunes, enfermedades inflamatorias y alérgicas.Reivindicación 1: Un derivado de tetrahidro-pirido-pirimidina de la fórmula (1), y/o los tautómeros y/o los N-óxidos y/o las sales farmacéuticamente aceptables del mismo; en donde: Y se selecciona a partir de O ó NR3; R1 se selecciona a partir de fenilo, piridilo, pirimidinilo, pirazinilo, piridazinilo, 1,2,3-triazinilo, 1,2,4-triazinilo, 1,3,5-triazinilo, o -C(O)-R4 en donde: R4 se selecciona a partir de alquilo C1-8, halo-alquilo C1-8, hidroxi-alquilo C1-8, alcoxilo C1-8-alquilo C1-8, alquilo C1-8-sulfonil-alquilo C1-8, heterociclilo, heterocicliloxilo, heterociclil-alquilo C1-8, cicloalquilo C3-12, cicloalquilo C3-12-alquilo C1-8, heteroarilo, heteroariloxilo, heteroaril-alquilo C1-8, hidroxilo, alcoxilo C1-8, amino, N-alquilo C1-8-amino, o N,N-di-alquilo C1-8-amino, en donde “alquilo C1-8” en N-alquilo C1-8-amino y N,N-di-alquilo C1-8-amino puede estar insustituido o sustituido por halógeno, hidroxilo, o alcoxilo C1-4; en donde “cicloalquilo C3-12” en cicloalquilo C3-12 y cicloalquilo C3-12-alquilo C1-8, puede estar insustituido o sustituido por 1 a 5 sustituyentes seleccionados independientemente a partir de oxo, halógeno, alquilo C1-8, halo-alquilo C1-8, hidroxi-alquilo C1-8, hidroxilo, alcoxilo C1-8, alcoxilo C1-8-alquilo C1-8, amino, N-alquilo C1-8-amino, N,N-di-alquilo C1-8-amino, alquilo C1-8-carbonilo, halo-alquilo C1-8-carbonilo, hidroxi-alquilo C1-8-carbonilo o alcoxilo C1-8-alquilo C1-8-carbonilo; en donde “heterociclilo” se selecciona a partir de oxiranilo, aziridinilo, oxetanilo, tietanilo, acetitinilo, pirrolidinilo, tetrahidro-furanilo, tetrahidro-tiofenilo, 2,3-dihidro-furanilo, 2,5-dihidro-furanilo, 2,3-dihidro-tiofenilo, 1-pirrolinilo, 2-pirrolinilo, 3-pirrolinilo, tetrahidro-piranilo, piperidinilo, tetrahidro-tiopiranilo, morfolinilo, tiomorfolinilo, piperazinilo, azepanilo, tiepanilo u oxepanilo; cada uno de los cuales está insustituido o sustituido por 1 a 5 sustituyentes seleccionados independientemente a partir de oxo, halógeno, alquilo C1-8, halo-alquilo C1-8, hidroxi-alquilo C1-8, hidroxilo, alcoxilo C1-8, alcoxilo C1-8-alquilo C1-8, amino, N-alquilo C1-8-amino, N,N-di-alquilo C1-8-amino, alquilo C1-8-carbonilo, halo-alquilo C1-8-carbonilo, hidroxialquilo C1-8-carbonilo o alcoxilo C1-8-alquilo C1-8-carbonilo; en donde “heterociclilo” se puede unir en un heteroátomo o en un átomo de carbono, y en donde los heteroátomos de N y/o S también se pueden oxidar opcionalmente hasta diferentes estados de oxidación; en donde “heteroarilo” se selecciona a partir de: furanilo, tiofenilo, pirrolilo, imidazolilo, pirazolilo, tiazolilo, isotiazolilo, oxazolilo, isoxazolilo, 1,2,5-oxadiazolilo, 1,2,4-oxadiazolilo, 1,2,3-oxadiazolilo, 1,3,4-oxadiazolilo, 1,2,5-tiadiazolilo, 1,2,4-tiadiazolilo, 1,2,3-tiadiazolilo, 1,3,4-tiadiazolilo, 1,2,3-triazolilo, 1,2,4-triazolilo, 1,2,5-triazolilo, piridilo, pirimidinilo, pirazinilo, piridazinilo, 1,2,3-triazinilo, 1,2,4-triazinilo o 1,3,5-triazinilo; cada uno de los cuales está insustituido o sustituido por 1 a 5 sustituyentes seleccionados independientemente a partir de halógeno, alquilo C1-8, halo-alquilo C1-8, hidroxi-alquilo C1-8, hidroxilo, alcoxilo C1-8, alcoxilo C1-8-alquilo C1-8, amino, N-alquilo C1-8-amino, N,N-di-alquilo C1-8-amino, alquilo C1-8-carbonilo, halo-alquilo C1-8-carbonilo, hidroxialquilo C1-8-carbonilo o alcoxilo C1-8-alquilo C1-8-carbonilo; en donde “heteroarilo” se puede unir en un heteroátomo o en un átomo de carbono, y en donde los heteroátomos de N y/o S también se pueden oxidar opcionalmente hasta diferentes estados de oxidación; R2 se selecciona a partir de fenilo, naftilo, piridilo, pirimidinilo, pirazinilo, piridazinilo, quinolinilo o isoquinolinilo, cada uno de los cuales está insustituido o sustituido por 1 a 5 sustituyentes seleccionados independientemente a partir de halógeno, ciano, nitro, alquilo C1-8, haloalquilo C1-8, hidroxi-alquilo C1-8, hidroxilo, alcoxilo C1-8, alcoxilo C1-8-alquilo C1-8, amino, N-alquilo C1-8-amino, N,N-di-alquilo C1-8-amino, alquilo C1-8-carbonilo, halo-alquilo C1-8-carbonilo, hidroxi-alquilo C1-8-carbonilo o alcoxilo C1-8-alquilo C1-8-carbonilo; R3 se selecciona a partir de H, alquilo C1-4, o halo-alquilo C1-4; y m se selecciona a partir de 0 ó 1.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36158910P | 2010-07-06 | 2010-07-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR084970A1 true AR084970A1 (es) | 2013-07-24 |
Family
ID=44532774
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110102390A AR084970A1 (es) | 2010-07-06 | 2011-07-04 | Derivados de tetrahidro-pirido-pirimidina, una composicion farmaceutica en base al compuesto y un proceso para su preparacion |
| ARP190102244A AR115927A2 (es) | 2010-07-06 | 2019-08-07 | Derivados de tetrahidro-pirido-pirimidina |
| ARP200101358A AR118919A2 (es) | 2010-07-06 | 2020-05-12 | Derivados de tetrahidro-pirido-pirimidina |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP190102244A AR115927A2 (es) | 2010-07-06 | 2019-08-07 | Derivados de tetrahidro-pirido-pirimidina |
| ARP200101358A AR118919A2 (es) | 2010-07-06 | 2020-05-12 | Derivados de tetrahidro-pirido-pirimidina |
Country Status (40)
| Country | Link |
|---|---|
| US (9) | US8653092B2 (es) |
| EP (1) | EP2590974B1 (es) |
| JP (1) | JP5770842B2 (es) |
| KR (1) | KR101560066B1 (es) |
| CN (1) | CN102971317B (es) |
| AR (3) | AR084970A1 (es) |
| AU (1) | AU2011275777C1 (es) |
| BR (1) | BR112013000275B1 (es) |
| CA (1) | CA2802132C (es) |
| CL (1) | CL2013000033A1 (es) |
| CO (1) | CO6670566A2 (es) |
| CR (1) | CR20130004A (es) |
| DK (1) | DK2590974T3 (es) |
| DO (1) | DOP2013000027A (es) |
| EA (1) | EA024123B1 (es) |
| EC (1) | ECSP13012420A (es) |
| ES (1) | ES2494718T3 (es) |
| GT (1) | GT201300009A (es) |
| HK (1) | HK1179966A1 (es) |
| HR (1) | HRP20140778T1 (es) |
| IL (1) | IL223795A (es) |
| JO (1) | JO2939B1 (es) |
| MA (1) | MA34361B1 (es) |
| MX (1) | MX2012015088A (es) |
| MY (1) | MY166026A (es) |
| NI (1) | NI201300002A (es) |
| NZ (1) | NZ604302A (es) |
| PE (1) | PE20130650A1 (es) |
| PH (1) | PH12013500031A1 (es) |
| PL (1) | PL2590974T3 (es) |
| PT (1) | PT2590974E (es) |
| RS (1) | RS53490B1 (es) |
| SG (1) | SG186187A1 (es) |
| SI (1) | SI2590974T1 (es) |
| TN (1) | TN2012000578A1 (es) |
| TW (1) | TWI534145B (es) |
| UA (1) | UA112517C2 (es) |
| UY (1) | UY33486A (es) |
| WO (1) | WO2012004299A1 (es) |
| ZA (1) | ZA201209117B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8759362B2 (en) * | 2008-10-24 | 2014-06-24 | Purdue Pharma L.P. | Bicycloheteroaryl compounds and their use as TRPV1 ligands |
| UA112517C2 (uk) | 2010-07-06 | 2016-09-26 | Новартіс Аг | Тетрагідропіридопіримідинові похідні |
| JO3733B1 (ar) | 2011-04-05 | 2021-01-31 | Bayer Ip Gmbh | استخدام 3,2-دايهيدروايميدازو[1, 2 -c]كوينازولينات مستبدلة |
| WO2013001445A1 (en) | 2011-06-27 | 2013-01-03 | Novartis Ag | Solid forms and salts of tetrahydro-pyrido-pyrimidine derivatives |
| EA029473B1 (ru) * | 2011-12-15 | 2018-03-30 | Новартис Аг | Применение ингибиторов pi3k для лечения острой и церебральной малярии |
| PT2794600T (pt) | 2011-12-22 | 2018-03-13 | Novartis Ag | Derivados de 2,3-di-hidro-benzo[1,4]oxazina e compostos relacionados como inibidores de fosfoinositídeo-3-cinase (pi3k) para o tratamento de, por exemplo, artrite reumatoide |
| CN104870017B (zh) | 2012-11-08 | 2020-08-14 | 理森制药股份公司 | 含有PDE4抑制剂和PI3δ或双重PI3δ-γ激酶抑制剂的药物组合物 |
| MX2015006192A (es) * | 2012-11-16 | 2015-08-10 | Merck Sharp & Dohme | Inhibidores de purina de fosfatidilinositol 3-quinasa delta humana. |
| CA2891009A1 (en) | 2012-11-16 | 2014-05-22 | Merck Sharp & Dohme Corp. | Purine inhibitors of human phosphatidylinositol 3-kinase delta |
| EP2742940B1 (en) | 2012-12-13 | 2017-07-26 | IP Gesellschaft für Management mbH | Fumarate salt of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-l-aza-bicyclo-[2.2.2]octane for adminstration once daily, twice daily or thrice daily |
| UY35675A (es) | 2013-07-24 | 2015-02-27 | Novartis Ag | Derivados sustituidos de quinazolin-4-ona |
| WO2015162584A1 (en) | 2014-04-24 | 2015-10-29 | Novartis Ag | Crystalline forms of the sulfate salt of n-[5-(3-imidazol-1-yl-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide |
| GB201506786D0 (en) * | 2015-04-21 | 2015-06-03 | Ucb Biopharma Sprl | Therapeutic use |
| EP3292120B1 (en) * | 2015-05-04 | 2019-06-19 | H. Hoffnabb-La Roche Ag | Tetrahydropyridopyrimidines and tetrahydropyridopyridines as inhibitors of hbsag (hbv surface antigen) and hbv dna production for the treatment of hepatitis b virus infections |
| KR20180133840A (ko) | 2015-12-04 | 2018-12-17 | 노파르티스 아게 | 면역종양학을 위한 조성물 및 방법 |
| AU2017204936B2 (en) * | 2016-02-10 | 2019-06-27 | Novartis Ag | Use of inhibitors of the activity or function of PI3K for the treatment of primary Sjogren's Syndrome |
| EP3601561A2 (en) | 2017-03-22 | 2020-02-05 | Novartis AG | Compositions and methods for immunooncology |
| US10421765B2 (en) | 2017-05-26 | 2019-09-24 | Board Of Regents, The University Of Texas System | Tetrahydropyrido[4,3-d]pyrimidine inhibitors of ATR kinase |
| DK3651768T3 (da) | 2017-07-13 | 2024-03-18 | Univ Texas | Heterocykliske inhibitorer af atr-kinase |
| EP3668839B1 (en) | 2017-08-17 | 2023-04-12 | Board of Regents, The University of Texas System | Heterocyclic inhibitors of atr kinase |
| US10894052B2 (en) | 2018-03-16 | 2021-01-19 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of ATR kinase |
| CN114315826B (zh) * | 2021-11-30 | 2023-05-16 | 西安交通大学 | 一种吡啶并嘧啶类化合物及其应用 |
| KR20230160977A (ko) | 2022-05-17 | 2023-11-27 | 에이치앤오바이오시스(주) | 항암 치료에 사용되는 5종 이상의 생약 추출물 |
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