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AR084102A1 - Comprimido farmaceutico que comprende el solvato de dimetilsulfoxido de la n-{3-[3-ciclopropil-5-(2-fluoro-4-yodo-fenilamino)-6,8-dimetil-2,4,7-trioxo-3,4,6,7-tetrahidro-2h-pirido[4,3-d]pirimidin-1-il]fenil}acetamida, su uso para preparar un medicamento util para tratar el cancer en un ser humano y procedimiento para preparar dichos comprimidos - Google Patents

Comprimido farmaceutico que comprende el solvato de dimetilsulfoxido de la n-{3-[3-ciclopropil-5-(2-fluoro-4-yodo-fenilamino)-6,8-dimetil-2,4,7-trioxo-3,4,6,7-tetrahidro-2h-pirido[4,3-d]pirimidin-1-il]fenil}acetamida, su uso para preparar un medicamento util para tratar el cancer en un ser humano y procedimiento para preparar dichos comprimidos

Info

Publication number
AR084102A1
AR084102A1 ARP110104773A ARP110104773A AR084102A1 AR 084102 A1 AR084102 A1 AR 084102A1 AR P110104773 A ARP110104773 A AR P110104773A AR P110104773 A ARP110104773 A AR P110104773A AR 084102 A1 AR084102 A1 AR 084102A1
Authority
AR
Argentina
Prior art keywords
prepare
compressed
dimethyl
trioxo
iodo
Prior art date
Application number
ARP110104773A
Other languages
English (en)
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46314827&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR084102(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of AR084102A1 publication Critical patent/AR084102A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2813—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Comprimido farmacéutico que comprende: a) una cantidad de fármaco, que es el solvato de dimetilsulfóxido de la N{3-[3-ciclopropil-5-(2-fluoro-4-yodo-fenilamino)-6,8-dimetil-2,4,7-trioxo-3,4,6,7-tetrahidro-2H-pirido[4,3-d]pirimidin-1-il]fenil}acetamida, seleccionada entre 0,5635 mg y 2,254 mg; en el que el comprimido contiene de 25% a 89% en peso de uno o más excipientes, en el que los excipientes carecen sustancialmente de agua y la cantidad de fármaco no solvatado no supera 20%. Los excipientes se seleccionan entre: celulosa microcristalina, celulosa en polvo, almidón pregelatinizado, almidón, lactosa, fosfato dicálcico, lactitol, manitol, sorbitol y maltodextrina. Su uso para preparar un medicamento útil para tratar el cáncer en un ser humano. Procedimiento para preparar dichos comprimidos.
ARP110104773A 2010-12-20 2011-12-19 Comprimido farmaceutico que comprende el solvato de dimetilsulfoxido de la n-{3-[3-ciclopropil-5-(2-fluoro-4-yodo-fenilamino)-6,8-dimetil-2,4,7-trioxo-3,4,6,7-tetrahidro-2h-pirido[4,3-d]pirimidin-1-il]fenil}acetamida, su uso para preparar un medicamento util para tratar el cancer en un ser humano y procedimiento para preparar dichos comprimidos AR084102A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201061424967P 2010-12-20 2010-12-20

Publications (1)

Publication Number Publication Date
AR084102A1 true AR084102A1 (es) 2013-04-24

Family

ID=46314827

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP110104773A AR084102A1 (es) 2010-12-20 2011-12-19 Comprimido farmaceutico que comprende el solvato de dimetilsulfoxido de la n-{3-[3-ciclopropil-5-(2-fluoro-4-yodo-fenilamino)-6,8-dimetil-2,4,7-trioxo-3,4,6,7-tetrahidro-2h-pirido[4,3-d]pirimidin-1-il]fenil}acetamida, su uso para preparar un medicamento util para tratar el cancer en un ser humano y procedimiento para preparar dichos comprimidos
ARP210101433A AR122185A2 (es) 2010-12-20 2021-05-27 Comprimido farmacéutico que comprende el solvato de dimetilsulfóxido de la n-3-[3-ciclopropil-5-(2-fluoro-4-yodo-fenilamino)-6,8-dimetil-2,4,7-trioxo-3,4,6,7-tetrahidro-2h-pirido[4,3-d]pirimidin-1-il]fenilacetamida, su uso para preparar un medicamento útil para tratar el cáncer en un ser humano y procedimiento para preparar dichos comprimidos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP210101433A AR122185A2 (es) 2010-12-20 2021-05-27 Comprimido farmacéutico que comprende el solvato de dimetilsulfóxido de la n-3-[3-ciclopropil-5-(2-fluoro-4-yodo-fenilamino)-6,8-dimetil-2,4,7-trioxo-3,4,6,7-tetrahidro-2h-pirido[4,3-d]pirimidin-1-il]fenilacetamida, su uso para preparar un medicamento útil para tratar el cáncer en un ser humano y procedimiento para preparar dichos comprimidos

Country Status (37)

Country Link
US (5) US8580304B2 (es)
EP (4) EP3808343A1 (es)
JP (2) JP6126014B2 (es)
KR (1) KR101911109B1 (es)
CN (1) CN103998041B (es)
AR (2) AR084102A1 (es)
AU (1) AU2011349422B2 (es)
BR (1) BR112013015602B1 (es)
CA (1) CA2822701C (es)
CL (1) CL2013001779A1 (es)
CR (1) CR20130352A (es)
CY (1) CY1123376T1 (es)
DK (3) DK4159205T3 (es)
DO (1) DOP2013000138A (es)
EA (1) EA025198B1 (es)
ES (3) ES2985024T3 (es)
FI (2) FI4159205T3 (es)
HR (3) HRP20240564T1 (es)
HU (3) HUE066526T2 (es)
IL (1) IL226855A (es)
JO (1) JO3594B1 (es)
LT (3) LT2654736T (es)
MA (1) MA34883B1 (es)
MX (1) MX2013007073A (es)
MY (1) MY170501A (es)
NZ (1) NZ612157A (es)
PE (1) PE20140040A1 (es)
PL (3) PL2654736T3 (es)
PT (3) PT4159205T (es)
RS (2) RS65497B1 (es)
SG (1) SG191054A1 (es)
SI (3) SI2654736T1 (es)
TW (1) TWI505828B (es)
UA (1) UA113158C2 (es)
UY (1) UY33818A (es)
WO (1) WO2012088033A2 (es)
ZA (1) ZA201304189B (es)

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EA201390913A1 (ru) 2014-04-30
CA2822701C (en) 2018-10-23
JO3594B1 (ar) 2020-07-05
HRP20240564T1 (hr) 2024-09-27
HUE066526T2 (hu) 2024-08-28
US20140154316A1 (en) 2014-06-05
PT4159204T (pt) 2024-05-07
HUE066525T2 (hu) 2024-08-28
ES2985024T3 (es) 2024-11-04
UA113158C2 (xx) 2016-12-26
UY33818A (es) 2012-07-31
WO2012088033A2 (en) 2012-06-28
HRP20201409T1 (hr) 2020-11-27
HRP20240563T1 (hr) 2024-08-16
US20120183613A1 (en) 2012-07-19
RS65496B1 (sr) 2024-06-28
ES2982775T3 (es) 2024-10-17
BR112013015602B1 (pt) 2022-03-03
US9399021B2 (en) 2016-07-26
SI4159205T1 (sl) 2024-06-28
JP2017137299A (ja) 2017-08-10
US9271941B2 (en) 2016-03-01
EA025198B1 (ru) 2016-11-30
US9155706B2 (en) 2015-10-13
ES2820536T3 (es) 2021-04-21
MY170501A (en) 2019-08-08
PT4159205T (pt) 2024-05-08
PL4159205T3 (pl) 2024-06-24
CR20130352A (es) 2013-12-18
CN103998041B (zh) 2016-08-17
US8580304B2 (en) 2013-11-12
DK2654736T3 (da) 2020-09-14
SG191054A1 (en) 2013-08-30
US20130266649A1 (en) 2013-10-10
HUE050788T2 (hu) 2021-01-28
TW201249441A (en) 2012-12-16
WO2012088033A3 (en) 2014-03-13
TWI505828B (zh) 2015-11-01
US20140037726A1 (en) 2014-02-06
LT4159204T (lt) 2024-05-10
KR101911109B1 (ko) 2018-10-23
PL4159204T3 (pl) 2024-07-01
EP4159205A1 (en) 2023-04-05
EP4159205B1 (en) 2024-02-14
PE20140040A1 (es) 2014-02-26
DK4159204T3 (da) 2024-05-21
EP2654736B1 (en) 2020-07-01
FI4159204T3 (fi) 2024-04-22
KR20130130028A (ko) 2013-11-29
CN103998041A (zh) 2014-08-20
LT2654736T (lt) 2020-09-25
CA2822701A1 (en) 2012-06-28
EP2654736A4 (en) 2015-04-22
EP3808343A1 (en) 2021-04-21
EP4159204A1 (en) 2023-04-05
DK4159205T3 (da) 2024-05-13
BR112013015602A2 (pt) 2017-02-21
IL226855A (en) 2017-04-30
PT2654736T (pt) 2020-09-24
EP4159204B1 (en) 2024-02-14
EP2654736A2 (en) 2013-10-30
SI4159204T1 (sl) 2024-06-28
PL2654736T3 (pl) 2020-12-14
AU2011349422A1 (en) 2013-05-02
JP6126014B2 (ja) 2017-05-10
DOP2013000138A (es) 2013-11-30
LT4159205T (lt) 2024-05-10
AU2011349422B2 (en) 2015-12-10
JP2014510704A (ja) 2014-05-01
ZA201304189B (en) 2014-02-26
AR122185A2 (es) 2022-08-24
CY1123376T1 (el) 2021-12-31
NZ612157A (en) 2015-05-29
RS65497B1 (sr) 2024-06-28
MX2013007073A (es) 2013-09-26
FI4159205T3 (fi) 2024-04-23
CL2013001779A1 (es) 2014-06-27
US20140099365A1 (en) 2014-04-10
SI2654736T1 (sl) 2020-10-30
MA34883B1 (fr) 2014-02-01

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