AR084098A1 - Procesos para la preparacion de enaminas - Google Patents
Procesos para la preparacion de enaminasInfo
- Publication number
- AR084098A1 AR084098A1 ARP110104519A ARP110104519A AR084098A1 AR 084098 A1 AR084098 A1 AR 084098A1 AR P110104519 A ARP110104519 A AR P110104519A AR P110104519 A ARP110104519 A AR P110104519A AR 084098 A1 AR084098 A1 AR 084098A1
- Authority
- AR
- Argentina
- Prior art keywords
- mixture
- vapor phase
- reaction zone
- alkylaminoalkyl
- alkoxyalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
- C07C209/52—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of imines or imino-ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/27—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Containers And Plastic Fillers For Packaging (AREA)
Abstract
Procesos para la preparación de enaminas.Reivindicación 1: Un proceso que incluye: (A) una primera mezcla que tome contacto con una segunda mezcla en la zona de reacción, (i) en la que dicha primera mezcla contiene una amina que contiene la fórmula (1), en la que R4 y R5 son cada una independientemente seleccionada a partir de alquil C1-8, cicloalquil C3-8, alcoxialquil C2-8, arilalquil C7-12, alquilaminoalquil C2-8, aril y heteroaril o R4 y R5 tomados conjuntamente con N representa un anillo saturado o no saturado 5- ó 6-membrado y (ii) en la que dicha segunda mezcla contiene un solvente no-polar-de-alto-punto-ebullición y un carbonilo (es decir, un aldehído o una quetona) que contiene la fórmula (2), (a) en la que R1 y R2 es cada uno independientemente seleccionado a partir de alquil C1-8, cicloalquil C3-8, alcoxialquil C2-8, arilalquil C7-12, alquilaminoalquil C2-8, aril y heteroaril, cada uno de los cuales es sustituido independientemente con uno o más S-R6 en el que cada R6 es independientemente seleccionado a partir de alquil C1-8, cicloalquil C3-8, alcoxialquil C2-8, arilalquil C7-12, alquilaminoalquil C2-8, aril y heteroaril y (b) en el que R3 es seleccionado a partir de H, alquil C1-8, cicloalquil C3-8, alcoxialquil C2-8, arilalquil C7-12, alquilaminoalquil C2-8, aril y heteroaril; (B) reaccionar en dicha zona de reacción dicha amina y dicho carbonilo para obtener una enamina y H2O, en la que dicha reacción se efectúa sometida a condiciones de destilación que incluyen (i) una presión desde alrededor de 100 Pascales (Pa) hasta alrededor de 120.000 Pa y (ii) una temperatura por debajo de alrededor de, pero preferentemente debajo de, la temperatura de descomposición termal de dicha enamina durante dicha reacción; y (C) remover una fase de vapor de dicha zona de reacción en la que dicha fase de vapor contiene dicho solvente no-polar-punto-alto-ebullición y H2O, en la que la proporción de (la cantidad de la primera mezcla adicionada a dicha zona de reacción):(la cantidad de fase de vapor removida de dicha zona de reacción) oscila desde alrededor de (1 parte de la primera mezcla adicionada):(1 parte de fase de vapor removida) hasta alrededor de (1 parte de la primera mezcla adicionada):(20 partes de fase de vapor removido).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41927710P | 2010-12-03 | 2010-12-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR084098A1 true AR084098A1 (es) | 2013-04-17 |
Family
ID=46162837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110104519A AR084098A1 (es) | 2010-12-03 | 2011-12-02 | Procesos para la preparacion de enaminas |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US20120142944A1 (es) |
| EP (1) | EP2646424B1 (es) |
| JP (1) | JP5927200B2 (es) |
| KR (1) | KR20130129211A (es) |
| CN (2) | CN103491963B (es) |
| AR (1) | AR084098A1 (es) |
| AU (1) | AU2011336875B2 (es) |
| BR (1) | BR112013013303B1 (es) |
| CA (1) | CA2818559A1 (es) |
| CO (1) | CO6700895A2 (es) |
| DK (1) | DK2646424T3 (es) |
| ES (1) | ES2549952T3 (es) |
| IL (1) | IL226575A (es) |
| MX (1) | MX337042B (es) |
| PL (1) | PL2646424T3 (es) |
| RU (1) | RU2620380C2 (es) |
| UA (1) | UA109469C2 (es) |
| WO (1) | WO2012074862A2 (es) |
| ZA (1) | ZA201303874B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2680696B1 (en) * | 2010-12-03 | 2015-05-06 | Dow AgroSciences LLC | Processes for the preparation of enamines |
| BR112013013309A8 (pt) * | 2010-12-03 | 2017-10-10 | Dow Agrosciences Llc | Processos para a preparação de enaminas |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3074940A (en) * | 1958-09-10 | 1963-01-22 | Monsanto Chemicals | Process for the manufacture of enamines |
| US3331875A (en) * | 1964-04-15 | 1967-07-18 | Eastman Kodak Co | Manufacture of enamines |
| DE1287571B (de) * | 1966-02-21 | 1969-01-23 | Frhr Von Hirsch Hubert | Verfahren zur Herstellung von Enaminen |
| DE2125247C3 (de) * | 1971-04-06 | 1981-07-23 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | Verfahren zum Applizieren von Lacken, Vergußmassen, Spachtelmassen, Überzugs- und Beschichtungsmassen |
| US3965791A (en) * | 1974-06-19 | 1976-06-29 | The Wurlitzer Company | Stop tablet assembly |
| US4824954A (en) * | 1984-11-06 | 1989-04-25 | Monsanto Company | Process for preparation of substituted pyridines |
| EP1230212B1 (en) * | 1999-11-16 | 2005-05-11 | Ciba SC Holding AG | Process for the preparation of ketimines |
| EP1474145B1 (en) * | 2002-02-04 | 2008-04-23 | F. Hoffmann-La Roche Ag | Quinoline derivatives as npy antagonists |
| JP3881648B2 (ja) * | 2003-10-08 | 2007-02-14 | シャープ株式会社 | 電子写真感光体およびそれを備える画像形成装置 |
| CN1271050C (zh) * | 2004-10-29 | 2006-08-23 | 浙江工业大学 | 2－取代烯胺或烯酰胺化合物的制备方法 |
| TW201309635A (zh) * | 2006-02-10 | 2013-03-01 | Dow Agrosciences Llc | 殺蟲性之ｎ-取代（６-鹵烷基吡啶-３-基）烷基磺醯亞胺（二） |
| US7728014B2 (en) * | 2006-09-07 | 2010-06-01 | Allergan, Inc. | Heteroaromatic compounds having sphingosine-1-phosphate (S1P) receptor agonist biological activity |
| JP5077969B2 (ja) * | 2007-02-09 | 2012-11-21 | ダウ アグロサイエンシィズ エルエルシー | ２−置換５−（１−アルキルチオ）アルキルピリジンの調製方法 |
| US7709648B2 (en) * | 2007-02-09 | 2010-05-04 | Dow Agrosciences Llc | Process for the preparation of 2-substituted-5-(1-alkylthio)alkylpyridines |
| JP4316634B2 (ja) * | 2007-05-10 | 2009-08-19 | シャープ株式会社 | エナミン化合物を含有する電子写真感光体とそれを備えた画像形成装置およびエナミン化合物とその製造方法 |
| WO2009007460A2 (en) * | 2007-07-11 | 2009-01-15 | Dsm Ip Assets B.V. | Enantioselective reduction |
| CN101125828A (zh) * | 2007-07-20 | 2008-02-20 | 云南瑞升烟草技术（集团）有限公司 | α-酮基烯胺衍生物凉味剂(3-MPC)的合成方法及其应用 |
| ES2383202T3 (es) * | 2007-07-27 | 2012-06-19 | Dow Agrosciences Llc | Pesticidas y usos de los mismos |
| JP5408894B2 (ja) * | 2008-04-02 | 2014-02-05 | 京セラドキュメントソリューションズ株式会社 | 電子写真感光体、およびこれを備えた画像形成装置 |
| ITMI20081084A1 (it) * | 2008-06-16 | 2009-12-17 | Phf Sa | Processo per la preparazione di brinzolamide |
| DK2315750T3 (da) * | 2008-07-01 | 2013-02-18 | Dow Agrosciences Llc | Forbedret fremgangsmåde til fremstilling af 2-trifluormethyl-5-(1-substituerede) alkylpyridiner |
-
2011
- 2011-11-23 JP JP2013542062A patent/JP5927200B2/ja active Active
- 2011-11-23 WO PCT/US2011/061986 patent/WO2012074862A2/en active Application Filing
- 2011-11-23 ES ES11844252.4T patent/ES2549952T3/es active Active
- 2011-11-23 EP EP11844252.4A patent/EP2646424B1/en active Active
- 2011-11-23 CA CA2818559A patent/CA2818559A1/en not_active Abandoned
- 2011-11-23 UA UAA201308353A patent/UA109469C2/ru unknown
- 2011-11-23 MX MX2013006191A patent/MX337042B/es active IP Right Grant
- 2011-11-23 US US13/303,206 patent/US20120142944A1/en not_active Abandoned
- 2011-11-23 CN CN201180058182.2A patent/CN103491963B/zh active Active
- 2011-11-23 DK DK11844252.4T patent/DK2646424T3/en active
- 2011-11-23 AU AU2011336875A patent/AU2011336875B2/en active Active
- 2011-11-23 KR KR1020137014023A patent/KR20130129211A/ko not_active Application Discontinuation
- 2011-11-23 PL PL11844252T patent/PL2646424T3/pl unknown
- 2011-11-23 BR BR112013013303-1A patent/BR112013013303B1/pt active IP Right Grant
- 2011-11-23 CN CN201510673821.6A patent/CN105175358A/zh active Pending
- 2011-11-23 RU RU2013130242A patent/RU2620380C2/ru active
- 2011-12-02 AR ARP110104519A patent/AR084098A1/es active IP Right Grant
-
2013
- 2013-05-26 IL IL226575A patent/IL226575A/en active IP Right Grant
- 2013-05-28 ZA ZA2013/03874A patent/ZA201303874B/en unknown
- 2013-05-30 CO CO13132884A patent/CO6700895A2/es unknown
-
2014
- 2014-02-04 US US14/172,443 patent/US20140155628A1/en not_active Abandoned
-
2015
- 2015-07-24 US US14/807,981 patent/US20150329507A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MX2013006191A (es) | 2013-07-29 |
| MX337042B (es) | 2016-02-10 |
| EP2646424A2 (en) | 2013-10-09 |
| CN103491963A (zh) | 2014-01-01 |
| CA2818559A1 (en) | 2012-06-07 |
| EP2646424B1 (en) | 2015-09-30 |
| WO2012074862A3 (en) | 2013-09-19 |
| ZA201303874B (en) | 2014-08-27 |
| AU2011336875A1 (en) | 2013-05-30 |
| JP5927200B2 (ja) | 2016-06-01 |
| CN103491963B (zh) | 2015-09-16 |
| US20120142944A1 (en) | 2012-06-07 |
| US20150329507A1 (en) | 2015-11-19 |
| RU2013130242A (ru) | 2015-01-10 |
| KR20130129211A (ko) | 2013-11-27 |
| ES2549952T3 (es) | 2015-11-03 |
| UA109469C2 (xx) | 2015-08-25 |
| IL226575A (en) | 2016-05-31 |
| DK2646424T3 (en) | 2016-01-11 |
| BR112013013303A2 (pt) | 2016-09-13 |
| RU2620380C2 (ru) | 2017-05-25 |
| JP2014505024A (ja) | 2014-02-27 |
| PL2646424T3 (pl) | 2016-01-29 |
| CO6700895A2 (es) | 2013-06-28 |
| AU2011336875B2 (en) | 2016-09-01 |
| US20140155628A1 (en) | 2014-06-05 |
| EP2646424A4 (en) | 2015-01-21 |
| WO2012074862A2 (en) | 2012-06-07 |
| CN105175358A (zh) | 2015-12-23 |
| BR112013013303B1 (pt) | 2018-11-06 |
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Legal Events
| Date | Code | Title | Description |
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| FB | Suspension of granting procedure | ||
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