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AR073807A1 - PROCESS TO PREPARE SUNITINIB MALATE, SALT OF A WEAKER ACID THAN MALATE AS A INTERMEDIARY COMPOUND, AND PROCESS TO PREPARE SUCH INTERMEDIARY SALT. - Google Patents

PROCESS TO PREPARE SUNITINIB MALATE, SALT OF A WEAKER ACID THAN MALATE AS A INTERMEDIARY COMPOUND, AND PROCESS TO PREPARE SUCH INTERMEDIARY SALT.

Info

Publication number
AR073807A1
AR073807A1 ARP090103893A AR073807A1 AR 073807 A1 AR073807 A1 AR 073807A1 AR P090103893 A ARP090103893 A AR P090103893A AR 073807 A1 AR073807 A1 AR 073807A1
Authority
AR
Argentina
Prior art keywords
salt
prepare
malate
intermediary
sunitinib
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Bernardino Mangion
Original Assignee
Medichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem Sa filed Critical Medichem Sa
Publication of AR073807A1 publication Critical patent/AR073807A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Reivindicacion 1: un procedimiento para preparar la sal de ácido málico de sunitinib de Formula (1): dicho procedimiento consiste en: (i) proporcionar una solucion que comprende una sal de adicion de ácido de sunitinib en un solvente orgánico, donde dicha sal es la sal de un ácido mas débil que el ácido málico; (ii) tratar dicha solucion con ácido málico, para obtener una mezcla que comprende malato de sunitinib; (iii) aislar malato de sunitinib de la mezcla; y (iv) opcionalmente, purificar dicho malato de sunitinib.Claim 1: A process for preparing the sunitinib malic acid salt of Formula (1): said process consists of: (i) providing a solution comprising a sunitinib acid addition salt in an organic solvent, wherein said salt is the salt of an acid weaker than malic acid; (ii) treating said solution with malic acid, to obtain a mixture comprising sunitinib malate; (iii) isolate sunitinib malate from the mixture; and (iv) optionally, purify said sunitinib malate.

ARP090103893 2008-10-10 2009-10-09 PROCESS TO PREPARE SUNITINIB MALATE, SALT OF A WEAKER ACID THAN MALATE AS A INTERMEDIARY COMPOUND, AND PROCESS TO PREPARE SUCH INTERMEDIARY SALT. AR073807A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10434408P 2008-10-10 2008-10-10

Publications (1)

Publication Number Publication Date
AR073807A1 true AR073807A1 (en) 2010-12-01

Family

ID=41466916

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090103893 AR073807A1 (en) 2008-10-10 2009-10-09 PROCESS TO PREPARE SUNITINIB MALATE, SALT OF A WEAKER ACID THAN MALATE AS A INTERMEDIARY COMPOUND, AND PROCESS TO PREPARE SUCH INTERMEDIARY SALT.

Country Status (4)

Country Link
EP (1) EP2350056A1 (en)
CN (1) CN102177155A (en)
AR (1) AR073807A1 (en)
WO (1) WO2010041134A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8618309B2 (en) 2008-07-24 2013-12-31 Teva Pharmaceutical Industries Ltd. Sunitinib and salts thereof and their polymorphs
US20120220783A1 (en) * 2009-09-16 2012-08-30 Ranbaxy Laboratories Limited Salts of sunitinib
EP2828251B1 (en) 2012-03-23 2018-10-31 Laurus Labs Limited An improved process for the preparation of sunitinib and its acid addition salts thereof
WO2014167436A2 (en) * 2013-04-10 2014-10-16 Shilpa Medicare Limited Sunitinib glucuronate salt & process for preparation thereof
CA2838587A1 (en) * 2013-10-18 2015-04-18 Hari Babu Matta Pure crystalline form ii of l-malic acid salt of sunitinib and processes for its preparation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100713960B1 (en) * 2000-02-15 2007-05-02 수젠, 인크. Pyrrole Substituted 2-Indolinone Protein Kinase Inhibitors
GEP20063777B (en) * 2001-08-15 2006-03-27 Upjohn Co Crystals Including Malic Acid Salt of N-[2-(Diethylamino) Ethyl]-5-[(5-Fluoro-2-Oxo-3h-Indole-3-Ylidene) Methyl]-2, 4-Dimethyl-1h-Pyrrole-3-Carboxamide, Processes for Its Preparation and Compositions Thereof
US8618309B2 (en) * 2008-07-24 2013-12-31 Teva Pharmaceutical Industries Ltd. Sunitinib and salts thereof and their polymorphs

Also Published As

Publication number Publication date
CN102177155A (en) 2011-09-07
WO2010041134A1 (en) 2010-04-15
EP2350056A1 (en) 2011-08-03

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