AR073259A1 - Derivados de furosemida utiles como diureticos - Google Patents
Derivados de furosemida utiles como diureticosInfo
- Publication number
- AR073259A1 AR073259A1 ARP090102830A ARP090102830A AR073259A1 AR 073259 A1 AR073259 A1 AR 073259A1 AR P090102830 A ARP090102830 A AR P090102830A AR P090102830 A ARP090102830 A AR P090102830A AR 073259 A1 AR073259 A1 AR 073259A1
- Authority
- AR
- Argentina
- Prior art keywords
- ono2
- group
- xch
- independently selected
- diuretics
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Furan Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Reivindicacion 1: Un compuesto que tiene la formula general 1: en la que X se selecciona entre el grupo que consiste en: un enlace, -NHCH2(CH2)nCH2OC(O)-, -CH2NHC(O)CH2NHC(O)-, -CH2OC(O)-, -OCH(CH3)OC(O)-, -OCH2OC(O)-, -O-, -NR1-, -CR1R3-, -(CH2)p-, -(CH2)qNR1C(O)-, -CHR5NR2C(O)-, -(CH2)qC(O)-, -(CH2)qC(O)NR1-, y el grupo de formulas 2; R1, R2, R4, R7 y R8, en cada caso en el que aparecen, se seleccionan independientemente entre el grupo que consiste en hidrogeno y alquilo C1-7; R3 es hidrogeno, alquilo C1-4, -CH2ONO2 u -ONO2; R5 y R9 se seleccionan independientemente entre el grupo que consiste en hidrogeno, -CH3, -CH2CH3, -CH(CH3)2, -CH(CH3)3, -CH2OH, -CH(OH)CH3 y - CH2C6H5; g es 0 o 1; p es 0, 1, 2, 3, 4, 5, 6 o 7; q es 1, 2, 3, 4 o 5; v y w se seleccionan independientemente entre el grupo que consiste en 0, 1, 2 y 3, con la condicion de que v + w sea 1, 2, 3 o 4; R se selecciona entre el grupo que consiste en -(CH2)xCH(ONO2)(CH2)yCH3, -(CH2)xCH(ONO2)(CH2)yCH(ONO2)(CH2)zCH3; -(CH2)xCH(ONO2)(CH2)yCH2(ONO2), -(CH2)xCH(ONO2)(CR1R2)CH2(ONO2), -CR1R2R3 con la condicion de que R3 sea -CH2ONO2 u -ONO2, -(CH2)x(ONO2), -O-C(O)-(CH2)xCH(ONO2)(CH2)yCH2(ONO2), y las formulas 3 y 4 con la condicion de que X sea CR1R3 y R3 sea -CH2ONO2 u -ONO2, el grupo de formulas 5 con la condicion de que cuando R es -O-C(O)-(CH2)xCH(ONO2)(CH2)yCH2(ONO2) o la formula 3 entonces X se selecciona entre el grupo que consiste en un enlace, -NR1-, -CR1R3-, -(CH2)p-, -(CH2)qNR1C(O)-, -CHR5NR2C(O)- (CH2)qC(O)-, -(CH2)qC(O)NR1-, el grupo de formula 6; h, j y k se seleccionan independientemente entre el grupo que consiste en 0, 1 y 2; m, n, x, y y z se seleccionan independientemente entre el grupo que consiste en 0, 1, 2, 3 y 4; r y s se seleccionan independientemente entre el grupo que consiste en 0, 1, 2 y 3, con la condicion de que r + s sea 1, 2, 3 o 4.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13725008P | 2008-07-29 | 2008-07-29 | |
| US18903408P | 2008-08-15 | 2008-08-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR073259A1 true AR073259A1 (es) | 2010-10-28 |
Family
ID=41119341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090102830A AR073259A1 (es) | 2008-07-29 | 2009-07-24 | Derivados de furosemida utiles como diureticos |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8119806B2 (es) |
| EP (1) | EP2326652B1 (es) |
| JP (1) | JP2011529892A (es) |
| AR (1) | AR073259A1 (es) |
| AU (1) | AU2009276843A1 (es) |
| CA (1) | CA2731957A1 (es) |
| TW (1) | TW201011032A (es) |
| WO (1) | WO2010014516A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2369924B1 (en) * | 2008-11-26 | 2014-11-26 | Merck Sharp & Dohme Corp. | Nitrooxy cycloalkane derivatives |
| JO3350B1 (ar) | 2011-03-07 | 2019-03-13 | Merck Sharp & Dohme | مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات |
| CN110407846B (zh) * | 2018-04-26 | 2021-09-14 | 鲁南制药集团股份有限公司 | 一种5-单硝酸异山梨酯的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN156817B (es) * | 1981-02-10 | 1985-11-09 | Scras | |
| GB8808001D0 (en) * | 1988-04-06 | 1988-05-05 | Scras | Stereospecific preparative process for furol(3,4-c)pyridine derivatives |
| WO2004098538A2 (en) * | 2003-03-13 | 2004-11-18 | Nitromed, Inc. | Nitrosated and nitrosylated compounds, compositions and methods of use |
| AU2004246821A1 (en) | 2003-06-19 | 2004-12-23 | Nicox S.A. | Enalapril-nitroxyderivatives derivatives and related compounds as ace inhibitors for the treatment of cardiovascular diseases |
| DE602004011230T2 (de) * | 2003-07-31 | 2009-01-02 | Nicox S.A., Sophia Antipolis | Nitrooxyderivate von losartan, valsatan, candesartan, telmisartan, eprosartan and olmesartan als angiotensin-ii-rezeptor-blocker zur behandlung von herz-kreislauf-erkrankungen |
| CA2536967A1 (en) * | 2003-08-28 | 2005-03-17 | Nitromed, Inc. | Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use |
| WO2005030135A2 (en) * | 2003-09-26 | 2005-04-07 | Nitromed, Inc. | Nitrosated glutamic acid compounds, compositions and methods of use |
| WO2007137980A1 (en) * | 2006-05-29 | 2007-12-06 | Nicox S.A. | Nitrated heterocyclic compounds as endothelin receptor antagonist |
| TW200831463A (en) * | 2006-09-12 | 2008-08-01 | Speedel Experimenta Ag | Nitrate esters of aminoalcohols |
| TW200831079A (en) * | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Angiotensin II receptor antagonists |
| CA2671421A1 (en) * | 2006-12-13 | 2008-06-26 | Merck & Co., Inc. | Nitroderivatives as angiotensin ii receptor antagonists |
| CN101568732B (zh) | 2006-12-15 | 2015-10-07 | 皇家飞利浦电子股份有限公司 | 具有频率控制的脉动流体冷却 |
-
2009
- 2009-07-24 AR ARP090102830A patent/AR073259A1/es unknown
- 2009-07-27 CA CA2731957A patent/CA2731957A1/en not_active Abandoned
- 2009-07-27 AU AU2009276843A patent/AU2009276843A1/en not_active Abandoned
- 2009-07-27 EP EP09790831.3A patent/EP2326652B1/en not_active Not-in-force
- 2009-07-27 US US12/509,698 patent/US8119806B2/en not_active Expired - Fee Related
- 2009-07-27 JP JP2011521211A patent/JP2011529892A/ja active Pending
- 2009-07-27 WO PCT/US2009/051788 patent/WO2010014516A1/en active Application Filing
- 2009-07-28 TW TW098125384A patent/TW201011032A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011529892A (ja) | 2011-12-15 |
| US20100029678A1 (en) | 2010-02-04 |
| TW201011032A (en) | 2010-03-16 |
| EP2326652A1 (en) | 2011-06-01 |
| US8119806B2 (en) | 2012-02-21 |
| WO2010014516A1 (en) | 2010-02-04 |
| CA2731957A1 (en) | 2010-02-04 |
| EP2326652B1 (en) | 2014-04-16 |
| AU2009276843A1 (en) | 2010-02-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |