AR079726A1 - Terapia combinada para enfermedad pulmonar obstructiva cronica (epoc) . composicion farmaceutica.frasco de aerosol. metodo.conjunto de componentes - Google Patents
Terapia combinada para enfermedad pulmonar obstructiva cronica (epoc) . composicion farmaceutica.frasco de aerosol. metodo.conjunto de componentesInfo
- Publication number
- AR079726A1 AR079726A1 ARP100104922A ARP100104922A AR079726A1 AR 079726 A1 AR079726 A1 AR 079726A1 AR P100104922 A ARP100104922 A AR P100104922A AR P100104922 A ARP100104922 A AR P100104922A AR 079726 A1 AR079726 A1 AR 079726A1
- Authority
- AR
- Argentina
- Prior art keywords
- copd
- pulmonary disease
- chronic obstructive
- obstructive pulmonary
- aerosol
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/124—Aerosols; Foams characterised by the propellant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/04—Methods of, or means for, filling the material into the containers or receptacles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B31/00—Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
- B65B31/003—Adding propellants in fluid form to aerosol containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B7/00—Closing containers or receptacles after filling
- B65B7/16—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
- B65B7/28—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers
- B65B7/2842—Securing closures on containers
- B65B7/285—Securing closures on containers by deformation of the closure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Dispersion Chemistry (AREA)
- Mechanical Engineering (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
Abstract
Formulacion en aerosol que es apropiada para administrar a pacientes de enfermedad pulmonar obstructiva cronica (EPOC) por medio de un inhalador presurizado de dosis medida (pMDI), que comprende bromuro de glicopirronio en combinacion con formoterol. La formulacion comprende además un propelente de HFA, un cosolvente, y una cantidad de ácido inorgánico que es suficiente para estabilizar tanto el componente de bromuro de glicopirronio como el de formoterol. Opcionalmente la formulacion comprende además dipropionato de beclometasona. Frasco de aerosol. Método para rellenar el frasco. Conjunto de componentes. Reivindicacion 1: Una composicion farmacéutica caracterizada porque comprende: (a) bromuro de glicopirronio; y (b) formoterol o una sal del mismo; disueltos en un propelente de HFA y un cosolvente, que se caracteriza porque dicha composicion contiene una cantidad de HCI 1 M en el rango entre 0,1 y 0,3 microgramos/microlitro.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09180671 | 2009-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR079726A1 true AR079726A1 (es) | 2012-02-15 |
Family
ID=42107420
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100104922A AR079726A1 (es) | 2009-12-23 | 2010-12-22 | Terapia combinada para enfermedad pulmonar obstructiva cronica (epoc) . composicion farmaceutica.frasco de aerosol. metodo.conjunto de componentes |
| ARP190102199A AR115897A2 (es) | 2009-12-23 | 2019-08-02 | Composición farmacéutica para enfermedad pulmonar obstructiva crónica (epoc), frasco de aerosol que lo comprende, y método para rellenarlo |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP190102199A AR115897A2 (es) | 2009-12-23 | 2019-08-02 | Composición farmacéutica para enfermedad pulmonar obstructiva crónica (epoc), frasco de aerosol que lo comprende, y método para rellenarlo |
Country Status (40)
| Country | Link |
|---|---|
| US (3) | US20110150782A1 (es) |
| EP (1) | EP2515855B3 (es) |
| JP (2) | JP5914354B2 (es) |
| KR (2) | KR101757951B1 (es) |
| CN (2) | CN102665679B (es) |
| AR (2) | AR079726A1 (es) |
| AU (3) | AU2010334859A1 (es) |
| BR (1) | BR112012015337B8 (es) |
| CA (1) | CA2785321C (es) |
| CL (1) | CL2012001705A1 (es) |
| CO (1) | CO6541628A2 (es) |
| CY (2) | CY1115116T1 (es) |
| DK (1) | DK2515855T6 (es) |
| EA (2) | EA021917B1 (es) |
| ES (1) | ES2468840T7 (es) |
| FI (2) | FI2515855T6 (es) |
| GE (1) | GEP20156311B (es) |
| HK (2) | HK1174566A1 (es) |
| HR (1) | HRP20140582T4 (es) |
| HU (1) | HUS1800001I1 (es) |
| IL (1) | IL260932B (es) |
| LT (1) | LTC2515855I2 (es) |
| LU (1) | LUC00060I2 (es) |
| MA (1) | MA33823B1 (es) |
| MX (1) | MX2012006878A (es) |
| MY (1) | MY156949A (es) |
| NL (1) | NL300923I2 (es) |
| NO (1) | NO2018001I1 (es) |
| NZ (1) | NZ600790A (es) |
| PE (2) | PE20160853A1 (es) |
| PL (1) | PL2515855T6 (es) |
| PT (1) | PT2515855E (es) |
| RS (1) | RS53391B2 (es) |
| SG (1) | SG181868A1 (es) |
| SI (1) | SI2515855T1 (es) |
| TN (1) | TN2012000269A1 (es) |
| TW (1) | TWI495468B (es) |
| UA (1) | UA113832C2 (es) |
| WO (1) | WO2011076843A2 (es) |
| ZA (1) | ZA201204615B (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5914354B2 (ja) * | 2009-12-23 | 2016-05-11 | シエシー ファルマセウティチィ ソシエタ ペル アチオニ | Ｃｏｐｄ用併用療法 |
| ES2464520T3 (es) | 2009-12-23 | 2014-06-03 | Chiesi Farmaceutici S.P.A. | Formulación en aerosol para EPOC |
| RU2561052C2 (ru) * | 2009-12-23 | 2015-08-20 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Комбинированное лечение хронического обструктивного заболевания легких |
| AU2012216890A1 (en) * | 2011-02-17 | 2013-09-05 | Cipla Limited | Combination of glycopyrrolate and a beta2 -agonist |
| DK2765994T3 (en) | 2011-10-11 | 2019-03-04 | Chiesi Farm Spa | Crystalline microparticles of a beta agonist coated with a fatty acid |
| KR20150096371A (ko) * | 2012-10-23 | 2015-08-24 | 시플라 리미티드 | 티오트로피움 및 히드로플루오로알칸을 포함하는 약학적 조성물 |
| PL3409270T3 (pl) | 2013-07-11 | 2021-08-09 | Chiesi Farmaceutici S.P.A. | Preparat proszkowy zawierający środek antycholinergiczny, kortykosteroid i środek beta- adrenergiczny do podawania wziewnego |
| LT3089735T (lt) * | 2013-12-30 | 2018-09-10 | Chiesi Farmaceutici S.P.A. | Glikopironio bromido ir formoterolio derinio stabili suslėgta aerozolinė tirpalo kompozicija |
| MY176191A (en) * | 2013-12-30 | 2020-07-24 | Chiesi Farm Spa | Stable pressurised aerosol solution composition of glycopyrronium bromide and formoterol combination |
| US11039621B2 (en) | 2014-02-19 | 2021-06-22 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
| US9622483B2 (en) | 2014-02-19 | 2017-04-18 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
| US11039620B2 (en) | 2014-02-19 | 2021-06-22 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
| US9554992B2 (en) * | 2014-06-09 | 2017-01-31 | Chiesi Farmaceutici S.P.A. | Inhalation particles comprising a combination of an anticholinergic, a corticosteroid and a beta-adrenergic |
| GB201416909D0 (en) * | 2014-09-25 | 2014-11-12 | Prosonix Ltd | Method of forming concentrated solution |
| WO2016170518A1 (en) | 2015-04-24 | 2016-10-27 | Glenmark Specialty S.A. | Pharmaceutical compositions comprising arformoterol and glycopyrronium |
| MD3628331T2 (ro) * | 2015-11-16 | 2021-12-31 | Chiesi Farm Spa | Procedeu de preparare unei formulări sub formă de pulbere uscată care cuprinde un anticolinergic, un corticosteroid și un beta-adrenergic |
| GB2545025A (en) * | 2015-12-04 | 2017-06-07 | Mexichem Fluor Sa De Cv | Pharmaceutical composition |
| MA43782A (fr) | 2016-03-31 | 2021-04-28 | Chiesi Farm Spa | Dispositif d'inhalation d'aérosol |
| US10098837B2 (en) * | 2016-07-28 | 2018-10-16 | Chiesi Farmaceutici S.P.A. | Combination therapy for COPD |
| ES2956521T3 (es) * | 2016-09-19 | 2023-12-22 | Mexichem Fluor Sa De Cv | Composición farmacéutica que comprende bromuro de tiotropio |
| CN109715148A (zh) | 2016-09-19 | 2019-05-03 | 墨西哥氟石股份公司 | 药物组合物 |
| CA3037092C (en) * | 2016-09-19 | 2022-06-21 | Mexichem Fluor S.A. De C.V. | Stable pharmaceutical compositions comprising glycopyrrolate and 1,1-difluoroethane (hfa-152a) suitable for use in metered dose inhalers (mdis) |
| CA3060020A1 (en) | 2017-05-11 | 2018-11-15 | Chiesi Farmaceutici S.P.A. | A process for preparing a dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic |
| KR20240105510A (ko) | 2017-05-11 | 2024-07-05 | 키에시 파르마슈티시 엣스. 피. 에이. | 항콜린제, 코르티코스테로이드 및 베타-아드레날린성 약물을 포함하는 건조 분말 제제의 제조 방법 |
| WO2021110239A1 (en) * | 2019-12-02 | 2021-06-10 | Chiesi Farmaceutici S.P.A. | Stainles steel can for pressurised metered dose inhalers |
| CA3186956A1 (en) | 2020-07-31 | 2022-02-03 | Chemo Research , S.L. | Combination therapy for inhalation administration |
| CN116419749A (zh) | 2020-10-09 | 2023-07-11 | 奇斯药制品公司 | 用于加压定量吸入器的药物制剂 |
| WO2023227782A1 (en) | 2022-05-27 | 2023-11-30 | Chiesi Farmaceutici S.P.A. | A pharmaceutical formulation for pressurised metered dose inhaler |
| WO2023227781A1 (en) | 2022-05-27 | 2023-11-30 | Chiesi Farmaceutici S.P.A. | A pharmaceutical formulation for pressurised metered dose inhaler |
| WO2023227783A1 (en) | 2022-05-27 | 2023-11-30 | Chiesi Farmaceutici S.P.A. | A pharmaceutical formulation for pressurised metered dose inhaler |
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| GB0008660D0 (en) | 2000-04-07 | 2000-05-31 | Arakis Ltd | The treatment of respiratory diseases |
| JP5392880B2 (ja) * | 2000-05-22 | 2014-01-22 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | 加圧式定量吸入器のための安定な製薬学的溶液製剤 |
| US20060257324A1 (en) * | 2000-05-22 | 2006-11-16 | Chiesi Farmaceutici S.P.A. | Pharmaceutical solution formulations for pressurised metered dose inhalers |
| SK286394B6 (sk) | 2001-03-30 | 2008-09-05 | Jagotec Ag | Lekárske aerosólové prípravky |
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| EP1321159A1 (en) | 2001-12-21 | 2003-06-25 | CHIESI FARMACEUTICI S.p.A. | Pressurized metered dose inhaler (pMDI) actuators with laser drilled orifices |
| GEP20063986B (en) | 2002-03-01 | 2006-12-11 | Chiesi Farma Spa | Formoterol superfine formulation |
| PL375868A1 (en) | 2002-12-16 | 2005-12-12 | Boehringer Ingelheim Pharma Gmbh & Co.Kg | Tiotropium containing hfc solution formulations |
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| GB0505545D0 (en) | 2005-03-17 | 2005-04-27 | Glaxo Group Ltd | Inhalation devices |
| EP1879620A2 (en) | 2005-03-30 | 2008-01-23 | Schering Corporation | Medicaments and methods combining an anticholinergic, a corticosteroid, and a long acting beta agonist |
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| EP1894568A1 (en) | 2006-08-31 | 2008-03-05 | Novartis AG | Pharmaceutical compositions for the treatment of inflammatory or obstructive airway diseases |
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| US20110132355A1 (en) * | 2009-06-09 | 2011-06-09 | William Gerhart | Treatment of chronic obstructive pulmonary disease with nebulized beta 2-agonist or combined nebulized beta 2-agonist and anticholinergic administration |
| JP5914354B2 (ja) * | 2009-12-23 | 2016-05-11 | シエシー ファルマセウティチィ ソシエタ ペル アチオニ | Ｃｏｐｄ用併用療法 |
| ES2464520T3 (es) * | 2009-12-23 | 2014-06-03 | Chiesi Farmaceutici S.P.A. | Formulación en aerosol para EPOC |
| RU2561052C2 (ru) | 2009-12-23 | 2015-08-20 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Комбинированное лечение хронического обструктивного заболевания легких |
| ES2467928T3 (es) * | 2009-12-23 | 2014-06-13 | Chiesi Farmaceutici S.P.A. | Formulación en aerosol para EPOC |
| PL3409270T3 (pl) * | 2013-07-11 | 2021-08-09 | Chiesi Farmaceutici S.P.A. | Preparat proszkowy zawierający środek antycholinergiczny, kortykosteroid i środek beta- adrenergiczny do podawania wziewnego |
| LT3089735T (lt) * | 2013-12-30 | 2018-09-10 | Chiesi Farmaceutici S.P.A. | Glikopironio bromido ir formoterolio derinio stabili suslėgta aerozolinė tirpalo kompozicija |
| MY176191A (en) * | 2013-12-30 | 2020-07-24 | Chiesi Farm Spa | Stable pressurised aerosol solution composition of glycopyrronium bromide and formoterol combination |
| US9554992B2 (en) * | 2014-06-09 | 2017-01-31 | Chiesi Farmaceutici S.P.A. | Inhalation particles comprising a combination of an anticholinergic, a corticosteroid and a beta-adrenergic |
| US10098837B2 (en) * | 2016-07-28 | 2018-10-16 | Chiesi Farmaceutici S.P.A. | Combination therapy for COPD |
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