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AR074833A1 - Agentes lipopeptidicos antibacterianos para el tratamiento de infecciones con grampositivos - Google Patents

Agentes lipopeptidicos antibacterianos para el tratamiento de infecciones con grampositivos

Info

Publication number
AR074833A1
AR074833A1 ARP090105021A ARP090105021A AR074833A1 AR 074833 A1 AR074833 A1 AR 074833A1 AR P090105021 A ARP090105021 A AR P090105021A AR P090105021 A ARP090105021 A AR P090105021A AR 074833 A1 AR074833 A1 AR 074833A1
Authority
AR
Argentina
Prior art keywords
compounds
antibacterial
lipopeptidic
grampositives
infections
Prior art date
Application number
ARP090105021A
Other languages
English (en)
Inventor
Andre Lee Pearson
Chester A Metcalf
Jing Li
Original Assignee
Cubist Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cubist Pharm Inc filed Critical Cubist Pharm Inc
Publication of AR074833A1 publication Critical patent/AR074833A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compuestos lipopéptidos, composiciones farmacéuticas de estos compuestos y los métodos de uso de estos compuestos como compuestos antibacterianos. Estos compuestos son particularmente útiles contra una variedad de bacterias, que incluyen cepas resistentes. Los compuestos son útiles como agentes antibacterianos contra Clostridium difficile. Reivindicación 1: Un compuesto caracterizado porque es de la fórmula (1) y sus sales farmacéuticamente aceptables, en donde R es -C(=O)A; A se selecciona de alquilo, alquenilo, cicloalquilo, arilo, heteroarilo, y NHRA; y RA se selecciona de alquilo y cicloalquilo.
ARP090105021A 2008-12-22 2009-12-21 Agentes lipopeptidicos antibacterianos para el tratamiento de infecciones con grampositivos AR074833A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13987508P 2008-12-22 2008-12-22

Publications (1)

Publication Number Publication Date
AR074833A1 true AR074833A1 (es) 2011-02-16

Family

ID=41718893

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090105021A AR074833A1 (es) 2008-12-22 2009-12-21 Agentes lipopeptidicos antibacterianos para el tratamiento de infecciones con grampositivos

Country Status (27)

Country Link
US (3) US8507647B2 (es)
EP (2) EP2674437A1 (es)
JP (1) JP5670914B2 (es)
KR (1) KR101717795B1 (es)
CN (1) CN102325787B (es)
AR (1) AR074833A1 (es)
AU (1) AU2009330245C1 (es)
BR (1) BRPI0923567A2 (es)
CA (1) CA2747965C (es)
CY (1) CY1114883T1 (es)
DK (1) DK2379580T3 (es)
ES (1) ES2442167T3 (es)
HK (1) HK1161886A1 (es)
HR (1) HRP20131170T1 (es)
IL (1) IL213638A0 (es)
MX (1) MX2011006803A (es)
NZ (1) NZ594019A (es)
PL (1) PL2379580T3 (es)
PT (1) PT2379580E (es)
RS (1) RS53152B (es)
RU (1) RU2512396C2 (es)
SG (1) SG172299A1 (es)
SI (1) SI2379580T1 (es)
SM (1) SMT201400037B (es)
TW (1) TWI444198B (es)
WO (1) WO2010075215A1 (es)
ZA (1) ZA201104693B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140037877A (ko) 2011-05-26 2014-03-27 큐비스트 파마슈티컬즈 인코포레이티드 Cb-183,315 조성물 및 관련 방법
US10377699B2 (en) * 2013-11-06 2019-08-13 The University Of Hong Kong Daptomycin analogues and a method for the preparation of daptomycin or a daptomycin analogue
WO2015172047A1 (en) * 2014-05-08 2015-11-12 Merck Sharp & Dohme Corp. Cyclic peptide compounds and related methods, salts and compositions
US11667674B2 (en) * 2016-04-08 2023-06-06 Versitech Limited Antibacterial cyclic lipopeptides
US10647746B2 (en) 2016-04-08 2020-05-12 Versitech Limited Antibacterial cyclic lipopeptides
EP3445767B1 (en) * 2016-04-22 2020-02-19 Astrazeneca AB Macrocyclic mcl1 inhibitors for treating cancer
US10098890B2 (en) 2016-10-29 2018-10-16 Cipla Limited Stable carfilzomib formulations
IT201600127655A1 (it) * 2016-12-16 2018-06-16 Gnosis Spa Processo per la purificazione di antibiotici lipopolipeptidici
US10072045B1 (en) 2017-06-26 2018-09-11 Ramapo Pharmaceuticals, Inc. Antibacterial lipopeptides and methods for their preparation and use
US10526343B2 (en) 2018-03-26 2020-01-07 University Of Sharjah Heterocyclic systems and pharmaceutical applications thereof
RU2762182C1 (ru) * 2020-12-08 2021-12-16 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" Гауземицины А и В - гликолипопептидные антибактериальные антибиотики и способ их получения

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DE3376424D1 (en) 1982-02-27 1988-06-01 Beecham Group Plc Antibacterial 1-normon-2-yl-heterocyclic compounds
US4396543A (en) 1982-05-21 1983-08-02 Eli Lilly And Company Derivatives of A-21978C cyclic peptides
IL68700A0 (en) * 1982-05-21 1983-09-30 Lilly Co Eli Improvements relating to a-21978c cyclic peptide derivatives and their production
US4399067A (en) 1982-05-21 1983-08-16 Eli Lilly And Company Derivatives of A-21978C cyclic peptides
US4524135A (en) 1982-05-21 1985-06-18 Eli Lilly And Company A-21978C cyclic peptides
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Also Published As

Publication number Publication date
CY1114883T1 (el) 2016-12-14
NZ594019A (en) 2013-08-30
CN102325787B (zh) 2014-05-28
MX2011006803A (es) 2011-09-06
DK2379580T3 (da) 2014-01-20
CA2747965A1 (en) 2010-07-01
AU2009330245C1 (en) 2013-09-26
KR20110114592A (ko) 2011-10-19
HK1161886A1 (en) 2012-08-10
TW201028161A (en) 2010-08-01
PT2379580E (pt) 2014-01-20
EP2379580A1 (en) 2011-10-26
JP5670914B2 (ja) 2015-02-18
RS53152B (en) 2014-06-30
SG172299A1 (en) 2011-07-28
AU2009330245B2 (en) 2013-05-02
KR101717795B1 (ko) 2017-03-17
BRPI0923567A2 (pt) 2016-09-27
IL213638A0 (en) 2011-07-31
AU2009330245A1 (en) 2011-08-04
ES2442167T3 (es) 2014-02-10
HRP20131170T1 (hr) 2014-01-03
CN102325787A (zh) 2012-01-18
EP2379580B1 (en) 2013-10-23
RU2512396C2 (ru) 2014-04-10
US20150337013A1 (en) 2015-11-26
RU2011130278A (ru) 2013-01-27
US8507647B2 (en) 2013-08-13
SI2379580T1 (sl) 2014-02-28
SMT201400037B (it) 2014-05-07
WO2010075215A1 (en) 2010-07-01
EP2674437A1 (en) 2013-12-18
TWI444198B (zh) 2014-07-11
US20100184649A1 (en) 2010-07-22
PL2379580T3 (pl) 2014-05-30
US20140073558A1 (en) 2014-03-13
ZA201104693B (en) 2013-01-30
CA2747965C (en) 2017-06-27
JP2012513467A (ja) 2012-06-14

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