AR051295A1 - Derivados de pirimidina y su uso - Google Patents
Derivados de pirimidina y su usoInfo
- Publication number
- AR051295A1 AR051295A1 ARP050103930A ARP050103930A AR051295A1 AR 051295 A1 AR051295 A1 AR 051295A1 AR P050103930 A ARP050103930 A AR P050103930A AR P050103930 A ARP050103930 A AR P050103930A AR 051295 A1 AR051295 A1 AR 051295A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- cycloalkyl
- trifluoromethoxy
- trifluoromethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Procedimientos para su preparacion, a su uso para el tratamiento y/o la profilaxis de enfermedades, así como a su uso para la preparacion de medicamentos para el tratamiento y/o profilaxis de enfermedades, preferentemente para el tratamiento y/o la prevencion de enfermedades cardiovasculares, en particular, dislipidemias, arteriosclerosis, insuficiencia cardíaca, trombosis y síndrome metabolico. Reivindicacion 1: Compuesto de formula (1) en la que A representa O o S, uno de los miembros de anillo D y E representa N y el otro CH; Z representa (CH2)m, O o N-R9, en los que m significa el numero 0, 1 o 2 y R9 significa H o alquilo C1-6, n representa el numero 0, 1 o 2; R1 representa arilo C6-10 o heteroarilo de 5 a 10 miembros, que respectivamente pueden estar sustituidos hasta cuatro veces, de manera igual o diferente, por sustituyentes seleccionados entre la serie de halogeno, nitro, ciano, alquilo C1-6, que a su vez puede estar sustituido por hidroxilo, cicloalquilo C3-8, fenilo, hidroxi, alcoxi C1-6, trifluorometilo, trifluorometoxi, amino, mono- y di-alquil C1-6-amino, R10-C(O)-NH-, R11-C(O)-, R12R13N-C(O)-NH- y R14R15N-C(O)-, en los que R10 significa H, alquilo C1-6, cicloalquilo C3-8, fenilo o alcoxi C1-6; R11 significa H, alquilo C1-6, cicloalquilo C3-8, fenilo, hidroxilo o alcoxi C1-6 y R12, R13, R14 y R15 son iguales o diferentes e, independientemente entre sí, significan H, alquilo C1-6, cicloalquilo C3-8 o fenilo, o R1 representa cicloalquilo C3-7 o un heterociclo de 5 o 6 miembros, que respectivamente pueden estar sustituidos hasta dos veces, de manera igual o diferente, por alquilo C1-6, alcoxi C1-6, trifluorometilo o trifluorometoxi, o la agrupacion -Z-R1 representa un grupo de formula (2) en la que R18 significa H, halogeno, alquilo C1-6, alcoxi C1-6, trifluorometilo o trifluorometoxi y * significa el sitio de enlace; R2 representa H, arilo C6-10, alquilo C1-6, alquenilo C2-6 o alquinilo C2-6, pudiendo el alquilo, alquenilo y alquinilo estar respectivamente sustituidos por trifluorometilo, alcoxi C1-6, trifluorometoxi, F, ciano, cicloalquilo C3-6, arilo C6-10 o heteroarilo de 5 o 6 miembros, pudiendo todos los grupos arilo y heteroarilo citados estar a su vez respectivamente sustituidos hasta tres veces, de manera igual o diferente, por sustituyentes seleccionados entre la serie de halogeno, nitro, ciano, alquilo C1-6, hidroxi, alcoxi C1-6, trifluorometilo y trifluorometoxi; R3 y R4 son iguales o diferentes e, independientemente entre sí, representan H, alquilo C1-6, alquenilo C2-6, alcoxi C1-6, trifluorometilo, trifluorometoxi o halogeno; R5 y R6 son iguales o diferentes e, independientemente entre sí, representan H, alquilo C1-6, alcoxi C1-6 o fenoxi, o juntos con el átomo de C al que están unidos, forman un anillo cicloalquilo C3-8; R7 representa un grupo de formula -NHR16 u -OR17, en el que R16 significa H, alquilo C1-6 o alquil C1-6-sulfonilo y R17 significa H o representa un grupo hidrolizable, que puede transformarse en el ácido carboxílico correspondiente, y R8 representa H o alquilo C1-6, así como sus sales, solvatos y los solvatos de las sales.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004046623A DE102004046623A1 (de) | 2004-09-25 | 2004-09-25 | Neue Pyrimidin-Derivate und ihre Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR051295A1 true AR051295A1 (es) | 2007-01-03 |
Family
ID=35063041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050103930A AR051295A1 (es) | 2004-09-25 | 2005-09-20 | Derivados de pirimidina y su uso |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20080261990A1 (es) |
| EP (1) | EP1797045A1 (es) |
| JP (1) | JP2008514559A (es) |
| KR (1) | KR20070055621A (es) |
| CN (1) | CN101065364A (es) |
| AR (1) | AR051295A1 (es) |
| AU (1) | AU2005287589A1 (es) |
| BR (1) | BRPI0517327A (es) |
| CA (1) | CA2582492A1 (es) |
| DE (1) | DE102004046623A1 (es) |
| EC (1) | ECSP077340A (es) |
| GT (1) | GT200500266A (es) |
| IL (1) | IL182136A0 (es) |
| MA (1) | MA28882B1 (es) |
| MX (1) | MX2007003428A (es) |
| NO (1) | NO20072051L (es) |
| PE (1) | PE20060657A1 (es) |
| RU (1) | RU2007115215A (es) |
| SV (1) | SV2007002235A (es) |
| TW (1) | TW200628451A (es) |
| UY (1) | UY29127A1 (es) |
| WO (1) | WO2006032384A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103071154A (zh) | 2007-04-13 | 2013-05-01 | 千年药品公司 | 用起因子xa抑制剂作用的化合物的组合抗凝治疗 |
| KR100813387B1 (ko) * | 2007-06-26 | 2008-03-12 | 신명곤 | 부형제 첨가없이 인삼농축액으로 유동성 및 저장성이우수한 인삼농축액환 제조 방법 |
| EP4137137A1 (en) | 2010-05-26 | 2023-02-22 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| CA2809958A1 (en) | 2010-08-31 | 2012-03-08 | Snu R & Db Foundation | Use of the fetal reprogramming of a ppar ? agonist |
| CA2853285C (en) | 2011-10-28 | 2020-05-05 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| BR112014010228B1 (pt) | 2011-10-28 | 2020-09-29 | Lumena Pharmaceuticals Llc | Uso de inibidores de reciclagem de ácido biliar para o tratamento de hipercolemia e doença hepática colestática |
| CN103130732A (zh) * | 2011-11-22 | 2013-06-05 | 上海博康精细化工有限公司 | 3,5-二甲基-4-氯甲基异噁唑的制备方法 |
| MX2015013193A (es) | 2013-03-15 | 2016-04-15 | Lumena Pharmaceuticals Inc | Inhibidores del reciclaje de acidos biliares para el tratamiento de colangitis esclerosante primaria y enfermedad inflamatoria intestinal. |
| WO2014144485A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of barrett's esophagus and gastroesophageal reflux disease |
| WO2017190050A1 (en) * | 2016-04-28 | 2017-11-02 | Cornell University | Inhibitors of soluble adenylyl cyclase |
| KR20210137467A (ko) | 2019-02-12 | 2021-11-17 | 미룸 파마슈티컬스, 인크. | 담즙 염 유출 펌프 결핍을 갖는 환자에서 asbti에 대한 유전자형 및 용량-의존성 반응 |
| CN115598267B (zh) * | 2022-12-13 | 2023-05-09 | 山东省食品药品检验研究院 | 一种格列齐特中潜在遗传毒性杂质的分析方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU72201A (sh) * | 1999-04-28 | 2005-07-19 | Aventis Pharma Deutschland Gmbh. | Derivati di-aril kiseline kao ppar receptorski ligandi |
| GB0214254D0 (en) * | 2002-06-20 | 2002-07-31 | Glaxo Group Ltd | Chemical compounds |
-
2004
- 2004-09-25 DE DE102004046623A patent/DE102004046623A1/de not_active Withdrawn
-
2005
- 2005-09-10 RU RU2007115215/04A patent/RU2007115215A/ru not_active Application Discontinuation
- 2005-09-10 JP JP2007532798A patent/JP2008514559A/ja active Pending
- 2005-09-10 AU AU2005287589A patent/AU2005287589A1/en not_active Abandoned
- 2005-09-10 KR KR1020077009268A patent/KR20070055621A/ko not_active Application Discontinuation
- 2005-09-10 WO PCT/EP2005/009734 patent/WO2006032384A1/de active Application Filing
- 2005-09-10 US US11/663,813 patent/US20080261990A1/en not_active Abandoned
- 2005-09-10 CA CA002582492A patent/CA2582492A1/en not_active Abandoned
- 2005-09-10 CN CNA2005800404273A patent/CN101065364A/zh active Pending
- 2005-09-10 BR BRPI0517327-2A patent/BRPI0517327A/pt not_active Application Discontinuation
- 2005-09-10 MX MX2007003428A patent/MX2007003428A/es not_active Application Discontinuation
- 2005-09-10 EP EP05782757A patent/EP1797045A1/de not_active Withdrawn
- 2005-09-20 AR ARP050103930A patent/AR051295A1/es unknown
- 2005-09-23 TW TW094132926A patent/TW200628451A/zh unknown
- 2005-09-23 PE PE2005001101A patent/PE20060657A1/es not_active Application Discontinuation
- 2005-09-23 GT GT200500266A patent/GT200500266A/es unknown
- 2005-09-23 UY UY29127A patent/UY29127A1/es not_active Application Discontinuation
- 2005-09-23 SV SV2005002235A patent/SV2007002235A/es not_active Application Discontinuation
-
2007
- 2007-03-22 IL IL182136A patent/IL182136A0/en unknown
- 2007-03-23 EC EC2007007340A patent/ECSP077340A/es unknown
- 2007-03-30 MA MA29787A patent/MA28882B1/fr unknown
- 2007-04-20 NO NO20072051A patent/NO20072051L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL182136A0 (en) | 2007-07-24 |
| SV2007002235A (es) | 2007-03-20 |
| UY29127A1 (es) | 2006-04-28 |
| BRPI0517327A (pt) | 2008-10-07 |
| MX2007003428A (es) | 2008-03-13 |
| NO20072051L (no) | 2007-06-07 |
| TW200628451A (en) | 2006-08-16 |
| KR20070055621A (ko) | 2007-05-30 |
| US20080261990A1 (en) | 2008-10-23 |
| AU2005287589A1 (en) | 2006-03-30 |
| EP1797045A1 (de) | 2007-06-20 |
| RU2007115215A (ru) | 2008-11-10 |
| CN101065364A (zh) | 2007-10-31 |
| JP2008514559A (ja) | 2008-05-08 |
| WO2006032384A1 (de) | 2006-03-30 |
| MA28882B1 (fr) | 2007-09-03 |
| CA2582492A1 (en) | 2006-03-30 |
| PE20060657A1 (es) | 2006-08-12 |
| DE102004046623A1 (de) | 2006-03-30 |
| GT200500266A (es) | 2006-05-11 |
| ECSP077340A (es) | 2007-04-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |