[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

AR055144A1 - Inhibidor de secrecion acida - Google Patents

Inhibidor de secrecion acida

Info

Publication number
AR055144A1
AR055144A1 ARP060103754A ARP060103754A AR055144A1 AR 055144 A1 AR055144 A1 AR 055144A1 AR P060103754 A ARP060103754 A AR P060103754A AR P060103754 A ARP060103754 A AR P060103754A AR 055144 A1 AR055144 A1 AR 055144A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
atom
optionally
acid secretion
heterocycle
Prior art date
Application number
ARP060103754A
Other languages
English (en)
Inventor
M Kajino
A Hasuoka
H Nishida
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37517870&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR055144(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of AR055144A1 publication Critical patent/AR055144A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

La presente provee un compuesto que tiene un efecto inhibidor de secrecion de ácidos superior y que muestra una actividad antiulceras, y similares. La presente provee un compuesto representado por la formula (1) en donde R1 es un grupo heterocíclico monocíclico que contiene N opcionalmente condensado con un anillo benceno o un heterociclo, el grupo heterocíclico monocíclico que contiene N opcionalmente condensado con un anillo benceno o un heterociclo opcionalmente tiene sustituyentes(s); R2 es un grupo arilo C6-14 opcionalmente sustituido, tienilo opcionalmente sustituido o piridilo opcionalmente sustituido, R3 y R4 son cada uno un átomo de H o uno de R3 y R4 es un átomo de H y el otro es un grupo alquilo inferior opcionalmente sustituido, acilo, un átomo de halogeno, ciano o nitro y R5 es un grupo alquilo o una de sus sales.
ARP060103754A 2005-08-30 2006-08-29 Inhibidor de secrecion acida AR055144A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005250356 2005-08-30
JP2006100626 2006-03-31

Publications (1)

Publication Number Publication Date
AR055144A1 true AR055144A1 (es) 2007-08-08

Family

ID=37517870

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060103754A AR055144A1 (es) 2005-08-30 2006-08-29 Inhibidor de secrecion acida

Country Status (33)

Country Link
US (7) US7498337B2 (es)
EP (2) EP2327692B9 (es)
JP (3) JP4035559B1 (es)
KR (2) KR101408561B1 (es)
CN (1) CN101300229B (es)
AR (1) AR055144A1 (es)
AT (1) ATE504567T1 (es)
AU (1) AU2006285641A1 (es)
BR (2) BRPI0615111B8 (es)
CA (1) CA2621182C (es)
CR (1) CR9755A (es)
CY (2) CY1111922T1 (es)
DE (1) DE602006021195D1 (es)
DK (2) DK1919865T3 (es)
ES (2) ES2364498T3 (es)
GE (1) GEP20105044B (es)
HK (2) HK1118547A1 (es)
HR (2) HRP20110473T1 (es)
IL (1) IL189375A (es)
JO (1) JO2791B1 (es)
MA (1) MA29773B1 (es)
ME (1) ME00610B (es)
NO (1) NO341894B1 (es)
NZ (1) NZ566378A (es)
PE (2) PE20070540A1 (es)
PL (2) PL2327692T3 (es)
PT (2) PT2327692E (es)
RS (2) RS52473B9 (es)
SI (2) SI1919865T1 (es)
TW (1) TWI358296B (es)
UA (1) UA94424C2 (es)
WO (1) WO2007026916A1 (es)
ZA (1) ZA200802488B (es)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS52473B9 (sr) * 2005-08-30 2019-07-31 Takeda Pharmaceuticals Co 1-heterociklilsulfonil, 2-aminometil, 5-(hetero-)aril supstituisani derivati 1-h-pirola kao inhibitori sekrecije kiseline
US8933105B2 (en) * 2007-02-28 2015-01-13 Takeda Pharmaceutical Company Limited Pyrrole compounds
US20090156642A1 (en) * 2007-09-28 2009-06-18 Takeda Pharmaceutical Company Limited 5-Membered heterocyclic compound
US8334301B2 (en) 2007-09-28 2012-12-18 Takeda Pharmaceutical Company Limited 5-Membered heterocyclic compound
US8309580B2 (en) 2007-11-01 2012-11-13 Takeda Pharmaceutical Company Limited Heterocyclic compound
WO2010013823A2 (en) * 2008-07-28 2010-02-04 Takeda Pharmaceutical Company Limited Pharmaceutical composition
WO2010021149A1 (ja) * 2008-08-21 2010-02-25 武田薬品工業株式会社 酸分泌抑制スピロ化合物
MY152008A (en) * 2008-08-27 2014-08-15 Takeda Pharmaceutical Pyrrole compounds
KR101814357B1 (ko) 2009-02-25 2018-01-04 다케다 야쿠힌 고교 가부시키가이샤 피롤 화합물의 제조 방법
CA2756086A1 (en) 2009-03-26 2010-09-30 Takeda Pharmaceutical Company Limited Pyrazole compound
RU2586276C2 (ru) * 2009-07-09 2016-06-10 Раквалиа Фарма Инк. Антагонист кислотного насоса для лечения заболеваний, связанных с патологическим нарушением моторики желудочно-кишечного тракта
WO2012095691A1 (en) * 2011-01-15 2012-07-19 Jubilant Life Sciences Ltd. An improved process for producing aminopyridines
CN102863371B (zh) * 2011-07-06 2016-04-13 中国科学院上海有机化学研究所 氟代二氢吡咯或氟代吡咯
RU2015102333A (ru) * 2012-06-27 2016-08-20 Такеда Фармасьютикал Компани Лимитед Жидкие препараты аминов и органических кислот, стабилизированные солями
WO2014019442A1 (zh) * 2012-08-03 2014-02-06 上海恒瑞医药有限公司 苯并呋喃类衍生物、其制备方法及其在医药上的应用
CA2891523A1 (en) * 2012-11-19 2014-05-22 Jiangsu Hansoh Pharmaceutical Co., Ltd. Pyrrole sulfonamide derivative, preparation method for same, and medical application thereof
CA2902624C (en) 2013-02-28 2021-05-18 Takeda Pharmaceutical Company Limited Method for producing sulfonyl chloride compound
KR102084185B1 (ko) 2013-08-29 2020-03-04 주식회사 대웅제약 테트라히드로사이클로펜타피롤 유도체 및 이의 제조방법
KR102129842B1 (ko) 2013-10-02 2020-07-06 주식회사 대웅제약 술포닐인돌 유도체 및 이의 제조방법
CN103951652B (zh) * 2014-04-18 2015-09-23 潍坊博创国际生物医药研究院 5-(2-氟苯基)-n-甲基-1-(3-吡啶基磺酰基)-1h-吡咯-3-甲胺水溶性有机酸盐和注射剂及它们的制备方法
CN105367550A (zh) * 2014-08-11 2016-03-02 江苏柯菲平医药股份有限公司 四氢环戊二烯并[c]吡咯类衍生物、其制备方法及其在医药上的应用
CN105646451A (zh) * 2014-11-12 2016-06-08 江苏豪森药业集团有限公司 钾离子竞争性酸阻滞剂的晶型及其制备方法
CN104447491B (zh) * 2014-11-19 2017-06-23 连云港恒运医药有限公司 含吡咯环质子泵抑制剂的半富马酸盐及其中间体和医药用途
CN106957252B (zh) * 2014-11-19 2019-11-19 连云港恒运药业有限公司 一种质子泵抑制剂中间体及其制备方法
WO2016078594A1 (zh) * 2014-11-19 2016-05-26 江苏豪森药业集团有限公司 含吡咯环质子泵抑制剂的半富马酸盐及其晶型、中间体和医药用途
CN104356043B (zh) * 2014-11-27 2016-10-26 重庆威尔德浩瑞医药化工有限公司 一种制备5-(2-氟苯基)-1h-吡咯-3-甲醛的方法
CN105693693A (zh) * 2014-11-27 2016-06-22 江苏柯菲平医药股份有限公司 一种吡咯类胃酸分泌和抑制剂化合物盐的制备
CN105708812A (zh) * 2014-12-02 2016-06-29 江苏柯菲平医药股份有限公司 一种5-（2-氟苯基）-n-甲基-1-（3-吡啶基磺酰基）-1h-吡咯-3-甲氨冻干粉针及其制备方法
CN104860923B (zh) * 2015-01-21 2018-01-12 山东康美乐医药科技有限公司 富马酸沃诺拉赞的制备方法
CN105985278A (zh) * 2015-01-27 2016-10-05 江苏柯菲平医药股份有限公司 吡咯磺酰类衍生物、其制备方法及其在医药上的应用
CN105982867A (zh) * 2015-02-27 2016-10-05 江苏柯菲平医药股份有限公司 一种h009冻干粉针及其制备方法
CN106031710B (zh) * 2015-03-16 2019-03-12 南京优科制药有限公司 一种富马酸氟呐普拉赞的注射剂及其制备方法
CN104814964B (zh) * 2015-04-16 2018-07-31 广东赛烽医药科技有限公司 一种抗胃幽门螺旋杆菌的药物组合物、制备方法及其应用
KR101613245B1 (ko) * 2015-04-27 2016-04-18 주식회사 대웅제약 신규의 4-메톡시 피롤 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
CN105315258A (zh) * 2015-05-16 2016-02-10 南京海纳医药科技有限公司 富马酸沃诺拉赞多晶型及其制备方法
CN104860926B (zh) * 2015-06-10 2017-06-30 浙江诚意药业股份有限公司 一种富马酸沃诺拉赞的制备方法
CN104945313A (zh) * 2015-06-19 2015-09-30 洪帅金 一种2-甲基-3-溴吡啶的制备方法
CN104926790B (zh) * 2015-06-29 2017-07-07 江苏奥赛康药业股份有限公司 一种高纯度Vonoprazan Fumarate化合物及其中间体、杂质以及它们的制备方法
EP4257577A3 (en) 2015-06-30 2023-12-20 Takeda Pharmaceutical Company Limited Method for producing pyrrole compound
CN104974082A (zh) * 2015-07-26 2015-10-14 陈吉美 一种2-甲基-4-溴吡啶的制备方法
CN106432191A (zh) * 2015-08-10 2017-02-22 陕西合成药业股份有限公司 一种新的吡咯类衍生物、其制备方法及其在医药上的应用
CN105106203B (zh) * 2015-08-17 2019-04-05 江苏豪森药业集团有限公司 富马酸沃诺拉赞的药物组合物及其制备方法
CN105085484B (zh) * 2015-08-21 2017-11-24 南京济群医药科技股份有限公司 一种富马酸沃诺拉赞的制备方法
CN105030725B (zh) * 2015-08-26 2019-12-10 迪沙药业集团有限公司 一种富马酸沃诺拉赞肠溶组合物及其制备方法
CN105030720B (zh) * 2015-08-26 2019-12-10 迪沙药业集团有限公司 一种富马酸沃诺拉赞肠溶片及其制备方法
CN106478597A (zh) * 2015-09-02 2017-03-08 中美华世通生物医药科技（武汉）有限公司 富马酸沃诺拉赞单晶及其制备方法和用途
CN106511344A (zh) * 2015-09-14 2017-03-22 王虹 一种胃酸分泌抑制剂的新用途
CN106632246A (zh) * 2015-10-30 2017-05-10 江苏柯菲平医药股份有限公司 一种吡咯类胃酸分泌抑制剂化合物盐的晶型及其制备
CN105198802A (zh) * 2015-11-03 2015-12-30 江苏梦得电镀化学品有限公司 一种2-甲基-3-溴吡啶的制备方法
CN105294653B (zh) * 2015-11-16 2017-08-15 山东罗欣药业集团股份有限公司 富马酸沃诺拉赞的制备工艺
CN105440019A (zh) * 2015-12-17 2016-03-30 昆明贵研药业有限公司 一种治疗胃酸疾病药物的制备方法
CN105503828A (zh) * 2015-12-24 2016-04-20 北京康立生医药技术开发有限公司 一种吡咯衍生物的富马酸盐的制备方法
CN105461690B (zh) * 2015-12-24 2018-07-24 南京济群医药科技股份有限公司 高纯度((5-(2-氟苯基)-1-(吡啶-3-基磺酰基)-1h-吡咯-3-基)甲基)(甲基)氨基甲酸叔丁酯的制备方法
KR102081920B1 (ko) * 2016-03-25 2020-02-26 주식회사 대웅제약 1-(5-(2,4-다이플루오로페닐)-1-((3-플루오로페닐)술포닐)-4-메톡시-1h-피롤-3-일)-n-메틸메탄아민 염의 신규한 결정형
KR20170113040A (ko) * 2016-03-25 2017-10-12 주식회사 대웅제약 1-(5-(2,4-다이플루오로페닐)-1-((3-플루오로페닐)술포닐)-4-메톡시-1h-피롤-3-일)-n-메틸메탄아민의 신규한 산부가염
CN106074406A (zh) * 2016-06-12 2016-11-09 佛山市腾瑞医药科技有限公司 一种富马酸沃诺拉赞分散片及其制备方法
CN106146466A (zh) * 2016-06-30 2016-11-23 珠海赛隆药业股份有限公司（长沙）医药研发中心 富马酸沃诺拉赞中间体、其制备方法和制备富马酸沃诺拉赞的方法
KR101777971B1 (ko) 2016-07-05 2017-09-12 제일약품주식회사 이미다조[1,2-a]피리딘 유도체, 이의 제조방법 및 이의 용도
CN106187852B (zh) * 2016-07-07 2019-01-15 江西同和药业股份有限公司 一种富马酸沃诺拉赞中间体的制备方法
CN106431871A (zh) * 2016-08-17 2017-02-22 济南贝莱尔化学科技有限公司 一种2′‑溴代邻氟苯乙酮的制备方法
CN106243008B (zh) * 2016-08-22 2018-09-04 山东金城生物药业有限公司 富马酸沃诺拉赞中间体5-(2-氟苯基)-1h-吡咯-3-甲醛的制备方法
CN107778207A (zh) * 2016-08-25 2018-03-09 广东东阳光药业有限公司 富马酸沃诺拉赞中间体及其制备方法和用途
CN106397404A (zh) * 2016-08-31 2017-02-15 山东新华制药股份有限公司 5‑（2‑氟苯基）‑1‑（吡啶‑3‑基磺酰基）‑1h‑吡咯‑3‑甲醛的制备方法
CN106380464A (zh) * 2016-08-31 2017-02-08 山东新华制药股份有限公司 氟呐普拉赞关键中间体的制备方法
CN107814758B (zh) * 2016-09-12 2022-10-11 江苏柯菲平医药股份有限公司 一种吡咯磺酸类化合物盐型制备
CN107879964B (zh) * 2016-09-29 2023-02-10 江苏柯菲平医药股份有限公司 1-(5-(2-氟苯基)-1-(3-(3-甲氧丙氧基)苯磺酰氯)-1h-吡咯-3-基)-n-甲基胺的制备方法
CN108069891B (zh) * 2016-11-16 2022-09-20 江苏柯菲平医药股份有限公司 一类甲基甲胺盐酸盐的a晶型、制备及其应用
CN106892900A (zh) * 2017-04-10 2017-06-27 山东裕欣药业有限公司 一种富马酸沃诺拉赞及其制备方法
CN107011327A (zh) * 2017-04-19 2017-08-04 刘德鹏 一种治疗消化性溃疡的药物化合物及其制备方法
CN106905216A (zh) * 2017-04-19 2017-06-30 刘德鹏 一种质子泵抑制剂药物化合物及其制备方法
CN108794449B (zh) * 2017-05-05 2023-08-04 广东东阳光药业有限公司 一种氘代富马酸沃诺拉赞代谢物的合成方法
KR102233455B1 (ko) 2017-06-21 2021-03-29 주식회사 대웅제약 4-메톡시피롤 유도체의 중간체 제조 방법
TWI838340B (zh) 2017-07-10 2024-04-11 日商武田藥品工業股份有限公司 含有沃諾拉贊的製劑
KR20190057569A (ko) 2017-11-20 2019-05-29 제일약품주식회사 7-아미노-1h-인돌-5-카르복사미드 유도체 및 이의 용도
KR102443292B1 (ko) * 2017-12-27 2022-09-14 닛뽕 케미파 가부시키가이샤 1-[5-(2-플루오로페닐)-1-(피리딘-3-일술포닐)-1h-피롤-3-일]-n-메틸메탄아민모노푸마르산염의 제조법
CN108558831B (zh) * 2018-06-08 2021-07-27 上海璃道医药科技有限公司 取代吡咯-4-烷基胺类化合物及其用途
CN109053684A (zh) * 2018-08-09 2018-12-21 珠海润都制药股份有限公司 一种富马酸沃诺拉赞及其中间体的制备方法
KR102126576B1 (ko) 2018-09-19 2020-06-24 주식회사 대웅제약 4-메톡시 피롤 유도체의 제조 방법
CN110272409A (zh) * 2019-03-11 2019-09-24 南京百迪尔生物医药有限公司 一步法合成沃诺拉赞的新方法
KR102222443B1 (ko) 2019-04-11 2021-03-03 일동제약(주) 1-[5-(2-플루오로페닐)-1-(피리딘-3-일술포닐)-1h-피롤-3-일]-n-메틸메탄아민의 신규염, 이의 제조방법 및 이를 포함하는 약제학적 조성물
CN112300123B (zh) * 2019-08-02 2023-07-18 上海天慈国际药业有限公司 一种沃诺拉赞中间体的制备方法
CN110627628A (zh) * 2019-09-24 2019-12-31 上海应用技术大学 一种β-碘代二氟丙酮类衍生物及其制备方法
CN112830920A (zh) * 2019-11-25 2021-05-25 杭州华东医药集团新药研究院有限公司 一种杂环衍生物、其药物组合物及用途
CN111018835B (zh) * 2019-12-16 2022-09-20 株洲千金药业股份有限公司 一种沃诺拉赞的纯化方法
CN113527536B (zh) * 2020-04-21 2024-03-22 杭州德柯医疗科技有限公司 一种含氟多糖高分子化合物及其制备方法
CN114349737B (zh) * 2020-04-26 2023-06-09 南京烁慧医药科技有限公司 一种含磺酰胺结构的化合物及其应用、一种药物组合物及其应用
CN111484458B (zh) * 2020-05-25 2022-12-27 南京竹园医药科技有限公司 一种2-羟基-5-磺酸基嘧啶的制备方法
PE20231652A1 (es) * 2020-06-17 2023-10-17 Ildong Pharmaceutical Co Ltd Nuevo inhibidor de la secrecion de acido y uso del mismo
CN111943932B (zh) * 2020-08-06 2023-07-14 四川国康药业有限公司 一种可以治疗消化性溃疡的3-吡啶磺酰-1-n-杂吡咯衍生物及其制备方法和用途
CN114149411A (zh) * 2020-09-08 2022-03-08 鲁南制药集团股份有限公司 一种沃诺拉赞中间体及其制备方法与应用
CN112812099B (zh) * 2021-01-19 2022-04-26 珠海赛隆药业股份有限公司 一种用于治疗消化性溃疡的化合物及其制法和用途
CN114989138B (zh) * 2021-03-02 2023-06-13 天地恒一制药股份有限公司 沃诺拉赞盐及其晶型、制备方法和用途
WO2023280290A1 (zh) * 2021-07-09 2023-01-12 天地恒一制药股份有限公司 一种吡咯磺酰类衍生物、及其制备方法与应用
CN113620930B (zh) * 2021-07-12 2022-08-16 南京烁慧医药科技有限公司 一种含磺酰胺结构的化合物及其制备方法和应用、一种药物组合物及应用
CN114105962B (zh) * 2021-10-26 2024-11-05 南京烁慧医药科技有限公司 一种含磺酰胺结构的化合物及其制备方法和应用、一种药物组合物及应用
KR20230102353A (ko) * 2021-12-30 2023-07-07 주식회사 대웅제약 삼중음성유방암의 예방 또는 치료용 약학적 조성물
KR20230114147A (ko) 2022-01-24 2023-08-01 순천향대학교 산학협력단 칼륨 경쟁적 위산분비 억제제의 신규한 공결정, 이의 제조방법 및 이를 포함하는 약제학적 조성물
CN115232107A (zh) * 2022-07-29 2022-10-25 南京唯创远医药科技有限公司 一种高纯度富马酸伏诺拉生的制备方法
US12060148B2 (en) 2022-08-16 2024-08-13 Honeywell International Inc. Ground resonance detection and warning system and method
CN116023364A (zh) * 2023-01-31 2023-04-28 山东铂源药业股份有限公司 一种富马酸沃诺拉赞的制备方法
CN117462507B (zh) * 2023-12-28 2024-03-15 山东齐都药业有限公司 富马酸伏诺拉生药物组合物及其制备方法

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2031514T3 (es) 1986-08-29 1992-12-16 Pfizer Inc. 2-guanidino-4-ariltiazoles para el tratamiento de ulceras pepticas.
US5128366A (en) 1990-07-05 1992-07-07 Shinogi & Co., Ltd. Pyrrole derivatives
WO1992004025A1 (en) 1990-08-31 1992-03-19 Warner-Lambert Company Amino acid analogs as cck antagonists
CA2119155C (en) 1991-10-18 1999-06-15 Dennis Paul Phillion Fungicides for the control of take-all disease of plants
MX9205392A (es) 1991-10-29 1993-04-01 Du Pont Triazolcarbozamidas herbicidas y procedimiento para su obtencion.
JPH06135961A (ja) 1992-10-23 1994-05-17 Nippon Iyakuhin Kogyo Kk 新規ジフェニルピロリルフラン誘導体
US5286742A (en) * 1992-11-03 1994-02-15 American Cyanamid Company Pyrrole thiocarboxamide insecticidal and acaricidal agents
US5480902A (en) * 1993-08-31 1996-01-02 American Cyanamid Company Thienylpyrrole fungicidal agents
JPH08119936A (ja) 1994-10-18 1996-05-14 Fujisawa Pharmaceut Co Ltd 複素環式誘導体
JPH0930967A (ja) 1995-07-17 1997-02-04 Chugai Pharmaceut Co Ltd 抗潰瘍剤
WO1998008815A1 (en) 1996-08-28 1998-03-05 The Procter & Gamble Company Substituted cyclic amine metalloprotease inhibitors
KR20000062284A (ko) 1996-12-23 2000-10-25 블레어 큐. 퍼거슨 인자 Ｘａ 억제제로서의 질소 함유 헤테로방향족 화합물
JPH11209344A (ja) 1998-01-26 1999-08-03 Kyowa Hakko Kogyo Co Ltd 含窒素複素環化合物
GB9817548D0 (en) * 1998-08-12 1998-10-07 Novartis Ag Organic compounds
DE60020226T2 (de) 1999-03-10 2006-02-02 Shionogi & Co., Ltd. Medizinische zubereitungen mit [2.2.1] und [3.1.1]bicycloskelett die antagonisten für sowohl pgd 2? als auch txa 2? rezeptoren sind
DE19913483A1 (de) 1999-03-25 2000-09-28 Goedecke Ag Verfahren zur Herstellung von Heterocyclischen Carbamaten aus Aza-Heterocyclen und Kohlendioxid
TW575561B (en) 1999-03-25 2004-02-11 Hoffmann La Roche 1-arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives
AU3783100A (en) 1999-06-14 2000-12-21 Dow Agrosciences Llc Substituted triazoles, imidazoles and pyrazoles as herbicides
AU7812900A (en) * 1999-08-26 2001-03-19 Aventis Pharmaceuticals Inc. Substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benozopyrans
EP1284260A4 (en) 2000-05-22 2004-03-31 Takeda Chemical Industries Ltd TYROSINE PHOSPHATASE INHIBITORS
US6589978B2 (en) 2000-06-30 2003-07-08 Hoffman-La Roche Inc. 1-sulfonyl pyrrolidine derivatives
GB0016453D0 (en) 2000-07-04 2000-08-23 Hoffmann La Roche Pyrrole derivatives
CA2460594A1 (en) 2001-10-01 2003-04-10 Taisho Pharmaceutical Co., Ltd. Mch receptor antagonists
BR0214031A (pt) 2001-11-08 2004-10-19 Upjohn Co Compostos de heteroarila azabicìclico substituìdos para o tratamento de doenças
JP2005520792A (ja) 2001-11-22 2005-07-14 チバ　スペシャルティ　ケミカルズ　ホールディング　インコーポレーテッド ピロール合成
EP1466902A4 (en) 2001-12-28 2005-11-09 Takeda Pharmaceutical ANTAGONISTS OF THE ANDROGEN RECEPTOR
AU2003216274A1 (en) 2002-02-11 2003-09-04 Neurocrine Biosciences, Inc. Pyrrole derivatives as ligands of melanocortin receptors
WO2003068740A1 (en) 2002-02-14 2003-08-21 Wyeth Pyrrolylalkylidene-hydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands
TW200306191A (en) 2002-02-22 2003-11-16 Teijin Ltd Pyrrolopyrimidine derivatives
BR0310068A (pt) * 2002-05-17 2005-03-08 Merckle Gmbh Uso de um ou mais de um composto, combinação, e, composição farmacêutica
WO2003106427A2 (en) 2002-06-13 2003-12-24 E.I. Du Pont De Nemours And Company Pyrazolecarboxamide insecticides
DE10228103A1 (de) 2002-06-24 2004-01-15 Bayer Cropscience Ag Fungizide Wirkstoffkombinationen
US7186716B2 (en) 2002-08-12 2007-03-06 Sugen, Inc. 3-Pyrrol-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors
JP2004315511A (ja) 2003-03-31 2004-11-11 Taisho Pharmaceut Co Ltd Ｍｃｈ受容体アンタゴニスト
ES2351393T3 (es) * 2003-05-26 2011-02-03 Takeda Pharmaceutical Company Limited Sulfopirroles.
JP2005044740A (ja) 2003-07-25 2005-02-17 Taniguchi Heaters Kk 空焚きセンサー内蔵の液中用ヒーター
JP4239860B2 (ja) 2004-03-08 2009-03-18 ヤマハ株式会社 擦弦楽器用駒および擦弦楽器
EP1769092A4 (en) 2004-06-29 2008-08-06 Europ Nickel Plc IMPROVED LIXIVIATION OF BASE METALS
JP2006100626A (ja) 2004-09-30 2006-04-13 Fuji Photo Film Co Ltd 半導体発光装置
ES2402362T3 (es) 2004-09-30 2013-05-03 Takeda Pharmaceutical Company Limited Inhibidores de la bomba de protones
EP1655284A1 (en) 2004-10-26 2006-05-10 Aponetics AG 2-Phenylsulfopyrroles
RS52473B9 (sr) * 2005-08-30 2019-07-31 Takeda Pharmaceuticals Co 1-heterociklilsulfonil, 2-aminometil, 5-(hetero-)aril supstituisani derivati 1-h-pirola kao inhibitori sekrecije kiseline
KR101366856B1 (ko) * 2007-03-29 2014-02-21 삼성전자주식회사 다양한 포트를 통해 입력되는 영상을 디스플레이하는디스플레이 장치

Also Published As

Publication number Publication date
US20110301174A1 (en) 2011-12-08
KR101115857B1 (ko) 2012-04-12
NZ566378A (en) 2011-03-31
PL2327692T3 (pl) 2012-12-31
CY1111922T1 (el) 2015-11-04
US8436187B2 (en) 2013-05-07
EP1919865B1 (en) 2011-04-06
US8338461B2 (en) 2012-12-25
JP5687293B2 (ja) 2015-03-18
RS52473B (en) 2013-02-28
MEP10009A (en) 2011-12-20
NO341894B1 (no) 2018-02-12
BR122017028096B1 (pt) 2021-04-13
CA2621182C (en) 2014-03-18
EP1919865A1 (en) 2008-05-14
JO2791B1 (en) 2014-03-15
ME00610B (me) 2011-12-20
RS51697B (en) 2011-10-31
US8338462B2 (en) 2012-12-25
CN101300229A (zh) 2008-11-05
PE20110009A1 (es) 2011-01-31
JP2008522952A (ja) 2008-07-03
TW200800185A (en) 2008-01-01
DK2327692T3 (da) 2012-10-15
PL1919865T3 (pl) 2011-09-30
HK1118547A1 (en) 2009-02-13
HK1158627A1 (en) 2012-07-20
CY1114415T1 (el) 2016-12-14
US20090143444A1 (en) 2009-06-04
EP2327692B9 (en) 2014-06-04
EP2327692A1 (en) 2011-06-01
SI1919865T1 (sl) 2011-07-29
KR101408561B1 (ko) 2014-06-19
JP4035559B1 (ja) 2008-01-23
RS52473B9 (sr) 2019-07-31
HRP20110473T1 (hr) 2011-07-31
NO20081464L (no) 2008-05-23
DK2327692T5 (da) 2014-06-23
ZA200802488B (en) 2009-06-24
BRPI0615111B8 (pt) 2021-05-25
EP2327692B1 (en) 2012-07-18
BRPI0615111A2 (pt) 2011-05-03
US8299261B2 (en) 2012-10-30
GEP20105044B (en) 2010-07-12
US7498337B2 (en) 2009-03-03
AU2006285641A1 (en) 2007-03-08
US20110144161A1 (en) 2011-06-16
KR20110091826A (ko) 2011-08-12
US7977488B2 (en) 2011-07-12
US8415368B2 (en) 2013-04-09
CN101300229B (zh) 2011-10-05
TWI358296B (en) 2012-02-21
PE20070540A1 (es) 2007-06-26
MA29773B1 (fr) 2008-09-01
US20070060623A1 (en) 2007-03-15
HRP20120792T1 (hr) 2012-10-31
PT2327692E (pt) 2012-10-11
JP2013100316A (ja) 2013-05-23
WO2007026916A1 (en) 2007-03-08
ATE504567T1 (de) 2011-04-15
UA94424C2 (en) 2011-05-10
CA2621182A1 (en) 2007-03-08
ES2391757T3 (es) 2012-11-29
BR122017028096B8 (pt) 2021-05-25
DE602006021195D1 (en) 2011-05-19
US20120088797A1 (en) 2012-04-12
IL189375A0 (en) 2008-06-05
KR20080039998A (ko) 2008-05-07
RU2008112153A (ru) 2009-10-10
PT1919865E (pt) 2011-07-11
JP2008056659A (ja) 2008-03-13
US20110301173A1 (en) 2011-12-08
CR9755A (es) 2013-06-14
US20090275591A1 (en) 2009-11-05
RU2415838C2 (ru) 2011-04-10
BRPI0615111B1 (pt) 2020-02-18
SI2327692T1 (sl) 2012-11-30
JP5204426B2 (ja) 2013-06-05
DK1919865T3 (da) 2011-05-23
ES2364498T3 (es) 2011-09-05
IL189375A (en) 2013-05-30

Similar Documents

Publication Publication Date Title
AR055144A1 (es) Inhibidor de secrecion acida
CO5721002A2 (es) Derivados de acido 3-(4-benciloxifenil) propanoico
DOP2011000061A (es) Compuestos de pirrol
CO6150158A2 (es) Piperidinas sustituidas que aumentan la actividad de p53 y su uso
AR054024A1 (es) Derivados de piridina -3- carboxamida como agonistas inversos de cb1
CO6140033A2 (es) Amino-imidazoles y su uso como medicamento para tratar discapacidad coognotiva enfermedad de alzheimer neurodegeneracion y demencia
AR068538A1 (es) Compuesto heterociclico de 5 miembros con actividad supresora de la secrecion de acido
AR058776A1 (es) Compuesto de piridina condensado
CO5640117A2 (es) Derivados de 2,4-diamonopirimidina
AR058885A1 (es) Compuestos de piperidina 3,5-sustituidos
ES2191484T3 (es) Compuestos heterociclicos como inhibidores de enzimas de rotamasa.
AR062209A1 (es) Pirazolopirimidinas moduladoras de receptores de glutamato metabotropicos mglur5, proceso para su preparacion, medicamentos que las contienen y usos en la prevencion y/o tratamiento de trastornos neurologicos agudos y cronicos.
AR068764A1 (es) N-piperazin amidas y su uso en medicamentos para el tratamiento de enfermedades mediadas por la inhibicion de faah.
PE20081530A1 (es) Nuevos compuestos 617
AR050288A1 (es) Derivados de hidroxamida utiles como inhibidores de histona desacetilasa
PE20141691A1 (es) Compuestos con actividad nematicida
DOP2006000045A (es) Derivados del (1,5-difenil-1h-pirazol-3-il oxadiazol, su preparacion y su aplicacion en terapeutica
CO6260132A2 (es) Derivados de oxadiazol como inhibidores de dgat
CO6331462A2 (es) Compuesto de fenil pirrol o una sal farmaceuticamente aceptable del mismo con actividad activadora de la glucoquinasa
AR053895A1 (es) Aminopirimidinas como moduladores de quinasas
AR070263A1 (es) Derivados de oxazepinopirimidinona arilamido sustituidos, utiles en el tratamiento y/o prevencion de enfermedades neurodegenerativas y otras, medicamentos que los contienen y proceso de preparacion e intermediarios.
MX2010000658A (es) Derivados de pirimidina 934.
AR068115A1 (es) Derivado del acido pirazolcarboxilico metodo de produccion del mismo y fungicida
AR055420A1 (es) Derivados de pirimidina sustituidos
AR103397A1 (es) Oxoborazoles microbicidas

Legal Events

Date Code Title Description
FG Grant, registration