AR048973A1 - (4-metoxi-7-morfolin-4-il-benzotiazol-2-il)amida del acido 4-hidroxi-4-metil-piperidin-1-carboxilico. proceso de preparacion y composiciones farmaceuticas - Google Patents
(4-metoxi-7-morfolin-4-il-benzotiazol-2-il)amida del acido 4-hidroxi-4-metil-piperidin-1-carboxilico. proceso de preparacion y composiciones farmaceuticasInfo
- Publication number
- AR048973A1 AR048973A1 ARP050102104A ARP050102104A AR048973A1 AR 048973 A1 AR048973 A1 AR 048973A1 AR P050102104 A ARP050102104 A AR P050102104A AR P050102104 A ARP050102104 A AR P050102104A AR 048973 A1 AR048973 A1 AR 048973A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydroxy
- methyl
- benzotiazol
- morfolin
- metoxi
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente trata de (4-metoxi-7-morfolin-4-il-benzotiazol-2-il)amida del ácido 4-hidroxi-4-metil-piperidin-1-carboxílico, proceso de síntesis y composiciones farmacéuticas que la contienen. Reivindicacion 1: El compuesto de formula (1) que es (4- metoxi-7-morfolin-4-il-benzotiazol-2-il)amida del ácido 4-hidroxi-4-metil-piperidin-1-carboxílico sales ácidas de adicion farmacéuticamente aceptables del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04102262 | 2004-05-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR048973A1 true AR048973A1 (es) | 2006-06-14 |
Family
ID=34967309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050102104A AR048973A1 (es) | 2004-05-24 | 2005-05-23 | (4-metoxi-7-morfolin-4-il-benzotiazol-2-il)amida del acido 4-hidroxi-4-metil-piperidin-1-carboxilico. proceso de preparacion y composiciones farmaceuticas |
Country Status (39)
| Country | Link |
|---|---|
| US (1) | US7368446B2 (es) |
| EP (1) | EP1753760B1 (es) |
| JP (1) | JP4668265B2 (es) |
| CN (1) | CN1956983B (es) |
| AR (1) | AR048973A1 (es) |
| AT (1) | ATE382619T1 (es) |
| AU (1) | AU2005247567B2 (es) |
| BR (1) | BRPI0511543B1 (es) |
| CA (1) | CA2567703C (es) |
| CR (1) | CR8703A (es) |
| CY (1) | CY1108104T1 (es) |
| DE (1) | DE602005004142T2 (es) |
| DK (1) | DK1753760T3 (es) |
| DO (1) | DOP2005000091A (es) |
| EA (1) | EA011279B1 (es) |
| EC (1) | ECSP067018A (es) |
| ES (1) | ES2297710T3 (es) |
| GT (1) | GT200500124A (es) |
| HK (1) | HK1105199A1 (es) |
| HN (1) | HN2005000238A (es) |
| HR (1) | HRP20080027T3 (es) |
| IL (1) | IL179364A (es) |
| MA (1) | MA28601B1 (es) |
| MX (1) | MXPA06013417A (es) |
| MY (1) | MY140011A (es) |
| NO (1) | NO336939B1 (es) |
| NZ (1) | NZ550763A (es) |
| PA (1) | PA8633901A1 (es) |
| PE (1) | PE20060274A1 (es) |
| PL (1) | PL1753760T3 (es) |
| PT (1) | PT1753760E (es) |
| RS (1) | RS50574B (es) |
| SI (1) | SI1753760T1 (es) |
| SV (1) | SV2006002125A (es) |
| TN (1) | TNSN06371A1 (es) |
| TW (1) | TWI358297B (es) |
| UA (1) | UA87142C2 (es) |
| WO (1) | WO2005116026A1 (es) |
| ZA (1) | ZA200609136B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE521512C2 (sv) * | 2001-06-25 | 2003-11-11 | Niconovum Ab | Anordning för administrering av en substans till främre delen av en individs munhåla |
| ES2285233T3 (es) * | 2002-12-20 | 2007-11-16 | Niconovum Ab | Un material en particulas que contiene nicotina y celulosa microcristalina fisicamente y quimicamente estable. |
| CA2646942C (en) | 2006-03-16 | 2014-07-29 | Niconovum Ab | Improved snuff composition |
| NZ583191A (en) * | 2007-07-23 | 2012-06-29 | Biotie Therapies Inc | 4-hydroxy-4-methyl-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide for the treatment of post-traumatic stress disorder |
| NZ593473A (en) | 2009-01-12 | 2013-02-22 | Pfizer Ltd | Sulfonamide derivatives |
| US8168785B2 (en) * | 2009-06-17 | 2012-05-01 | Biotie Therapies, Inc. | Benzothiazole derivatives |
| WO2011101861A1 (en) | 2010-01-29 | 2011-08-25 | Msn Laboratories Limited | Process for preparation of dpp-iv inhibitors |
| CA2804173C (en) | 2010-07-09 | 2015-01-13 | Pfizer Limited | Sulfonamide nav1.7 inhibitors |
| WO2012060844A1 (en) * | 2010-11-05 | 2012-05-10 | Biotie Therapies, Inc | A2a antagonists as cognition and motor function enhancers |
| US9387212B2 (en) * | 2012-04-20 | 2016-07-12 | Ucb Biopharma Sprl | Methods for treating Parkinson's disease |
| EP3310344A1 (en) * | 2015-06-19 | 2018-04-25 | Biotie Therapies, Inc. | Controlled-release tozadenant formulations |
| WO2018059531A1 (zh) * | 2016-09-30 | 2018-04-05 | 苏州晶云药物科技有限公司 | 一种腺苷a2a受体拮抗剂药物的晶型及其制备方法和用途 |
| BR112020003594A2 (pt) * | 2017-08-21 | 2020-09-01 | Merck Patent Gmbh | derivados de benzimidazol como antagonistas de receptor de adenosina |
| SG11202001340VA (en) * | 2017-08-21 | 2020-03-30 | Merck Patent Gmbh | Quinoxaline derivatives as adenosine receptor antagonists |
| WO2019141096A1 (zh) * | 2018-01-19 | 2019-07-25 | 四川科伦博泰生物医药股份有限公司 | 取代脲类化合物及其制备方法和用途 |
| WO2020132325A1 (en) | 2018-12-20 | 2020-06-25 | Kostrub Cory | Methods for treating cancer using tozadenant |
| DE102019110904B4 (de) | 2019-04-26 | 2022-01-20 | Helmholtz-Zentrum Dresden - Rossendorf E. V. | N-(4-methoxy-7-morpholinobenzo[d]thiazol-2-yl)-acetamid-Derivate und deren Verwendung |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH505543A (de) * | 1968-11-01 | 1971-04-15 | Ciba Geigy Ag | Schädlingsbekämpfungsmittel |
| NL7109150A (es) | 1970-07-06 | 1972-01-10 | ||
| US4028374A (en) * | 1975-11-03 | 1977-06-07 | Morton-Norwich Products, Inc. | Antibacterial thiocyanatobenzothiazoles |
| DE2656468A1 (de) | 1976-12-14 | 1978-06-15 | Boehringer Mannheim Gmbh | N-(benzthiazol-2-yl)-oxamidsaeure- derivate und verfahren zu ihrer herstellung |
| KR930005004B1 (ko) | 1985-04-15 | 1993-06-11 | 쟈안센 파아마슈우티카 엔. 부이. | 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법 |
| FI91859C (fi) | 1987-06-17 | 1994-08-25 | Eisai Co Ltd | Analogiamenetelmä antiallergisena aineena aktiivisen bentsotiatsolijohdannaisen valmistamiseksi |
| IL90337A0 (en) | 1988-05-24 | 1989-12-15 | Pfizer | Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents |
| WO1990015801A1 (en) | 1989-06-22 | 1990-12-27 | Pfizer Inc. | Substituted sulfonamides and related compounds in the treatment of asthma, arthritis and related diseases |
| ES2062248T3 (es) * | 1989-11-10 | 1994-12-16 | Agrolinz Agrarchemikalien | Procedimiento para la obtencion de ureas puras, asimetricamente disubstituidas. |
| DE69327572T2 (de) | 1992-05-21 | 2000-06-21 | Otsuka Pharmaceutical Factory, Inc. | Phosphonsäurediester-derivat |
| FR2753970B1 (fr) | 1996-10-01 | 1998-10-30 | Synthelabo | Derives de n-(benzothiazol-2-yl) piperidine-1-ethanamine, leur preparation et leur application en therapeutique |
| JPH11130761A (ja) | 1997-10-24 | 1999-05-18 | Otsuka Pharmaceut Co Ltd | ベンゾチアゾール誘導体 |
| KR20010031912A (ko) | 1997-11-10 | 2001-04-16 | 스티븐 비. 데이비스 | 벤조티아졸 단백질 티로신 키나제 억제제 |
| WO1999037630A1 (en) | 1998-01-23 | 1999-07-29 | Versicor, Inc. | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
| CA2345944A1 (en) | 1998-09-30 | 2000-04-06 | Neurogen Corporation | 2-piperazino alkylamino benzoazole derivatives: dopamine receptor subtype specific ligands |
| GB9824579D0 (en) * | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
| UA71587C2 (uk) | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Аміди антранілової кислоти та їхнє застосування як лікарських засобів |
| IL133680A0 (en) | 1999-09-10 | 2001-04-30 | Can Fite Technologies Ltd | Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist |
| JP5053498B2 (ja) | 2000-05-12 | 2012-10-17 | コーニング インコーポレイテッド | 保護被覆をもつ光ファイバプリフォームを製造する方法 |
| KR100526487B1 (ko) * | 2000-06-21 | 2005-11-08 | 에프. 호프만-라 로슈 아게 | 벤조티아졸 유도체 |
| US6727247B2 (en) * | 2001-12-10 | 2004-04-27 | Hoffman-La Roche Inc. | Substituted benzothiazole amide derivatives |
| US6713499B2 (en) * | 2001-12-12 | 2004-03-30 | Hoffman-La Roche Inc. | 7-Amino-benzothiazole derivatives |
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2005
- 2005-05-17 ES ES05741185T patent/ES2297710T3/es active Active
- 2005-05-17 PL PL05741185T patent/PL1753760T3/pl unknown
- 2005-05-17 DE DE602005004142T patent/DE602005004142T2/de active Active
- 2005-05-17 DK DK05741185T patent/DK1753760T3/da active
- 2005-05-17 PT PT05741185T patent/PT1753760E/pt unknown
- 2005-05-17 CN CN200580016875XA patent/CN1956983B/zh not_active Expired - Fee Related
- 2005-05-17 AU AU2005247567A patent/AU2005247567B2/en active Active
- 2005-05-17 BR BRPI0511543-4A patent/BRPI0511543B1/pt not_active IP Right Cessation
- 2005-05-17 AT AT05741185T patent/ATE382619T1/de active
- 2005-05-17 SI SI200530160T patent/SI1753760T1/sl unknown
- 2005-05-17 RS RSP-2008/0125A patent/RS50574B/sr unknown
- 2005-05-17 NZ NZ550763A patent/NZ550763A/en not_active IP Right Cessation
- 2005-05-17 MX MXPA06013417A patent/MXPA06013417A/es active IP Right Grant
- 2005-05-17 UA UAA200613530A patent/UA87142C2/ru unknown
- 2005-05-17 WO PCT/EP2005/005329 patent/WO2005116026A1/en active Application Filing
- 2005-05-17 CA CA2567703A patent/CA2567703C/en active Active
- 2005-05-17 JP JP2007513750A patent/JP4668265B2/ja not_active Expired - Fee Related
- 2005-05-17 EA EA200602048A patent/EA011279B1/ru not_active IP Right Cessation
- 2005-05-17 EP EP05741185A patent/EP1753760B1/en active Active
- 2005-05-18 US US11/132,019 patent/US7368446B2/en active Active
- 2005-05-20 TW TW094116495A patent/TWI358297B/zh not_active IP Right Cessation
- 2005-05-20 MY MYPI20052309A patent/MY140011A/en unknown
- 2005-05-20 DO DO2005000091A patent/DOP2005000091A/es unknown
- 2005-05-23 HN HN2005000238A patent/HN2005000238A/es unknown
- 2005-05-23 PE PE2005000569A patent/PE20060274A1/es active IP Right Grant
- 2005-05-23 AR ARP050102104A patent/AR048973A1/es not_active Application Discontinuation
- 2005-05-23 PA PA20058633901A patent/PA8633901A1/es unknown
- 2005-05-23 GT GT200500124A patent/GT200500124A/es unknown
- 2005-05-24 SV SV2005002125A patent/SV2006002125A/es unknown
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2006
- 2006-10-24 CR CR8703A patent/CR8703A/es unknown
- 2006-11-02 ZA ZA200609136A patent/ZA200609136B/xx unknown
- 2006-11-14 TN TNP2006000371A patent/TNSN06371A1/fr unknown
- 2006-11-16 IL IL179364A patent/IL179364A/en active IP Right Grant
- 2006-11-21 EC EC2006007018A patent/ECSP067018A/es unknown
- 2006-11-22 MA MA29481A patent/MA28601B1/fr unknown
- 2006-12-12 NO NO20065732A patent/NO336939B1/no not_active IP Right Cessation
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2007
- 2007-09-27 HK HK07110484.5A patent/HK1105199A1/xx not_active IP Right Cessation
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2008
- 2008-01-18 HR HR20080027T patent/HRP20080027T3/xx unknown
- 2008-02-28 CY CY20081100232T patent/CY1108104T1/el unknown
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