AR039122A1 - Derivados de ftalimido como inhibidores de monoamino oxidasa b - Google Patents
Derivados de ftalimido como inhibidores de monoamino oxidasa bInfo
- Publication number
- AR039122A1 AR039122A1 ARP030101023A ARP030101023A AR039122A1 AR 039122 A1 AR039122 A1 AR 039122A1 AR P030101023 A ARP030101023 A AR P030101023A AR P030101023 A ARP030101023 A AR P030101023A AR 039122 A1 AR039122 A1 AR 039122A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- halogen
- nr5r6
- ftalimide
- oxidasa
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Reivindicación 1: Compuestos de fórmula general (1) caracterizados porque X es -N= o -CH=; R1 es -CO-NR5R6; -CHR7-(CH2)n-CO-NR5R6; -(CH2)n-NR5R6, -(CH2)n-COOR8; -(CH2)n-CN, -CHR7-(CH2)n-CF3; -(CH2)n-NH-COR9; -(CH2)n-NH-COOR8; -(CH2)n-piperidinilo, -(CH2)n-morfolinilo, -(CH2)n-tetrahidrofuranilo; -(CH2)n-tiofenilo o -(CH2)n-isoxazolilo, donde el anillo heterocíclico puede ser sustituido por alquilo(C1-6), -(CH2)n-fenil, donde el anillo fenilo puede ser sustituido por halógeno o halógeno(C1-6)alquilo; -(CH2)p-OR8; -(CH2)p-SR8; -(CH2)p-SO-R9; o -(CH2)n-CS-NR5R6; R2 es H, alquilo C1-6, -(CH2)p-OR10, -(CH2)p-SR10; o bencilo, R3 es H o alquilo C1-6, R4 es halógeno, halógeno(C1-6)alquilo, ciano, alcoxi C1-6 o halógeno(C1-6)alcoxi; R5 y R6 son independientemente uno del otro H o alquilo C1-6; R7 es H, hidroxi o alcoxi C1-6; R8 es H o alquilo C1-6; R9 es alquilo C1-6; R10 es H o alquilo C1-6; m es 1, 2 o 3; n es 0 1 o 2; p es 1 o 2; como así también sus sales farmacéuticamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02007222 | 2002-03-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR039122A1 true AR039122A1 (es) | 2005-02-09 |
Family
ID=28051746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030101023A AR039122A1 (es) | 2002-03-27 | 2003-03-25 | Derivados de ftalimido como inhibidores de monoamino oxidasa b |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6660736B2 (es) |
| EP (1) | EP1490334A1 (es) |
| JP (1) | JP4202270B2 (es) |
| KR (1) | KR100592630B1 (es) |
| CN (1) | CN1277820C (es) |
| AR (1) | AR039122A1 (es) |
| AU (1) | AU2003226680B2 (es) |
| BR (1) | BR0308786A (es) |
| CA (1) | CA2477771A1 (es) |
| MX (1) | MXPA04009335A (es) |
| PL (1) | PL371439A1 (es) |
| RU (1) | RU2317289C2 (es) |
| WO (1) | WO2003080573A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6846832B2 (en) * | 2002-08-07 | 2005-01-25 | Hoffman-La Roche Inc. | 2,3-dihydro-isoindol-1-one derivatives |
| DE602004017206D1 (de) * | 2003-10-23 | 2008-11-27 | Hoffmann La Roche | Benzazepin-derivate als mao-b-hemmer |
| JP2008531987A (ja) * | 2005-02-22 | 2008-08-14 | マギル ユニバーシティー | 酸化ストレス測定デバイスおよび関連の方法 |
| EP2281556A1 (en) | 2005-02-25 | 2011-02-09 | F. Hoffmann-La Roche AG | Tablets with improved drugs substance dispersibility |
| TW200804347A (en) * | 2006-01-10 | 2008-01-16 | Janssen Pharmaceutica Nv | Urotensin II receptor antagonists |
| EP2049120A4 (en) | 2006-07-31 | 2011-09-07 | Janssen Pharmaceutica Nv | UROTENSIN II RECEPTOR ANTAGONISTS |
| CA2696609C (en) | 2007-08-27 | 2017-09-05 | Helicon Therapeutics, Inc. | Therapeutic isoxazole compounds |
| ES2379762T3 (es) * | 2008-08-02 | 2012-05-03 | Janssen Pharmaceutica N.V. | Antagonistas del receptor de la urotensina II |
| US20160362391A1 (en) * | 2013-11-25 | 2016-12-15 | Mylan Laboratories Ltd. | Improved Process for the Preparation of Pomalidomide and its Purification |
| WO2016198691A1 (en) | 2015-06-11 | 2016-12-15 | Basilea Pharmaceutica Ag | Efflux-pump inhibitors and therapeutic uses thereof |
| CN106188039B (zh) * | 2016-06-30 | 2019-01-01 | 广东工业大学 | 一种二酮衍生物及其制备方法与应用 |
| CN111183130B (zh) * | 2017-09-07 | 2023-10-20 | 恒翼生物医药(上海)股份有限公司 | 苯并杂环衍生物及包含其的医药组合物 |
| CN108752300B (zh) * | 2018-05-16 | 2022-03-25 | 中国科学院昆明植物研究所 | 苄烯叉苯肽类化合物及其药物组合物和其应用 |
| CN111072604B (zh) * | 2018-10-18 | 2022-11-04 | 广东东阳光药业有限公司 | α-氨基酰胺衍生物及其用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4524206A (en) | 1983-09-12 | 1985-06-18 | Mead Johnson & Company | 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives |
| JPH04295470A (ja) | 1991-03-22 | 1992-10-20 | Wakamoto Pharmaceut Co Ltd | モノアミンオキシダーゼ−ｂ酵素阻害活性を有する１，２，４−オキサジアゾール誘導体及びその製造法 |
| TW219935B (es) * | 1991-12-25 | 1994-02-01 | Mitsubishi Chemicals Co Ltd | |
| US5679715A (en) | 1995-06-07 | 1997-10-21 | Harris; Richard Y. | Method for treating multiple sclerosis |
| AU709323B2 (en) | 1996-03-15 | 1999-08-26 | Somerset Pharmaceuticals, Inc. | Method for preventing and treating peripheral neuropathy by administering selegiline |
| WO2001034172A2 (en) | 1999-11-05 | 2001-05-17 | Vela Pharmaceuticals Inc. | Methods and compositions for treating reward deficiency syndrome |
-
2003
- 2003-03-13 US US10/387,950 patent/US6660736B2/en not_active Expired - Fee Related
- 2003-03-20 PL PL03371439A patent/PL371439A1/xx not_active Application Discontinuation
- 2003-03-20 CA CA002477771A patent/CA2477771A1/en not_active Abandoned
- 2003-03-20 JP JP2003578328A patent/JP4202270B2/ja not_active Expired - Fee Related
- 2003-03-20 EP EP03744825A patent/EP1490334A1/en not_active Withdrawn
- 2003-03-20 AU AU2003226680A patent/AU2003226680B2/en not_active Ceased
- 2003-03-20 WO PCT/EP2003/002931 patent/WO2003080573A1/en active IP Right Grant
- 2003-03-20 CN CNB038070960A patent/CN1277820C/zh not_active Expired - Fee Related
- 2003-03-20 BR BR0308786-7A patent/BR0308786A/pt not_active IP Right Cessation
- 2003-03-20 MX MXPA04009335A patent/MXPA04009335A/es active IP Right Grant
- 2003-03-20 KR KR1020047015131A patent/KR100592630B1/ko not_active IP Right Cessation
- 2003-03-20 RU RU2004131651/04A patent/RU2317289C2/ru not_active IP Right Cessation
- 2003-03-25 AR ARP030101023A patent/AR039122A1/es unknown
- 2003-09-09 US US10/657,857 patent/US6903095B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP4202270B2 (ja) | 2008-12-24 |
| JP2005526796A (ja) | 2005-09-08 |
| MXPA04009335A (es) | 2005-01-25 |
| US6660736B2 (en) | 2003-12-09 |
| RU2317289C2 (ru) | 2008-02-20 |
| BR0308786A (pt) | 2005-01-11 |
| KR20040108688A (ko) | 2004-12-24 |
| RU2004131651A (ru) | 2005-07-10 |
| EP1490334A1 (en) | 2004-12-29 |
| CN1642911A (zh) | 2005-07-20 |
| KR100592630B1 (ko) | 2006-06-26 |
| CA2477771A1 (en) | 2003-10-02 |
| CN1277820C (zh) | 2006-10-04 |
| AU2003226680B2 (en) | 2009-05-07 |
| US20040229871A1 (en) | 2004-11-18 |
| AU2003226680A1 (en) | 2003-10-08 |
| PL371439A1 (en) | 2005-06-13 |
| WO2003080573A1 (en) | 2003-10-02 |
| US20030195208A1 (en) | 2003-10-16 |
| US6903095B2 (en) | 2005-06-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |