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AR013261A1 - PHARMACEUTICAL FORMULATIONS FOR CAMPTOTECINE ANALOGS IN A GELATIN CAPSULE - Google Patents

PHARMACEUTICAL FORMULATIONS FOR CAMPTOTECINE ANALOGS IN A GELATIN CAPSULE

Info

Publication number
AR013261A1
AR013261A1 ARP980103700A ARP980103700A AR013261A1 AR 013261 A1 AR013261 A1 AR 013261A1 AR P980103700 A ARP980103700 A AR P980103700A AR P980103700 A ARP980103700 A AR P980103700A AR 013261 A1 AR013261 A1 AR 013261A1
Authority
AR
Argentina
Prior art keywords
gelatin capsule
camptotecine
analogs
pharmaceutical formulations
release component
Prior art date
Application number
ARP980103700A
Other languages
Spanish (es)
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of AR013261A1 publication Critical patent/AR013261A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invencion se refiere a una composicion farmacéutica de topotecan estable en forma de una cápsula de gelatina. La invencion proporciona específicamenteuna matriz hidrofoba para la formulacion con toptecan HCl que se dispersa para minimizar cualquier reaccion química entre el fármaco activo, los excipientesy la humedad ambiental, con un componente de liberacion rápida y un componente de liberacion lenta.The invention relates to a stable topotecan pharmaceutical composition in the form of a gelatin capsule. The invention specifically provides a hydrophobic matrix for toptecan HCl formulation that disperses to minimize any chemical reaction between the active drug, excipients, and ambient humidity, with a quick release component and a slow release component.

ARP980103700A 1997-08-01 1998-07-28 PHARMACEUTICAL FORMULATIONS FOR CAMPTOTECINE ANALOGS IN A GELATIN CAPSULE AR013261A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90476197A 1997-08-01 1997-08-01

Publications (1)

Publication Number Publication Date
AR013261A1 true AR013261A1 (en) 2000-12-13

Family

ID=25419727

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980103700A AR013261A1 (en) 1997-08-01 1998-07-28 PHARMACEUTICAL FORMULATIONS FOR CAMPTOTECINE ANALOGS IN A GELATIN CAPSULE

Country Status (5)

Country Link
AR (1) AR013261A1 (en)
AU (1) AU8604598A (en)
CO (1) CO4970695A1 (en)
WO (1) WO1999006031A1 (en)
ZA (1) ZA986877B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6281223B1 (en) * 1999-04-13 2001-08-28 Supergen, Inc. Radioenhanced camptothecin derivative cancer treatments
AU2005222541B2 (en) * 1999-08-10 2008-07-24 Pharmacia & Upjohn S.P.A. Pharmaceutical formulations in hydroxypropylmethylcellulose capsules
GB9918885D0 (en) 1999-08-10 1999-10-13 Pharmacia & Upjohn Spa Pharmaceutical formulations in hydroxypropymethycellulose capsules
GB9925127D0 (en) * 1999-10-22 1999-12-22 Pharmacia & Upjohn Spa Oral formulations for anti-tumor compounds
AR046579A1 (en) 2003-11-12 2005-12-14 Smithkline Beecham Corp TOPOTECAN CRYSTAL COMPOSITE, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, PROCEDURE TO PREPARE IT AND ITS USE TO PREPARE SUCH PHARMACEUTICAL COMPOSITION
GT200500310A (en) 2004-11-19 2006-06-19 ORGANIC COMPOUNDS
SA06270147B1 (en) 2005-06-09 2009-12-22 نوفارتيس ايه جي Process for the Synthesis Of 5-(methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine
ITRM20050418A1 (en) * 2005-08-04 2007-02-05 Sigma Tau Ind Farmaceuti IMMEDIATE RELEASE THERAPEUTIC SYSTEMS FOR THE IMPROVED ORAL ABSORPTION OF 7 - [(E) -T-BUTYLOSSIMINOMETHYL] CAMPTOTECIN.
CA2820425A1 (en) 2010-12-20 2012-06-28 Colgate-Palmolive Company Gelatin encapsulated oral care composition containing hydrophilic active, hydrophobic structuring agent and oil carrier
MY163496A (en) * 2010-12-20 2017-09-15 Colgate Palmolive Co Non-aqueous oral care composition containing dental occlusion actives
MX347065B (en) * 2010-12-20 2017-04-11 Colgate Palmolive Co Gelatin encapsulated oral care composition containing dental occlusion actives, hydrophobic viscosity modifier and oil carrier.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8904182D0 (en) * 1989-02-23 1989-04-05 Glaxo Canada Pharmaceutical compositions
US5225404A (en) * 1989-11-06 1993-07-06 New York University Methods of treating colon tumors with tumor-inhibiting camptothecin compounds
US5468754A (en) * 1994-04-19 1995-11-21 Bionumerik Pharmaceuticals, Inc. 11,7 substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof
US5677286A (en) * 1995-04-27 1997-10-14 The University Of Michigan Glycosylated analogs of camptothecin

Also Published As

Publication number Publication date
WO1999006031A1 (en) 1999-02-11
CO4970695A1 (en) 2000-11-07
AU8604598A (en) 1999-02-22
ZA986877B (en) 1999-06-15

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