AR019197A1 - COMPUESTOS DERIVADOS DE PIPERIDINA ANTIHISTAMINICOS, COMPUESTOS INTERMEDIOS, PROCEDIMIENTO DE PREPARACIoN DE DERIVADOS DE PIPERIDINA Y PROCEDIMIENTOS DE PREPARACIoN DE INTERMEDIARIOS. - Google Patents
COMPUESTOS DERIVADOS DE PIPERIDINA ANTIHISTAMINICOS, COMPUESTOS INTERMEDIOS, PROCEDIMIENTO DE PREPARACIoN DE DERIVADOS DE PIPERIDINA Y PROCEDIMIENTOS DE PREPARACIoN DE INTERMEDIARIOS.Info
- Publication number
- AR019197A1 AR019197A1 ARP990103193A ARP990103193A AR019197A1 AR 019197 A1 AR019197 A1 AR 019197A1 AR P990103193 A ARP990103193 A AR P990103193A AR P990103193 A ARP990103193 A AR P990103193A AR 019197 A1 AR019197 A1 AR 019197A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- piperidine
- alkyl
- antihistaminics
- intermediaries
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 3
- 229940125715 antihistaminic agent Drugs 0.000 title 1
- 239000000739 antihistaminic agent Substances 0.000 title 1
- 239000002131 composite material Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000003053 piperidines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/76—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C235/78—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/90—Carboxylic acid amides having nitrogen atoms of carboxamide groups further acylated
- C07C233/91—Carboxylic acid amides having nitrogen atoms of carboxamide groups further acylated with carbon atoms of the carboxamide groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Derivados de piperidina de formula (I) y a un procedimiento para la preparacion de los mismos, donde: R1 es H o alquilo C1-6 y el resto alquiloC1-6 es lineal o ramificado; R2 es -COOH o -COO alquilo y el resto alquilo tiene C1-6 y es lineal o ramificado; o estereoisomeros o salesde adicion de ácido farmacéuticamente aceptables de los mismos utiles para el tratamiento de trastornos alérgicos. Dichos derivados sepreparan de acuerdo con el esquema 8II9, donde X es independientemente Cl, Br, o I, R1y R2 son alquilo C1-6 lineal o ramificado; R3 es H o alquiloC1-6 lineal o ramificado, esquemas (III).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10954298A | 1998-07-02 | 1998-07-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR019197A1 true AR019197A1 (es) | 2001-12-26 |
Family
ID=22328222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990103193A AR019197A1 (es) | 1998-07-02 | 1999-06-30 | COMPUESTOS DERIVADOS DE PIPERIDINA ANTIHISTAMINICOS, COMPUESTOS INTERMEDIOS, PROCEDIMIENTO DE PREPARACIoN DE DERIVADOS DE PIPERIDINA Y PROCEDIMIENTOS DE PREPARACIoN DE INTERMEDIARIOS. |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1091938B1 (es) |
| JP (1) | JP2002519411A (es) |
| KR (2) | KR100682447B1 (es) |
| CN (3) | CN100522921C (es) |
| AR (1) | AR019197A1 (es) |
| AT (1) | ATE485271T1 (es) |
| AU (1) | AU769284B2 (es) |
| BR (1) | BR9911794A (es) |
| CA (1) | CA2336380C (es) |
| DE (1) | DE69942876D1 (es) |
| DK (1) | DK1091938T3 (es) |
| ES (1) | ES2354968T3 (es) |
| HU (1) | HUP0104159A3 (es) |
| IL (6) | IL140649A0 (es) |
| NO (1) | NO319534B1 (es) |
| NZ (2) | NZ508477A (es) |
| PT (1) | PT1091938E (es) |
| TW (1) | TW533197B (es) |
| WO (1) | WO2000001671A2 (es) |
| ZA (1) | ZA200007034B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040044038A1 (en) | 2002-06-10 | 2004-03-04 | Barnaba Krochmal | Polymorphic form XVI of fexofenadine hydrochloride |
| CN101585763B (zh) * | 2009-06-06 | 2012-01-04 | 浙江大学宁波理工学院 | 一种合成2-[4-(4-氯丁酰基)苯基]-2-甲基丙酸的方法 |
| CN101585764B (zh) * | 2009-06-06 | 2012-02-15 | 浙江大学宁波理工学院 | 合成2—［4—(4—氯丁酰基)苯基］—2—甲基丙酸的方法 |
| CN101585767B (zh) * | 2009-06-06 | 2012-02-15 | 浙江大学宁波理工学院 | 一种合成2—[4—(4—氯丁酰基)苯基]—2—甲基丙酸酯的方法 |
| CN101585768B (zh) * | 2009-06-06 | 2012-01-04 | 浙江大学宁波理工学院 | 合成2-[4-(4-氯丁酰基)苯基]-2-甲基丙酸酯的方法 |
| EP2289867A3 (en) * | 2009-08-19 | 2012-04-25 | Jubilant Organosys Limited | A process for producing 4-(4-halo-1-oxybutyl)-alpha,alpha-dimethylbenzene acetic acid or alkyl esters thereof |
| JP6192554B2 (ja) * | 2014-02-03 | 2017-09-06 | 三菱電機株式会社 | 真空断熱材の製造方法 |
| CN112661693A (zh) * | 2021-01-27 | 2021-04-16 | 西北农林科技大学 | 一种非索非那定的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3839431A (en) * | 1970-07-13 | 1974-10-01 | Squibb & Sons Inc | Cyclopropylmethylphenylacetic acids and derivatives |
| US4254129A (en) * | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
| KR100257805B1 (ko) * | 1992-04-10 | 2000-07-01 | 슈테펜 엘. 네스비트 | 4-디페닐메틸 피페리딘 유도체 및 이의 제조방법 |
| US5654433A (en) * | 1993-01-26 | 1997-08-05 | Merrell Pharmaceuticals Inc. | Process for piperidine derivatives |
| WO1995000482A1 (en) * | 1993-06-24 | 1995-01-05 | Albany Molecular Research, Inc. | Piperidine derivatives and process for their production |
| CA2166059C (en) * | 1993-06-25 | 2005-08-16 | Richard Carl Krauss | Novel intermediates for the preparation of antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives |
| NZ306319A (en) * | 1995-05-08 | 1999-08-30 | Hoechst Marion Roussel Inc | 1-alkylphenyl substituted 4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-butanol derivatives and medicaments |
-
1999
- 1999-06-17 CN CNB2006100036278A patent/CN100522921C/zh not_active Expired - Fee Related
- 1999-06-17 WO PCT/US1999/013693 patent/WO2000001671A2/en not_active Application Discontinuation
- 1999-06-17 JP JP2000558076A patent/JP2002519411A/ja active Pending
- 1999-06-17 AT AT99928753T patent/ATE485271T1/de active
- 1999-06-17 HU HU0104159A patent/HUP0104159A3/hu unknown
- 1999-06-17 BR BR9911794-0A patent/BR9911794A/pt not_active Application Discontinuation
- 1999-06-17 CN CNB998081329A patent/CN1246312C/zh not_active Expired - Fee Related
- 1999-06-17 CA CA002336380A patent/CA2336380C/en not_active Expired - Fee Related
- 1999-06-17 DK DK99928753.5T patent/DK1091938T3/da active
- 1999-06-17 CN CN2008100922352A patent/CN101311165B/zh not_active Expired - Fee Related
- 1999-06-17 ES ES99928753T patent/ES2354968T3/es not_active Expired - Lifetime
- 1999-06-17 PT PT99928753T patent/PT1091938E/pt unknown
- 1999-06-17 KR KR1020067006908A patent/KR100682447B1/ko not_active Expired - Fee Related
- 1999-06-17 NZ NZ508477A patent/NZ508477A/en not_active IP Right Cessation
- 1999-06-17 NZ NZ528839A patent/NZ528839A/en not_active IP Right Cessation
- 1999-06-17 KR KR1020007015062A patent/KR100707904B1/ko not_active Expired - Fee Related
- 1999-06-17 IL IL14064999A patent/IL140649A0/xx active IP Right Grant
- 1999-06-17 DE DE69942876T patent/DE69942876D1/de not_active Expired - Lifetime
- 1999-06-17 AU AU45746/99A patent/AU769284B2/en not_active Ceased
- 1999-06-17 EP EP99928753A patent/EP1091938B1/en not_active Expired - Lifetime
- 1999-06-29 TW TW088111017A patent/TW533197B/zh not_active IP Right Cessation
- 1999-06-30 AR ARP990103193A patent/AR019197A1/es active IP Right Grant
-
2000
- 2000-11-29 ZA ZA200007034A patent/ZA200007034B/en unknown
- 2000-12-29 NO NO20006694A patent/NO319534B1/no not_active IP Right Cessation
- 2000-12-31 IL IL140649A patent/IL140649A/en not_active IP Right Cessation
-
2005
- 2005-09-22 IL IL171062A patent/IL171062A/en not_active IP Right Cessation
- 2005-09-22 IL IL171061A patent/IL171061A/en not_active IP Right Cessation
- 2005-09-22 IL IL171063A patent/IL171063A/en not_active IP Right Cessation
- 2005-10-19 IL IL171479A patent/IL171479A/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |