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AR018879A1 - Compuesto de [[4- (2-azido -3-metil -5- oxotetrahidrofuran -2il) -fenil] -hidrazono] propanodinitrilo de aplicacion en el analisis de cargas de levosimendan, preparaciones de referencia para la determinacion de impurezas genotoxicas utilizando dicho compuesto y metodos analiticos para la determinaci - Google Patents

Compuesto de [[4- (2-azido -3-metil -5- oxotetrahidrofuran -2il) -fenil] -hidrazono] propanodinitrilo de aplicacion en el analisis de cargas de levosimendan, preparaciones de referencia para la determinacion de impurezas genotoxicas utilizando dicho compuesto y metodos analiticos para la determinaci

Info

Publication number
AR018879A1
AR018879A1 ARP990102890A ARP990102890A AR018879A1 AR 018879 A1 AR018879 A1 AR 018879A1 AR P990102890 A ARP990102890 A AR P990102890A AR P990102890 A ARP990102890 A AR P990102890A AR 018879 A1 AR018879 A1 AR 018879A1
Authority
AR
Argentina
Prior art keywords
determination
levosimendan
oxotetrahydrofuran
azido
methyl
Prior art date
Application number
ARP990102890A
Other languages
English (en)
Original Assignee
Orion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corp filed Critical Orion Corp
Publication of AR018879A1 publication Critical patent/AR018879A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N2030/042—Standards
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se trata de un compuesto de [[4-(2-azido-3-metil]-5-oxotetrahidrofuran-2-il)fenil]hidrozono]propanodinitrilo, de aplicacion en el análisis de cargas delevosimendan caracterizado porque tiene la formula (I) y diaestereomeros del mismo, y al uso delmi smo como compuesto de referencia en la determinacion deimpurezas potencialmente genotoxicas en muestras de levosimendan. La invencion asimismo se refiere a un método analítico para la determinacion de impurezaspotencialmente genotoxicas enmuestras d e levosimendan en donde se emplea (I) como compuesto de referencia. El levosimendan es un medicamento que resulta utilen el tratamiento de la insuficiencia cardíaca.
ARP990102890A 1998-06-18 1999-06-16 Compuesto de [[4- (2-azido -3-metil -5- oxotetrahidrofuran -2il) -fenil] -hidrazono] propanodinitrilo de aplicacion en el analisis de cargas de levosimendan, preparaciones de referencia para la determinacion de impurezas genotoxicas utilizando dicho compuesto y metodos analiticos para la determinaci AR018879A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI981428A FI104718B (fi) 1998-06-18 1998-06-18 [[4-(2-atsido-3-metyyli-5-oksotetrahydrofuran-2-yyli)fenyyli]hydratsono]propaanidinitriili käytettäväksi referenssiaineena levosimendaanierien analyysissä

Publications (1)

Publication Number Publication Date
AR018879A1 true AR018879A1 (es) 2001-12-12

Family

ID=8552039

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990102890A AR018879A1 (es) 1998-06-18 1999-06-16 Compuesto de [[4- (2-azido -3-metil -5- oxotetrahidrofuran -2il) -fenil] -hidrazono] propanodinitrilo de aplicacion en el analisis de cargas de levosimendan, preparaciones de referencia para la determinacion de impurezas genotoxicas utilizando dicho compuesto y metodos analiticos para la determinaci

Country Status (28)

Country Link
US (1) US6340764B1 (es)
EP (1) EP1087956B1 (es)
JP (1) JP4550279B2 (es)
KR (1) KR100661772B1 (es)
CN (1) CN1129590C (es)
AR (1) AR018879A1 (es)
AT (1) ATE253566T1 (es)
AU (1) AU755699B2 (es)
BR (1) BR9911230A (es)
CA (1) CA2334864C (es)
CZ (1) CZ298659B6 (es)
DE (1) DE69912604D1 (es)
EA (1) EA002854B1 (es)
ES (1) ES2211113T3 (es)
FI (1) FI104718B (es)
HK (1) HK1032779A1 (es)
HR (1) HRP20000866B1 (es)
HU (1) HU229582B1 (es)
ID (1) ID29239A (es)
IL (1) IL139964A (es)
MX (1) MXPA00012436A (es)
NO (1) NO325393B1 (es)
NZ (1) NZ508557A (es)
PL (1) PL201772B1 (es)
RS (1) RS49929B (es)
SK (1) SK284353B6 (es)
WO (1) WO1999065888A2 (es)
ZA (1) ZA200006993B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2563776A1 (en) 2004-04-21 2005-11-10 Teva Pharmaceutical Industries Ltd. Processes for preparing montelukast sodium
FR2877013A1 (fr) * 2004-10-27 2006-04-28 Assist Publ Hopitaux De Paris Indentification d'une mutation de jak2 impliquee dans la polyglobulie de vaquez
JP2008510840A (ja) * 2005-07-05 2008-04-10 テバ ファーマシューティカル インダストリーズ リミティド モンテルカストの精製
CN104230816B (zh) * 2014-09-19 2017-02-15 成都新恒创药业有限公司 一种左西孟旦潜在基因毒性杂质及其制备、检测方法
CN104478809B (zh) * 2014-11-14 2016-08-17 成都新恒创药业有限公司 一种左西孟旦杂质及其制备和检测方法
CN105817632A (zh) * 2015-01-09 2016-08-03 中国科学院宁波材料技术与工程研究所 片状粉末的制备装置及方法
CN105784895B (zh) * 2015-10-30 2018-05-22 成都欣捷高新技术开发有限公司 一种用高效液相色谱仪检测左西孟旦中杂质的方法
CN111474289A (zh) * 2019-10-31 2020-07-31 武汉嘉诺康医药技术有限公司 一种利用反相色谱分离分析左西孟旦中右西孟旦的方法
JP2023507626A (ja) 2019-12-16 2023-02-24 テナックス・セラピューティクス，インコーポレイテッド 駆出率が保たれた心不全を伴う肺高血圧症（ＰＨ－ＨＦ－ｐＥＦ）を治療するためのレボシメンダン

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB383449A (en) * 1931-12-12 1932-11-17 Percy Charles Barton Improvements relating to masts, poles, or like supports and their manufacture
GB565546A (en) * 1943-04-13 1944-11-15 Leslie Frederick Reeve A pneumatically operated pickup unit for use in electric organs and the like
FI894035A (fi) * 1988-09-07 1990-03-08 Orion Yhtymae Oy Foerfarande foer framstaellning av nya substituerade pyridazinoner.
GB8903130D0 (en) * 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
GB2251615B (en) * 1991-01-03 1995-02-08 Orion Yhtymae Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
GB2266841A (en) * 1992-05-06 1993-11-17 Orion Yhtymae Oy Compounds for use as anti-ischemic medicaments
GB9606474D0 (en) * 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
GB9614098D0 (en) * 1996-07-05 1996-09-04 Orion Yhtymae Oy Transdermal delivery of levosimendan
GB9915179D0 (en) * 1999-06-29 1999-09-01 Orion Corp A method for the treatment or prevention of coronary graft vasospasm

Also Published As

Publication number Publication date
PL347577A1 (en) 2002-04-08
FI104718B (fi) 2000-03-31
ZA200006993B (en) 2002-02-28
PL201772B1 (pl) 2009-05-29
CZ298659B6 (cs) 2007-12-12
HK1032779A1 (en) 2001-08-03
BR9911230A (pt) 2001-03-06
HUP0102020A3 (en) 2002-04-29
EP1087956A2 (en) 2001-04-04
AU4786399A (en) 2000-01-05
SK284353B6 (sk) 2005-02-04
IL139964A (en) 2003-07-06
NO20006444D0 (no) 2000-12-15
JP4550279B2 (ja) 2010-09-22
CN1306527A (zh) 2001-08-01
EA002854B1 (ru) 2002-10-31
ES2211113T3 (es) 2004-07-01
NZ508557A (en) 2002-05-31
DE69912604D1 (de) 2003-12-11
WO1999065888A2 (en) 1999-12-23
CN1129590C (zh) 2003-12-03
FI981428A (fi) 1999-12-19
KR20010072622A (ko) 2001-07-31
HU229582B1 (en) 2014-02-28
HRP20000866A2 (en) 2001-12-31
US6340764B1 (en) 2002-01-22
EA200100055A1 (ru) 2001-06-25
FI981428A0 (fi) 1998-06-18
KR100661772B1 (ko) 2006-12-28
MXPA00012436A (es) 2002-06-04
ATE253566T1 (de) 2003-11-15
HRP20000866B1 (en) 2009-02-28
SK18722000A3 (sk) 2001-09-11
HUP0102020A2 (hu) 2001-12-28
EP1087956B1 (en) 2003-11-05
RS49929B (sr) 2008-09-29
JP2002518383A (ja) 2002-06-25
AU755699B2 (en) 2002-12-19
WO1999065888A3 (en) 2000-01-27
NO20006444L (no) 2000-12-15
YU76700A (sh) 2002-11-15
IL139964A0 (en) 2002-02-10
CA2334864C (en) 2008-01-15
CA2334864A1 (en) 1999-12-23
NO325393B1 (no) 2008-04-21
CZ20004555A3 (en) 2001-05-16
ID29239A (id) 2001-08-16

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