AR017256A1 - Compuestos de indol sustituidos, metodo para la sintesis en fase solida de los mismos, conjuntos de combinacion para ser empleados en dicho metodo, uso delos compuestos para preparar un medicamento y composiciones farmaceuticas que los comprenden - Google Patents
Compuestos de indol sustituidos, metodo para la sintesis en fase solida de los mismos, conjuntos de combinacion para ser empleados en dicho metodo, uso delos compuestos para preparar un medicamento y composiciones farmaceuticas que los comprendenInfo
- Publication number
- AR017256A1 AR017256A1 ARP980104124A ARP980104124A AR017256A1 AR 017256 A1 AR017256 A1 AR 017256A1 AR P980104124 A ARP980104124 A AR P980104124A AR P980104124 A ARP980104124 A AR P980104124A AR 017256 A1 AR017256 A1 AR 017256A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- straight chain
- compounds
- prepare
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un compuesto de indol sustituido que tiene la formula (I) en donde: R1 es alquilo C1-6 de cadena recta, alquilo C3-7 de cadena ramificada, cicloalquiloC3-7, fenilo, fenilalquilo C7-12, o alquilo C1-6 de cadena recta sustituido con un compuesto seleccionado del grupo (II); R2 es alquenilo C2-6 de cadena recta,alquenilo C3-7 de cadena ramificada, cicloalquenilo C3-7, fenilo, o un compuesto seleccionado del grupo (III); R3 es hidrogeno, alquilo C1-6 de cadena rectaopcionalmente sustituido con un COOR5, alquilo C3-7 de cadena ramificada, cicloalquilo C3-7, o fenilalquilo C7-12 opcionalmente sustituido con un grupo COOR5,fenilo o acilo; R4 es hidrogeno, fluor, cloro, bromo, nitro, alquilo C1-6 de cadena recta, alquilo C3-7 de cadena ramificada,cicloalquilo C3-7, o alcoxi C1-6;R5 es hidrogeno, alquilo C1-6 de cadena recta, o fenilalquilo C7-12; y todas sus formas cristalinas, sales farmacéuticamente aceptables de los mismos,enantiomeros de los mismos y mezclas racémicas de los mismos, que tienen actividad farmacologica, métodos en fase solida para preparar dichos compuestos,conjuntos de combinacion para ser empleados en los métodos, uso de los mismos para preparar un medicamento util para el tratamiento de condiciones asociadascon la deficiencia de estrogeno, y composiciones farmacéuticas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91607697A | 1997-08-21 | 1997-08-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR017256A1 true AR017256A1 (es) | 2001-09-05 |
Family
ID=25436672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980104124A AR017256A1 (es) | 1997-08-21 | 1998-08-20 | Compuestos de indol sustituidos, metodo para la sintesis en fase solida de los mismos, conjuntos de combinacion para ser empleados en dicho metodo, uso delos compuestos para preparar un medicamento y composiciones farmaceuticas que los comprenden |
Country Status (4)
| Country | Link |
|---|---|
| AR (1) | AR017256A1 (es) |
| AU (1) | AU9025898A (es) |
| WO (1) | WO1999009007A1 (es) |
| ZA (1) | ZA987554B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001002355A2 (en) * | 1999-07-01 | 2001-01-11 | Axys Pharmaceuticals, Inc. | Indole synthesis |
| EP1251855A1 (en) * | 2000-01-28 | 2002-10-30 | Endorecherche, Inc. | Selective estrogen receptor modulators in combination with estrogens |
| PE20011091A1 (es) * | 2000-02-09 | 2001-12-05 | Procter & Gamble | Procesos de fase solida para elaborar compuestos indolicos |
| WO2002028839A1 (en) * | 2000-10-06 | 2002-04-11 | Neurogen Corporation | Benzimidazole and indole derivatives as crf receptor modulators |
| IL145876A0 (en) | 2000-10-17 | 2002-07-25 | Pfizer Prod Inc | Methods and kits for improving vascular health |
| TW200307542A (en) | 2002-05-30 | 2003-12-16 | Astrazeneca Ab | Novel compounds |
| SE0201635D0 (sv) | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
| SE0202241D0 (sv) | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
| SE0301569D0 (sv) | 2003-05-27 | 2003-05-27 | Astrazeneca Ab | Novel compounds |
| BRPI0413234A (pt) | 2003-08-01 | 2006-10-03 | Genelabs Tech Inc | derivados de imidazola bicìclica contra flaviviridae |
| SE0302232D0 (sv) | 2003-08-18 | 2003-08-18 | Astrazeneca Ab | Novel Compounds |
| US20050089936A1 (en) * | 2003-10-23 | 2005-04-28 | Jianping Cai | Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid amides |
| PT1719773E (pt) | 2004-02-24 | 2009-06-03 | Japan Tobacco Inc | Compostos heterotetracíclicos fundidos e a sua utilização como inibidores da polimerase do hcv |
| US20070049593A1 (en) | 2004-02-24 | 2007-03-01 | Japan Tobacco Inc. | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor |
| US7659263B2 (en) | 2004-11-12 | 2010-02-09 | Japan Tobacco Inc. | Thienopyrrole compound and use thereof as HCV polymerase inhibitor |
| GB0500604D0 (en) | 2005-01-13 | 2005-02-16 | Astrazeneca Ab | Novel process |
| JP2009538289A (ja) | 2006-05-26 | 2009-11-05 | アストラゼネカ・アクチエボラーグ | ビアリールまたはヘテロアリール置換インドール |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2199978A1 (en) * | 1995-07-18 | 1997-02-06 | Kyowa Hakko Kogyo Co., Ltd. | Indole derivatives |
| GB9610811D0 (en) * | 1996-05-23 | 1996-07-31 | Pharmacia Spa | Combinatorial solid phase synthesis of a library of indole derivatives |
-
1998
- 1998-08-20 AR ARP980104124A patent/AR017256A1/es unknown
- 1998-08-20 WO PCT/US1998/017236 patent/WO1999009007A1/en active Application Filing
- 1998-08-20 AU AU90258/98A patent/AU9025898A/en not_active Abandoned
- 1998-08-20 ZA ZA9807554A patent/ZA987554B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999009007A1 (en) | 1999-02-25 |
| ZA987554B (en) | 2000-02-21 |
| AU9025898A (en) | 1999-03-08 |
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