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AR004717A1 - Sal de bis-indolilmaleimida, formulacion farmaceutica que la comprende y su uso para la fabricacion de dicha formulacion - Google Patents

Sal de bis-indolilmaleimida, formulacion farmaceutica que la comprende y su uso para la fabricacion de dicha formulacion

Info

Publication number
AR004717A1
AR004717A1 ARP960105255A ARP960105255A AR004717A1 AR 004717 A1 AR004717 A1 AR 004717A1 AR P960105255 A ARP960105255 A AR P960105255A AR P960105255 A ARP960105255 A AR P960105255A AR 004717 A1 AR004717 A1 AR 004717A1
Authority
AR
Argentina
Prior art keywords
formulation
indolilmaleimida
sal
bis
manufacture
Prior art date
Application number
ARP960105255A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR004717A1 publication Critical patent/AR004717A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Esta invención proporciona nuevos derivados nuevos derivados macrocíclicos bisindolilmaleimida de fórmula (I) y sus solvatos. La invención proporcionaademás la preparación, formulaciones farmacéuticas y procedimientos de uso para inhibir laProteina Quinasa C en mamíferos.
ARP960105255A 1995-11-20 1996-11-20 Sal de bis-indolilmaleimida, formulacion farmaceutica que la comprende y su uso para la fabricacion de dicha formulacion AR004717A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US697095P 1995-11-20 1995-11-20

Publications (1)

Publication Number Publication Date
AR004717A1 true AR004717A1 (es) 1999-03-10

Family

ID=21723527

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP960105255A AR004717A1 (es) 1995-11-20 1996-11-20 Sal de bis-indolilmaleimida, formulacion farmaceutica que la comprende y su uso para la fabricacion de dicha formulacion
ARP960105254A AR004336A1 (es) 1995-11-20 1996-11-20 Procedimiento para preparar una sal de metansulfonato de bisindolilmaleimida

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP960105254A AR004336A1 (es) 1995-11-20 1996-11-20 Procedimiento para preparar una sal de metansulfonato de bisindolilmaleimida

Country Status (34)

Country Link
US (3) US5710145A (es)
EP (1) EP0776895B1 (es)
JP (1) JP3348859B2 (es)
KR (1) KR100304210B1 (es)
CN (1) CN1093759C (es)
AR (2) AR004717A1 (es)
AT (1) ATE172199T1 (es)
AU (1) AU711125B2 (es)
BR (1) BR9611724A (es)
CA (1) CA2237221C (es)
CO (1) CO4750823A1 (es)
CY (1) CY2103B1 (es)
CZ (1) CZ297524B6 (es)
DE (1) DE69600784T2 (es)
DK (1) DK0776895T3 (es)
EA (1) EA000967B1 (es)
EG (1) EG23871A (es)
ES (1) ES2122764T3 (es)
HU (1) HU226821B1 (es)
IL (1) IL124417A (es)
MX (1) MX9803792A (es)
MY (1) MY118068A (es)
NO (1) NO310196B1 (es)
NZ (1) NZ323571A (es)
PE (1) PE22798A1 (es)
PL (1) PL184715B1 (es)
RO (1) RO120074B1 (es)
SI (1) SI0776895T1 (es)
TR (1) TR199800759T2 (es)
TW (1) TW403754B (es)
UA (1) UA61897C2 (es)
WO (1) WO1997018809A1 (es)
YU (1) YU49315B (es)
ZA (1) ZA969646B (es)

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US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US6093740A (en) * 1997-04-30 2000-07-25 Eli Lilly And Company Therapeutic treatment for skin disorders
AR017200A1 (es) 1997-12-23 2001-08-22 Astrazeneca Ab Compuestos inhibidores de la proteina cinasa c, sales farmaceuticamente aceptables de los mismos, formulaciones farmaceuitcas que los comprenden, usode las mismas y proceso para la sintesis de dichos compuestos
JP3646651B2 (ja) * 1998-01-30 2005-05-11 ダイソー株式会社 ブタントリオール誘導体の製造法
US6103712A (en) * 1998-03-05 2000-08-15 Eli Lilly And Company Therapeutic treatment for asthma
US6103713A (en) * 1998-03-05 2000-08-15 Eli Lilly And Company Therapeutic treatment for autoimmune diseases
US6291446B1 (en) * 1998-03-05 2001-09-18 Eli Lilly And Company Therapeutic treatment for cytomegalovirus infection
US6225301B1 (en) * 1998-03-05 2001-05-01 Eli Lilly And Company Therapeutic treatment for renal dysfunction
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CA2245029A1 (en) 1998-03-13 1999-09-13 University Of British Columbia Granulatimide compounds as g2 checkpoint inhibitors
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US6841567B1 (en) * 1999-02-12 2005-01-11 Cephalon, Inc. Cyclic substituted fused pyrrolocarbazoles and isoindolones
US6492406B1 (en) 1999-05-21 2002-12-10 Astrazeneca Ab Pharmaceutically active compounds
US6284783B1 (en) 1999-06-09 2001-09-04 The Uab Research Foundation Use of bisindolylmaleimide compounds to induce Fas-mediated apoptosis
US6399780B1 (en) 1999-08-20 2002-06-04 Cephalon, Inc. Isomeric fused pyrrolocarbazoles and isoindolones
US7087613B2 (en) * 1999-11-11 2006-08-08 Osi Pharmaceuticals, Inc. Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
UA74803C2 (uk) 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
US6852688B2 (en) 2000-03-10 2005-02-08 University Of Florida Compositions for treating diabetic retinopathy and methods of using same
US20030224415A1 (en) * 2001-06-29 2003-12-04 Gala Design, Inc. Selection free growth of host cells containing multiple integrating vectors
CA2413156C (en) * 2000-07-03 2009-08-18 Gala Design, Inc. Expression vectors
AU2001271614B2 (en) * 2000-07-03 2007-05-31 Catalent Pharma Solutions, Llc Host cells containing multiple integrating vectors
US6300106B1 (en) * 2000-11-22 2001-10-09 Ppg Industries Ohio, Inc. Method of preparing 3-[2-{(Methylsulfonyl)oxy}-ethoxy ]-4-(triphenylmethoxy)-1-butanol, methane sulfonate
US7384738B2 (en) * 2002-03-28 2008-06-10 Bremel Robert D Retrovirus-based genomic screening
US20040038304A1 (en) * 2002-03-28 2004-02-26 Gala Design, Inc. Antibody libraries
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US7232842B2 (en) * 2003-01-10 2007-06-19 Board Of Trustees Of The Leland Stanford Junior University Kinase inhibitors and associated pharmaceutical compositions and methods of use
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US8508369B2 (en) 2006-09-01 2013-08-13 Intermec Ip Corp. RFID tag system with block coding, such as space-time block coding
AR069799A1 (es) * 2007-12-21 2010-02-17 Novartis Ag Composicion farmaceutica
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US9265764B2 (en) * 2009-02-27 2016-02-23 Massachusetts Institute Of Technology Uses of chemicals to modulate GSK-3 signaling for treatment of bipolar disorder and other brain disorders
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JO3589B1 (ar) 2014-08-06 2020-07-05 Novartis Ag مثبطات كيناز البروتين c وطرق استخداماتها
CN110300584A (zh) 2016-12-19 2019-10-01 克罗马德姆公司 治疗色素沉着过度病症的方法
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US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors

Also Published As

Publication number Publication date
WO1997018809A1 (en) 1997-05-29
DK0776895T3 (da) 1999-06-23
TW403754B (en) 2000-09-01
EA199800374A1 (ru) 1998-10-29
US6015807A (en) 2000-01-18
PL326754A1 (en) 1998-10-26
YU60996A (sh) 1999-03-04
TR199800759T2 (xx) 2001-01-22
AU1054897A (en) 1997-06-11
SI0776895T1 (en) 1999-04-30
AR004336A1 (es) 1998-11-04
NO982182D0 (no) 1998-05-13
MY118068A (en) 2004-08-30
CZ150298A3 (cs) 1998-12-16
US5710145A (en) 1998-01-20
JP3348859B2 (ja) 2002-11-20
EA000967B1 (ru) 2000-08-28
HU226821B1 (en) 2009-11-30
CN1202825A (zh) 1998-12-23
EP0776895A1 (en) 1997-06-04
KR100304210B1 (ko) 2001-11-05
HUP9903377A3 (en) 2000-04-28
CA2237221C (en) 2003-03-25
CA2237221A1 (en) 1997-05-29
IL124417A (en) 2002-11-10
MX9803792A (es) 1998-09-30
EG23871A (en) 2007-11-27
PE22798A1 (es) 1998-05-11
CY2103B1 (en) 2002-04-05
YU49315B (sh) 2005-06-10
US6117861A (en) 2000-09-12
UA61897C2 (en) 2003-12-15
NO982182L (no) 1998-05-13
BR9611724A (pt) 1999-06-01
NO310196B1 (no) 2001-06-05
CZ297524B6 (cs) 2007-01-03
PL184715B1 (pl) 2002-12-31
KR19990067596A (ko) 1999-08-25
EP0776895B1 (en) 1998-10-14
ZA969646B (en) 1998-05-18
DE69600784D1 (de) 1998-11-19
NZ323571A (en) 1998-12-23
JPH11500149A (ja) 1999-01-06
HUP9903377A2 (hu) 2000-02-28
IL124417A0 (en) 1998-12-06
ES2122764T3 (es) 1998-12-16
CO4750823A1 (es) 1999-03-31
DE69600784T2 (de) 1999-04-08
CN1093759C (zh) 2002-11-06
RO120074B1 (ro) 2005-08-30
AU711125B2 (en) 1999-10-07
ATE172199T1 (de) 1998-10-15

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