AP823A - Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase. - Google Patents
Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase. Download PDFInfo
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- AP823A AP823A APAP/P/1998/001351A AP9801351A AP823A AP 823 A AP823 A AP 823A AP 9801351 A AP9801351 A AP 9801351A AP 823 A AP823 A AP 823A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9606508.1A GB9606508D0 (en) | 1996-03-28 | 1996-03-28 | Chemical componds |
| GBGB9623001.6A GB9623001D0 (en) | 1996-11-05 | 1996-11-05 | Chemical compounds |
| PCT/EP1997/001530 WO1997036903A1 (en) | 1996-03-28 | 1997-03-26 | Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AP9801351A0 AP9801351A0 (en) | 1998-09-30 |
| AP823A true AP823A (en) | 2000-04-25 |
Family
ID=26309008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| APAP/P/1998/001351A AP823A (en) | 1996-03-28 | 1997-03-26 | Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase. |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US5994344A (de) |
| EP (1) | EP0891362B1 (de) |
| JP (1) | JP4118337B2 (de) |
| KR (1) | KR20000005039A (de) |
| CN (1) | CN1067075C (de) |
| AP (1) | AP823A (de) |
| AR (1) | AR006401A1 (de) |
| AT (1) | ATE261969T1 (de) |
| AU (1) | AU726649B2 (de) |
| BR (1) | BR9708449A (de) |
| CA (1) | CA2250209A1 (de) |
| CO (1) | CO4790152A1 (de) |
| CZ (1) | CZ309798A3 (de) |
| DE (1) | DE69728139T2 (de) |
| DK (1) | DK0891362T3 (de) |
| EA (1) | EA001437B1 (de) |
| EE (1) | EE9800335A (de) |
| ES (1) | ES2217404T3 (de) |
| HU (1) | HUP9900567A3 (de) |
| IL (1) | IL125859A0 (de) |
| IS (1) | IS4837A (de) |
| NO (1) | NO984470L (de) |
| NZ (1) | NZ331490A (de) |
| PE (1) | PE55298A1 (de) |
| PL (1) | PL329153A1 (de) |
| PT (1) | PT891362E (de) |
| SK (1) | SK132498A3 (de) |
| TR (1) | TR199801935T2 (de) |
| WO (1) | WO1997036903A1 (de) |
| YU (1) | YU41198A (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9719189D0 (en) * | 1997-09-09 | 1997-11-12 | Glaxo Group Ltd | New therapeutic method |
| PE107899A1 (es) * | 1997-09-09 | 1999-11-17 | Glaxo Group Ltd | Derivados de pirrolopirrolona como inhibidores de elastasa leucocitaria |
| GB9719187D0 (en) * | 1997-09-09 | 1997-11-12 | Glaxo Group Ltd | Compounds |
| GB9719172D0 (en) | 1997-09-09 | 1997-11-12 | Glaxo Group Ltd | Compounds |
| GB9821199D0 (en) * | 1998-09-30 | 1998-11-25 | Glaxo Group Ltd | Chemical compounds |
| GB9905418D0 (en) * | 1999-03-09 | 1999-05-05 | Glaxo Group Ltd | Process |
| WO2004081015A1 (en) * | 2003-03-10 | 2004-09-23 | Hetero Drugs Limited | Amorphous clopidogrel hydrogen sulfate |
| AU2004220225B2 (en) | 2003-03-14 | 2010-06-17 | Ono Pharmaceutical Co., Ltd. | Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient |
| US8530509B2 (en) | 2003-06-20 | 2013-09-10 | Siga Technologies, Inc. | Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
| US8039504B2 (en) * | 2003-06-20 | 2011-10-18 | Siga Technologies, Inc. | Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
| US7692037B2 (en) * | 2004-09-02 | 2010-04-06 | Eastman Chemical Company | Optimized liquid-phase oxidation |
| GB2418427A (en) | 2004-09-02 | 2006-03-29 | Univ Cambridge Tech | Ligands for G-protein coupled receptors |
| EP1790637B1 (de) | 2004-09-13 | 2014-01-29 | Ono Pharmaceutical Co., Ltd. | Derivate von N-4-Piperidylharnstoff und diese als Wirkstoff enthaltende Medikamente |
| GB0512238D0 (en) * | 2005-06-15 | 2005-07-27 | Univ Cambridge Tech | Anti-inflammatory agents |
| JPWO2007105637A1 (ja) | 2006-03-10 | 2009-07-30 | 小野薬品工業株式会社 | 含窒素複素環誘導体およびそれらを有効成分とする薬剤 |
| ES2552733T3 (es) | 2007-11-16 | 2015-12-01 | Rigel Pharmaceuticals, Inc. | Compuestos de carboxamida, sulfonamida y amina para trastornos metabólicos |
| WO2009076631A1 (en) | 2007-12-12 | 2009-06-18 | Rigel Pharmaceuticals, Inc. | Carboxamide, sulfonamide and amine compounds for metabolic disorders |
| KR101662333B1 (ko) | 2008-04-23 | 2016-10-04 | 리겔 파마슈티칼스, 인크. | 대사성 장애의 치료를 위한 카르복스아미드 화합물 |
| GEP20186885B (en) * | 2012-12-18 | 2018-08-10 | Chiesi Farma Spa | Novel compounds |
| US20220354833A1 (en) | 2019-09-17 | 2022-11-10 | Mereo Biopharma 4 Limited | Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease |
| PT4106757T (pt) | 2020-04-16 | 2023-11-17 | Mereo Biopharma 5 Inc | Métodos que envolvem o inibidor da elastase neutrofílica alvelestat para o tratamento de doenças respiratórias mediadas pela deficiência de alfa 1 antitripsina |
| JP2024540952A (ja) | 2021-10-20 | 2024-11-06 | メレオ バイオファーマ ４ リミテッド | 線維化の治療における使用のための好中球エラスターゼ阻害剤 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993024519A1 (en) * | 1992-06-04 | 1993-12-09 | Zeneca Limited | Lactam dipeptides having hle inhibiting activity |
| WO1995021855A1 (en) * | 1994-02-11 | 1995-08-17 | Zeneca Limited | Diastereomeric pure trifluoromethyl ketone peptide derivatives as inhibitors of human leukocyte elastase |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2932650A (en) * | 1957-11-19 | 1960-04-12 | Arthur C Cope | 2-6-diazabicyclo (3. 3. 0) octanes |
| US4997950A (en) * | 1989-04-20 | 1991-03-05 | Richard Finbar Murphy | Novel C-terminal gastrin antagonists |
| US5610296A (en) * | 1994-12-05 | 1997-03-11 | G. D. Searle & Co. | Process for the preparation of amidino phenyl pyrrolidine beta-alanine urea analogs |
-
1997
- 1997-03-26 JP JP53490797A patent/JP4118337B2/ja not_active Expired - Fee Related
- 1997-03-26 CA CA002250209A patent/CA2250209A1/en not_active Abandoned
- 1997-03-26 TR TR1998/01935T patent/TR199801935T2/xx unknown
- 1997-03-26 IL IL12585997A patent/IL125859A0/xx unknown
- 1997-03-26 US US09/155,323 patent/US5994344A/en not_active Expired - Fee Related
- 1997-03-26 DE DE69728139T patent/DE69728139T2/de not_active Expired - Fee Related
- 1997-03-26 BR BR9708449A patent/BR9708449A/pt unknown
- 1997-03-26 AT AT97915439T patent/ATE261969T1/de not_active IP Right Cessation
- 1997-03-26 NZ NZ331490A patent/NZ331490A/en unknown
- 1997-03-26 ES ES97915439T patent/ES2217404T3/es not_active Expired - Lifetime
- 1997-03-26 AR ARP970101212A patent/AR006401A1/es not_active Application Discontinuation
- 1997-03-26 AU AU22917/97A patent/AU726649B2/en not_active Ceased
- 1997-03-26 CN CN97194959A patent/CN1067075C/zh not_active Expired - Lifetime
- 1997-03-26 PE PE1997000244A patent/PE55298A1/es not_active Application Discontinuation
- 1997-03-26 SK SK1324-98A patent/SK132498A3/sk unknown
- 1997-03-26 KR KR1019980707664A patent/KR20000005039A/ko not_active Withdrawn
- 1997-03-26 EP EP97915439A patent/EP0891362B1/de not_active Expired - Lifetime
- 1997-03-26 PL PL97329153A patent/PL329153A1/xx unknown
- 1997-03-26 HU HU9900567A patent/HUP9900567A3/hu unknown
- 1997-03-26 CZ CZ983097A patent/CZ309798A3/cs unknown
- 1997-03-26 AP APAP/P/1998/001351A patent/AP823A/en active
- 1997-03-26 EE EE9800335A patent/EE9800335A/xx unknown
- 1997-03-26 PT PT97915439T patent/PT891362E/pt unknown
- 1997-03-26 WO PCT/EP1997/001530 patent/WO1997036903A1/en active IP Right Grant
- 1997-03-26 DK DK97915439T patent/DK0891362T3/da active
- 1997-03-26 EA EA199800773A patent/EA001437B1/ru not_active IP Right Cessation
- 1997-03-31 CO CO97015902A patent/CO4790152A1/es unknown
-
1998
- 1998-08-28 IS IS4837A patent/IS4837A/is unknown
- 1998-09-23 YU YU41198A patent/YU41198A/sh unknown
- 1998-09-25 NO NO984470A patent/NO984470L/no not_active Application Discontinuation
-
1999
- 1999-10-15 US US09/418,644 patent/US6057457A/en not_active Expired - Fee Related
-
2000
- 2000-03-03 US US09/517,963 patent/US6215002B1/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993024519A1 (en) * | 1992-06-04 | 1993-12-09 | Zeneca Limited | Lactam dipeptides having hle inhibiting activity |
| WO1995021855A1 (en) * | 1994-02-11 | 1995-08-17 | Zeneca Limited | Diastereomeric pure trifluoromethyl ketone peptide derivatives as inhibitors of human leukocyte elastase |
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