AP452A - "Diborane reduction of certain aryl piperidines". - Google Patents

"Diborane reduction of certain aryl piperidines". Download PDF

Info

Publication number: AP452A
Authority: AP; ARIPO
Prior art keywords: formula; compound; process according; diborane; solution
Prior art date: 1993-03-13

Application number

APAP/P/1994/000624A

Other languages

English (en)

Other versions

AP9400624A0 (en

Inventor

Sidney Edward Callander

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-13

Filing date

1994-03-10

Publication date

1996-01-19

1994-03-10 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

1994-04-30 Publication of AP9400624A0 publication Critical patent/AP9400624A0/xx

1996-01-19 Application granted granted Critical

1996-01-19 Publication of AP452A publication Critical patent/AP452A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

APAP/P/1994/000624A 1993-03-13 1994-03-10 "Diborane reduction of certain aryl piperidines". AP452A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939305175A GB9305175D0 (en)	1993-03-13	1993-03-13	Novel process
PCT/EP1994/000694 WO1994021609A1 (fr)	1993-03-13	1994-03-08	Procede de preparation de carbinols acryl-piperidiniques

Publications (2)

Publication Number	Publication Date
AP9400624A0 AP9400624A0 (en)	1994-04-30
AP452A true AP452A (en)	1996-01-19

Family

ID=10731995

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/1994/000624A AP452A (en)	1993-03-13	1994-03-10	"Diborane reduction of certain aryl piperidines".

Country Status (27)

Country	Link
US (1)	US5681962A (fr)
EP (1)	EP0688317B1 (fr)
JP (1)	JPH08507540A (fr)
KR (1)	KR100296719B1 (fr)
CN (2)	CN1041918C (fr)
AP (1)	AP452A (fr)
AT (1)	ATE207898T1 (fr)
AU (1)	AU682497B2 (fr)
BR (1)	BR9406035A (fr)
CA (1)	CA2158175A1 (fr)
CZ (1)	CZ235595A3 (fr)
DE (1)	DE69428886T2 (fr)
DZ (1)	DZ1758A1 (fr)
ES (1)	ES2164700T3 (fr)
FI (1)	FI954272A (fr)
GB (1)	GB9305175D0 (fr)
HU (1)	HUT72087A (fr)
IL (1)	IL108946A (fr)
MA (1)	MA23134A1 (fr)
NO (1)	NO306717B1 (fr)
NZ (1)	NZ262735A (fr)
PH (1)	PH31434A (fr)
PL (1)	PL176907B1 (fr)
RU (1)	RU2141477C1 (fr)
SK (1)	SK281977B6 (fr)
WO (1)	WO1994021609A1 (fr)
ZA (1)	ZA941716B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6444190B2 (en)	1995-08-03	2002-09-03	Fmc Corporation	Reduction compositions and processes for making the same
ES2121685B1 (es) *	1996-04-10	1999-09-16	Vita Invest Sa	Procedimiento para la obtencion de (+)-trans-4(4-fluoro-fenil)-3-hidroximetil-1-metilpiperidina.
JP3446468B2 (ja)	1996-04-15	2003-09-16	旭硝子株式会社	ピペリジンカルビノール類の製造方法
US5936090A (en) *	1996-05-24	1999-08-10	Fmc Corporation	Processes for the reduction of imide ester functionality
EP1384720A1 (fr)	1996-06-13	2004-01-28	SUMIKA FINE CHEMICALS Co., Ltd.	Procédé de séchage pour le chlorhydrate de paroxetine
GB9623359D0 (en) *	1996-11-09	1997-01-08	Smithkline Beecham Plc	Novel process
GB9710004D0 (en) *	1997-05-17	1997-07-09	Knoll Ag	Chemical process
HUP0003958A3 (en)	1997-05-29	2001-06-28	Smithkline Beecham Plc	Process for preparation of 4-aryl-piperidines and intermediates
ES2149687B1 (es) *	1998-04-08	2001-05-16	Medichem Sa	Procedimiento de obtencion de (+-)-trans-4-(4-fluorofenil)-3-hidroximetilpiperidinas e intermedios de sintesis para las mismas.
GB0003232D0 (en) *	2000-02-11	2000-04-05	Smithkline Beecham Plc	Novel composition
US6720003B2 (en)	2001-02-16	2004-04-13	Andrx Corporation	Serotonin reuptake inhibitor formulations
IL160694A0 (en) *	2001-09-14	2004-08-31	Medichem Sa	Intermediate compounds for the preparation of mirtazapine and the production methods thereof
WO2008013248A1 (fr) *	2006-07-24	2008-01-31	Sumitomo Chemical Company, Limited	Procédé de production de (±)-trans-4-(4- fluorophényl)-3-hydroxyméthylpipéridine
JP5165951B2 (ja) *	2006-07-24	2013-03-21	住友化学株式会社	（±）−トランス−４−（４−フルオロフェニル）−３−ヒドロキシメチルピペリジンの製造方法
CN109020872B (zh) *	2018-06-26	2020-05-12	浙江邦富生物科技有限责任公司	一种盐酸帕罗西汀关键中间体的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4007196A (en) *	1973-01-30	1977-02-08	A/S Ferrosan	4-Phenylpiperidine compounds
EP0374675A2 (fr) *	1988-12-22	1990-06-27	Novo Nordisk A/S	Réduction de dérivés de pipéridinedione et intermédiaires

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5470262A (en) *	1977-11-09	1979-06-05	Daiichi Kagaku Yakuhin Kk	Manufacture of pyrrolidinee22methanol
FR2581242B1 (fr) *	1985-04-24	1988-08-26	Telemecanique Electrique	Dispositif de commande electrique adaptable a un dispositif de commutation a deux etats
DE3680184D1 (de) *	1985-08-10	1991-08-14	Beecham Group Plc	Verfahren zur herstellung von arylpiperidincarbinol.
US5258517A (en) *	1992-08-06	1993-11-02	Sepracor, Inc.	Method of preparing optically pure precursors of paroxetine

1993
- 1993-03-13 GB GB939305175A patent/GB9305175D0/en active Pending
1994
- 1994-03-07 PH PH47890A patent/PH31434A/en unknown
- 1994-03-08 EP EP94909935A patent/EP0688317B1/fr not_active Expired - Lifetime
- 1994-03-08 BR BR9406035A patent/BR9406035A/pt not_active Application Discontinuation
- 1994-03-08 RU RU95121634A patent/RU2141477C1/ru active
- 1994-03-08 AU AU62587/94A patent/AU682497B2/en not_active Ceased
- 1994-03-08 CN CN94191430A patent/CN1041918C/zh not_active Expired - Fee Related
- 1994-03-08 DE DE69428886T patent/DE69428886T2/de not_active Expired - Fee Related
- 1994-03-08 CA CA002158175A patent/CA2158175A1/fr not_active Abandoned
- 1994-03-08 ES ES94909935T patent/ES2164700T3/es not_active Expired - Lifetime
- 1994-03-08 SK SK1140-95A patent/SK281977B6/sk unknown
- 1994-03-08 CZ CZ952355A patent/CZ235595A3/cs unknown
- 1994-03-08 JP JP6520592A patent/JPH08507540A/ja active Pending
- 1994-03-08 KR KR1019950703844A patent/KR100296719B1/ko not_active IP Right Cessation
- 1994-03-08 WO PCT/EP1994/000694 patent/WO1994021609A1/fr not_active Application Discontinuation
- 1994-03-08 NZ NZ262735A patent/NZ262735A/en unknown
- 1994-03-08 US US08/522,403 patent/US5681962A/en not_active Expired - Fee Related
- 1994-03-08 PL PL94310469A patent/PL176907B1/pl unknown
- 1994-03-08 HU HU9502661A patent/HUT72087A/hu unknown
- 1994-03-08 AT AT94909935T patent/ATE207898T1/de not_active IP Right Cessation
- 1994-03-09 DZ DZ940019A patent/DZ1758A1/fr active
- 1994-03-10 AP APAP/P/1994/000624A patent/AP452A/en active
- 1994-03-11 IL IL108946A patent/IL108946A/xx active IP Right Grant
- 1994-03-11 ZA ZA941716A patent/ZA941716B/xx unknown
- 1994-03-11 MA MA23441A patent/MA23134A1/fr unknown
1995
- 1995-09-12 NO NO953598A patent/NO306717B1/no not_active IP Right Cessation
- 1995-09-12 FI FI954272A patent/FI954272A/fi unknown
1998
- 1998-05-21 CN CN98109273A patent/CN1055470C/zh not_active Expired - Fee Related

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4007196A (en) *	1973-01-30	1977-02-08	A/S Ferrosan	4-Phenylpiperidine compounds
EP0374675A2 (fr) *	1988-12-22	1990-06-27	Novo Nordisk A/S	Réduction de dérivés de pipéridinedione et intermédiaires

Also Published As

Publication number	Publication date
ES2164700T3 (es)	2002-03-01
NO306717B1 (no)	1999-12-13
US5681962A (en)	1997-10-28
DZ1758A1 (fr)	2002-02-17
PH31434A (en)	1998-11-03
CN1203226A (zh)	1998-12-30
CA2158175A1 (fr)	1994-09-29
PL176907B1 (pl)	1999-08-31
GB9305175D0 (en)	1993-04-28
RU2141477C1 (ru)	1999-11-20
HUT72087A (en)	1996-03-28
ATE207898T1 (de)	2001-11-15
DE69428886D1 (de)	2001-12-06
KR100296719B1 (ko)	2001-10-24
EP0688317B1 (fr)	2001-10-31
SK114095A3 (en)	1996-01-10
IL108946A0 (en)	1994-06-24
NO953598L (no)	1995-09-12
JPH08507540A (ja)	1996-08-13
DE69428886T2 (de)	2002-04-25
ZA941716B (en)	1995-01-13
AU6258794A (en)	1994-10-11
PL310469A1 (en)	1995-12-11
WO1994021609A1 (fr)	1994-09-29
AU682497B2 (en)	1997-10-09
CN1041918C (zh)	1999-02-03
CN1055470C (zh)	2000-08-16
MA23134A1 (fr)	1994-10-01
CN1119012A (zh)	1996-03-20
FI954272A0 (fi)	1995-09-12
BR9406035A (pt)	1996-01-02
AP9400624A0 (en)	1994-04-30
SK281977B6 (sk)	2001-09-11
EP0688317A1 (fr)	1995-12-27
IL108946A (en)	1997-11-20
CZ235595A3 (en)	1996-01-17
FI954272A (fi)	1995-09-12
NO953598D0 (no)	1995-09-12
NZ262735A (en)	1996-10-28

Publication	Publication Date	Title
AP452A (en)	1996-01-19	"Diborane reduction of certain aryl piperidines".
EP0223403B1 (fr)	1993-08-04	Dérivé de pipéridine, sa préparation et son utilisation comme médicament
US20050085456A1 (en)	2005-04-21	Compounds useful in therapy
ZA201000714B (en)	2010-10-27	Salts of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide and their preparation
NZ230956A (en)	1991-03-26	Piperidinyl benzimidazole derivatives
JP2011184451A (ja)	2011-09-22	有機ホウ素および有機アルミニウムアジドからのテトラゾール誘導体の調製のための方法
US6274735B1 (en)	2001-08-14	Process and intermediates for preparation of substituted piperidines
US6716985B2 (en)	2004-04-06	Process for making paroxetine
KR20070064370A (ko)	2007-06-20	4-(3-설폰일페닐)-피페리딘의 합성 공정
AU9129891A (en)	1992-08-17	Process and intermediates for preparing azabicyclo(2.2.2)octan-3-imines
CA1330086C (fr)	1994-06-07	Composes piperidynyles, disubstitues en 1,4
KR20000017193A (ko)	2000-03-25	치환된 피페리딘-에폭시드의 제조방법
ZA200007034B (en)	2002-04-08	Novel antihistaminic piperidine derivatives and intermediates for the preparation thereof.
EP2238129B1 (fr)	2011-08-17	Procédé de préparation de darifénacine bromhydrique
WO2000026187A1 (fr)	2000-05-11	Procede de production de 4-arylpiperidine-3-carbinols et composes correspondants
EP2616464B1 (fr)	2018-01-03	Procédé amélioré de préparation d'un précurseur de sufentanil base
US6916929B2 (en)	2005-07-12	Method for preparing 4-methylamino-4-phenylpiperidine
WO2002032870A1 (fr)	2002-04-25	Procede de preparation de composes de -4-aryle piperidine substitue en position 3
JP5165951B2 (ja)	2013-03-21	（±）−トランス−４−（４−フルオロフェニル）−３−ヒドロキシメチルピペリジンの製造方法
EP0491562A1 (fr)	1992-06-24	Composés de spirofurane
US20040171837A1 (en)	2004-09-02	Method for preparing 4-amino-4-phenylpiperidines
NZ523652A (en)	2004-04-30	4-(2,3-dimethoxybenzoyl)-pyridine or 4-((2,3-dimethoxyphenyl)-4-pyridine
WO2004058710A1 (fr)	2004-07-15	Nouveaux derives de benzamide et procede de fabrication associe
UA82297C2 (en)	2008-03-25	Benzimidazolone carboxylic acid derivatives