AP2002002708A0 - 2-Aminothiazoline derivatives and their use as no-synthase inhibitors. - Google Patents
2-Aminothiazoline derivatives and their use as no-synthase inhibitors.Info
- Publication number
- AP2002002708A0 AP2002002708A0 APAP/P/2002/002708A AP2002002708A AP2002002708A0 AP 2002002708 A0 AP2002002708 A0 AP 2002002708A0 AP 2002002708 A AP2002002708 A AP 2002002708A AP 2002002708 A0 AP2002002708 A0 AP 2002002708A0
- Authority
- AP
- ARIPO
- Prior art keywords
- radical
- pyridyl
- derivatives
- synthase inhibitors
- phenyl
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- REGFWZVTTFGQOJ-UHFFFAOYSA-N 4,5-dihydro-1,3-thiazol-2-amine Chemical class NC1=NCCS1 REGFWZVTTFGQOJ-UHFFFAOYSA-N 0.000 title 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- -1 pyridyl N-oxide Chemical group 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 102100029438 Nitric oxide synthase, inducible Human genes 0.000 abstract 1
- 101710089543 Nitric oxide synthase, inducible Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical compound O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/18—Nitrogen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention concerns 2-aminithiazoline derivatives of formula (I) wherein: either R1 is a hydrogen atom or an alkyl radical and R2 is an alkyl, -alk-NH2, -CH-R3, -CH2-S-R4 or phenyl radical substituted by a nitro or NH-C(=NH)CH3 radical; or R1 is an alkyl radical and R2 is a hydrogen atom; R3 is a cycloalkyl (3-6C), pyridyl, pyridyl N-oxide, thienyl, thiazolyl, imidazolyl, pyrazinyl, triazolyl, phenyl or phenyl radical substituted by a nitro, hydroxy or carboxy radical; R4 represents a pyridyl or pyridyl N-oxide radical; alk represents an alkylene radical or their pharmaceutically acceptable salts excluding some known compounds, and the use of said derivatives as inducible NO-synthase inhibitors.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0007397A FR2810037B1 (en) | 2000-06-09 | 2000-06-09 | USE OF 2-AMINOTHIAZOLINE DERIVATIVES AS INDUCTIBLE NO-SYNTHASE INHIBITORS |
| PCT/FR2001/001760 WO2001094325A1 (en) | 2000-06-09 | 2001-06-07 | 2-aminothiazoline derivatives and their use as no-synthase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AP2002002708A0 true AP2002002708A0 (en) | 2002-12-31 |
Family
ID=8851134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| APAP/P/2002/002708A AP2002002708A0 (en) | 2000-06-09 | 2001-06-07 | 2-Aminothiazoline derivatives and their use as no-synthase inhibitors. |
Country Status (28)
| Country | Link |
|---|---|
| EP (1) | EP1299365B1 (en) |
| JP (1) | JP4238026B2 (en) |
| KR (1) | KR20030025931A (en) |
| CN (1) | CN1202096C (en) |
| AP (1) | AP2002002708A0 (en) |
| AR (1) | AR029937A1 (en) |
| AT (1) | ATE305460T1 (en) |
| AU (1) | AU2001266124A1 (en) |
| BR (1) | BR0111986A (en) |
| CA (1) | CA2411760C (en) |
| DE (1) | DE60113689T2 (en) |
| DK (1) | DK1299365T3 (en) |
| DZ (1) | DZ3367A1 (en) |
| EA (1) | EA200300010A1 (en) |
| EC (1) | ECSP024375A (en) |
| ES (1) | ES2248347T3 (en) |
| FR (1) | FR2810037B1 (en) |
| HR (1) | HRP20020970A2 (en) |
| HU (1) | HUP0301000A2 (en) |
| IL (1) | IL153328A0 (en) |
| MA (1) | MA25814A1 (en) |
| MX (1) | MXPA02012071A (en) |
| NO (1) | NO20025884L (en) |
| NZ (1) | NZ522968A (en) |
| OA (1) | OA12286A (en) |
| PL (1) | PL360285A1 (en) |
| WO (1) | WO2001094325A1 (en) |
| ZA (1) | ZA200209769B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60140964D1 (en) * | 2001-09-26 | 2010-02-11 | Yissum Res Dev Co | Sphingolipiden |
| CA2465695A1 (en) * | 2001-11-09 | 2003-05-15 | Aventis Pharma S.A. | 2-amino-thiazoline derivatives and their use as inhibitors of inducible no-synthase |
| WO2003039446A2 (en) * | 2001-11-09 | 2003-05-15 | Aventis Pharma S.A. | Use of 2-amino-4-pyridylmethyl-thiazoline derivatives as inhibitors of inducible no-synthase |
| JP4365681B2 (en) * | 2001-11-09 | 2009-11-18 | アベンティス・ファーマ・ソシエテ・アノニム | 2-Amino-4-heteroarylethyl-thiazoline derivatives and their use as inhibitors of inducible NO synthase |
| AU2002238889A1 (en) * | 2002-03-14 | 2003-09-22 | Dainippon Pharmaceutical Co., Ltd. | Nitrogen monoxide synthase inhibitors |
| ATE375333T1 (en) | 2002-08-07 | 2007-10-15 | Neuraxon Inc | AMINOBENZOTHIAZOLE COMPOUNDS WITH NOS-INHIBITING EFFECT |
| DE10332560B4 (en) * | 2003-07-11 | 2010-07-08 | Chiracon Gmbh | Process for the preparation of β-heteroaryl-2-alanine compounds via 2-amino-2- (heteroarylmethyl) -carboxylic acid compounds |
| KR101800507B1 (en) | 2015-09-18 | 2018-01-18 | 주식회사 이엔이티아이 | How to take advantage of the purification plants equipment and self-cleaning screen to clean up pollution by continue flowing sewage and process wastewater into the river |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5066662A (en) * | 1990-05-21 | 1991-11-19 | Warner-Lambert Company | Substituted oxazolidin-2-ones and 1,2,4-oxadiazolin-5-ones and derivatives thereof acting at muscarinic receptors |
| CN1095710A (en) * | 1992-11-27 | 1994-11-30 | 惠尔康基金会集团公司 | Enzyme Inhibitors |
| DK0724570T3 (en) * | 1993-10-21 | 1999-09-27 | Searle & Co | Amidino derivatives as NO synthase inhibitors |
| AU4149696A (en) * | 1994-11-15 | 1996-06-06 | Merck & Co., Inc. | Substituted heterocycles as inhibitors of nitric oxide synthase |
| ATE289311T1 (en) * | 1999-12-24 | 2005-03-15 | Kyowa Hakko Kogyo Kk | CONDENSED PURINE DERIVATIVES |
-
2000
- 2000-06-09 FR FR0007397A patent/FR2810037B1/en not_active Expired - Fee Related
-
2001
- 2001-06-07 EP EP01943580A patent/EP1299365B1/en not_active Expired - Lifetime
- 2001-06-07 EA EA200300010A patent/EA200300010A1/en unknown
- 2001-06-07 DK DK01943580T patent/DK1299365T3/en active
- 2001-06-07 KR KR1020027016766A patent/KR20030025931A/en not_active Withdrawn
- 2001-06-07 AU AU2001266124A patent/AU2001266124A1/en not_active Abandoned
- 2001-06-07 CA CA002411760A patent/CA2411760C/en not_active Expired - Fee Related
- 2001-06-07 NZ NZ522968A patent/NZ522968A/en unknown
- 2001-06-07 WO PCT/FR2001/001760 patent/WO2001094325A1/en active IP Right Grant
- 2001-06-07 JP JP2002501875A patent/JP4238026B2/en not_active Expired - Fee Related
- 2001-06-07 OA OA1200200372A patent/OA12286A/en unknown
- 2001-06-07 MX MXPA02012071A patent/MXPA02012071A/en active IP Right Grant
- 2001-06-07 AR ARP010102730A patent/AR029937A1/en not_active Application Discontinuation
- 2001-06-07 HR HR20020970A patent/HRP20020970A2/en not_active Application Discontinuation
- 2001-06-07 AT AT01943580T patent/ATE305460T1/en not_active IP Right Cessation
- 2001-06-07 PL PL36028501A patent/PL360285A1/en unknown
- 2001-06-07 HU HU0301000A patent/HUP0301000A2/en unknown
- 2001-06-07 ES ES01943580T patent/ES2248347T3/en not_active Expired - Lifetime
- 2001-06-07 DZ DZ013367A patent/DZ3367A1/en active
- 2001-06-07 CN CNB01813386XA patent/CN1202096C/en not_active Expired - Fee Related
- 2001-06-07 IL IL15332801A patent/IL153328A0/en unknown
- 2001-06-07 DE DE60113689T patent/DE60113689T2/en not_active Expired - Lifetime
- 2001-06-07 BR BR0111986-9A patent/BR0111986A/en not_active Application Discontinuation
- 2001-06-07 AP APAP/P/2002/002708A patent/AP2002002708A0/en unknown
-
2002
- 2002-12-02 ZA ZA200209769A patent/ZA200209769B/en unknown
- 2002-12-06 NO NO20025884A patent/NO20025884L/en not_active Application Discontinuation
- 2002-12-09 EC EC2002004375A patent/ECSP024375A/en unknown
- 2002-12-09 MA MA26939A patent/MA25814A1/en unknown
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