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NZ612185A - Topical combination formulations of macrocyclic lactones with synthetic pyrethroids - Google Patents

Topical combination formulations of macrocyclic lactones with synthetic pyrethroids

Info

Publication number
NZ612185A
NZ612185A NZ612185A NZ61218511A NZ612185A NZ 612185 A NZ612185 A NZ 612185A NZ 612185 A NZ612185 A NZ 612185A NZ 61218511 A NZ61218511 A NZ 61218511A NZ 612185 A NZ612185 A NZ 612185A
Authority
NZ
New Zealand
Prior art keywords
pyrethroid
macrocyclic lactone
macrocyclic lactones
combination formulations
synthetic pyrethroids
Prior art date
Application number
NZ612185A
Inventor
Robert Holmes
Original Assignee
Merial Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Inc filed Critical Merial Inc
Priority to NZ627856A priority Critical patent/NZ627856A/en
Publication of NZ612185A publication Critical patent/NZ612185A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Dermatology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

Disclosed is a pharmaceutically or veterinarily acceptable formulation adapted to be topically applied to an animal, which formulation comprises; a) an effective amount of the pyrethroid deltamethrin; b) an effective amount of at least one macrocyclic lactone which is eprinomectin; c) a pharmaceutically acceptable system of solvents and/or suspending agents and excipients wherein the system provides for acceptable storage stability for both the pyrethroid and the macrocyclic lactone; wherein the macrocyclic lactone and the pyrethroid are both dissolved in a solvent (such as propylene glycol dicaprylate/dicaprate (MIGLYOL 840)), or, wherein the macrocyclic lactone is dissolved in an organic solvent (such as propylene glycol) and the pyrethroid is suspended in an aqueous phase; and wherein the system provides storage stability for greater than 3 months.
NZ612185A 2010-12-07 2011-12-06 Topical combination formulations of macrocyclic lactones with synthetic pyrethroids NZ612185A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NZ627856A NZ627856A (en) 2010-12-07 2011-12-06 Topical combination formulations of macrocyclic lactones with synthetic pyrethroids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42074410P 2010-12-07 2010-12-07
PCT/US2011/063497 WO2012078605A1 (en) 2010-12-07 2011-12-06 Topical combination formulations of macrocyclic lactones with synthetic pyrethroids

Publications (1)

Publication Number Publication Date
NZ612185A true NZ612185A (en) 2015-10-30

Family

ID=45464088

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ612185A NZ612185A (en) 2010-12-07 2011-12-06 Topical combination formulations of macrocyclic lactones with synthetic pyrethroids
NZ627856A NZ627856A (en) 2010-12-07 2011-12-06 Topical combination formulations of macrocyclic lactones with synthetic pyrethroids

Family Applications After (1)

Application Number Title Priority Date Filing Date
NZ627856A NZ627856A (en) 2010-12-07 2011-12-06 Topical combination formulations of macrocyclic lactones with synthetic pyrethroids

Country Status (3)

Country Link
AU (1) AU2011338573B2 (en)
NZ (2) NZ612185A (en)
WO (1) WO2012078605A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104483426A (en) * 2014-11-27 2015-04-01 黑龙江省乳品工业技术开发中心 Predicting method of reduction of content of acetochlor in lactation of dairy cattle and application
WO2016139331A1 (en) 2015-03-05 2016-09-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of melanoma
WO2017144546A1 (en) 2016-02-23 2017-08-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of nasopharyngeal carcinoma
EP3956446A1 (en) 2019-04-17 2022-02-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treatment of nlrp3 inflammasome mediated il-1beta dependent disorders
EP3760045A1 (en) * 2019-07-04 2021-01-06 Laboratorios Virbac Mexico SA DE CV Topical composition against rhipicephalus (boophilus) microplus
WO2021198511A1 (en) 2020-04-03 2021-10-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treatment of sars-cov-2 infection
WO2022008597A1 (en) 2020-07-08 2022-01-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical composition for the treatment of infectious diseases

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US4199569A (en) 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
US4427663A (en) 1982-03-16 1984-01-24 Merck & Co., Inc. 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
EP0237482A1 (en) 1986-03-06 1987-09-16 Ciba-Geigy Ag Derivatives of C(29)-carbonyloxy-milbemycine against parasites in animals and plants
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Also Published As

Publication number Publication date
AU2011338573B2 (en) 2016-07-28
NZ627856A (en) 2016-03-31
WO2012078605A1 (en) 2012-06-14
AU2011338573A1 (en) 2013-07-11

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Legal Events

Date Code Title Description
ASS Change of ownership

Owner name: MERIAL, INC., US

Effective date: 20151022

PSEA Patent sealed
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Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 06 DEC 2018 BY FB RICE

Effective date: 20160202

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 06 DEC 2019 BY COMPUTER PACKAGES INC

Effective date: 20181120

ASS Change of ownership

Owner name: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC., US

Effective date: 20190328

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Effective date: 20191203

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Effective date: 20201118

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Effective date: 20231127