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NZ609186A - Novel anti-cancer agents - Google Patents

Novel anti-cancer agents

Info

Publication number
NZ609186A
NZ609186A NZ609186A NZ60918611A NZ609186A NZ 609186 A NZ609186 A NZ 609186A NZ 609186 A NZ609186 A NZ 609186A NZ 60918611 A NZ60918611 A NZ 60918611A NZ 609186 A NZ609186 A NZ 609186A
Authority
NZ
New Zealand
Prior art keywords
cancer agents
novel anti
imidazolidine
triazin
amino
Prior art date
Application number
NZ609186A
Inventor
Antony Wilks Burgess
Francesca Walker
Keith Geoffrey Watson
Helen Witchard
Guillaume Lessene
Original Assignee
Inst Medical W & E Hall
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Medical W & E Hall filed Critical Inst Medical W & E Hall
Publication of NZ609186A publication Critical patent/NZ609186A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Provided are 5-((1,3,5-triazin-2-yl)amino)imidazolidine-2,4-dione derivative compounds of Formula I, where the variables are as described in the specification. Examples of the compounds are 1-[4-(4-aminomethyl-benzylamino)-6-(4-methoxybenzylamino)-{ 1,3,5} -triazin-2-yl-amino]-imidazolidine-2,4-dione and 1-[4,6-Bis-(4-methoxybenzylamino)-{ 1,3,5} -triazin-2-yl-amino]-imidazolidine-2,4-dione. The compounds may be useful in the treatment of cancer.
NZ609186A 2010-10-27 2011-10-27 Novel anti-cancer agents NZ609186A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40726510P 2010-10-27 2010-10-27
PCT/AU2011/001376 WO2012054978A1 (en) 2010-10-27 2011-10-27 Novel anti-cancer agents

Publications (1)

Publication Number Publication Date
NZ609186A true NZ609186A (en) 2015-08-28

Family

ID=45992970

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ609186A NZ609186A (en) 2010-10-27 2011-10-27 Novel anti-cancer agents

Country Status (12)

Country Link
US (3) US8835629B2 (en)
EP (1) EP2632916B1 (en)
JP (2) JP6184866B2 (en)
KR (1) KR101896924B1 (en)
CN (1) CN103476769B (en)
AU (1) AU2011320024B2 (en)
CA (1) CA2814120C (en)
ES (1) ES2621932T3 (en)
HU (1) HUE032522T2 (en)
NZ (1) NZ609186A (en)
PL (1) PL2632916T3 (en)
WO (1) WO2012054978A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011320024B2 (en) * 2010-10-27 2014-10-30 The Walter And Eliza Hall Institute Of Medical Research Novel anti-cancer agents
KR101853785B1 (en) 2013-11-20 2018-05-02 주식회사 만도 Device for controlling 3 phase-motor and method for keeping high torgue of the same
WO2016070241A1 (en) * 2014-11-03 2016-05-12 Ctxt Pty Ltd Triazine compounds, compositions and synthesis
US20200128829A1 (en) * 2017-06-08 2020-04-30 University Of South Alabama Antimicrobial Compounds
CN111902403B (en) 2018-01-17 2024-05-17 奥里吉恩发现科技有限公司 Substituted alkynylene compounds as anticancer agents

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1035771A (en)
US2742466A (en) 1956-04-17 Chx n nhx c c
US3145203A (en) 1961-11-30 1964-08-18 Geigy Chem Corp Hydrazones of 5-nitro-2-furaldehyde
JPS5277163A (en) 1975-12-24 1977-06-29 Asahi Chem Ind Co Ltd Stabilized polyurethane composition
FR2524467A1 (en) 1982-03-30 1983-10-07 Adir DISUBSTITUTED POLYMETHYLENE IMINES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
JPS62192474A (en) 1986-02-19 1987-08-24 Canon Inc Recording fluid
US4932998A (en) 1986-09-30 1990-06-12 Idemitsu Kosan Company Limited Triazine derivatives, and herbicides comprising the same as the effective ingredient
US4844731A (en) 1986-12-27 1989-07-04 Idemitsu Company Co., Ltd. Triazine derivatives
US5187045A (en) 1988-09-07 1993-02-16 Minnesota Mining And Manufacturing Company Halomethyl-1,3,5-triazines containing a sensitizer moiety
KR940001728B1 (en) 1989-02-20 1994-03-05 이데미쓰 고산 가부시끼가이샤 Triazine derivatives and herbicides having the same as active ingredients
US5536722A (en) 1991-11-12 1996-07-16 Pfizer Inc. Triazine derivatives for enhancing antitumor activity
EP0629622B1 (en) 1992-02-28 1998-11-11 Zenyaku Kogyo Kabushikikaisha S-triazine derivative and remedy for estrogen-dependent diseases containing the same as active ingredient
US5574057A (en) * 1993-02-03 1996-11-12 University Of Utah Research Foundation Naamidine A extracted from sea sponges and methods for its use as an anti-tumor agent
US6566384B1 (en) 1996-08-07 2003-05-20 Darwin Discovery Ltd. Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
FR2757056B1 (en) 1996-12-17 2003-03-14 Oreal COMPOSITIONS COMPRISING A DIBENZOYLMETHANE DERIVATIVE, A 1,3,5-TRIAZINE DERIVATIVE AND AN AMIDE COMPOUND AND USES THEREOF
FR2757057A1 (en) 1996-12-17 1998-06-19 Oreal COMPOSITIONS COMPRISING A DIBENZOYLMETHANE DERIVATIVE, A 1,3,5-TRIAZINE DERIVATIVE, AND A BENZALMALONATE FUNCTIONAL SILICY DERIVATIVE AND USES THEREOF
EP0945447A1 (en) 1998-03-27 1999-09-29 Janssen Pharmaceutica N.V. Trisubstituted 1,3,5-triazine derivatives for treatment of HIV infections
US6262053B1 (en) 1999-06-23 2001-07-17 Parker Hughes Institute Melamine derivatives as potent anti-cancer agents
ATE521353T1 (en) * 2000-10-23 2011-09-15 Glaxosmithkline Llc NEW TRIS-SUBSTITUTED 8H-PYRIDOÄ2,3-DÜPYRIMIDINE-7-ONE DERIVATIVE FOR THE TREATMENT OF CSBP/P38KINASE-MEDIATED DISEASES
US7173032B2 (en) * 2001-09-21 2007-02-06 Reddy Us Therapeutics, Inc. Methods and compositions of novel triazine compounds
EP1441683A4 (en) * 2001-10-12 2005-10-26 Univ New York TRISUBSTITUTED TRIAZINE COMPOUNDS WITH ANTI-TUBULIN ACTIVITY, METHODS OF MAKING AND USING SAME
CN1697831A (en) * 2002-09-23 2005-11-16 雷迪美国治疗公司 Methods and compositions of novel triazine compounds
AU2011320024B2 (en) * 2010-10-27 2014-10-30 The Walter And Eliza Hall Institute Of Medical Research Novel anti-cancer agents

Also Published As

Publication number Publication date
KR101896924B1 (en) 2018-09-10
US20130261119A1 (en) 2013-10-03
EP2632916B1 (en) 2017-01-11
CN103476769A (en) 2013-12-25
US9221799B2 (en) 2015-12-29
AU2011320024A1 (en) 2013-05-02
JP2017137323A (en) 2017-08-10
HUE032522T2 (en) 2017-09-28
US20150045365A1 (en) 2015-02-12
WO2012054978A1 (en) 2012-05-03
KR20130141554A (en) 2013-12-26
US20160145243A1 (en) 2016-05-26
CA2814120C (en) 2018-08-07
AU2011320024B2 (en) 2014-10-30
CA2814120A1 (en) 2012-05-03
PL2632916T3 (en) 2017-07-31
JP6184866B2 (en) 2017-08-23
ES2621932T3 (en) 2017-07-05
EP2632916A4 (en) 2014-04-23
CN103476769B (en) 2016-06-01
EP2632916A1 (en) 2013-09-04
JP2013540778A (en) 2013-11-07
US8835629B2 (en) 2014-09-16

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Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 27 OCT 2018 BY FB RICE

Effective date: 20151203

LAPS Patent lapsed