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NZ511618A - Kininogen fragment 2 peptides with the formula of at least X-His-Lys-X-Lys-X - Google Patents

Kininogen fragment 2 peptides with the formula of at least X-His-Lys-X-Lys-X

Info

Publication number
NZ511618A
NZ511618A NZ511618A NZ51161899A NZ511618A NZ 511618 A NZ511618 A NZ 511618A NZ 511618 A NZ511618 A NZ 511618A NZ 51161899 A NZ51161899 A NZ 51161899A NZ 511618 A NZ511618 A NZ 511618A
Authority
NZ
New Zealand
Prior art keywords
lys
gly
formula
gln
asp
Prior art date
Application number
NZ511618A
Inventor
R Keith Mccrae
Original Assignee
Univ Temple
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Temple filed Critical Univ Temple
Publication of NZ511618A publication Critical patent/NZ511618A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A compound has the formula X1-His-Lys-X-Lys-X2 wherein X is any amino acid, X1 is a the segment His-Gly-His-Glu-Gln-Gln-His-Gly-Leu-Gly-His-Gly (SEQ ID NO:1) or a N-terminal truncation fragment containing at least one amino acid and X2 is zero amino acids or the segment Leu-Asp-Asp-Asp-Leu-Glu-His-Gln-Gly-Gly-His-Val (SEQ ID NO:2) or a C-terminal truncation fragment containing at least one amino acid. The compound may optionally comprise an amino-terminal and/or a carboxy-terminal protecting group. Also described are pharmaceutical compositions comprising the compounds with a pharmaceutically acceptable carrier.
NZ511618A 1998-11-10 1999-11-05 Kininogen fragment 2 peptides with the formula of at least X-His-Lys-X-Lys-X NZ511618A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10783398P 1998-11-10 1998-11-10
PCT/US1999/026419 WO2000027866A1 (en) 1998-11-10 1999-11-05 Inhibition of angiogenesis by high molecular weight kininogen and peptide analogs thereof

Publications (1)

Publication Number Publication Date
NZ511618A true NZ511618A (en) 2003-06-30

Family

ID=22318715

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ511618A NZ511618A (en) 1998-11-10 1999-11-05 Kininogen fragment 2 peptides with the formula of at least X-His-Lys-X-Lys-X

Country Status (8)

Country Link
EP (1) EP1137659A4 (en)
JP (1) JP2002529474A (en)
AU (1) AU773862B2 (en)
CA (1) CA2350915A1 (en)
IL (1) IL142822A0 (en)
NZ (1) NZ511618A (en)
WO (1) WO2000027866A1 (en)
ZA (1) ZA200104130B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6994852B1 (en) 1999-11-12 2006-02-07 Temple University-Of The Commonwealth System Of Higher Education Inhibition of angiogenesis by antibodies against high molecular weight kininogen domain 5
WO2001034195A1 (en) * 1999-11-12 2001-05-17 Temple University Of The Commonwealth System Of Higher Education Inhibition of angiogenesis by antibodies against high molecular weight kininogen domain 5
WO2002014369A2 (en) * 2000-07-24 2002-02-21 Attenuon, Llc Human kininogen d5 domain polypeptides and their use
US7098187B2 (en) 2002-09-13 2006-08-29 Attenuon, Llc Human kininogen D3 domain polypeptide as an anti-angiogenic and anti-tumor agent
SE0301431D0 (en) 2003-05-19 2003-05-19 Dermagen Novel antimicrobial peptides
GB0821721D0 (en) * 2008-11-27 2008-12-31 Hansa Medical Ab Antimicrobial therapy
CN104211807B (en) * 2014-08-22 2017-10-20 北京蛋白质组研究中心 It is a kind of to resist monoclonal antibody of two kinds of polypeptides and its preparation method and application
CN104155457B (en) * 2014-08-22 2016-11-16 北京蛋白质组研究中心 Relevant " the box-like mark of the polypeptide-protein groups " detection kit of a kind of colorectal cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5596079A (en) * 1991-12-16 1997-01-21 Smith; James R. Mimetics of senescent cell derived inhibitors of DNA synthesis
US5756291A (en) * 1992-08-21 1998-05-26 Gilead Sciences, Inc. Aptamers specific for biomolecules and methods of making
JPH0782172A (en) * 1993-09-17 1995-03-28 Hoechst Japan Ltd Wound healing agent
CA2189340A1 (en) * 1994-05-04 1995-11-16 James W. Dennis Modulators of cytokines of the tgf-.beta. superfamily and methods for assaying for same
JPH08208692A (en) * 1994-09-28 1996-08-13 Sumitomo Pharmaceut Co Ltd New cell adhesion inhibiting peptide derivative
EP0808627A2 (en) * 1996-05-22 1997-11-26 Hoechst Aktiengesellschaft Use of non-peptide bradykinin antagonists for treating and preventing chronic fibrogenetic liver diseases, acute liver diseases and complications thereof
CA2187728A1 (en) * 1996-05-29 1997-11-29 Mary Lou Guerinot Iron-regulated metal transporters and uses therefor

Also Published As

Publication number Publication date
ZA200104130B (en) 2002-05-21
AU773862B2 (en) 2004-06-10
IL142822A0 (en) 2002-03-10
CA2350915A1 (en) 2000-05-18
AU1910600A (en) 2000-05-29
WO2000027866A1 (en) 2000-05-18
EP1137659A1 (en) 2001-10-04
JP2002529474A (en) 2002-09-10
EP1137659A4 (en) 2005-08-10

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Legal Events

Date Code Title Description
ASS Change of ownership

Owner name: TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM, US

Free format text: OLD OWNER(S): TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; R. KEITH MCCRAE

PSEA Patent sealed
RENW Renewal (renewal fees accepted)