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NZ237732A - Neutral metalloprotease inhibitors and pharmaceutical compositions - Google Patents

Neutral metalloprotease inhibitors and pharmaceutical compositions

Info

Publication number
NZ237732A
NZ237732A NZ237732A NZ23773291A NZ237732A NZ 237732 A NZ237732 A NZ 237732A NZ 237732 A NZ237732 A NZ 237732A NZ 23773291 A NZ23773291 A NZ 23773291A NZ 237732 A NZ237732 A NZ 237732A
Authority
NZ
New Zealand
Prior art keywords
pharmaceutical compositions
metalloprotease inhibitors
neutral metalloprotease
neutral
inhibitors
Prior art date
Application number
NZ237732A
Inventor
Roger Edward Markwell
Sharooq Rahman Shahzad
Robert William Ward
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of NZ237732A publication Critical patent/NZ237732A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NZ237732A 1990-04-10 1991-04-08 Neutral metalloprotease inhibitors and pharmaceutical compositions NZ237732A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909008065A GB9008065D0 (en) 1990-04-10 1990-04-10 Novel compounds

Publications (1)

Publication Number Publication Date
NZ237732A true NZ237732A (en) 1993-08-26

Family

ID=10674178

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ237732A NZ237732A (en) 1990-04-10 1991-04-08 Neutral metalloprotease inhibitors and pharmaceutical compositions

Country Status (10)

Country Link
EP (1) EP0527761A1 (en)
JP (1) JPH05506651A (en)
AU (1) AU637903B2 (en)
CA (1) CA2080228A1 (en)
GB (1) GB9008065D0 (en)
IE (1) IE911165A1 (en)
NZ (1) NZ237732A (en)
PT (1) PT97281A (en)
WO (1) WO1991015506A1 (en)
ZA (1) ZA912574B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0520573A1 (en) * 1991-06-27 1992-12-30 Glaxo Inc. Cyclic imide derivatives
GB9122859D0 (en) * 1991-10-28 1991-12-11 Smithkline Beecham Plc Novel compounds
US5326760A (en) * 1992-06-29 1994-07-05 Glaxo, Inc. Aminobutanoic acid compounds having metalloprotease inhibiting properties
US5840698A (en) * 1994-10-27 1998-11-24 Affymax Technologies N.V. Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5831004A (en) * 1994-10-27 1998-11-03 Affymax Technologies N.V. Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5827840A (en) * 1996-08-01 1998-10-27 The Research Foundation Of State University Of New York Promotion of wound healing by chemically-modified tetracyclines

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8726714D0 (en) * 1987-11-14 1987-12-16 Beecham Group Plc Compounds
EP0401963A1 (en) * 1989-04-13 1990-12-12 Beecham Group p.l.c. Phosphonopeptides with collagenase inhibiting activity

Also Published As

Publication number Publication date
PT97281A (en) 1992-01-31
WO1991015506A1 (en) 1991-10-17
EP0527761A1 (en) 1993-02-24
ZA912574B (en) 1992-10-28
AU637903B2 (en) 1993-06-10
JPH05506651A (en) 1993-09-30
GB9008065D0 (en) 1990-06-06
CA2080228A1 (en) 1991-10-11
IE911165A1 (en) 1991-10-23
AU7650291A (en) 1991-10-30

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