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NO991761L - Nye piperidin-kotokarbonsyre-derivater, deres fremstilling og anvendelse - Google Patents

Nye piperidin-kotokarbonsyre-derivater, deres fremstilling og anvendelse

Info

Publication number
NO991761L
NO991761L NO991761A NO991761A NO991761L NO 991761 L NO991761 L NO 991761L NO 991761 A NO991761 A NO 991761A NO 991761 A NO991761 A NO 991761A NO 991761 L NO991761 L NO 991761L
Authority
NO
Norway
Prior art keywords
preparation
acid derivatives
cotocarboxylic
new piperidine
piperidine
Prior art date
Application number
NO991761A
Other languages
English (en)
Other versions
NO991761D0 (no
Inventor
Wilfried Lubisch
Ller Achim M
J Rgen Delzer
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of NO991761D0 publication Critical patent/NO991761D0/no
Publication of NO991761L publication Critical patent/NO991761L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Piperidin-ketokarboksylsyre-derivater med den generelle formel I. og deres tautomere og isomere former, og fysiologisk aksepterbare salter derav, hvor variablene har betydningene gitt i beskrivelsen, fremstilling av disse forbindelser og anvendelse av dem som medikamenter.
NO991761A 1996-10-15 1999-04-14 Nye piperidin-kotokarbonsyre-derivater, deres fremstilling og anvendelse NO991761L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19642591A DE19642591A1 (de) 1996-10-15 1996-10-15 Neue Piperidin-Ketocarbonsäure-Derivate, deren Herstellung und Anwendung
PCT/EP1997/005202 WO1998016512A1 (de) 1996-10-15 1997-09-23 Neue piperidin-ketocarbonsäure-derivate, deren herstellung und anwendung

Publications (2)

Publication Number Publication Date
NO991761D0 NO991761D0 (no) 1999-04-14
NO991761L true NO991761L (no) 1999-04-14

Family

ID=7808858

Family Applications (1)

Application Number Title Priority Date Filing Date
NO991761A NO991761L (no) 1996-10-15 1999-04-14 Nye piperidin-kotokarbonsyre-derivater, deres fremstilling og anvendelse

Country Status (24)

Country Link
US (1) US6380220B1 (no)
EP (1) EP0934273A1 (no)
JP (1) JP2001501955A (no)
KR (1) KR20000049130A (no)
CN (1) CN1239950A (no)
AR (1) AR009379A1 (no)
AU (1) AU736754B2 (no)
BG (1) BG103338A (no)
BR (1) BR9711908A (no)
CA (1) CA2268917A1 (no)
CO (1) CO4930264A1 (no)
CZ (1) CZ126899A3 (no)
DE (1) DE19642591A1 (no)
HR (1) HRP970549A2 (no)
HU (1) HUP9904104A3 (no)
IL (1) IL129089A0 (no)
NO (1) NO991761L (no)
NZ (1) NZ334979A (no)
PL (1) PL332720A1 (no)
RU (1) RU2189974C2 (no)
SK (1) SK38599A3 (no)
TR (1) TR199900819T2 (no)
WO (1) WO1998016512A1 (no)
ZA (1) ZA979175B (no)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK15062000A3 (sk) * 1998-04-20 2001-05-10 Basf Aktiengesellschaft Amidy s heterocyklickými substituentmi, ich príprava a použitie
KR20010042840A (ko) * 1998-04-20 2001-05-25 스타르크, 카르크 신규한 치환된 아미드, 그의 제조 및 그의 용도
DE19817459A1 (de) 1998-04-20 1999-10-21 Basf Ag Neue heterozyklische substituierte Amide, Herstellung und Anwendung
US6562827B1 (en) 1998-04-20 2003-05-13 Abbott Laboratories Heterocyclically substituted amides used as calpain inhibitors
US6117870A (en) * 1998-11-12 2000-09-12 Fujirebio Kabushiki Kaisha Cyclic amide derivatives
AU6936500A (en) * 1999-08-24 2001-03-19 Regents Of The University Of California, The Non-quinoline inhibitors of malaria parasites
ES2244474T3 (es) 1999-09-29 2005-12-16 Ortho-Mcneil Pharmaceutical, Inc. Isonipecotamida para el tratamiento de trastornos mediados por integrina.
CA2414960C (en) 2000-06-30 2012-04-10 Seikagaku Corporation Epoxycarboxamide compound, azide compound, and amino alcohol compound, and process for preparing .alpha.keto amide compound using them
DE10114762A1 (de) * 2001-03-26 2002-10-02 Knoll Gmbh Verwendung von Cysteinprotease-Inhibitoren
EP1389205B1 (en) 2001-04-09 2005-12-21 Ortho-McNeil Pharmaceutical Research Inc. Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders
US7691843B2 (en) 2002-07-11 2010-04-06 Pfizer Inc. N-hydroxyamide derivatives possessing antibacterial activity
WO2005016883A2 (en) * 2003-08-14 2005-02-24 Icos Corporation Acrylamide derivatives as vla-1 integrin antagonists and uses thereof
ES2381879T3 (es) 2006-12-29 2012-06-01 Abbott Gmbh & Co. Kg Compuestos de carboxamida y su uso como inhibidores de calpaína
TWI453019B (zh) * 2007-12-28 2014-09-21 Abbvie Deutschland 甲醯胺化合物
TWI519530B (zh) 2009-02-20 2016-02-01 艾伯維德國有限及兩合公司 羰醯胺化合物及其作為鈣蛋白酶（ｃａｌｐａｉｎ）抑制劑之用途
US8236798B2 (en) 2009-05-07 2012-08-07 Abbott Gmbh & Co. Kg Carboxamide compounds and their use as calpain inhibitors
US9051304B2 (en) 2009-12-22 2015-06-09 AbbVie Deutschland GmbH & Co. KG Carboxamide compounds and their use as calpain inhibitors V
US8598211B2 (en) 2009-12-22 2013-12-03 Abbvie Inc. Carboxamide compounds and their use as calpain inhibitors IV
CN103501784A (zh) 2010-12-09 2014-01-08 Abbvie德国有限责任两合公司 甲酰胺化合物及它们作为钙蛋白酶抑制剂v的用途
JP2015512427A (ja) 2012-04-03 2015-04-27 アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー カルボキサミド化合物およびそれのカルパイン阻害薬ｖとしての使用
EP3426674A4 (en) 2016-03-09 2019-08-14 Blade Therapeutics, Inc. CYCLIC KETO AMID COMPOUNDS AS CALPAIN MODULATORS AND METHOD FOR THE PRODUCTION AND USE THEREOF
EP3481835A4 (en) 2016-07-05 2020-02-26 Blade Therapeutics, Inc. CALPAIN MODULATORS AND THEIR THERAPEUTIC USES
PE20191153A1 (es) 2016-09-28 2019-09-05 Blade Therapeutics Inc Moduladores de calpainas y usos terapeuticos de los mismos
CN110612102A (zh) 2017-06-01 2019-12-24 卫材R&D管理有限公司 含有吡唑并喹啉衍生物的路易氏体病治疗剂
CN116585316A (zh) 2017-06-01 2023-08-15 卫材R&D管理有限公司 包含pde9抑制剂的药物组合物
US20210009564A1 (en) * 2018-03-28 2021-01-14 Blade Therapertics, Inc. Calpain modulators and therapeutic uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0564552A1 (en) * 1990-12-28 1993-10-13 Cortex Pharmaceuticals, Inc. Use of calpain inhibitors in the inhibition and treatment of neurodegeneration
JPH06504547A (ja) 1990-12-28 1994-05-26 ジョージア・テック・リサーチ・コーポレーション ペプチドケトアミド、ケト酸およびケトエステル
CA2071621C (en) * 1991-06-19 1996-08-06 Ahihiko Hosoda Aldehyde derivatives
AU4544993A (en) 1992-06-24 1994-01-24 Cortex Pharmaceuticals, Inc. Use of calpain inhibitors in the inhibition and treatment of medical conditions associated with increased calpain activity
US5541290A (en) 1993-06-24 1996-07-30 Harbeson; Scott L. Optically pure calpain inhibitor compounds

Also Published As

Publication number Publication date
PL332720A1 (en) 1999-10-11
HRP970549A2 (en) 1998-08-31
CO4930264A1 (es) 2000-06-27
AU736754B2 (en) 2001-08-02
CN1239950A (zh) 1999-12-29
ZA979175B (en) 1999-04-14
AU4777097A (en) 1998-05-11
HUP9904104A3 (en) 2001-01-29
CA2268917A1 (en) 1998-04-23
SK38599A3 (en) 2000-04-10
HUP9904104A2 (hu) 2000-05-28
TR199900819T2 (xx) 1999-06-21
BG103338A (bg) 2000-01-31
DE19642591A1 (de) 1998-04-16
RU2189974C2 (ru) 2002-09-27
CZ126899A3 (cs) 1999-07-14
NO991761D0 (no) 1999-04-14
AR009379A1 (es) 2000-04-12
WO1998016512A1 (de) 1998-04-23
US6380220B1 (en) 2002-04-30
KR20000049130A (ko) 2000-07-25
BR9711908A (pt) 1999-08-24
JP2001501955A (ja) 2001-02-13
NZ334979A (en) 2001-02-23
IL129089A0 (en) 2000-02-17
EP0934273A1 (de) 1999-08-11

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Legal Events

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