NO995433L - Protease-inhibitorer - Google Patents
Protease-inhibitorerInfo
- Publication number
- NO995433L NO995433L NO995433A NO995433A NO995433L NO 995433 L NO995433 L NO 995433L NO 995433 A NO995433 A NO 995433A NO 995433 A NO995433 A NO 995433A NO 995433 L NO995433 L NO 995433L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- het
- 6alkyl
- 6alkenyl
- cycloalkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/99—Enzyme inactivation by chemical treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Genetics & Genomics (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- General Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Foreliggende oppfinnelse angår forbindelser med formel (I): R4 R3 R1 N-f)n O hvor: d) YerArellerNR1R2; R1 er R", R"C(O), R"C(S), R"SO2, R"OC(O), R"R'NC(O) eller R"R'NC(S); R2 er H, Ci-ealkyl, C2-6alkenyl, Ar-Co-6alkyl eller Hel-CQ.Qa\ky\; R3 er H, C2-6alkenyl, C2-6alkynyl, Het, Ar eller Ci-ealkyl eventuelt substituert med OR1, SR1, NR'2, N(R')C(O)OR", CO2R', CO2NR'2, N(C=NH)NH2, Het eller Ar; _ R4 er H, Ci.ealkyl, C2-6alkenyl, Ar-Co-6alkyl eller Het-Cn-ealkyl; R5, R-V2' er - Ar-CO-6alkyl, Het-C0.6alkyl, adamantyl-C(O)- Ar-C(O)-. Het-C(O)- eller; R6 er R", R"C(0), R"C(S), R"SO2, R"OC(O), R"R'NC(O). R"R'NC(S),eller R"OC(O)NR'CH(R*)C(O); R7 er Ca.gcykloalkyl-Co-ealkyl, Ar-Crj-ealkyl, Het-Cø-ealkyl, Ar- Crj.ealkoksy, Het-Crj-ealkoksy eller C-|-6alkyl eventuelt substituert med OR1, SR', NR'2, N(R')C(O)OR", C02R1, CO2NR'2, N(C=NH)NH2, Het eller Ar; R* er H, Ci^alkyl. C2-6alkenyl, Cs^cykloalkyl-CQ-S-alkyl, Ar-Co_6alkyl, Het-Crj-6alkyl; hver R' er uavhengig H, C-i^alkyl, C2-ealkenyl, Ar-Co-6alkyl eller Het-Co-ealkyl; hver R" er uavhengig C-i^alkyl, C3_6cykloalkyl-Co-6-alkyl, Ar-Co-6alkyl eller Het-Crj-ealkyl; R1" er H, C^øalkyl, Ca-scykloalkyl-Co-ealkyl, Ar-Cø-ealkyl eller Het- Z er C(O) eller CH2; og ner 1, 2 eller 3; eller et farmasøytisk godtagbart salt derav, som er inhibitorer av cystein- proteaser, spesielt cathepsin K og er nyttige ved behandling av sykdommer hvor hemning av bentap er en faktor.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4686597P | 1997-05-08 | 1997-05-08 | |
PCT/US1998/009192 WO1998050534A1 (en) | 1997-05-08 | 1998-05-06 | Protease inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
NO995433D0 NO995433D0 (no) | 1999-11-05 |
NO995433L true NO995433L (no) | 1999-11-05 |
Family
ID=21945814
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO995433A NO995433L (no) | 1997-05-08 | 1999-11-05 | Protease-inhibitorer |
Country Status (18)
Country | Link |
---|---|
US (1) | US6369077B1 (no) |
EP (1) | EP0991753A4 (no) |
JP (1) | JP2001525809A (no) |
KR (1) | KR20010012316A (no) |
CN (1) | CN1255162A (no) |
AU (1) | AU7288598A (no) |
BR (1) | BR9808502A (no) |
CA (1) | CA2289010A1 (no) |
CO (1) | CO4950617A1 (no) |
HU (1) | HUP0001285A3 (no) |
IL (1) | IL131661A0 (no) |
MA (1) | MA26494A1 (no) |
NO (1) | NO995433L (no) |
PE (1) | PE73799A1 (no) |
PL (1) | PL336625A1 (no) |
TR (1) | TR199902752T2 (no) |
WO (1) | WO1998050534A1 (no) |
ZA (1) | ZA983843B (no) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TR200001399T2 (tr) * | 1997-11-18 | 2000-11-21 | Teijin Limited | Siklik amin türevleri ve ilaç olarak kullanımları. |
CO5150165A1 (es) * | 1998-11-13 | 2002-04-29 | Smithkline Beecham Plc | Inhibidores de proteasa: tipo catepsina k |
CO5180541A1 (es) * | 1998-12-23 | 2002-07-30 | Smithkline Beechman Corp | Inhibidores de proteasa del tipo de 1,3-diaminocetonas con anillo de 8-14 miembros |
WO2000069815A1 (en) * | 1999-05-13 | 2000-11-23 | Teijin Limited | Ureido-substituted cyclic amine derivatives and their use as drug |
ATE277903T1 (de) | 1999-05-14 | 2004-10-15 | Bristol Myers Squibb Pharma Re | Zyklische aminderivate und ihre verwendung |
DK1179341T3 (da) * | 1999-05-18 | 2006-03-27 | Teijin Ltd | Lægemidler eller forebyggende midler mod sygdomme der er associeret med chemokiner |
WO2001010439A1 (fr) * | 1999-08-04 | 2001-02-15 | Teijin Limited | Antagonistes d'amine cyclique ccr3 |
WO2001042208A1 (fr) * | 1999-12-08 | 2001-06-14 | Teijin Limited | Antagonistes du recepteur ccr5 de la cycloamine |
ES2225297T3 (es) | 1999-12-21 | 2005-03-16 | Smithkline Beecham Corporation | Antagonistas del receptor de urotensina ii. |
AU780006B2 (en) | 2000-03-06 | 2005-02-24 | Acadia Pharmaceuticals, Inc. | Azacyclic compounds for use in the treatment of serotonin related diseases |
SK13632002A3 (sk) * | 2000-03-21 | 2003-02-04 | Smithkline Beecham Corporation | C1-6-alkyl-4-amino-azepán-3-ónové zlúčeniny, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty |
US6410566B1 (en) | 2000-05-16 | 2002-06-25 | Teijin Limited | Cyclic amine derivatives and their use as drugs |
US8211916B2 (en) | 2000-06-20 | 2012-07-03 | Wayne State University | N- and O-substituted 4-[2-(diphenylmethoxy)-ethyl]-1-[(phenyl)methyl]piperidine analogs and methods of treating CNS disorders therewith |
WO2001098266A2 (en) | 2000-06-20 | 2001-12-27 | Wayne State University | N-and o-substituted 4-[2-(diphenylmethoxy)-ethyl]-1-[(phenyl)methyl]piperidine analogs and methods of treating cns disorders therewith |
US6395753B1 (en) * | 2001-08-30 | 2002-05-28 | Kowa Co., Ltd. | Cyclic amine compounds and pharmaceutical composition containing the same |
RU2315051C2 (ru) | 2001-12-28 | 2008-01-20 | Акадиа Фармасьютикалз, Инк. | Спироазациклические соединения, способ ингибирования активности или активации серотонинового 5-нт2а рецептора, способ лечения болезненного состояния, связанного с серотониновым 5-нт2а рецептором, и их применение |
JP2005515254A (ja) | 2002-01-17 | 2005-05-26 | スミスクライン ビーチャム コーポレーション | カテプシンk阻害剤として有用なシクロアルキルケトアミド誘導体 |
US7538222B2 (en) | 2002-06-24 | 2009-05-26 | Acadia Pharmaceuticals, Inc. | N-substituted piperidine derivatives as serotonin receptor agents |
WO2004000808A2 (en) | 2002-06-24 | 2003-12-31 | Acadia Pharmaceuticals Inc. | N-substituted piperidine derivatives as serotonin receptor agents |
US7253186B2 (en) | 2002-06-24 | 2007-08-07 | Carl-Magnus Andersson | N-substituted piperidine derivatives as serotonin receptor agents |
KR100962972B1 (ko) | 2002-07-26 | 2010-06-09 | 주식회사유한양행 | 1-페닐피페리딘-3-온 유도체 및 그의 제조방법 |
ES2367135T3 (es) | 2003-01-16 | 2011-10-28 | Acadia Pharmaceuticals Inc. | Agonistas inversos selectivos de los receptores 2a o 2c de serotonina utilzados como agentes terapéuticos para enfermedades neurodegenerativas. |
US20040192674A1 (en) * | 2003-02-14 | 2004-09-30 | Marquis Robert W. | Cathepsin L inhibitors |
US7109243B2 (en) * | 2003-03-24 | 2006-09-19 | Irm Llc | Inhibitors of cathepsin S |
US7384970B2 (en) * | 2003-03-24 | 2008-06-10 | Irm Llc | Inhibitors of cathepsin S |
US8017791B2 (en) | 2003-03-28 | 2011-09-13 | Wayne State University | Tri-substituted 2-benzhydryl-5-benzylamino-tetrahydro-pyran-4-ol and 6-benzhydryl-4-benzylamino-tetrahydro-pyran-3-ol analogues, and novel, 3,6-disubstituted pyran derivatives |
WO2005105075A1 (en) | 2004-04-16 | 2005-11-10 | Wayne State University | Tri-substitued 2-benzhydryl-5-benzlamino-tetrahydro-pyran-4-ol and 6-benzhydryl-4-benzylamino-tetrahydro-pyran-3-ol analogues, and novel 3,6-disubstituted pyran derivatives |
US7173051B2 (en) * | 2003-06-13 | 2007-02-06 | Irm, Llc | Inhibitors of cathepsin S |
US7256207B2 (en) * | 2003-08-20 | 2007-08-14 | Irm Llc | Inhibitors of cathepsin S |
US20050261278A1 (en) | 2004-05-21 | 2005-11-24 | Weiner David M | Selective serotonin receptor inverse agonists as therapeutics for disease |
US7820695B2 (en) | 2004-05-21 | 2010-10-26 | Acadia Pharmaceuticals, Inc. | Selective serotonin receptor inverse agonists as therapeutics for disease |
JP2008512461A (ja) * | 2004-09-07 | 2008-04-24 | スミスクライン・ビーチャム・コーポレイション | 新規化合物 |
US7790899B2 (en) | 2004-09-27 | 2010-09-07 | Acadia Pharmaceuticals, Inc. | Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms |
CN101035759B (zh) | 2004-09-27 | 2011-06-15 | 阿卡蒂亚药品公司 | N-(4-氟苄基)-n-(1-甲基哌啶-4-基)-n’-(4-(2-甲基丙氧基)苯基甲基)脲及其酒石酸盐的合成和晶形 |
CN102558075A (zh) | 2004-12-03 | 2012-07-11 | 先灵公司 | 作为cb1拮抗剂的取代哌嗪 |
MX2008002363A (es) * | 2005-08-17 | 2008-03-18 | Schering Corp | Ligandos novedosos de cinasa basados en quinolina de alta afinidad. |
US8067415B2 (en) | 2005-11-01 | 2011-11-29 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of CCR2 |
WO2007053498A1 (en) * | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
WO2007053495A2 (en) * | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
AR058985A1 (es) * | 2006-01-13 | 2008-03-05 | Schering Corp | Diaril piperidinas como moduladores de cb1. |
AR059021A1 (es) * | 2006-01-18 | 2008-03-05 | Schering Corp | Moduladores de receptores cannabinoides |
JPWO2008029924A1 (ja) * | 2006-09-08 | 2010-01-21 | 大日本住友製薬株式会社 | 環状アミノアルキルカルボキサミド誘導体 |
PL2134330T3 (pl) | 2007-03-19 | 2013-10-31 | Acadia Pharm Inc | Kombinacje odwrotnych agonistów i antagonistów 5-HT2A z antypsychotykami |
WO2008130616A2 (en) * | 2007-04-19 | 2008-10-30 | Schering Corporation | Diaryl morpholines as cb1 modulators |
BRPI0814806A2 (pt) * | 2007-06-28 | 2015-02-03 | Intervet Int Bv | Pirazinas substituídas como antagonistas de cb1 |
CN101790521A (zh) * | 2007-06-28 | 2010-07-28 | 英特维特国际股份有限公司 | 作为cb1拮抗剂的取代哌嗪 |
US8686152B2 (en) | 2010-03-10 | 2014-04-01 | Janssen Pharmaceutica Nv | 4,4-disubstituted piperidine derivatives useful as inhibitors of dipeptidyl peptidase-1 (DPP-1) |
CN102933214A (zh) * | 2010-03-10 | 2013-02-13 | 詹森药业有限公司 | 可用作二肽基肽酶-1(dpp-1)抑制剂的4,4-二取代的哌啶衍生物 |
AU2015240519B2 (en) | 2014-04-04 | 2019-08-15 | X-Rx, Inc. | Substituted spirocyclic inhibitors of autotaxin |
CA2992728A1 (en) | 2015-07-20 | 2017-01-26 | Acadia Pharmaceuticals Inc. | Methods for preparing n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and polymorphic form c |
US10953000B2 (en) | 2016-03-25 | 2021-03-23 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome P450 modulators |
WO2017165635A1 (en) | 2016-03-25 | 2017-09-28 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome p450 modulators |
WO2018118626A1 (en) | 2016-12-20 | 2018-06-28 | Acadia Pharmaceuticals Inc. | Pimavanserin alone or in combination for use in the treatment of alzheimer's disease psychosis |
WO2018200977A1 (en) | 2017-04-28 | 2018-11-01 | Acadia Pharmaceuticals Inc. | Pimavanserin for treating impulse control disorder |
EP3675827A1 (en) | 2017-08-30 | 2020-07-08 | Acadia Pharmaceuticals Inc. | Formulations of pimavanserin |
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DE2804416A1 (de) | 1978-02-02 | 1979-08-09 | Boehringer Mannheim Gmbh | Neue purin-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
ES482439A0 (es) | 1978-07-18 | 1980-04-01 | Hoechst Ag | Procedimiento para la preparacion de nuevos derivados de 1-(4-aminopiperidino)-3,4-dihidroisoquinoleina. |
US4301151A (en) | 1979-11-27 | 1981-11-17 | Merck & Co., Inc. | Long-lasting agonists of enkephalin |
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US4680283A (en) * | 1984-09-26 | 1987-07-14 | Merck & Co., Inc. | Analogs of substance P and eledoisin |
DK386089A (da) | 1988-08-12 | 1990-02-13 | Japan Tobacco Inc | Katekolderivater |
IE903196A1 (en) | 1989-09-05 | 1991-03-13 | Searle & Co | Substituted n-benzylpiperidine amides |
US5204462A (en) | 1990-03-30 | 1993-04-20 | Japan Tobacco, Inc. | 4h-3,1-benzoxazin-4-one derivative |
US5514694A (en) * | 1992-09-21 | 1996-05-07 | Georgia Tech Research Corp | Peptidyl ketoamides |
WO1994027967A1 (en) * | 1993-05-26 | 1994-12-08 | Smithkline Beecham Laboratoires Pharmaceutiques | Novel compounds |
US5827866A (en) | 1995-06-07 | 1998-10-27 | Ortho Pharmaceutical Corporation | Peptidyl heterocycles useful in the treatment of thrombin related disorders |
DZ2285A1 (fr) | 1996-08-08 | 2002-12-25 | Smithkline Beecham Corp | Inhibiteurs de protéase de la cystéine. |
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1998
- 1998-05-06 PE PE1998000344A patent/PE73799A1/es not_active Application Discontinuation
- 1998-05-06 CN CN98804794A patent/CN1255162A/zh active Pending
- 1998-05-06 BR BR9808502-6A patent/BR9808502A/pt not_active Application Discontinuation
- 1998-05-06 AU AU72885/98A patent/AU7288598A/en not_active Abandoned
- 1998-05-06 WO PCT/US1998/009192 patent/WO1998050534A1/en not_active Application Discontinuation
- 1998-05-06 TR TR1999/02752T patent/TR199902752T2/xx unknown
- 1998-05-06 HU HU0001285A patent/HUP0001285A3/hu unknown
- 1998-05-06 JP JP54841898A patent/JP2001525809A/ja not_active Ceased
- 1998-05-06 IL IL13166198A patent/IL131661A0/xx unknown
- 1998-05-06 PL PL98336625A patent/PL336625A1/xx not_active Application Discontinuation
- 1998-05-06 US US09/423,325 patent/US6369077B1/en not_active Expired - Fee Related
- 1998-05-06 MA MA25064A patent/MA26494A1/fr unknown
- 1998-05-06 KR KR1019997010268A patent/KR20010012316A/ko not_active Application Discontinuation
- 1998-05-06 CA CA002289010A patent/CA2289010A1/en not_active Abandoned
- 1998-05-06 EP EP98920274A patent/EP0991753A4/en not_active Withdrawn
- 1998-05-07 ZA ZA983843A patent/ZA983843B/xx unknown
- 1998-05-08 CO CO98025629A patent/CO4950617A1/es unknown
-
1999
- 1999-11-05 NO NO995433A patent/NO995433L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US6369077B1 (en) | 2002-04-09 |
CO4950617A1 (es) | 2000-09-01 |
NO995433D0 (no) | 1999-11-05 |
TR199902752T2 (xx) | 2000-06-21 |
EP0991753A1 (en) | 2000-04-12 |
HUP0001285A2 (hu) | 2000-09-28 |
CN1255162A (zh) | 2000-05-31 |
WO1998050534A1 (en) | 1998-11-12 |
PL336625A1 (en) | 2000-07-03 |
IL131661A0 (en) | 2001-01-28 |
ZA983843B (en) | 1998-11-09 |
KR20010012316A (ko) | 2001-02-15 |
BR9808502A (pt) | 2000-05-23 |
MA26494A1 (fr) | 2004-12-20 |
PE73799A1 (es) | 1999-10-22 |
CA2289010A1 (en) | 1998-11-12 |
EP0991753A4 (en) | 2001-07-11 |
HUP0001285A3 (en) | 2000-10-30 |
AU7288598A (en) | 1998-11-27 |
JP2001525809A (ja) | 2001-12-11 |
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