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NO983444L - Benzo(c)kinolizin derivater, deres fremstilling og anvendelse som 5<alfa>-reduktaseinhibitorer - Google Patents

Benzo(c)kinolizin derivater, deres fremstilling og anvendelse som 5<alfa>-reduktaseinhibitorer

Info

Publication number
NO983444L
NO983444L NO983444A NO983444A NO983444L NO 983444 L NO983444 L NO 983444L NO 983444 A NO983444 A NO 983444A NO 983444 A NO983444 A NO 983444A NO 983444 L NO983444 L NO 983444L
Authority
NO
Norway
Prior art keywords
benzo
preparation
alfa
reductase inhibitors
quinolizine derivatives
Prior art date
Application number
NO983444A
Other languages
English (en)
Other versions
NO983444D0 (no
NO320155B1 (no
Inventor
Antonio Guarna
Mario Serio
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of NO983444L publication Critical patent/NO983444L/no
Publication of NO983444D0 publication Critical patent/NO983444D0/no
Publication of NO320155B1 publication Critical patent/NO320155B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D455/00Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/227Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28Antiandrogens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D455/00Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO19983444A 1996-02-09 1998-07-24 Benzo(c)kinolizinderivater, deres fremstilling, farmasoytisk sammensetning som inneholder derivatene, og anvendelse av derivatene til a fremstille et legemiddel NO320155B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96FI000019A IT1286545B1 (it) 1996-02-09 1996-02-09 Derivati benzo(c) chinolizinici,loro preparazione ed uso come inibitori delle 5-alfa-riduttasi
PCT/EP1997/000552 WO1997029107A1 (en) 1996-02-09 1997-02-07 BENZO[C]QUINOLIZINE DERIVATIVES, THEIR PREPARATION AND USE AS 5α-REDUCTASES INHIBITORS

Publications (3)

Publication Number Publication Date
NO983444L true NO983444L (no) 1998-07-24
NO983444D0 NO983444D0 (no) 1998-07-24
NO320155B1 NO320155B1 (no) 2005-11-07

Family

ID=11351478

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19983444A NO320155B1 (no) 1996-02-09 1998-07-24 Benzo(c)kinolizinderivater, deres fremstilling, farmasoytisk sammensetning som inneholder derivatene, og anvendelse av derivatene til a fremstille et legemiddel
NO20045132A NO20045132L (no) 1996-02-09 2004-11-24 Benzo(c)kinolizinderivater, deres fremstilling og anvendelse som 5alfa- reduktaseinhibitorer

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20045132A NO20045132L (no) 1996-02-09 2004-11-24 Benzo(c)kinolizinderivater, deres fremstilling og anvendelse som 5alfa- reduktaseinhibitorer

Country Status (26)

Country Link
US (3) US6303622B1 (no)
EP (1) EP0880520B1 (no)
JP (1) JP2000504680A (no)
KR (1) KR100480448B1 (no)
CN (1) CN1116296C (no)
AT (1) ATE237614T1 (no)
AU (1) AU711886C (no)
BG (1) BG64596B1 (no)
CZ (1) CZ298061B6 (no)
DE (1) DE69720966T2 (no)
DK (1) DK0880520T3 (no)
EA (1) EA000975B1 (no)
EE (1) EE04058B1 (no)
ES (1) ES2192263T3 (no)
HK (1) HK1018783A1 (no)
HU (1) HUP9900509A3 (no)
IL (2) IL125628A0 (no)
IT (1) IT1286545B1 (no)
MX (1) MX9806229A (no)
NO (2) NO320155B1 (no)
NZ (1) NZ331256A (no)
PL (1) PL187618B1 (no)
PT (1) PT880520E (no)
SK (1) SK283299B6 (no)
UA (1) UA67724C2 (no)
WO (1) WO1997029107A1 (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITFI970193A1 (it) * 1997-08-01 1999-02-01 Applied Research Systems Uso di derivati benzo(c) chinolizinici come regolatori della crescita delle piante e composizioni ad uso agricolo che contengono tali
EP0926148A1 (en) * 1997-12-23 1999-06-30 Applied Research Systems Ars Holding N.V. Benzo (C)quinolizine derivatives, their preparation and use as 5-alphareductases inhibitors
IL141212A0 (en) 1998-08-03 2002-03-10 Applied Research Systems Process for the synthesis of (1h)-benzo [c] quinolizin-3-one derivatives
MX2007014114A (es) 2005-05-10 2008-03-14 Intermune Inc Derivados de piridona para modular el sistema de proteina cinasa activada por estres.
US20070155738A1 (en) 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
KR20080087070A (ko) * 2005-05-20 2008-09-30 알란토스 파마슈티컬즈 홀딩, 인코포레이티드 피리미딘 또는 트리아진 융합된 비시클릭 메탈로프로테아제억제제
ES2567283T3 (es) 2008-06-03 2016-04-21 Intermune, Inc. Compuestos y métodos para tratar trastornos inflamatorios y fibróticos
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
EP3126362B1 (en) 2014-04-02 2022-01-12 Intermune, Inc. Anti-fibrotic pyridinones
CN105001216B (zh) * 2015-07-08 2017-03-01 中国科学院兰州化学物理研究所 一种喹嗪酮的制备方法
CN107089980B (zh) * 2017-05-11 2019-08-30 合肥工业大学 一种手性苯并[a]喹嗪-2-酮类化合物及其不对称催化合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1534278A (fr) * 1966-08-15 1968-07-26 Bristol Myers Co Procédé de fabrication de 1, 4-dihydroquinoléine-n-carboxylates d'alcoyle
US3455929A (en) * 1966-08-15 1969-07-15 Bristol Myers Co Esters of 1,4-dihydroquinoline-n-carboxylic acids and thione acids
US3625877A (en) * 1968-01-08 1971-12-07 Eastman Kodak Co High-modulus polycarbonate compositions
SU1027166A1 (ru) * 1981-09-11 1983-07-07 Киевский Ордена Ленина Государственный Университет Им.Т.Г.Шевченко Способ получени 1,2-полиметиленкетоцианоазагетероциклов
IE57014B1 (en) 1983-03-25 1992-03-11 Wyeth John & Brother Ltd Benzoquinolizines

Also Published As

Publication number Publication date
IT1286545B1 (it) 1998-07-15
CZ298061B6 (cs) 2007-06-06
US6552034B2 (en) 2003-04-22
JP2000504680A (ja) 2000-04-18
EE04058B1 (et) 2003-06-16
ATE237614T1 (de) 2003-05-15
IL125628A (en) 2006-10-31
UA67724C2 (en) 2004-07-15
AU711886B2 (en) 1999-10-21
EA000975B1 (ru) 2000-08-28
CN1210536A (zh) 1999-03-10
SK104498A3 (en) 1998-12-02
PL328123A1 (en) 1999-01-18
DE69720966D1 (de) 2003-05-22
EE9800233A (et) 1998-12-15
CZ228998A3 (cs) 1998-10-14
HUP9900509A2 (hu) 1999-06-28
PT880520E (pt) 2003-07-31
HUP9900509A3 (en) 1999-11-29
AU711886C (en) 2002-10-17
NO983444D0 (no) 1998-07-24
NZ331256A (en) 1999-06-29
NO320155B1 (no) 2005-11-07
PL187618B1 (pl) 2004-08-31
BG102661A (en) 1999-04-30
EP0880520A1 (en) 1998-12-02
US6303622B1 (en) 2001-10-16
WO1997029107A1 (en) 1997-08-14
KR100480448B1 (ko) 2005-08-31
IL125628A0 (en) 1999-04-11
ITFI960019A0 (no) 1996-02-09
NO20045132L (no) 1998-07-24
BG64596B1 (bg) 2005-08-31
DK0880520T3 (da) 2003-08-11
ITFI960019A1 (it) 1997-08-09
HK1018783A1 (en) 2000-01-07
KR19990082126A (ko) 1999-11-15
DE69720966T2 (de) 2004-05-19
EA199800701A1 (ru) 1999-02-25
EP0880520B1 (en) 2003-04-16
SK283299B6 (sk) 2003-05-02
US20010044542A1 (en) 2001-11-22
CN1116296C (zh) 2003-07-30
AU1767297A (en) 1997-08-28
US20010047098A1 (en) 2001-11-29
US6555549B2 (en) 2003-04-29
ES2192263T3 (es) 2003-10-01
MX9806229A (es) 1998-11-30

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Legal Events

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Representative=s name: ONSAGERS AS, POSTBOKS 6963 ST OLAVS PLASS, 0130 OS

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