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NO972911L - Stabiliserte ribozym-analoger - Google Patents

Stabiliserte ribozym-analoger

Info

Publication number
NO972911L
NO972911L NO972911A NO972911A NO972911L NO 972911 L NO972911 L NO 972911L NO 972911 A NO972911 A NO 972911A NO 972911 A NO972911 A NO 972911A NO 972911 L NO972911 L NO 972911L
Authority
NO
Norway
Prior art keywords
analogues
ribozyme
making
stabilized
stabilized ribozyme
Prior art date
Application number
NO972911A
Other languages
English (en)
Other versions
NO972911D0 (no
Inventor
John Goodchild
Steven M Nesbitt
Original Assignee
Hybridon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybridon Inc filed Critical Hybridon Inc
Publication of NO972911D0 publication Critical patent/NO972911D0/no
Publication of NO972911L publication Critical patent/NO972911L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
    • C12N2310/3125—Methylphosphonates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification

Landscapes

  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
  • Amplifiers (AREA)
  • Saccharide Compounds (AREA)

Abstract

Det beskrives stabiliserte ribozym-analoger som har evne til endonukleolytisk å spalte en sekvens av 3' til 5' koblede ribonukleotider. Disse ribozym-analogene innbefatter modifikasjoner i bestemte sløyfe-, katalytisk kjerne- og flankerende region-nukleotider, hvilket gjør dem mer resistente overfor nukleaser.Det beskrives også fremgangsmåter for fremstilling og utnyttelse av ribozym-analogen ifølge oppfinnelsen, samt farmasøytiske formuleringer og sett som inneholder slike rjbozym-analoger.
NO972911A 1994-12-22 1997-06-20 Stabiliserte ribozym-analoger NO972911L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/361,687 US5545729A (en) 1994-12-22 1994-12-22 Stabilized ribozyme analogs
PCT/US1995/015871 WO1996019568A2 (en) 1994-12-22 1995-12-05 Stabilized ribozyme analogs

Publications (2)

Publication Number Publication Date
NO972911D0 NO972911D0 (no) 1997-06-20
NO972911L true NO972911L (no) 1997-08-19

Family

ID=23423065

Family Applications (1)

Application Number Title Priority Date Filing Date
NO972911A NO972911L (no) 1994-12-22 1997-06-20 Stabiliserte ribozym-analoger

Country Status (7)

Country Link
US (1) US5545729A (no)
EP (1) EP0795010A2 (no)
JP (1) JPH10510992A (no)
AU (1) AU4417296A (no)
CA (1) CA2208427A1 (no)
NO (1) NO972911L (no)
WO (1) WO1996019568A2 (no)

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US6335434B1 (en) 1998-06-16 2002-01-01 Isis Pharmaceuticals, Inc., Nucleosidic and non-nucleosidic folate conjugates
US8153602B1 (en) 1991-11-19 2012-04-10 Isis Pharmaceuticals, Inc. Composition and methods for the pulmonary delivery of nucleic acids
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WO1997006252A1 (en) * 1995-08-08 1997-02-20 Hybridon, Inc. Synthetic oligonucleotides with enhanced ribonuclease activity
US20080160524A1 (en) * 1996-01-24 2008-07-03 Third Wave Technologies, Inc. Methods and Compositions for Detecting Target Sequences
US5985557A (en) 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
US6706471B1 (en) 1996-01-24 2004-03-16 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US7195871B2 (en) * 1996-01-24 2007-03-27 Third Wave Technologies, Inc Methods and compositions for detecting target sequences
US6875572B2 (en) 1996-01-24 2005-04-05 Third Wave Technologies, Inc. Nucleic acid detection assays
US7122364B1 (en) 1998-03-24 2006-10-17 Third Wave Technologies, Inc. FEN endonucleases
US6274369B1 (en) * 1996-02-02 2001-08-14 Invitrogen Corporation Method capable of increasing competency of bacterial cell transformation
EP2374890B1 (en) 1996-11-29 2012-11-14 Third Wave Technologies, Inc. Fen-1 endonucleases, mixtures and cleavage methods
US6300483B1 (en) * 1997-06-19 2001-10-09 Ribozyme Pharmaceuticals, Inc. Compositions inducing cleavage of RNA motifs
EP0887405A1 (en) * 1997-06-25 1998-12-30 Gene Shears Pty Limited Process for producing stabilised RNA molecules within cells, RNA molecules thus produced and nucleic acid precursors of such molecules
EP1012331B1 (en) 1997-07-01 2006-03-29 Isis Pharmaceuticals, Inc. Compositions and methods for the delivery of oligonucleotides via the alimentary canal
US8182991B1 (en) 1997-11-26 2012-05-22 Third Wave Technologies, Inc. FEN-1 endonucleases, mixtures and cleavage methods
AU753270B2 (en) 1998-05-21 2002-10-10 Isis Pharmaceuticals, Inc. Compositions and methods for topical delivery of oligonucleotides
WO1999060012A1 (en) 1998-05-21 1999-11-25 Isis Pharmaceuticals, Inc. Compositions and methods for non-parenteral delivery of oligonucleotides
US6656730B1 (en) 1999-06-15 2003-12-02 Isis Pharmaceuticals, Inc. Oligonucleotides conjugated to protein-binding drugs
WO2002070755A2 (en) * 2000-11-15 2002-09-12 Third Wave Technologies, Inc. Fen endonucleases
US20030124196A1 (en) 2001-08-22 2003-07-03 Susan Weinbach Pulsatile release compositions and methods for enhanced intestinal drug absorption
EP1578767A4 (en) * 2002-12-04 2008-01-09 Algos Therapeutics Inc METHOD AND MATERIALS FOR MODULATING TRPM2
US8084432B2 (en) * 2003-02-13 2011-12-27 Isis Pharmaceuticals, Inc. Compositions and methods for treatment of pouchitis
WO2005097817A2 (en) 2004-04-05 2005-10-20 Alnylam Pharmaceuticals, Inc. Process and reagents for oligonucleotide synthesis and purification
CA2562151C (en) 2004-04-30 2016-09-06 Alnylam Pharmaceuticals, Inc. Oligonucleotides comprising a c5-modified pyrimidine
WO2006088490A2 (en) 2004-06-30 2006-08-24 Alnylam Pharmaceuticals, Inc. Oligonucleotides comprising a non-phosphate backbone linkage
DK2385141T3 (da) * 2005-10-07 2013-10-28 Speedx Pty Ltd Flerkomponentnukleinsyreenzymer og fremgangsmåder til anvendelse heraf
EP1934348B1 (en) * 2005-10-11 2018-05-02 Ben-Gurion University Of The Negev Research And Development Authority Compositions for silencing the expression of vdac1 and uses thereof
KR100652903B1 (ko) * 2005-12-21 2006-12-04 한국과학기술연구원 초흡수성 고분자를 함유한 제습제의 제조 방법 및 그 제조장치
US9127311B2 (en) * 2006-10-06 2015-09-08 Speedx Pty Ltd Molecular switches and methods for their use
US9279127B2 (en) * 2006-11-01 2016-03-08 The Medical Research Fund At The Tel-Aviv Sourasky Medical Center Adipocyte-specific constructs and methods for inhibiting platelet-type 12 lipoxygenase expression
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JP6008841B2 (ja) 2010-05-03 2016-10-19 エータイアー ファーマ， インコーポレイテッド メチオニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
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Also Published As

Publication number Publication date
WO1996019568A3 (en) 1996-09-06
WO1996019568A2 (en) 1996-06-27
NO972911D0 (no) 1997-06-20
AU4417296A (en) 1996-07-10
US5545729A (en) 1996-08-13
JPH10510992A (ja) 1998-10-27
EP0795010A2 (en) 1997-09-17
CA2208427A1 (en) 1996-06-27

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